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The map label for this gene is cytR [H]

Identifier: 23100931

GI number: 23100931

Start: 3611980

End: 3612963

Strand: Reverse

Name: cytR [H]

Synonym: OB3476

Alternate gene names: 23100931

Gene position: 3612963-3611980 (Counterclockwise)

Preceding gene: 23100932

Following gene: 23100930

Centisome position: 99.52

GC content: 35.87

Gene sequence:

>984_bases
TTGACAACGATTCTAGAAGTAGCAAAAAAAGCTGGTGTTTCTGTAGCAACTGTTTCTCGCGTCCTTAATAATCGTCATCA
AGTGAGAGAAGTGACTCGATCAAAAGTTGAGCAAGCGATTGTAGCGTTGAATTATGAGCCAAGTGTCTTAGGTAGAAATT
TACGTAATTCAGAAAGTCGCTTATTATTAGTTCTTATTCCTAGTATCGCCAACCCATTTTACACAGAAATTATTAATGGA
ATTGAAGATTCTGCGATTAAAGAAGGATATAACATTATGCTATGCGAGACGGACTCTAATCCACAACGAGAAGCAATTTA
TTTTAACCTAGTTCGAAATCGAATGGCTGATGGGATTATTTTAATGGATCCTACGATTAATCGGAATAATGTATTACAGC
TAGCAAATCAACATCCAATAGTACAGTGTAGTGAATTTGATAAGGACGGATTAATTTCCTATGTATCCATCAATAATGAA
TTAGCTGCTTATCAAGCAGTAAAACATTTAATTAAAATTGGTAGACAAAGAATCGCCCTTATAAACTCAGAGGAAAAATT
TTTGTATGCCAGAGAACGTCGAGCTGGGTATGAAAGGGCTTTTCGAGAATATGGTCGATCTGTCAATCCCAGTTATATCT
ATAATATAAACGGTTTAAGCTTTGAAAATGGACAACAAGCGATGCGAATGCTGTTGGAGCAAAAAGAAAAGCCAGATGCC
GTTTTTGCTGTATCAGATATTTTTGCAATAGGTGCATTGAAAGAGATACATGAGGTTGGTCTTTCTGTTCCAGAAGAAAT
TGCCATTATAGGGTTTGATAAGATTAGTTTTTCTAATATGACATATCCCACATTAACGACAATAGCTCAACCGATGTACC
GCATGGGAAGTATATCCGCAGAGATGATAATCGCAAAAATTCGTGGAGAGAAGGTAGAAAGTCGTTTATTAGAACATGAA
TTAATTATTCGAGAGTCTACATAG

Upstream 100 bases:

>100_bases
TGTTCACCTTGATGTATTAGAGAAAATTTAAAATTGAATTGACAACAATGTGTGAAAAAAGTAAAATTTTTGTAATCGAT
TACAAAAAAGGAGGGATTCT

Downstream 100 bases:

>100_bases
GAGGAGATGAAAATTACCAAACAAATAGCAGTTGTTACAGGAGTAAGTCATGGAGATGGTATTGGGGCTGCGACATGTAG
AAAGTTGGCTGAACAAGGTA

Product: transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTTILEVAKKAGVSVATVSRVLNNRHQVREVTRSKVEQAIVALNYEPSVLGRNLRNSESRLLLVLIPSIANPFYTEIING
IEDSAIKEGYNIMLCETDSNPQREAIYFNLVRNRMADGIILMDPTINRNNVLQLANQHPIVQCSEFDKDGLISYVSINNE
LAAYQAVKHLIKIGRQRIALINSEEKFLYARERRAGYERAFREYGRSVNPSYIYNINGLSFENGQQAMRMLLEQKEKPDA
VFAVSDIFAIGALKEIHEVGLSVPEEIAIIGFDKISFSNMTYPTLTTIAQPMYRMGSISAEMIIAKIRGEKVESRLLEHE
LIIREST

Sequences:

