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The map label for this gene is pgcA [H]

Identifier: 23100492

GI number: 23100492

Start: 3147702

End: 3149435

Strand: Reverse

Name: pgcA [H]

Synonym: OB3037

Alternate gene names: 23100492

Gene position: 3149435-3147702 (Counterclockwise)

Preceding gene: 23100495

Following gene: 23100491

Centisome position: 86.75

GC content: 35.64

Gene sequence:

>1734_bases
GTGCAAAACTGGGAAAAAATGTTTGAAAAGTGGAATATGTTTACAGCGTTAGATGATTCTCTGAAAATAAATTTAAATAA
ACTAAAGAATGATAGAAGTGCGTTGGAAGATGCTTTTTATCAAGAACTATCTTTTGGTACAGCAGGCATGCGAGGGATTC
TTGGAGCAGGAACAAATCGGATGAACATTTATACCATAAGAAAAGCAGTTAATGGATTGGCTGATTATTTGTTAACGAAC
TATAATGATGCAAAAAATAGAGGGATTGTCATTGCCTATGATTCTCGGTATATGTCTAAAGAATTTGCAATTGAATCCGC
GAAGGTATTAGGATACTACGGTATACATACATATGTATTTGAATCATTGCGCCCGACTCCTTTGCTATCATTTGCAGTCC
GACATCTGAATACTGTAGCAGGTATTATGATAACCGCTAGTCATAATCCGCCAGAATATAATGGATTTAAAGTTTATAAT
GAACATGGAGCTCAGATTGTCCCAGCTGAAGCGAAGTTAATTGTGGAATCCATACAGCAAACAAAAGACGAACTAACTGT
ACCGATATTAGAACAATCGCAAGTCGAAGAACAAGAGAAGTTAACCTGGTTAAATGATGAAGTAGATCAAGCTTATTTAG
AAAGATTATACGAAATAACTCAACTTTCATTGGAAGATAAGCAAAGTGAAAAGGATATACAGATTGTATTTACACCATTA
CACGGTACTGCTCTTGATTTAGTAACAAAAGGACTTAAGCAACTTCAATTCTCTAAGATTGCAGTGGTGGAAGAACAAGC
TCAACCCGATCCTGAGTTTTCAACAGTAGAATCCCCAAATCCAGAAGAACATCAAGCATTTTCTAAAGCAATTAATTTAG
GAAAGCAAACAAATGCAGATATTTTATTAGGTACAGATCCAGATGCAGATCGATTAGGTGTAGCAGTGAAAAATTCAGAA
GGTGAATATCAAGTGCTATCTGGAAATCAACTTGGTGTATTGTTATTTGATTATATTGTTAAACACATCGATAAGTCTAA
ATCTGTGAAACCTCGTATGATTAAAACAGTGGTAACGACAGAGTTAGGACGTGCGATTGCAGAAGCAAATCAAGTAGAGT
CAATTGATACGTTAACGGGCTTTAAATATATTGGAGAAAAAATAAATCATTACGATACGACAGGTGAAACTTTCTTATTC
GGATTTGAAGAAAGCTACGGTTATTTAATCAGTGATTTTGTACGTGATAAAGATGCTGTTCAGGCGGCCATGATGGCCAC
GGAAATGGCATACTATTGGAAGCAGCAAGGAAAAACATTATTTGATGCATTGGATGTATTATATGAAAAATATGGCTATT
ATTTAGAAGGAATGACTTCTTTAACCTTGAAAGGGCAAGAAGGTTCACAACAAATGGAGGAGATCTTAACCTCTATTAGG
GAGAAACCTTTTGCTGAGATTGGTGGAATGAAGGTAATTGCTATCGAGGACTATTCTTCTTCTGTTCGTACTTTAACATT
AGAGGATAAGCAGGAAACTATTATTCTGCCAAAGGAAAATATGATTAAGTATTTGTTAGAAGATGACGGTTGGGTATGTT
TCCGACCATCTGGTACAGAACCGAAAATCAAATATTATTATGGTGTACGTGGAACAAACGCAGAAGATAGTGAGCAGCGT
TTACTTGGGCTTAAAGAATCGTTAGAACAGCGAGTTAATCGTATTATTGATTAA

Upstream 100 bases:

>100_bases
TAGTAATTGCCTATTTTAAGTATCGCTAAACGAGAGTTATAGTATTAGTGATAAAAGTATGCTAAAATTTTGGCATATTG
TTATTTGGGAGGATACGTGT

Downstream 100 bases:

