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The map label for this gene is upp

Identifier: 23100439

GI number: 23100439

Start: 3094795

End: 3095424

Strand: Reverse

Name: upp

Synonym: OB2984

Alternate gene names: 23100439

Gene position: 3095424-3094795 (Counterclockwise)

Preceding gene: 23100440

Following gene: 23100438

Centisome position: 85.26

GC content: 39.52

Gene sequence:

>630_bases
ATGGGTAATGTATTTGTATTTGATCATCCGTTAATTCAACATAAATTAACGTACATACGTGACAAAAACACGGGAACAAA
AGAATTTCGTGAACTTGTTGATGAAGTTGCGATGTTGATGGCTTTTGAAATTACACGTGATCTTCCCGTGAAAGAAGTCA
ATGTCGATACTCCAGTAACTACGGCGCCTTCAAAAGTACTTGCTGGGAAAAAGTTAGGATTAGTTCCTATTTTGCGTGCG
GGACTTGGGATGGTAGATGGTGTTCGTAAGTTAATCCCGGCTGCAAAAGTTGGACATGTTGGTCTATATCGTGATCCAGA
AACATTCAAACCTGTGGAGTATTATGTCAAACTTCCAAACGATATTGAAGAACGTGAAATCATTGTGATTGATCCAATGT
TAGCAACAGGTGGTTCTGCAAATGATGCCATTGCAGCAATCAAAAAACGAGGTGCTAAAAATATTCGTCTCATGTGTTTA
ATCGCTGCTCCAGAAGGTGTTGAAGTAGTGAAAGAAGCACATCCAGATGTGGATATTTATTTAGCGGCTATGGATGAACG
TCTAGATGATCATGGTTACATTATTCCTGGTCTTGGAGATGCCGGAGATCGCTTATTCGGTACAAAATAA

Upstream 100 bases:

>100_bases
TTTGTAAAGACTTACCAACTTAATAACAATACTTGAAAGCAGAGGAGATTTTCAGTACAATTTTAAAGATATATCTTTTA
ATATAAGGAGTGATCTTAAG

Downstream 100 bases:

>100_bases
AGAAACAAATTGATAATTTCATTTAAATTACGGTTAATTCCTTTGGTATAGCAATTTACATGAGAATCTTTTCTCTAAAA
GTAATTGATTGCTCAAGGGA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGNVFVFDHPLIQHKLTYIRDKNTGTKEFRELVDEVAMLMAFEITRDLPVKEVNVDTPVTTAPSKVLAGKKLGLVPILRA
GLGMVDGVRKLIPAAKVGHVGLYRDPETFKPVEYYVKLPNDIEEREIIVIDPMLATGGSANDAIAAIKKRGAKNIRLMCL
IAAPEGVEVVKEAHPDVDIYLAAMDERLDDHGYIIPGLGDAGDRLFGTK

Sequences:

>Translated_209_residues
MGNVFVFDHPLIQHKLTYIRDKNTGTKEFRELVDEVAMLMAFEITRDLPVKEVNVDTPVTTAPSKVLAGKKLGLVPILRA
GLGMVDGVRKLIPAAKVGHVGLYRDPETFKPVEYYVKLPNDIEEREIIVIDPMLATGGSANDAIAAIKKRGAKNIRLMCL
IAAPEGVEVVKEAHPDVDIYLAAMDERLDDHGYIIPGLGDAGDRLFGTK
>Mature_208_residues
GNVFVFDHPLIQHKLTYIRDKNTGTKEFRELVDEVAMLMAFEITRDLPVKEVNVDTPVTTAPSKVLAGKKLGLVPILRAG
LGMVDGVRKLIPAAKVGHVGLYRDPETFKPVEYYVKLPNDIEEREIIVIDPMLATGGSANDAIAAIKKRGAKNIRLMCLI
AAPEGVEVVKEAHPDVDIYLAAMDERLDDHGYIIPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=33.1683168316832, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=33.1683168316832, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=8e-15,
Organism=Escherichia coli, GI87082118, Length=201, Percent_Identity=49.2537313432836, Blast_Score=214, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17539892, Length=213, Percent_Identity=26.7605633802817, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17539894, Length=213, Percent_Identity=26.7605633802817, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=40.1041666666667, Blast_Score=129, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=32.512315270936, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=32.512315270936, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=32.512315270936, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=32.512315270936, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21358379, Length=195, Percent_Identity=25.1282051282051, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_OCEIH (Q8EM74)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693906.1
- ProteinModelPortal:   Q8EM74
- SMR:   Q8EM74
- GeneID:   1016733
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2984
- NMPDR:   fig|221109.1.peg.2987
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- ProtClustDB:   PRK00129
- BioCyc:   OIHE221109:OB2984-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22914; Mature: 22783

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNVFVFDHPLIQHKLTYIRDKNTGTKEFRELVDEVAMLMAFEITRDLPVKEVNVDTPVT
CCCEEEECCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
TAPSKVLAGKKLGLVPILRAGLGMVDGVRKLIPAAKVGHVGLYRDPETFKPVEYYVKLPN
CCCHHHHCCCCCCHHHHHHHCCCHHHHHHHHHCCHHCCCCCCCCCCCCCCCEEEEEECCC
DIEEREIIVIDPMLATGGSANDAIAAIKKRGAKNIRLMCLIAAPEGVEVVKEAHPDVDIY
CCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCEEEE
LAAMDERLDDHGYIIPGLGDAGDRLFGTK
EEEECCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GNVFVFDHPLIQHKLTYIRDKNTGTKEFRELVDEVAMLMAFEITRDLPVKEVNVDTPVT
CCEEEECCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
TAPSKVLAGKKLGLVPILRAGLGMVDGVRKLIPAAKVGHVGLYRDPETFKPVEYYVKLPN
CCCHHHHCCCCCCHHHHHHHCCCHHHHHHHHHCCHHCCCCCCCCCCCCCCCEEEEEECCC
DIEEREIIVIDPMLATGGSANDAIAAIKKRGAKNIRLMCLIAAPEGVEVVKEAHPDVDIY
CCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCEEEE
LAAMDERLDDHGYIIPGLGDAGDRLFGTK
EEEECCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376