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The map label for this gene is norM

Identifier: 28563918

GI number: 28563918

Start: 1142815

End: 1144158

Strand: Reverse

Name: norM

Synonym: OB1092

Alternate gene names: 28563918

Gene position: 1144158-1142815 (Counterclockwise)

Preceding gene: 23098549

Following gene: 23098543

Centisome position: 31.51

GC content: 34.97

Gene sequence:

>1344_bases
ATGTACCAAACAACAACACTAAAAGATAAAATTAAACTTTTTATAATTATTTTACTGCCAATATTAATCACACAAGTAAG
TATTAATCTAATGAGTTTCTTTGACACGATGATGTCTGGACAATTTAGTGCCAGAGATCTGGCAGGTGTTGCAATCGGTT
CAAGTCTATGGGTTCCCATCTTAACTGGGATTAACGGGATTGTCTTATCGATCACTCCTATTATCGCACACTTGATCGGT
GCTAAAAACAAGAAGGATATACCACAAGTAATTCAACAAGGCATATACTTATCTTTTGTATTATCAATAATTATTATTGT
AATAGGTGGAATAGCATTAGATCCTATTCTACAAGCGATGAGTCTCGAAAAAGAAGTACAACGTATAGCAAAATACTACT
TAATTACTTTGGGAACTGGGATTGTACCTTTATTTCTATTCCATACTATCCGAAGTTTTATGGATGGCTTAGGACAAACA
CGTTCCTCGATGATTATTATCCTCATATCATTACCGATCAATGCAGTATTAAATTACATATTGATATTTGGTAAGTTCGG
TATTCCAGCATTTGGTGGAATCGGTGCAGGTATAGCGACTAGTCTAACTTATTGGATTATAAGTGGAATTTCGATATTTA
TGATTCATCGTGTCTACCCATTCCATAGTTATAAAGTTTTTCAAAAAATCCTACCGCCTACACTATCATACTGGGCGGAC
CAACTAAAAATTGGGCTTCCCATTGGATTAGCTATATTCTTTGAAACAAGTATTTTCTCAGCAGTAACGCTGTTGATGAG
TGAATATAATACAAATACCATTGCGGCTCACCAAGCTGCAATGAACTTTGCTAGTTTGCTATATATGTTACCTTTAAGTG
TAGGTATGGCGTTGACTATAGCAGTTGGTTTTGAAGTTGGTGCTAAACGATTACACGATGCTAAAAGATACACGTACTTG
GGAATTATGGGAGGATTATTCATTGCTATTTTTGCAGGTATAATTCTATATACATTTGATGATGTTGTTGCCAGATTATA
TAATTCTAATCCAGAAGTGATTGAACTTACAAAGCAATTTATTATTTTTGCTATCTTTTATCAATTAGCTGATGCGATAG
GAGCACCCATACAAGGAGCTTTACGCGGGTATAAAGATGTGAATATGACATTAGTTATCGCCTTAATATCCTACTGGATC
ATTGGGCTACCAACAGGCTATTTATTAGCAAATTATACTGCATTAGAGCCGTTTGGTTACTGGGTTGGTATCATTGTTGG
GCTAAGCACAGGAGCTATTGCATTATTAGCCAGACTATTATTTATTCAGAAAAAATCGGTATAG

Upstream 100 bases:

>100_bases
TCATTCCTTTCCCAACACATTATATCAGCGTATAATAGTCAATGCACTATATAATTACGTTATATTAATAAGGAAATTAA
AAAAGGAAGAAGATTTGCAT

Downstream 100 bases:

>100_bases
ATATGAACAAAAGCGCAAGCGACCGTTTATCACCGTATGTCCTGCGCCCCTGTTTTTCAAGGGGTGGTTCGACTGGTCGA
ACTTCTTTATTTCTTTGAGA

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MYQTTTLKDKIKLFIIILLPILITQVSINLMSFFDTMMSGQFSARDLAGVAIGSSLWVPILTGINGIVLSITPIIAHLIG
AKNKKDIPQVIQQGIYLSFVLSIIIIVIGGIALDPILQAMSLEKEVQRIAKYYLITLGTGIVPLFLFHTIRSFMDGLGQT
RSSMIIILISLPINAVLNYILIFGKFGIPAFGGIGAGIATSLTYWIISGISIFMIHRVYPFHSYKVFQKILPPTLSYWAD
QLKIGLPIGLAIFFETSIFSAVTLLMSEYNTNTIAAHQAAMNFASLLYMLPLSVGMALTIAVGFEVGAKRLHDAKRYTYL
GIMGGLFIAIFAGIILYTFDDVVARLYNSNPEVIELTKQFIIFAIFYQLADAIGAPIQGALRGYKDVNMTLVIALISYWI
IGLPTGYLLANYTALEPFGYWVGIIVGLSTGAIALLARLLFIQKKSV