>100_bases
CAGTTGGTTTACGTAATTATATTGACAGATGAAGAAAAAAAGTATTTAATAGGTATATACTTATAGCAAATTAAAGGGGA
GTAGCTGTACATTTAAAGTC

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MQNWEKMFEKWNMFTALDDSLKINLNKLKNDRSALEDAFYQELSFGTAGMRGILGAGTNRMNIYTIRKAVNGLADYLLTN
YNDAKNRGIVIAYDSRYMSKEFAIESAKVLGYYGIHTYVFESLRPTPLLSFAVRHLNTVAGIMITASHNPPEYNGFKVYN
EHGAQIVPAEAKLIVESIQQTKDELTVPILEQSQVEEQEKLTWLNDEVDQAYLERLYEITQLSLEDKQSEKDIQIVFTPL
HGTALDLVTKGLKQLQFSKIAVVEEQAQPDPEFSTVESPNPEEHQAFSKAINLGKQTNADILLGTDPDADRLGVAVKNSE
GEYQVLSGNQLGVLLFDYIVKHIDKSKSVKPRMIKTVVTTELGRAIAEANQVESIDTLTGFKYIGEKINHYDTTGETFLF
GFEESYGYLISDFVRDKDAVQAAMMATEMAYYWKQQGKTLFDALDVLYEKYGYYLEGMTSLTLKGQEGSQQMEEILTSIR
EKPFAEIGGMKVIAIEDYSSSVRTLTLEDKQETIILPKENMIKYLLEDDGWVCFRPSGTEPKIKYYYGVRGTNAEDSEQR
LLGLKESLEQRVNRIID

Sequences:

>Translated_577_residues
MQNWEKMFEKWNMFTALDDSLKINLNKLKNDRSALEDAFYQELSFGTAGMRGILGAGTNRMNIYTIRKAVNGLADYLLTN
YNDAKNRGIVIAYDSRYMSKEFAIESAKVLGYYGIHTYVFESLRPTPLLSFAVRHLNTVAGIMITASHNPPEYNGFKVYN
EHGAQIVPAEAKLIVESIQQTKDELTVPILEQSQVEEQEKLTWLNDEVDQAYLERLYEITQLSLEDKQSEKDIQIVFTPL
HGTALDLVTKGLKQLQFSKIAVVEEQAQPDPEFSTVESPNPEEHQAFSKAINLGKQTNADILLGTDPDADRLGVAVKNSE
GEYQVLSGNQLGVLLFDYIVKHIDKSKSVKPRMIKTVVTTELGRAIAEANQVESIDTLTGFKYIGEKINHYDTTGETFLF
GFEESYGYLISDFVRDKDAVQAAMMATEMAYYWKQQGKTLFDALDVLYEKYGYYLEGMTSLTLKGQEGSQQMEEILTSIR
EKPFAEIGGMKVIAIEDYSSSVRTLTLEDKQETIILPKENMIKYLLEDDGWVCFRPSGTEPKIKYYYGVRGTNAEDSEQR
LLGLKESLEQRVNRIID
>Mature_577_residues
MQNWEKMFEKWNMFTALDDSLKINLNKLKNDRSALEDAFYQELSFGTAGMRGILGAGTNRMNIYTIRKAVNGLADYLLTN
YNDAKNRGIVIAYDSRYMSKEFAIESAKVLGYYGIHTYVFESLRPTPLLSFAVRHLNTVAGIMITASHNPPEYNGFKVYN
EHGAQIVPAEAKLIVESIQQTKDELTVPILEQSQVEEQEKLTWLNDEVDQAYLERLYEITQLSLEDKQSEKDIQIVFTPL
HGTALDLVTKGLKQLQFSKIAVVEEQAQPDPEFSTVESPNPEEHQAFSKAINLGKQTNADILLGTDPDADRLGVAVKNSE
GEYQVLSGNQLGVLLFDYIVKHIDKSKSVKPRMIKTVVTTELGRAIAEANQVESIDTLTGFKYIGEKINHYDTTGETFLF
GFEESYGYLISDFVRDKDAVQAAMMATEMAYYWKQQGKTLFDALDVLYEKYGYYLEGMTSLTLKGQEGSQQMEEILTSIR
EKPFAEIGGMKVIAIEDYSSSVRTLTLEDKQETIILPKENMIKYLLEDDGWVCFRPSGTEPKIKYYYGVRGTNAEDSEQR
LLGLKESLEQRVNRIID

