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The map label for this gene is cvrA [H]

Identifier: 23100495

GI number: 23100495

Start: 3151002

End: 3152804

Strand: Reverse

Name: cvrA [H]

Synonym: OB3040

Alternate gene names: 23100495

Gene position: 3152804-3151002 (Counterclockwise)

Preceding gene: 23100497

Following gene: 23100492

Centisome position: 86.84

GC content: 37.27

Gene sequence:

>1803_bases
ATGGTTCCTTCTCTATTATTTGAAATAATGTTAATCGGAGTGCTTGGAGTGGCATCTCAATGGATTGCATGGCGCTTTCG
ATTACCAGCCATCGTCGTAATGTCGGTTACAGGGTTAGCAATCGGTCCTGTCTTTGGAGTTATTAATCCAGAAGAGGATT
TCGGGGCACTTTATAGTCCATTTATCTCAGCGGCAGTAGCAATTATACTATTTGAAGGTAGTTTGAATTTAAGCTTTAAG
GAGTTACGTGGAATAGGAAGGCCTGTATTTCGGATATCAACGATTGGAGCCTTTATTGCATGGATATTAGGGTCGTTAAC
GGCTCATTATATAGCTGGACTATCTTGGGCAGTAGCGTTTGTTATTGGTGGTTTATTTGTTGTTACAGGTCCAACTGTAA
TAATGCCACTACTTCGTCAAGCCAAATTGAAGGCTCGTCCTGCCAAAATTTTAAAATGGGAAGGGATTATTGTAGACCCG
ATTGGAGCACTTCTAGCGGTGTTTGCATTTGAAATTATCACCTTTTTAACGGCATCAAATCCAGATGCAATGCAATTAAT
ACTATTTTTCGCAGCTTCGTTGTTTGCAGTATTCATCGGCTATGTTCTTGGTAAAGGACTTGGTTGGATGTTTGAAATGG
GACATATACCTGAATTTTTAAAGTCCCCAGCCATTGTAGTTGTCGTTCTATTATGTTTTACACTTGCAGATGAAGTAATG
CATGAAACAGGACTACTATCGGTAACAGCAATGGGTATTACCCTAGCTAATATGGGAATAAGTTCTATTTCTGATATGCG
TCATTTTAAAGAGAATATTTCAGTATTGCTTATTTCCACAATATTTATAATGTTAACTGCTTCTTTAGATAGAGAAACGA
TCATGCAAATATTTAGCCCAAATATTATTTTATATGTGCTTCTTATGATGTTTGCAGTTCGTCCATTGTCTATATTCTTA
TCGACAATTGGAACTGGCCTAAGCTTAAATGAAAAGACATTACTTGGTTGGATTGCACCACGTGGAATTGTTGCATTAAC
GGTTTCAGGTTATTTCGCAAATGTGTTAAGTGACGCAGGATATGAGGATGCTTCTATTTTAACAGCTCTTACATTTGCGC
TTGTTATATTTACCGTAGTGGCACATGGATTTTCTATTGGTTGGTTATCAAAGAAATTGGGATTGTCTAACGAAGGTAAT
CCAGGAGCATTAATAGTTGGCAGTAATCCATTTACTATTGAACTTGCCAAATCACTAGGAGAAGCAAAATACCCAGCAAT
CATTGTAAGTTCTTCATGGGAAGATCTAGCATTAGCTCGAAATGCCGGATTGCATGTTTATCACGGTAGTATGCTATCAG
AACAAACAGAGCAACATCTTGATACGATACCTTATGAGTATTTACTAACCGTAACACATGATCATGCCTATAATTCTCTT
ATCTGTACAACGTTTATGCCGGAGTATGGAAGGACAAATGTATTTAAAGTCAGTCCTTATACGAACTTTGAAGATGGTTA
CTCTACTGGAGTAGTTTCAAAAGTAGGCGGACGTATTTTATTTGATAAAAAGTTCTCCTTGGAAGAACTCGTCGAAAAAG
TAGAGGATGGATTTACGATAAGACAGACGACATTGAGTGAAAAATTTACGTTTGATCATTATAAGGAAAAGAAAGATCCA
GAAACGGTATTCTTATTTTTAATCAAGCCTTCTGGACAGCTTAAATTCTTCTCTGAAGAAATGCGTACTATTCCAGTGTC
AGGAGATGTGATCGTTAGCTTAACAAAGCCGAATAATGAGTAA

Upstream 100 bases:

>100_bases
TACAGTATCTAAATAATTCACCCACGCTAAATTTATTTACATATCACCCTGACATATATAAAATGTTTTTATATCAAAAA
AAGAAAAAGGAGGGTAATGT

Downstream 100 bases:

>100_bases
TTAAAAACTCCTTGGAAAACCAGTATTTGGTCATTCCAAGGAGTTTTACATTATTCTATATTTGAGTCGTAACTCCATTC
ATATTAATTAGTAGGAAGTT

Product: Na(+):H(+) antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MVPSLLFEIMLIGVLGVASQWIAWRFRLPAIVVMSVTGLAIGPVFGVINPEEDFGALYSPFISAAVAIILFEGSLNLSFK
ELRGIGRPVFRISTIGAFIAWILGSLTAHYIAGLSWAVAFVIGGLFVVTGPTVIMPLLRQAKLKARPAKILKWEGIIVDP
IGALLAVFAFEIITFLTASNPDAMQLILFFAASLFAVFIGYVLGKGLGWMFEMGHIPEFLKSPAIVVVVLLCFTLADEVM
HETGLLSVTAMGITLANMGISSISDMRHFKENISVLLISTIFIMLTASLDRETIMQIFSPNIILYVLLMMFAVRPLSIFL
STIGTGLSLNEKTLLGWIAPRGIVALTVSGYFANVLSDAGYEDASILTALTFALVIFTVVAHGFSIGWLSKKLGLSNEGN
PGALIVGSNPFTIELAKSLGEAKYPAIIVSSSWEDLALARNAGLHVYHGSMLSEQTEQHLDTIPYEYLLTVTHDHAYNSL
ICTTFMPEYGRTNVFKVSPYTNFEDGYSTGVVSKVGGRILFDKKFSLEELVEKVEDGFTIRQTTLSEKFTFDHYKEKKDP
ETVFLFLIKPSGQLKFFSEEMRTIPVSGDVIVSLTKPNNE

Sequences:

>Translated_600_residues
MVPSLLFEIMLIGVLGVASQWIAWRFRLPAIVVMSVTGLAIGPVFGVINPEEDFGALYSPFISAAVAIILFEGSLNLSFK
ELRGIGRPVFRISTIGAFIAWILGSLTAHYIAGLSWAVAFVIGGLFVVTGPTVIMPLLRQAKLKARPAKILKWEGIIVDP
IGALLAVFAFEIITFLTASNPDAMQLILFFAASLFAVFIGYVLGKGLGWMFEMGHIPEFLKSPAIVVVVLLCFTLADEVM
HETGLLSVTAMGITLANMGISSISDMRHFKENISVLLISTIFIMLTASLDRETIMQIFSPNIILYVLLMMFAVRPLSIFL
STIGTGLSLNEKTLLGWIAPRGIVALTVSGYFANVLSDAGYEDASILTALTFALVIFTVVAHGFSIGWLSKKLGLSNEGN
PGALIVGSNPFTIELAKSLGEAKYPAIIVSSSWEDLALARNAGLHVYHGSMLSEQTEQHLDTIPYEYLLTVTHDHAYNSL
ICTTFMPEYGRTNVFKVSPYTNFEDGYSTGVVSKVGGRILFDKKFSLEELVEKVEDGFTIRQTTLSEKFTFDHYKEKKDP
ETVFLFLIKPSGQLKFFSEEMRTIPVSGDVIVSLTKPNNE
>Mature_600_residues
MVPSLLFEIMLIGVLGVASQWIAWRFRLPAIVVMSVTGLAIGPVFGVINPEEDFGALYSPFISAAVAIILFEGSLNLSFK
ELRGIGRPVFRISTIGAFIAWILGSLTAHYIAGLSWAVAFVIGGLFVVTGPTVIMPLLRQAKLKARPAKILKWEGIIVDP
IGALLAVFAFEIITFLTASNPDAMQLILFFAASLFAVFIGYVLGKGLGWMFEMGHIPEFLKSPAIVVVVLLCFTLADEVM
HETGLLSVTAMGITLANMGISSISDMRHFKENISVLLISTIFIMLTASLDRETIMQIFSPNIILYVLLMMFAVRPLSIFL
STIGTGLSLNEKTLLGWIAPRGIVALTVSGYFANVLSDAGYEDASILTALTFALVIFTVVAHGFSIGWLSKKLGLSNEGN
PGALIVGSNPFTIELAKSLGEAKYPAIIVSSSWEDLALARNAGLHVYHGSMLSEQTEQHLDTIPYEYLLTVTHDHAYNSL
ICTTFMPEYGRTNVFKVSPYTNFEDGYSTGVVSKVGGRILFDKKFSLEELVEKVEDGFTIRQTTLSEKFTFDHYKEKKDP
ETVFLFLIKPSGQLKFFSEEMRTIPVSGDVIVSLTKPNNE