>Translated_327_residues
MTTILEVAKKAGVSVATVSRVLNNRHQVREVTRSKVEQAIVALNYEPSVLGRNLRNSESRLLLVLIPSIANPFYTEIING
IEDSAIKEGYNIMLCETDSNPQREAIYFNLVRNRMADGIILMDPTINRNNVLQLANQHPIVQCSEFDKDGLISYVSINNE
LAAYQAVKHLIKIGRQRIALINSEEKFLYARERRAGYERAFREYGRSVNPSYIYNINGLSFENGQQAMRMLLEQKEKPDA
VFAVSDIFAIGALKEIHEVGLSVPEEIAIIGFDKISFSNMTYPTLTTIAQPMYRMGSISAEMIIAKIRGEKVESRLLEHE
LIIREST
>Mature_326_residues
TTILEVAKKAGVSVATVSRVLNNRHQVREVTRSKVEQAIVALNYEPSVLGRNLRNSESRLLLVLIPSIANPFYTEIINGI
EDSAIKEGYNIMLCETDSNPQREAIYFNLVRNRMADGIILMDPTINRNNVLQLANQHPIVQCSEFDKDGLISYVSINNEL
AAYQAVKHLIKIGRQRIALINSEEKFLYARERRAGYERAFREYGRSVNPSYIYNINGLSFENGQQAMRMLLEQKEKPDAV
FAVSDIFAIGALKEIHEVGLSVPEEIAIIGFDKISFSNMTYPTLTTIAQPMYRMGSISAEMIIAKIRGEKVESRLLEHEL
IIREST

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=328, Percent_Identity=38.719512195122, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1790194, Length=328, Percent_Identity=32.9268292682927, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1787948, Length=324, Percent_Identity=30.2469135802469, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1789068, Length=331, Percent_Identity=30.2114803625378, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI48994940, Length=317, Percent_Identity=30.9148264984227, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789202, Length=300, Percent_Identity=30.3333333333333, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788474, Length=312, Percent_Identity=28.525641025641, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787580, Length=316, Percent_Identity=27.2151898734177, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1786540, Length=341, Percent_Identity=28.4457478005865, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790715, Length=314, Percent_Identity=28.9808917197452, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1787906, Length=328, Percent_Identity=25, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1789456, Length=331, Percent_Identity=27.190332326284, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790192, Length=278, Percent_Identity=24.4604316546763, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786268, Length=312, Percent_Identity=24.6794871794872, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790689, Length=307, Percent_Identity=21.4983713355049, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36985; Mature: 36854

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTILEVAKKAGVSVATVSRVLNNRHQVREVTRSKVEQAIVALNYEPSVLGRNLRNSESR
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHCCCCCCCCCC
LLLVLIPSIANPFYTEIINGIEDSAIKEGYNIMLCETDSNPQREAIYFNLVRNRMADGII
EEEEEECCCCCHHHHHHHHCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEE
LMDPTINRNNVLQLANQHPIVQCSEFDKDGLISYVSINNELAAYQAVKHLIKIGRQRIAL
EECCCCCCCCHHEECCCCCEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHCHHHEEE
INSEEKFLYARERRAGYERAFREYGRSVNPSYIYNINGLSFENGQQAMRMLLEQKEKPDA
ECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCC
VFAVSDIFAIGALKEIHEVGLSVPEEIAIIGFDKISFSNMTYPTLTTIAQPMYRMGSISA
EEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEECCCCCCHHHHHHHHHHHHHCCCHH
EMIIAKIRGEKVESRLLEHELIIREST
HHHHHHHCCHHHHHHHHHHHHEEECCC
>Mature Secondary Structure 
TTILEVAKKAGVSVATVSRVLNNRHQVREVTRSKVEQAIVALNYEPSVLGRNLRNSESR
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHCCCCCCCCCC
LLLVLIPSIANPFYTEIINGIEDSAIKEGYNIMLCETDSNPQREAIYFNLVRNRMADGII
EEEEEECCCCCHHHHHHHHCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEE
LMDPTINRNNVLQLANQHPIVQCSEFDKDGLISYVSINNELAAYQAVKHLIKIGRQRIAL
EECCCCCCCCHHEECCCCCEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHCHHHEEE
INSEEKFLYARERRAGYERAFREYGRSVNPSYIYNINGLSFENGQQAMRMLLEQKEKPDA
ECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCC
VFAVSDIFAIGALKEIHEVGLSVPEEIAIIGFDKISFSNMTYPTLTTIAQPMYRMGSISA
EEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEECCCCCCHHHHHHHHHHHHHCCCHH
EMIIAKIRGEKVESRLLEHELIIREST
HHHHHHHCCHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]