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=562, Percent_Identity=34.1637010676157, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI31377548, Length=579, Percent_Identity=33.160621761658, Blast_Score=276, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI71993870, Length=542, Percent_Identity=30.4428044280443, Blast_Score=242, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71993878, Length=311, Percent_Identity=32.7974276527331, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323934, Length=555, Percent_Identity=32.6126126126126, Blast_Score=239, Evalue=7e-64,
Organism=Drosophila melanogaster, GI20129809, Length=549, Percent_Identity=32.0582877959927, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24651977, Length=436, Percent_Identity=34.6330275229358, Blast_Score=245, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24653722, Length=572, Percent_Identity=27.2727272727273, Blast_Score=214, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 65432; Mature: 65432

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNWEKMFEKWNMFTALDDSLKINLNKLKNDRSALEDAFYQELSFGTAGMRGILGAGTNR
CCCHHHHHHHCCCHHEECCCEEEEHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCC
MNIYTIRKAVNGLADYLLTNYNDAKNRGIVIAYDSRYMSKEFAIESAKVLGYYGIHTYVF
EEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHEEHHHHHHHH
ESLRPTPLLSFAVRHLNTVAGIMITASHNPPEYNGFKVYNEHGAQIVPAEAKLIVESIQQ
HHCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCCEEEEECCCCEEECHHHHHHHHHHHH
TKDELTVPILEQSQVEEQEKLTWLNDEVDQAYLERLYEITQLSLEDKQSEKDIQIVFTPL
HHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
HGTALDLVTKGLKQLQFSKIAVVEEQAQPDPEFSTVESPNPEEHQAFSKAINLGKQTNAD
CCHHHHHHHHHHHHHHHHHHEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
ILLGTDPDADRLGVAVKNSEGEYQVLSGNQLGVLLFDYIVKHIDKSKSVKPRMIKTVVTT
EEEECCCCCHHCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
ELGRAIAEANQVESIDTLTGFKYIGEKINHYDTTGETFLFGFEESYGYLISDFVRDKDAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCHHHH
QAAMMATEMAYYWKQQGKTLFDALDVLYEKYGYYLEGMTSLTLKGQEGSQQMEEILTSIR
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHCCCCEEEEEECCCCHHHHHHHHHHHH
EKPFAEIGGMKVIAIEDYSSSVRTLTLEDKQETIILPKENMIKYLLEDDGWVCFRPSGTE
CCCHHHHCCEEEEEEECCCCCEEEEEEECCCCEEECCHHHHHHHHCCCCCEEEECCCCCC
PKIKYYYGVRGTNAEDSEQRLLGLKESLEQRVNRIID
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNWEKMFEKWNMFTALDDSLKINLNKLKNDRSALEDAFYQELSFGTAGMRGILGAGTNR
CCCHHHHHHHCCCHHEECCCEEEEHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCC
MNIYTIRKAVNGLADYLLTNYNDAKNRGIVIAYDSRYMSKEFAIESAKVLGYYGIHTYVF
EEEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHEEHHHHHHHH
ESLRPTPLLSFAVRHLNTVAGIMITASHNPPEYNGFKVYNEHGAQIVPAEAKLIVESIQQ
HHCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCCEEEEECCCCEEECHHHHHHHHHHHH
TKDELTVPILEQSQVEEQEKLTWLNDEVDQAYLERLYEITQLSLEDKQSEKDIQIVFTPL
HHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
HGTALDLVTKGLKQLQFSKIAVVEEQAQPDPEFSTVESPNPEEHQAFSKAINLGKQTNAD
CCHHHHHHHHHHHHHHHHHHEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
ILLGTDPDADRLGVAVKNSEGEYQVLSGNQLGVLLFDYIVKHIDKSKSVKPRMIKTVVTT
EEEECCCCCHHCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
ELGRAIAEANQVESIDTLTGFKYIGEKINHYDTTGETFLFGFEESYGYLISDFVRDKDAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCHHHH
QAAMMATEMAYYWKQQGKTLFDALDVLYEKYGYYLEGMTSLTLKGQEGSQQMEEILTSIR
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCHHCCCCEEEEEECCCCHHHHHHHHHHHH
EKPFAEIGGMKVIAIEDYSSSVRTLTLEDKQETIILPKENMIKYLLEDDGWVCFRPSGTE
CCCHHHHCCEEEEEEECCCCCEEEEEEECCCCEEECCHHHHHHHHCCCCCEEEECCCCCC
PKIKYYYGVRGTNAEDSEQRLLGLKESLEQRVNRIID
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]