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 65669; Mature: 65669

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPSLLFEIMLIGVLGVASQWIAWRFRLPAIVVMSVTGLAIGPVFGVINPEEDFGALYSP
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHCCCCCCHHHHHHHHH
FISAAVAIILFEGSLNLSFKELRGIGRPVFRISTIGAFIAWILGSLTAHYIAGLSWAVAF
HHHHHHHHHEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGGLFVVTGPTVIMPLLRQAKLKARPAKILKWEGIIVDPIGALLAVFAFEIITFLTASN
HHCCHHHHCCHHHHHHHHHHHHHCCCCCHHEEECCEEECHHHHHHHHHHHHHHHHHHCCC
PDAMQLILFFAASLFAVFIGYVLGKGLGWMFEMGHIPEFLKSPAIVVVVLLCFTLADEVM
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHH
HETGLLSVTAMGITLANMGISSISDMRHFKENISVLLISTIFIMLTASLDRETIMQIFSP
HHCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
NIILYVLLMMFAVRPLSIFLSTIGTGLSLNEKTLLGWIAPRGIVALTVSGYFANVLSDAG
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEECCCCEEEEEEHHHHHHHHHCCC
YEDASILTALTFALVIFTVVAHGFSIGWLSKKLGLSNEGNPGALIVGSNPFTIELAKSLG
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEECCCCCEEHHHHHCC
EAKYPAIIVSSSWEDLALARNAGLHVYHGSMLSEQTEQHLDTIPYEYLLTVTHDHAYNSL
CCCCCEEEEECCCHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCEEEEEEEECCCCCCE
ICTTFMPEYGRTNVFKVSPYTNFEDGYSTGVVSKVGGRILFDKKFSLEELVEKVEDGFTI
EEEECCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCEEEEECCCCHHHHHHHHHCCCEE
RQTTLSEKFTFDHYKEKKDPETVFLFLIKPSGQLKFFSEEMRTIPVSGDVIVSLTKPNNE
EEHHHHHHCCHHHHHCCCCCCEEEEEEECCCCCEEEEHHHHHEECCCCCEEEEEECCCCC
>Mature Secondary Structure
MVPSLLFEIMLIGVLGVASQWIAWRFRLPAIVVMSVTGLAIGPVFGVINPEEDFGALYSP
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHCCCCCCHHHHHHHHH
FISAAVAIILFEGSLNLSFKELRGIGRPVFRISTIGAFIAWILGSLTAHYIAGLSWAVAF
HHHHHHHHHEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGGLFVVTGPTVIMPLLRQAKLKARPAKILKWEGIIVDPIGALLAVFAFEIITFLTASN
HHCCHHHHCCHHHHHHHHHHHHHCCCCCHHEEECCEEECHHHHHHHHHHHHHHHHHHCCC
PDAMQLILFFAASLFAVFIGYVLGKGLGWMFEMGHIPEFLKSPAIVVVVLLCFTLADEVM
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHH
HETGLLSVTAMGITLANMGISSISDMRHFKENISVLLISTIFIMLTASLDRETIMQIFSP
HHCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
NIILYVLLMMFAVRPLSIFLSTIGTGLSLNEKTLLGWIAPRGIVALTVSGYFANVLSDAG
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEECCCCEEEEEEHHHHHHHHHCCC
YEDASILTALTFALVIFTVVAHGFSIGWLSKKLGLSNEGNPGALIVGSNPFTIELAKSLG
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEECCCCCEEHHHHHCC
EAKYPAIIVSSSWEDLALARNAGLHVYHGSMLSEQTEQHLDTIPYEYLLTVTHDHAYNSL
CCCCCEEEEECCCHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCEEEEEEEECCCCCCE
ICTTFMPEYGRTNVFKVSPYTNFEDGYSTGVVSKVGGRILFDKKFSLEELVEKVEDGFTI
EEEECCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCEEEEECCCCHHHHHHHHHCCCEE
RQTTLSEKFTFDHYKEKKDPETVFLFLIKPSGQLKFFSEEMRTIPVSGDVIVSLTKPNNE
EEHHHHHHCCHHHHHCCCCCCEEEEEEECCCCCEEEEHHHHHEECCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]