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The map label for this gene is mmgB [H]

Identifier: 23100467

GI number: 23100467

Start: 3121236

End: 3122087

Strand: Reverse

Name: mmgB [H]

Synonym: OB3012

Alternate gene names: 23100467

Gene position: 3122087-3121236 (Counterclockwise)

Preceding gene: 23100468

Following gene: 23100466

Centisome position: 86.0

GC content: 38.5

Gene sequence:

>852_bases
ATGAATATCCAAAATGTTATGGTGGTCGGAGCAGGACAAATGGGCGCAGGTATTGCGCTTGTTTGTGCTCGTTCGGGTTA
CCAAGTTTACCTATTTGATGAAAGTAAAGAAGCACAGCAACGAGGATATGCGCAAATTGAAAAAATACTAGAAAAAGATG
TAACCAAAGATAAGATCTCTGAAACAGAAAAAAACCAAGCATTAAACCGGATTACGTTAGCTAACGAAATCAAAGAAGTA
GGAAATTGTGATATGGCGATAGAAGCTGTAGTCGAAAATATGAACGTGAAGATGTCTGTTTTCCAAGAGTTAGATAAATA
TGCACCTAGTCATGCTATATTAGCCTCCAATACATCATCATTACCAATTACAGAAGTAGCAGCAGTAACAAATCGACCAC
AACAAGTTATCGGCATGCACTTTATGAACCCAGTACCGATCATGAAACTAGTGGAAATTATTCGTGGCTTAGAAACAAGT
GATGAAACGTATCAATTTGTTCATGAAATGTCAGAATCATTAGGTAAATCAACTGTTGAGGTACGAGATTTTCCGGGATT
TGTAGCCAATCGTGTCTTGATGCCGATGATAAATGAAGCCGTTTACACCGTATTTGAAGGTGTGGCTTCTCCGCAAGATG
TAGATCAAGTAATGAAGCTAGGCATGAACCACCCGATGGGACCTTTACAACTTGCTGATTTTATTGGATTGGATACATGT
CTATATATTATGGAGGTATTACATGAAGGATTTGGAGATAGTAAATACCGCCCGTGTCCATTATTAAGGCAGTATGTTAA
AGCAGGTCGTCTAGGTAAGAAAGTAGGTCGGGGTTTTTACACATATGATTAA

Upstream 100 bases:

>100_bases
TGGCGGCGGAAAGGGAATCGCTGCTATTTGTAGTGGAAGTGGGCAAGGAGATGCCATTCTTATTGAAGTACCAGCTGAAA
ATTAACGAGGAGGGATAACT

Downstream 100 bases:

>100_bases
TACTCACTAGAGAGAGGTGTCTGTCATGTCGATGTTAATGCTATCTGATGAACAAAAAATGTTACAAAAAATGGTGCGTG
ATTTTGCAACACAAGAAGTG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MNIQNVMVVGAGQMGAGIALVCARSGYQVYLFDESKEAQQRGYAQIEKILEKDVTKDKISETEKNQALNRITLANEIKEV
GNCDMAIEAVVENMNVKMSVFQELDKYAPSHAILASNTSSLPITEVAAVTNRPQQVIGMHFMNPVPIMKLVEIIRGLETS
DETYQFVHEMSESLGKSTVEVRDFPGFVANRVLMPMINEAVYTVFEGVASPQDVDQVMKLGMNHPMGPLQLADFIGLDTC
LYIMEVLHEGFGDSKYRPCPLLRQYVKAGRLGKKVGRGFYTYD

Sequences:

>Translated_283_residues
MNIQNVMVVGAGQMGAGIALVCARSGYQVYLFDESKEAQQRGYAQIEKILEKDVTKDKISETEKNQALNRITLANEIKEV
GNCDMAIEAVVENMNVKMSVFQELDKYAPSHAILASNTSSLPITEVAAVTNRPQQVIGMHFMNPVPIMKLVEIIRGLETS
DETYQFVHEMSESLGKSTVEVRDFPGFVANRVLMPMINEAVYTVFEGVASPQDVDQVMKLGMNHPMGPLQLADFIGLDTC
LYIMEVLHEGFGDSKYRPCPLLRQYVKAGRLGKKVGRGFYTYD
>Mature_283_residues
MNIQNVMVVGAGQMGAGIALVCARSGYQVYLFDESKEAQQRGYAQIEKILEKDVTKDKISETEKNQALNRITLANEIKEV
GNCDMAIEAVVENMNVKMSVFQELDKYAPSHAILASNTSSLPITEVAAVTNRPQQVIGMHFMNPVPIMKLVEIIRGLETS
DETYQFVHEMSESLGKSTVEVRDFPGFVANRVLMPMINEAVYTVFEGVASPQDVDQVMKLGMNHPMGPLQLADFIGLDTC
LYIMEVLHEGFGDSKYRPCPLLRQYVKAGRLGKKVGRGFYTYD

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=41.6666666666667, Blast_Score=232, Evalue=2e-61,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=39.344262295082, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=37.5886524822695, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=35.4948805460751, Blast_Score=161, Evalue=7e-40,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=35.4948805460751, Blast_Score=160, Evalue=8e-40,
Organism=Homo sapiens, GI115430219, Length=234, Percent_Identity=32.4786324786325, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=38.5159010600707, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1788682, Length=233, Percent_Identity=37.7682403433476, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1790281, Length=264, Percent_Identity=35.2272727272727, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=40.418118466899, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=37.9790940766551, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=36.5853658536585, Blast_Score=208, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=37.3239436619718, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=37.5886524822695, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=37.3239436619718, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=35.4609929078014, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71985923, Length=281, Percent_Identity=30.2491103202847, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=27.6595744680851, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193203623, Length=195, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=195, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=38.5159010600707, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=38.5159010600707, Blast_Score=190, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=38.5159010600707, Blast_Score=190, Evalue=8e-49,
Organism=Drosophila melanogaster, GI20129993, Length=228, Percent_Identity=28.0701754385965, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45549573, Length=241, Percent_Identity=28.2157676348548, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31500; Mature: 31500

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQNVMVVGAGQMGAGIALVCARSGYQVYLFDESKEAQQRGYAQIEKILEKDVTKDKIS
CCCCEEEEEECCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHH
ETEKNQALNRITLANEIKEVGNCDMAIEAVVENMNVKMSVFQELDKYAPSHAILASNTSS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCC
LPITEVAAVTNRPQQVIGMHFMNPVPIMKLVEIIRGLETSDETYQFVHEMSESLGKSTVE
CCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEE
VRDFPGFVANRVLMPMINEAVYTVFEGVASPQDVDQVMKLGMNHPMGPLQLADFIGLDTC
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIMEVLHEGFGDSKYRPCPLLRQYVKAGRLGKKVGRGFYTYD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNIQNVMVVGAGQMGAGIALVCARSGYQVYLFDESKEAQQRGYAQIEKILEKDVTKDKIS
CCCCEEEEEECCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHH
ETEKNQALNRITLANEIKEVGNCDMAIEAVVENMNVKMSVFQELDKYAPSHAILASNTSS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCC
LPITEVAAVTNRPQQVIGMHFMNPVPIMKLVEIIRGLETSDETYQFVHEMSESLGKSTVE
CCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEE
VRDFPGFVANRVLMPMINEAVYTVFEGVASPQDVDQVMKLGMNHPMGPLQLADFIGLDTC
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIMEVLHEGFGDSKYRPCPLLRQYVKAGRLGKKVGRGFYTYD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]