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The map label for this gene is uxuB [H]

Identifier: 23100867

GI number: 23100867

Start: 3550148

End: 3550966

Strand: Direct

Name: uxuB [H]

Synonym: OB3412

Alternate gene names: 23100867

Gene position: 3550148-3550966 (Clockwise)

Preceding gene: 23100866

Following gene: 23100882

Centisome position: 97.79

GC content: 41.15

Gene sequence:

>819_bases
ATGACACAACAATTTCATAATCTTAATGTTGTTATTACCGGTGCAAGCGGGGTAATTGGCAGTACCTTTGTGAAGGCTTT
AGTCAGCGAAGGAGCGAACGTTGGGTTGCTTGGACGCAACATAGATAAACTCCACAAAGTAATAGAAGAAACAAATTGCC
CTGAAAGAAGCATTGCTCTAGAGGCGGATGTACTGGATAAAGCGTCCCTTATTCATGCGAAACAACAGTTTAATGAACAA
TTTGGCAACATTCATGCCCTGATTAATTGTGCAGGAGGAAACCATCCTGATGCAACAACCGATGATGAACATTATAATCC
TAATACAGAGAAAAACCTGTTTGGACTTAGTGAAGAAGGTGTAGAGAGTGTATTTCGACTCAACTATACCGGTAGCTTTC
TCCCCATCCAAGTATTTGGCCAAGATTTAACGGAAGGTGAAGGGAACACAATTATTAATATCTCTTCCATGAATGCCTTT
CAGCCGCTCACAAAAATTCCTGCATATAGTGGTGCCAAGGCAGCAATTAGTAATTTCACGCAATGGCTCAGCACCTATTT
CGAAGGAAAAGTACGAGTAAATGCCATCGCACCTGGTTTTTTTGAGACATCGCAAAATAAGGCGTTACTCCGAAATCAAG
ATGGCTCCTATTCAACCAGAGCAAATAAAATACTCGGGCAGACACCGATGAATCGTTTTGGAGACCCGGAAGATTTAATT
GGAACACTGTTTTGGTTATTGGATTATAAGGCAAGTAAATTTGTGACAGGGGTCGTTATTCCTGTTGATGGAGGATTCTC
TTCTTACTCCGGAGTTTAA

Upstream 100 bases:

>100_bases
AGAATGATTTGGGGAGAAACTGGAAAAGCTGGCTATGGATTATTTGATCGTGCACTAGGTGCAACATACATTAACGGGCT
TATTGAAGGAGTAGAGACGA

Downstream 100 bases:

>100_bases
TCGTTAATAAGGAAAGCCGAACTAAAACGGATATGACACCTAGAATAGTTCTGCTTTTTAATTTATCTATTAAGATTGTT
TATTTTCGACTACTTTTAAA

Product: D-mannonate oxidoreductase

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTQQFHNLNVVITGASGVIGSTFVKALVSEGANVGLLGRNIDKLHKVIEETNCPERSIALEADVLDKASLIHAKQQFNEQ
FGNIHALINCAGGNHPDATTDDEHYNPNTEKNLFGLSEEGVESVFRLNYTGSFLPIQVFGQDLTEGEGNTIINISSMNAF
QPLTKIPAYSGAKAAISNFTQWLSTYFEGKVRVNAIAPGFFETSQNKALLRNQDGSYSTRANKILGQTPMNRFGDPEDLI
GTLFWLLDYKASKFVTGVVIPVDGGFSSYSGV

Sequences:

>Translated_272_residues
MTQQFHNLNVVITGASGVIGSTFVKALVSEGANVGLLGRNIDKLHKVIEETNCPERSIALEADVLDKASLIHAKQQFNEQ
FGNIHALINCAGGNHPDATTDDEHYNPNTEKNLFGLSEEGVESVFRLNYTGSFLPIQVFGQDLTEGEGNTIINISSMNAF
QPLTKIPAYSGAKAAISNFTQWLSTYFEGKVRVNAIAPGFFETSQNKALLRNQDGSYSTRANKILGQTPMNRFGDPEDLI
GTLFWLLDYKASKFVTGVVIPVDGGFSSYSGV
>Mature_271_residues
TQQFHNLNVVITGASGVIGSTFVKALVSEGANVGLLGRNIDKLHKVIEETNCPERSIALEADVLDKASLIHAKQQFNEQF
GNIHALINCAGGNHPDATTDDEHYNPNTEKNLFGLSEEGVESVFRLNYTGSFLPIQVFGQDLTEGEGNTIINISSMNAFQ
PLTKIPAYSGAKAAISNFTQWLSTYFEGKVRVNAIAPGFFETSQNKALLRNQDGSYSTRANKILGQTPMNRFGDPEDLIG
TLFWLLDYKASKFVTGVVIPVDGGFSSYSGV

