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The map label for this gene is mmgA [H]

Identifier: 23100468

GI number: 23100468

Start: 3122103

End: 3123293

Strand: Reverse

Name: mmgA [H]

Synonym: OB3013

Alternate gene names: 23100468

Gene position: 3123293-3122103 (Counterclockwise)

Preceding gene: 23100469

Following gene: 23100467

Centisome position: 86.03

GC content: 42.23

Gene sequence:

>1191_bases
ATGAGAAAATCAGTAATCGTATCTGGTGCGCGAACACCTTTTGGGAAATTTGGTGGAGCTTTAAGGCCGTTAAAAGCAAC
AGAGCTTGGAGGTATTGCAATTAAAGAAGCCATGGAACGAGCAAATATTGCAAATGATGTCGTTGATGAGGTAATCATGG
GAACCGTATTACAAGGCGGTCAAGGACAAATCCCATCACGTCAAGCGGCAAGAATTGCTGGTCTTCCATGGGAGACGCGA
TCGGAAACAATTAATAAAGTATGCGCATCTGGAATGCGAAGTGTTACGTTAGCAGATCAGTTAATCCGTCTAGGAGAAGA
GGAGATCATTGTAGCAGGTGGAATGGAGAGCATGAGTAATGCCCCGTACTTTTTACCGGATGCACGTTGGGGAAACCGAA
TGGGAGATAAATCGGTTGTAGATATGATGGTTCATGATGGTCTTACTTGTACATTTACAGGAAATCATATGGGGAACTAT
GGTAATTCTACAGCAGAAGATTTAGAGATTTCTAGAAAGCGCCAAGATGCTTGGGCATTTCGCAGTCATCAAAAATCGGT
TGAAGCCATCGAATCGAATAAGTTTGCTGATGAGATTGTACCTGTAGAAATTCCTAATCGAAAAGGCGATCCAATAATAG
TTGATACAGATGAAGCACCACGTAAAGATACGACGATAGATAAATTATCATCCTTACGTCCAGCATTTGATAAAGAGGGA
TCGATAACTGCGGGGAATGCTCCTGGAGTAAATGATGGAGCGGCAGCATTTGTCGTCATGTCGGATGAAAAAGCTGCGGA
ATTAAATAAAGAACCCCTTGCTTATATTCTCGGTCATGCAGAAGTTGCTGTAGAAGCAAAGGACTTCCCGCAAACACCCG
GAATTGTAATTAATAAATTGTTAGAAAAAACGGGCACTTCTAAAGAAGAAATTGACCTATACGAAATCAATGAAGCATTT
GCAGTTGTTGCGCTTGCGAGTGGACAGATTGCAGATATCGATGAAGAAAAAATAAATGTAAATGGTGGAGCCGTTGCACT
TGGTCATCCAATAGGGGCAAGTGGAGCACGTATCATTCTTACGCTTATCCATGAATTAAAACGTCGTGGCGGCGGAAAGG
GAATCGCTGCTATTTGTAGTGGAAGTGGGCAAGGAGATGCCATTCTTATTGAAGTACCAGCTGAAAATTAA

Upstream 100 bases:

>100_bases
CCTTTCGTCTTTGATAAATATGGAAGTAGGGAGGTATATCCTCTCTATTTTCCCATGTCAATATTGAACGAGCGTTCAAT
CATTATAAGGAGGTAAGAAA

Downstream 100 bases:

>100_bases
CGAGGAGGGATAACTATGAATATCCAAAATGTTATGGTGGTCGGAGCAGGACAAATGGGCGCAGGTATTGCGCTTGTTTG
TGCTCGTTCGGGTTACCAAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MRKSVIVSGARTPFGKFGGALRPLKATELGGIAIKEAMERANIANDVVDEVIMGTVLQGGQGQIPSRQAARIAGLPWETR
SETINKVCASGMRSVTLADQLIRLGEEEIIVAGGMESMSNAPYFLPDARWGNRMGDKSVVDMMVHDGLTCTFTGNHMGNY
GNSTAEDLEISRKRQDAWAFRSHQKSVEAIESNKFADEIVPVEIPNRKGDPIIVDTDEAPRKDTTIDKLSSLRPAFDKEG
SITAGNAPGVNDGAAAFVVMSDEKAAELNKEPLAYILGHAEVAVEAKDFPQTPGIVINKLLEKTGTSKEEIDLYEINEAF
AVVALASGQIADIDEEKINVNGGAVALGHPIGASGARIILTLIHELKRRGGGKGIAAICSGSGQGDAILIEVPAEN

Sequences:

>Translated_396_residues
MRKSVIVSGARTPFGKFGGALRPLKATELGGIAIKEAMERANIANDVVDEVIMGTVLQGGQGQIPSRQAARIAGLPWETR
SETINKVCASGMRSVTLADQLIRLGEEEIIVAGGMESMSNAPYFLPDARWGNRMGDKSVVDMMVHDGLTCTFTGNHMGNY
GNSTAEDLEISRKRQDAWAFRSHQKSVEAIESNKFADEIVPVEIPNRKGDPIIVDTDEAPRKDTTIDKLSSLRPAFDKEG
SITAGNAPGVNDGAAAFVVMSDEKAAELNKEPLAYILGHAEVAVEAKDFPQTPGIVINKLLEKTGTSKEEIDLYEINEAF
AVVALASGQIADIDEEKINVNGGAVALGHPIGASGARIILTLIHELKRRGGGKGIAAICSGSGQGDAILIEVPAEN
>Mature_396_residues
MRKSVIVSGARTPFGKFGGALRPLKATELGGIAIKEAMERANIANDVVDEVIMGTVLQGGQGQIPSRQAARIAGLPWETR
SETINKVCASGMRSVTLADQLIRLGEEEIIVAGGMESMSNAPYFLPDARWGNRMGDKSVVDMMVHDGLTCTFTGNHMGNY
GNSTAEDLEISRKRQDAWAFRSHQKSVEAIESNKFADEIVPVEIPNRKGDPIIVDTDEAPRKDTTIDKLSSLRPAFDKEG
SITAGNAPGVNDGAAAFVVMSDEKAAELNKEPLAYILGHAEVAVEAKDFPQTPGIVINKLLEKTGTSKEEIDLYEINEAF
AVVALASGQIADIDEEKINVNGGAVALGHPIGASGARIILTLIHELKRRGGGKGIAAICSGSGQGDAILIEVPAEN

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=46.4285714285714, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=43.1876606683805, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI167614485, Length=399, Percent_Identity=39.5989974937343, Blast_Score=281, Evalue=5e-76,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=35.6962025316456, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=30.7511737089202, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=27.3657289002558, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=47.0588235294118, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=48.2142857142857, Blast_Score=330, Evalue=7e-92,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=38.1546134663342, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=35.6608478802993, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1788683, Length=405, Percent_Identity=30.6172839506173, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=42.0512820512821, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=40.4092071611253, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=39.5408163265306, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17551802, Length=432, Percent_Identity=32.8703703703704, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=32.3979591836735, Blast_Score=194, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6325229, Length=391, Percent_Identity=43.9897698209719, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=34.9367088607595, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=47.5703324808184, Blast_Score=347, Evalue=9e-96,
Organism=Drosophila melanogaster, GI24640423, Length=388, Percent_Identity=46.1340206185567, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI17648125, Length=388, Percent_Identity=37.6288659793814, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=31.5165876777251, Blast_Score=178, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42069; Mature: 42069

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSVIVSGARTPFGKFGGALRPLKATELGGIAIKEAMERANIANDVVDEVIMGTVLQGG
CCCCEEEECCCCCHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGQIPSRQAARIAGLPWETRSETINKVCASGMRSVTLADQLIRLGEEEIIVAGGMESMSN
CCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCHHHHCC
APYFLPDARWGNRMGDKSVVDMMVHDGLTCTFTGNHMGNYGNSTAEDLEISRKRQDAWAF
CCEECCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
RSHQKSVEAIESNKFADEIVPVEIPNRKGDPIIVDTDEAPRKDTTIDKLSSLRPAFDKEG
HHHHHHHHHHHCCCCHHHEEEEECCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCC
SITAGNAPGVNDGAAAFVVMSDEKAAELNKEPLAYILGHAEVAVEAKDFPQTPGIVINKL
CEECCCCCCCCCCCEEEEEECCCHHHHCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHH
LEKTGTSKEEIDLYEINEAFAVVALASGQIADIDEEKINVNGGAVALGHPIGASGARIIL
HHHHCCCHHHEEEEECCCCEEEEEECCCCEECCCCCEEECCCCEEEECCCCCCCHHHHHH
TLIHELKRRGGGKGIAAICSGSGQGDAILIEVPAEN
HHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCC
>Mature Secondary Structure
MRKSVIVSGARTPFGKFGGALRPLKATELGGIAIKEAMERANIANDVVDEVIMGTVLQGG
CCCCEEEECCCCCHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGQIPSRQAARIAGLPWETRSETINKVCASGMRSVTLADQLIRLGEEEIIVAGGMESMSN
CCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCHHHHCC
APYFLPDARWGNRMGDKSVVDMMVHDGLTCTFTGNHMGNYGNSTAEDLEISRKRQDAWAF
CCEECCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
RSHQKSVEAIESNKFADEIVPVEIPNRKGDPIIVDTDEAPRKDTTIDKLSSLRPAFDKEG
HHHHHHHHHHHCCCCHHHEEEEECCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCC
SITAGNAPGVNDGAAAFVVMSDEKAAELNKEPLAYILGHAEVAVEAKDFPQTPGIVINKL
CEECCCCCCCCCCCEEEEEECCCHHHHCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHH
LEKTGTSKEEIDLYEINEAFAVVALASGQIADIDEEKINVNGGAVALGHPIGASGARIIL
HHHHCCCHHHEEEEECCCCEEEEEECCCCEECCCCCEEECCCCEEEECCCCCCCHHHHHH
TLIHELKRRGGGKGIAAICSGSGQGDAILIEVPAEN
HHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]