Sequences:

>Translated_447_residues
MYQTTTLKDKIKLFIIILLPILITQVSINLMSFFDTMMSGQFSARDLAGVAIGSSLWVPILTGINGIVLSITPIIAHLIG
AKNKKDIPQVIQQGIYLSFVLSIIIIVIGGIALDPILQAMSLEKEVQRIAKYYLITLGTGIVPLFLFHTIRSFMDGLGQT
RSSMIIILISLPINAVLNYILIFGKFGIPAFGGIGAGIATSLTYWIISGISIFMIHRVYPFHSYKVFQKILPPTLSYWAD
QLKIGLPIGLAIFFETSIFSAVTLLMSEYNTNTIAAHQAAMNFASLLYMLPLSVGMALTIAVGFEVGAKRLHDAKRYTYL
GIMGGLFIAIFAGIILYTFDDVVARLYNSNPEVIELTKQFIIFAIFYQLADAIGAPIQGALRGYKDVNMTLVIALISYWI
IGLPTGYLLANYTALEPFGYWVGIIVGLSTGAIALLARLLFIQKKSV
>Mature_447_residues
MYQTTTLKDKIKLFIIILLPILITQVSINLMSFFDTMMSGQFSARDLAGVAIGSSLWVPILTGINGIVLSITPIIAHLIG
AKNKKDIPQVIQQGIYLSFVLSIIIIVIGGIALDPILQAMSLEKEVQRIAKYYLITLGTGIVPLFLFHTIRSFMDGLGQT
RSSMIIILISLPINAVLNYILIFGKFGIPAFGGIGAGIATSLTYWIISGISIFMIHRVYPFHSYKVFQKILPPTLSYWAD
QLKIGLPIGLAIFFETSIFSAVTLLMSEYNTNTIAAHQAAMNFASLLYMLPLSVGMALTIAVGFEVGAKRLHDAKRYTYL
GIMGGLFIAIFAGIILYTFDDVVARLYNSNPEVIELTKQFIIFAIFYQLADAIGAPIQGALRGYKDVNMTLVIALISYWI
IGLPTGYLLANYTALEPFGYWVGIIVGLSTGAIALLARLLFIQKKSV

Specific function: Multidrug efflux pump

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Homologues:

Organism=Homo sapiens, GI153792564, Length=435, Percent_Identity=21.6091954022989, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI22907060, Length=441, Percent_Identity=19.7278911564626, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI38261960, Length=228, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994890, Length=440, Percent_Identity=34.0909090909091, Blast_Score=279, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6321821, Length=389, Percent_Identity=23.9074550128535, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320545, Length=425, Percent_Identity=23.0588235294118, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NORM_OCEIH (Q8CUL5)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692013.2
- GeneID:   1017066
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1092
- NMPDR:   fig|221109.1.peg.1093
- HOGENOM:   HBG479615
- ProtClustDB:   PRK01766
- BioCyc:   OIHE221109:OB1092-MONOMER
- InterPro:   IPR002528
- PANTHER:   PTHR11206
- TIGRFAMs:   TIGR00797

Pfam domain/function: PF01554 MatE

EC number: NA

Molecular weight: Translated: 49050; Mature: 49050

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xdf17fa8)-; HASH(0xe09eb90)-; HASH(0xdde84c0)-; HASH(0xc5ed9e4)-; HASH(0xcd73bc0)-; HASH(0xb7a5594)-; HASH(0xdcb38b4)-; HASH(0xdfa3a3c)-; HASH(0xd151f18)-; HASH(0xc5f1bc0)-; HASH(0xc5f2d3c)-; HASH(0xcd93698)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCHHHHHHHHHHHHHCCH
>Mature Secondary Structure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HHHHHHHHCCCHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12235376