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI31542939, Length=248, Percent_Identity=25, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI19923817, Length=269, Percent_Identity=26.3940520446097, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI40254992, Length=256, Percent_Identity=22.265625, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI10190704, Length=261, Percent_Identity=26.8199233716475, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI224922801, Length=174, Percent_Identity=25.8620689655172, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789208, Length=259, Percent_Identity=28.1853281853282, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790717, Length=260, Percent_Identity=28.4615384615385, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082160, Length=280, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788459, Length=217, Percent_Identity=26.2672811059908, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789378, Length=274, Percent_Identity=27.3722627737226, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI2367175, Length=262, Percent_Identity=26.3358778625954, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787335, Length=265, Percent_Identity=26.0377358490566, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788891, Length=266, Percent_Identity=25.5639097744361, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI2367365, Length=271, Percent_Identity=25.0922509225092, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787905, Length=257, Percent_Identity=25.2918287937743, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI72000259, Length=278, Percent_Identity=27.6978417266187, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115534694, Length=274, Percent_Identity=26.2773722627737, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=281, Percent_Identity=29.1814946619217, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=280, Percent_Identity=28.2142857142857, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=284, Percent_Identity=27.8169014084507, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=285, Percent_Identity=28.4210526315789, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=292, Percent_Identity=28.7671232876712, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17565030, Length=280, Percent_Identity=28.9285714285714, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=275, Percent_Identity=27.6363636363636, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=278, Percent_Identity=27.3381294964029, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=282, Percent_Identity=27.6595744680851, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=281, Percent_Identity=25.2669039145907, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=260, Percent_Identity=26.1538461538462, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=277, Percent_Identity=26.3537906137184, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=272, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=280, Percent_Identity=23.2142857142857, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=279, Percent_Identity=26.1648745519713, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=280, Percent_Identity=26.0714285714286, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=270, Percent_Identity=27.037037037037, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=263, Percent_Identity=24.3346007604563, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI23397609, Length=266, Percent_Identity=29.3233082706767, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24639444, Length=261, Percent_Identity=27.9693486590038, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221331218, Length=200, Percent_Identity=28.5, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665243, Length=200, Percent_Identity=28.5, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 29573; Mature: 29442

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQFHNLNVVITGASGVIGSTFVKALVSEGANVGLLGRNIDKLHKVIEETNCPERSIAL
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCHHEEE
EADVLDKASLIHAKQQFNEQFGNIHALINCAGGNHPDATTDDEHYNPNTEKNLFGLSEEG
EHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
VESVFRLNYTGSFLPIQVFGQDLTEGEGNTIINISSMNAFQPLTKIPAYSGAKAAISNFT
HHHHEEECCCCCEEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHCCCCCCHHHHHHHHH
QWLSTYFEGKVRVNAIAPGFFETSQNKALLRNQDGSYSTRANKILGQTPMNRFGDPEDLI
HHHHHHHCCCEEEEEECCCCEECCCCCEEEECCCCCCHHHHHHHHCCCCHHHCCCHHHHH
GTLFWLLDYKASKFVTGVVIPVDGGFSSYSGV
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TQQFHNLNVVITGASGVIGSTFVKALVSEGANVGLLGRNIDKLHKVIEETNCPERSIAL
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCHHEEE
EADVLDKASLIHAKQQFNEQFGNIHALINCAGGNHPDATTDDEHYNPNTEKNLFGLSEEG
EHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
VESVFRLNYTGSFLPIQVFGQDLTEGEGNTIINISSMNAFQPLTKIPAYSGAKAAISNFT
HHHHEEECCCCCEEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHCCCCCCHHHHHHHHH
QWLSTYFEGKVRVNAIAPGFFETSQNKALLRNQDGSYSTRANKILGQTPMNRFGDPEDLI
HHHHHHHCCCEEEEEECCCCEECCCCCEEEECCCCCCHHHHHHHHCCCCHHHCCCHHHHH
GTLFWLLDYKASKFVTGVVIPVDGGFSSYSGV
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]