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The map label for this gene is hemA [H]

Identifier: 23501226

GI number: 23501226

Start: 331662

End: 332939

Strand: Reverse

Name: hemA [H]

Synonym: BR0319

Alternate gene names: 23501226

Gene position: 332939-331662 (Counterclockwise)

Preceding gene: 23501227

Following gene: 23501224

Centisome position: 15.8

GC content: 58.45

Gene sequence:

>1278_bases
ATGGACTATCGCCGTTTTTTTGAAGAAGCGATCGACCAGTTACATGCCGAGAAGCGTTATCGCGTTTTTGCTGATCTTGA
GCGTATCGTTGGACGTTTCCCCCAAGCTATCTGGCGTAACAATGGCACAGCCCGTGAAATCACCGTATGGTGTTCCAACG
ATTATCTGGGAATGGGACATCACCCGGACGTCATAAAGGCTATGTGCGAGACCGCAGGCAGTGCCGGTTCAGGTGCTGGC
GGCACACGTAATATTTCCGGTAACAACCACCCGCTCGTCGAGCTGGAGAGCGAACTGGCCGACCTGCACGGCAAGGAAGC
CGGCCTGGTCTTCACATCCGGTTTCGTTTCCAACGAAGCTTCGATCTCGACCATCGCGCGGCTTCTGCCGAACTGCCTCA
TCCTTTCCGATGAACTGAACCATGCCTCGATGATCGAGGGTGTGCGCCATTCGGGCGCAGAAAAGAAGATTTTCCGCCAC
AACGATGTCGAGCATCTGGAACAGCTTCTGAAGGCTGCGGACCGCTCCCGCGCCAAGCTGATTGTGTTTGAATCCGTCTA
TTCGATGGACGGCGATATTGCGCCTATCGAAAAGATTGCCGATCTTGCCGACAAATATAACGCCATGACCTATATCGACG
AAGTCCATGCGGTCGGTATGTATGGTGCGCATGGCGGCGGCATCACCGAACGTGACGGCCTTGCCCATCGCATCGATATT
ATCGAAGGCACGCTTGCCAAGGCATTTGGCGCGCTCGGCGGCTATATCACCGGCTCACGCGCGATCATCGATGCGGTGCG
TTCCTATGCGCCGGGCTTCATCTTCACGACCTCGCTGCCGCCTGCCGTGGCTGCGGCCGCAACCGCTGCAATCCGCCACC
TGAAATCCTCGCAGGCTGAACGCGACGGCCAGCAGCGCCAGGCGCAACGTGCCAAGGACGTGCTTTCGGCTGCCGGACTG
CCCGTCATGCCGTCGCAGACCCATATCGTGCCGATCCTCGTGGGCGATCCGGAACTGTGCAAGAAGGCAAGCGACCGCCT
GCTCGAAGTGCACGGCATCTATATCCAGCCGATCAATTATCCAACCGTACCGCGCGGCACCGAGCGCCTGCGCATCACGC
CGTCGCCGCTGCACGACGACAAGCTGATCGACGGCCTGAAGGACGCGCTTCTGGAAGTCTGGAACGAGCTTGGTATTCCC
TTTGCCGAGCCTTCAGCACCGCAGGCAGCAAATTCGGACCGCATCATCCCGTTGATGGTTTCCAAGGCGGGCGGCTGA

Upstream 100 bases:

>100_bases
GCTCAATGCTCCTTCAAGCAAACGTGGCAAATTGCCCGACCATGGGCCATGGACGCCAAAGGCCAATGGCGCTAATTAGG
GCGAAGACAAGGAGCGCATT

Downstream 100 bases:

>100_bases
TAGCTCATCGAATATGAAACTGAAAAAGGCCGGTTTTCCCGGCCTTTTTCAGTTTCAGAGCCTGCTGGAATTCCATCAGG
CTTTTTGCTGCTTTGCCAGG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MDYRRFFEEAIDQLHAEKRYRVFADLERIVGRFPQAIWRNNGTAREITVWCSNDYLGMGHHPDVIKAMCETAGSAGSGAG
GTRNISGNNHPLVELESELADLHGKEAGLVFTSGFVSNEASISTIARLLPNCLILSDELNHASMIEGVRHSGAEKKIFRH
NDVEHLEQLLKAADRSRAKLIVFESVYSMDGDIAPIEKIADLADKYNAMTYIDEVHAVGMYGAHGGGITERDGLAHRIDI
IEGTLAKAFGALGGYITGSRAIIDAVRSYAPGFIFTTSLPPAVAAAATAAIRHLKSSQAERDGQQRQAQRAKDVLSAAGL
PVMPSQTHIVPILVGDPELCKKASDRLLEVHGIYIQPINYPTVPRGTERLRITPSPLHDDKLIDGLKDALLEVWNELGIP
FAEPSAPQAANSDRIIPLMVSKAGG

Sequences:

>Translated_425_residues
MDYRRFFEEAIDQLHAEKRYRVFADLERIVGRFPQAIWRNNGTAREITVWCSNDYLGMGHHPDVIKAMCETAGSAGSGAG
GTRNISGNNHPLVELESELADLHGKEAGLVFTSGFVSNEASISTIARLLPNCLILSDELNHASMIEGVRHSGAEKKIFRH
NDVEHLEQLLKAADRSRAKLIVFESVYSMDGDIAPIEKIADLADKYNAMTYIDEVHAVGMYGAHGGGITERDGLAHRIDI
IEGTLAKAFGALGGYITGSRAIIDAVRSYAPGFIFTTSLPPAVAAAATAAIRHLKSSQAERDGQQRQAQRAKDVLSAAGL
PVMPSQTHIVPILVGDPELCKKASDRLLEVHGIYIQPINYPTVPRGTERLRITPSPLHDDKLIDGLKDALLEVWNELGIP
FAEPSAPQAANSDRIIPLMVSKAGG
>Mature_425_residues
MDYRRFFEEAIDQLHAEKRYRVFADLERIVGRFPQAIWRNNGTAREITVWCSNDYLGMGHHPDVIKAMCETAGSAGSGAG
GTRNISGNNHPLVELESELADLHGKEAGLVFTSGFVSNEASISTIARLLPNCLILSDELNHASMIEGVRHSGAEKKIFRH
NDVEHLEQLLKAADRSRAKLIVFESVYSMDGDIAPIEKIADLADKYNAMTYIDEVHAVGMYGAHGGGITERDGLAHRIDI
IEGTLAKAFGALGGYITGSRAIIDAVRSYAPGFIFTTSLPPAVAAAATAAIRHLKSSQAERDGQQRQAQRAKDVLSAAGL
PVMPSQTHIVPILVGDPELCKKASDRLLEVHGIYIQPINYPTVPRGTERLRITPSPLHDDKLIDGLKDALLEVWNELGIP
FAEPSAPQAANSDRIIPLMVSKAGG

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=409, Percent_Identity=49.1442542787286, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI83977440, Length=409, Percent_Identity=49.1442542787286, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI83977444, Length=409, Percent_Identity=49.1442542787286, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=49.1315136476427, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=49.1315136476427, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI7657118, Length=356, Percent_Identity=35.6741573033708, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=35.9195402298851, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI119220554, Length=399, Percent_Identity=30.3258145363409, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI4758668, Length=386, Percent_Identity=30.3108808290155, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=28.2258064516129, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1790046, Length=398, Percent_Identity=34.1708542713568, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=33.0459770114943, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=376, Percent_Identity=34.8404255319149, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI32566772, Length=431, Percent_Identity=29.4663573085847, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17560914, Length=322, Percent_Identity=32.6086956521739, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17560912, Length=322, Percent_Identity=32.6086956521739, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI71982617, Length=280, Percent_Identity=28.2142857142857, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71982625, Length=280, Percent_Identity=28.2142857142857, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=48.8151658767773, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6320267, Length=399, Percent_Identity=28.8220551378446, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=292, Percent_Identity=25.3424657534247, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17137420, Length=412, Percent_Identity=50, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24662918, Length=374, Percent_Identity=36.096256684492, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI17136286, Length=397, Percent_Identity=29.4710327455919, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24653280, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653276, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653278, Length=273, Percent_Identity=29.3040293040293, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 46138; Mature: 46138

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYRRFFEEAIDQLHAEKRYRVFADLERIVGRFPQAIWRNNGTAREITVWCSNDYLGMGH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCC
HPDVIKAMCETAGSAGSGAGGTRNISGNNHPLVELESELADLHGKEAGLVFTSGFVSNEA
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCEEEECCCCCCCH
SISTIARLLPNCLILSDELNHASMIEGVRHSGAEKKIFRHNDVEHLEQLLKAADRSRAKL
HHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHCCCCCEE
IVFESVYSMDGDIAPIEKIADLADKYNAMTYIDEVHAVGMYGAHGGGITERDGLAHRIDI
EEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
IEGTLAKAFGALGGYITGSRAIIDAVRSYAPGFIFTTSLPPAVAAAATAAIRHLKSSQAE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RDGQQRQAQRAKDVLSAAGLPVMPSQTHIVPILVGDPELCKKASDRLLEVHGIYIQPINY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHCEEEEECEEEEECCC
PTVPRGTERLRITPSPLHDDKLIDGLKDALLEVWNELGIPFAEPSAPQAANSDRIIPLMV
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
SKAGG
ECCCC
>Mature Secondary Structure
MDYRRFFEEAIDQLHAEKRYRVFADLERIVGRFPQAIWRNNGTAREITVWCSNDYLGMGH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCC
HPDVIKAMCETAGSAGSGAGGTRNISGNNHPLVELESELADLHGKEAGLVFTSGFVSNEA
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCEEEECCCCCCCH
SISTIARLLPNCLILSDELNHASMIEGVRHSGAEKKIFRHNDVEHLEQLLKAADRSRAKL
HHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHCCCCCEE
IVFESVYSMDGDIAPIEKIADLADKYNAMTYIDEVHAVGMYGAHGGGITERDGLAHRIDI
EEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
IEGTLAKAFGALGGYITGSRAIIDAVRSYAPGFIFTTSLPPAVAAAATAAIRHLKSSQAE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RDGQQRQAQRAKDVLSAAGLPVMPSQTHIVPILVGDPELCKKASDRLLEVHGIYIQPINY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHCEEEEECEEEEECCC
PTVPRGTERLRITPSPLHDDKLIDGLKDALLEVWNELGIPFAEPSAPQAANSDRIIPLMV
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
SKAGG
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]