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The map label for this gene is fbaA [H]

Identifier: 23100460

GI number: 23100460

Start: 3113939

End: 3114793

Strand: Reverse

Name: fbaA [H]

Synonym: OB3005

Alternate gene names: 23100460

Gene position: 3114793-3113939 (Counterclockwise)

Preceding gene: 23100461

Following gene: 23100459

Centisome position: 85.79

GC content: 37.54

Gene sequence:

>855_bases
ATGCCTTTAGTATCAATGAAGGAAATGCTCGAAAAAGGTAAAGAGAATGGCTATGCGGTAGGTCAGTTTAATATAAACAA
TCTAGAGTATGTACAAGCTATTCTTCAAGCTGCGGAAGAAGAGAAGTCACCAGTTATTCTTGGTGTTTCTGAAGGAGCTG
GAAAATATATGGGTGGTTTCAACGTAGTCGTTGCTATGGTGAAATCATTAATGGATTCTTATGGTACAACTGTACCGGTT
GCGATTCATTTAGATCATGGATCTAGCTTCCAAAAATGTGCAGAAGCAATCCATGCTGGTTTTACTTCTGTTATGATAGA
TGGATCTCATTCTCCAATCGAAGAAAATATCGCCGTTACAGGAAAAGTTGTTGAATTAGCGCAAATCCACGGTGTATCTG
TTGAGGCAGAAGTTGGAACTGTTGGTGGGGAAGAAGATGGAGTAATCGGCGGAATTATGTATGCTGATTTAGAAGAGTGT
CAACGTCTTGTTAAAGAAGCTGAAATAGATTGCTTAGCTCCAGCACTAGGTTCCGTTCATGGAGAATATCAAGGAGAACC
AAATCTAGGATTTAAAGAAATGGAAGAAATTTTAAACGCAGTTAATGTACCTTTAGTACTTCATGGTGGTACAGGAATTC
CAACAAAGGATATTCAAAAAGCTATCTCTTTAGGAACTGCTAAAATTAATGTAAATACTGAAAATCAATTAGCTCAAACA
AGAGCAGTAAGAAAGACATTAGAAGAAAAACCAAATCTTTATGACCCTCGTAAGTACTTAGGGCCAGGAACTGCAGCAAT
TAAAGAAACCGTAAAAGGTAAAATGCGTGAATTTGGTTCTTCTAACCAAGCATAA

Upstream 100 bases:

>100_bases
TCTAACTTGTTGCACCAGAGACTGGTAGTTGGTATTCTTAATAATGTAATAAAAATGATATTGTTTTTTATTGCTATGTA
AATATAAGGAGGAACTTTTC

Downstream 100 bases:

>100_bases
TCACATAAATGAAATCAAAGAGCTGTACCAATGGTGCAGCTTTTCCAACAGTTTTCACAAAAAAGCGAGGAGGAATTGTA
ATGAAATTTTTTATTGATAC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MPLVSMKEMLEKGKENGYAVGQFNINNLEYVQAILQAAEEEKSPVILGVSEGAGKYMGGFNVVVAMVKSLMDSYGTTVPV
AIHLDHGSSFQKCAEAIHAGFTSVMIDGSHSPIEENIAVTGKVVELAQIHGVSVEAEVGTVGGEEDGVIGGIMYADLEEC
QRLVKEAEIDCLAPALGSVHGEYQGEPNLGFKEMEEILNAVNVPLVLHGGTGIPTKDIQKAISLGTAKINVNTENQLAQT
RAVRKTLEEKPNLYDPRKYLGPGTAAIKETVKGKMREFGSSNQA

Sequences:

>Translated_284_residues
MPLVSMKEMLEKGKENGYAVGQFNINNLEYVQAILQAAEEEKSPVILGVSEGAGKYMGGFNVVVAMVKSLMDSYGTTVPV
AIHLDHGSSFQKCAEAIHAGFTSVMIDGSHSPIEENIAVTGKVVELAQIHGVSVEAEVGTVGGEEDGVIGGIMYADLEEC
QRLVKEAEIDCLAPALGSVHGEYQGEPNLGFKEMEEILNAVNVPLVLHGGTGIPTKDIQKAISLGTAKINVNTENQLAQT
RAVRKTLEEKPNLYDPRKYLGPGTAAIKETVKGKMREFGSSNQA
>Mature_283_residues
PLVSMKEMLEKGKENGYAVGQFNINNLEYVQAILQAAEEEKSPVILGVSEGAGKYMGGFNVVVAMVKSLMDSYGTTVPVA
IHLDHGSSFQKCAEAIHAGFTSVMIDGSHSPIEENIAVTGKVVELAQIHGVSVEAEVGTVGGEEDGVIGGIMYADLEECQ
RLVKEAEIDCLAPALGSVHGEYQGEPNLGFKEMEEILNAVNVPLVLHGGTGIPTKDIQKAISLGTAKINVNTENQLAQTR
AVRKTLEEKPNLYDPRKYLGPGTAAIKETVKGKMREFGSSNQA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=288, Percent_Identity=39.2361111111111, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI87082041, Length=287, Percent_Identity=39.3728222996516, Blast_Score=207, Evalue=5e-55,
Organism=Escherichia coli, GI1788072, Length=271, Percent_Identity=38.3763837638376, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1789293, Length=346, Percent_Identity=26.0115606936416, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322790, Length=344, Percent_Identity=25.2906976744186, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30286; Mature: 30155

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMKEMLEKGKENGYAVGQFNINNLEYVQAILQAAEEEKSPVILGVSEGAGKYMGGF
CCCCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHCHH
NVVVAMVKSLMDSYGTTVPVAIHLDHGSSFQKCAEAIHAGFTSVMIDGSHSPIEENIAVT
HHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCEEH
GKVVELAQIHGVSVEAEVGTVGGEEDGVIGGIMYADLEECQRLVKEAEIDCLAPALGSVH
HHHHHHHHHCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHCCC
GEYQGEPNLGFKEMEEILNAVNVPLVLHGGTGIPTKDIQKAISLGTAKINVNTENQLAQT
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCEEEEECCHHHHHHH
RAVRKTLEEKPNLYDPRKYLGPGTAAIKETVKGKMREFGSSNQA
HHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PLVSMKEMLEKGKENGYAVGQFNINNLEYVQAILQAAEEEKSPVILGVSEGAGKYMGGF
CCCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHCHH
NVVVAMVKSLMDSYGTTVPVAIHLDHGSSFQKCAEAIHAGFTSVMIDGSHSPIEENIAVT
HHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCEEH
GKVVELAQIHGVSVEAEVGTVGGEEDGVIGGIMYADLEECQRLVKEAEIDCLAPALGSVH
HHHHHHHHHCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHCCC
GEYQGEPNLGFKEMEEILNAVNVPLVLHGGTGIPTKDIQKAISLGTAKINVNTENQLAQT
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCEEEEECCHHHHHHH
RAVRKTLEEKPNLYDPRKYLGPGTAAIKETVKGKMREFGSSNQA
HHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2457578; 1640835; 9353933; 9384377; 1556067 [H]