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The map label for this gene is uxuA

Identifier: 23100866

GI number: 23100866

Start: 3549118

End: 3550167

Strand: Direct

Name: uxuA

Synonym: OB3411

Alternate gene names: 23100866

Gene position: 3549118-3550167 (Clockwise)

Preceding gene: 23100864

Following gene: 23100867

Centisome position: 97.76

GC content: 36.29

Gene sequence:

>1050_bases
ATGCAATTATCTTTTCGATGGTATGGTGACAGTGATCCAGTCACTTTAAAACAGATTAAACAGATCCCTGACATGAAACA
TATCGTATCCGCAATTTACGATGTTCCTGTTGGTGACGTTTGGACAAAGGATAAAATTAATGCATTAAAATCTTCCATTG
AACAAGAAGGTCTTACATTATCCGTTATGGAGAGTCTTCCAGTCCATGAGTCTATTAAACTCGGAGAAGCGAATCGAGAT
AATTTAATAGAAAATTATAAGAAATCGTTAAGAAACCTTGGTGAATCGGGTATCAAAACAGTTTGTTATAACTTTATGCC
TGTATTTGACTGGACACGATCCAACTTGGATTATGAATTAGAAGATGGATCAAAAACGCTAATGTATGATAATGATTTCG
TAAAAGATATCGACCCCGTAACTACAAATCTTAATCTTCCAGGTTGGGATGAGAGTTACACAAAAGAAGAAATGGCTACC
TTAATTGAGAAATACCGTCAATTTGACGAAGAAGACTTATGGAAAAACCTAGAATACTTCTTAAATGCGGTTTTACCTAT
AGCCATTGAACATGATATTGACCTTACGATTCATCCAGATGATCCACCGTGGTCCATCTTTGGAATACCTAGAATTATTA
AAACAAAAGAAAGCTATCAACGCTTAATCGCGATTAATTCCTCCAAAAATAATGGTATTTGTTTTTGCACAGGCTCCTTA
GGATGCCTAGAAGAAAACGATCTTCCAGAAATAATTAAGGAGTTTGGCGACCACATCCACTTTGTCCATATGCGTAATAT
TAAGCGATTAGATAACCATTCTTTTGTGGAGAGCGGTCATCTATCGAAATATGGTTCTGTGGATATGAAAGCAGTAGTTC
GTGCATTAAAAGACATTAATTATAAAGGTACGATACGTCCAGATCACGGAAGAATGATTTGGGGAGAAACTGGAAAAGCT
GGCTATGGATTATTTGATCGTGCACTAGGTGCAACATACATTAACGGGCTTATTGAAGGAGTAGAGACGAATGACACAAC
AATTTCATAA

Upstream 100 bases:

>100_bases
GAGTGTTTATAAGCGTTTTAATTATTAACTATAGAACCGTAGAATTCCCCCTTACTGCTCCAAGATTCTTCCCTATTAAA
AACCTGAAGGAGGTAAACGA

Downstream 100 bases:

>100_bases
TCTTAATGTTGTTATTACCGGTGCAAGCGGGGTAATTGGCAGTACCTTTGTGAAGGCTTTAGTCAGCGAAGGAGCGAACG
TTGGGTTGCTTGGACGCAAC

Product: mannonate dehydratase

Products: NA

Alternate protein names: D-mannonate hydrolase

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MQLSFRWYGDSDPVTLKQIKQIPDMKHIVSAIYDVPVGDVWTKDKINALKSSIEQEGLTLSVMESLPVHESIKLGEANRD
NLIENYKKSLRNLGESGIKTVCYNFMPVFDWTRSNLDYELEDGSKTLMYDNDFVKDIDPVTTNLNLPGWDESYTKEEMAT
LIEKYRQFDEEDLWKNLEYFLNAVLPIAIEHDIDLTIHPDDPPWSIFGIPRIIKTKESYQRLIAINSSKNNGICFCTGSL
GCLEENDLPEIIKEFGDHIHFVHMRNIKRLDNHSFVESGHLSKYGSVDMKAVVRALKDINYKGTIRPDHGRMIWGETGKA
GYGLFDRALGATYINGLIEGVETNDTTIS

Sequences:

>Translated_349_residues
MQLSFRWYGDSDPVTLKQIKQIPDMKHIVSAIYDVPVGDVWTKDKINALKSSIEQEGLTLSVMESLPVHESIKLGEANRD
NLIENYKKSLRNLGESGIKTVCYNFMPVFDWTRSNLDYELEDGSKTLMYDNDFVKDIDPVTTNLNLPGWDESYTKEEMAT
LIEKYRQFDEEDLWKNLEYFLNAVLPIAIEHDIDLTIHPDDPPWSIFGIPRIIKTKESYQRLIAINSSKNNGICFCTGSL
GCLEENDLPEIIKEFGDHIHFVHMRNIKRLDNHSFVESGHLSKYGSVDMKAVVRALKDINYKGTIRPDHGRMIWGETGKA
GYGLFDRALGATYINGLIEGVETNDTTIS
>Mature_349_residues
MQLSFRWYGDSDPVTLKQIKQIPDMKHIVSAIYDVPVGDVWTKDKINALKSSIEQEGLTLSVMESLPVHESIKLGEANRD
NLIENYKKSLRNLGESGIKTVCYNFMPVFDWTRSNLDYELEDGSKTLMYDNDFVKDIDPVTTNLNLPGWDESYTKEEMAT
LIEKYRQFDEEDLWKNLEYFLNAVLPIAIEHDIDLTIHPDDPPWSIFGIPRIIKTKESYQRLIAINSSKNNGICFCTGSL
GCLEENDLPEIIKEFGDHIHFVHMRNIKRLDNHSFVESGHLSKYGSVDMKAVVRALKDINYKGTIRPDHGRMIWGETGKA
GYGLFDRALGATYINGLIEGVETNDTTIS

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1312

COG function: function code G; D-mannonate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannonate dehydratase family

Homologues:

Organism=Escherichia coli, GI1790778, Length=386, Percent_Identity=36.7875647668394, Blast_Score=254, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXUA_OCEIH (Q8EL21)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_694333.1
- ProteinModelPortal:   Q8EL21
- SMR:   Q8EL21
- GeneID:   1016219
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB3411
- NMPDR:   fig|221109.1.peg.3415
- HOGENOM:   HBG585927
- OMA:   RNNISEE
- ProtClustDB:   PRK03906
- BioCyc:   OIHE221109:OB3411-MONOMER
- BRENDA:   4.2.1.8
- HAMAP:   MF_00106
- InterPro:   IPR004628
- InterPro:   IPR013022
- Gene3D:   G3DSA:3.20.20.150
- PIRSF:   PIRSF016049
- TIGRFAMs:   TIGR00695

Pfam domain/function: PF03786 UxuA; SSF51658 Xyl_isomerase-like_TIM-brl

EC number: =4.2.1.8

Molecular weight: Translated: 39851; Mature: 39851

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSFRWYGDSDPVTLKQIKQIPDMKHIVSAIYDVPVGDVWTKDKINALKSSIEQEGLTL
CEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEE
SVMESLPVHESIKLGEANRDNLIENYKKSLRNLGESGIKTVCYNFMPVFDWTRSNLDYEL
EEHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
EDGSKTLMYDNDFVKDIDPVTTNLNLPGWDESYTKEEMATLIEKYRQFDEEDLWKNLEYF
CCCCEEEEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LNAVLPIAIEHDIDLTIHPDDPPWSIFGIPRIIKTKESYQRLIAINSSKNNGICFCTGSL
HHHHHCEEEECCEEEEECCCCCCEEEECCCHHHHCHHHHHEEEEEECCCCCCEEEEECCC
GCLEENDLPEIIKEFGDHIHFVHMRNIKRLDNHSFVESGHLSKYGSVDMKAVVRALKDIN
CCCCCCCHHHHHHHHCCCEEEEEHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHCC
YKGTIRPDHGRMIWGETGKAGYGLFDRALGATYINGLIEGVETNDTTIS
CCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQLSFRWYGDSDPVTLKQIKQIPDMKHIVSAIYDVPVGDVWTKDKINALKSSIEQEGLTL
CEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEE
SVMESLPVHESIKLGEANRDNLIENYKKSLRNLGESGIKTVCYNFMPVFDWTRSNLDYEL
EEHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
EDGSKTLMYDNDFVKDIDPVTTNLNLPGWDESYTKEEMATLIEKYRQFDEEDLWKNLEYF
CCCCEEEEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LNAVLPIAIEHDIDLTIHPDDPPWSIFGIPRIIKTKESYQRLIAINSSKNNGICFCTGSL
HHHHHCEEEECCEEEEECCCCCCEEEECCCHHHHCHHHHHEEEEEECCCCCCEEEEECCC
GCLEENDLPEIIKEFGDHIHFVHMRNIKRLDNHSFVESGHLSKYGSVDMKAVVRALKDIN
CCCCCCCHHHHHHHHCCCEEEEEHHHHHHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHCC
YKGTIRPDHGRMIWGETGKAGYGLFDRALGATYINGLIEGVETNDTTIS
CCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376