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The map label for this gene is vpr [H]

Identifier: 23100438

GI number: 23100438

Start: 3092370

End: 3094577

Strand: Reverse

Name: vpr [H]

Synonym: OB2983

Alternate gene names: 23100438

Gene position: 3094577-3092370 (Counterclockwise)

Preceding gene: 23100439

Following gene: 23100437

Centisome position: 85.24

GC content: 39.27

Gene sequence:

>2208_bases
ATGCATATCGGAAAACTTATCCCCATATTTCTTTATATAATTTTATTATTGATATTTAGTTATCCACAATTAACAACATT
TGCAGAATATAATCAGAAGGAATCCATTATTATTGAAGTGGAAGGTGATCCACATGAACAAGTTGAATATATTAAAGATT
ACCATCCTTTTATTGAAGTAATTTCAGTGTATGATACGATTTTTAATGGAATTGCCCTGCGAGGTTCCCCGGAACAACTT
CAGAAAATGGAATCCTTAGAATTCATTAAAGGTATCCATTCCGTACAACAATATCAAGCTATACCAACTACGAAAACTTC
AGTATTATCGGAATTACAACCGTCAATTACAGAGTTAGAACCGTATTCGTGGAATCATACTTCTTACACAGGCAAAGGTG
TAAAAGTAGGGGTCATCGACACGGGAATTGATTATGATCATCCAGATTTACAAGCGAATTATATGAACGGATATGATTTA
GTAGACCTTGATGAAGATCCTATGGAGACACAGCCTGAACAAGGAGTACCTACATCTCATGGAACTCATGTAGCAGGTAT
AATCGCTGCAAACGGTGATTTAAAGGGCATGGCTCCTGATGCAGAAATATATGCATATCGTGCTCTTGGCCCAGGTGGGG
CAGGGACTTCCGTGCAAGTATTAGCTGCCATGGAAAAAGCGATTGAAGATGAAGTAGATATTATTAATCTTTCATTAGGT
AACAATGTCAATGTTCCAGACTATCCAACGAGTCAAGCGGTAAATCGTGCTGCTGAATTAGGAATATTCGTAGTAATTGC
GAATGGAAATAGTGGTCCTGATGCATGGACTGTAGGTTCACCTGCTACAGCAAACAAAGCCTTTTCTGTGGGTGCTTCAA
CCACTCCTTCAACCGTTCCGGTATTAAATGATTCGTTTGAAGGTAAATCAATTCCGTTGTTAGAGATGCTTGGTTCCCCG
GAATGGGATTTGGAAAAAGATTATAATATTACCTCAATAGATGAGGAAGCAATCGGTTCTCTTTCTGGAAAAATAGCTCT
TGTACAACGAGGGAAGATACCTTTTTACCAATTAGCGAAGAAAGCGGAAGAATTAGGAGCAGAAGCAGTTCTTATATATA
ATAATGAAGCTGGTCCTTTCCAGGGATCTGTAGAGTTTCGTGATGATCCTGTCCAAATCCCTGTAGCAGCAATTTCCAAA
GAAGATGGGGAATGGTTAAAGCAACAAGTGGAGGAAAATAATCATTATTTCATTGATGCAACACGTGTAGATCAACCAAT
TCAAGTAGCACCATTTAGTTCAAGGGGGCCAGTGACAATTAACTGGCAGATAAAACCAGATATTATTGCGCCAGGTACTG
ACATTTGGAGTACCGTTCCAGGTGGATATCAAGCTATGAATGGGACGAGTATGGCTACCCCTCACGTGGCAGGAGCAGCA
GCAGTTATCAAGGAAGCGAAACCAAATTGGACAAATGATCAAATTATTGGAGCGATCCAAACATCTGCAGATCAACTTAT
GAATGATGAGGAGCTAGTAACTTCAACGGAACAAGGCATGGGAGTTATTGATGTAAACAAAGCTATTGATACAAGTACGA
TAATTCACAATGGTCAGCTACAGTTTGGTAAAGTGGACAACTACCGTGACGAGTTTCAGCATCAGCTTATTATAGAGAAT
ATGACCGATGAAACGCAGTCTTATCGATTCGATATTCCATATAAAGACAAAGGGATATCATGGAAGTTACCGAAGGCTTT
TCAGTTAGAACCTTTTGAAAAGAAGGAAATTCCAATAGAAGCATCTGTTACGGGACTGCAATTAGAAAAAGGGGTTCACC
AAGGCTGGATTGCTTTAGAGGAAGGGGATGCAGCATATCAACTACCGTACATTATCGTAAACAAAGAAGCAGACCAACCA
AAAACAGCTGGATTTGAGTTCTCGCTAAAAGCGCTCTCTGACGATTTATATCAATATCAACTATATATGACAGAGTCTGC
TCGAAAGCTGGAAGTTGATCTATATGATCCAGATACCCTTGTGTATAAGCGAAGATTGTTGGAAGAAAAAGACATCGATC
AAGGTCTACACAATGGTGAACTGACGGCGAAAGAAGCAGGAAAAGAAGGATTATATTTAGCTATTGTGACGGTATACTTA
GATGATGGAACGTATGAAAGTTCAGAAGCAATGGTCTACATCAAGTAG

Upstream 100 bases:

>100_bases
AAGAAAATTAATATGAATATTAATGAAAATAAATTAGATAAGTTCATCCGTATAAATACAGCAAAAACTTCAAAAGCTAT
GGAAATAAGGTGGTGCTCGG

Downstream 100 bases:

>100_bases
AATTATTATTGTTCACAAAAAAGTCATAAAACGAAAGTTGTTAAATAACATGAAGGAATTGATATGTGATACAGTGCACA
ATGAGGAAAAACAAGGTATG

Product: minor extracellular serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 735; Mature: 735

Protein sequence:

>735_residues
MHIGKLIPIFLYIILLLIFSYPQLTTFAEYNQKESIIIEVEGDPHEQVEYIKDYHPFIEVISVYDTIFNGIALRGSPEQL
QKMESLEFIKGIHSVQQYQAIPTTKTSVLSELQPSITELEPYSWNHTSYTGKGVKVGVIDTGIDYDHPDLQANYMNGYDL
VDLDEDPMETQPEQGVPTSHGTHVAGIIAANGDLKGMAPDAEIYAYRALGPGGAGTSVQVLAAMEKAIEDEVDIINLSLG
NNVNVPDYPTSQAVNRAAELGIFVVIANGNSGPDAWTVGSPATANKAFSVGASTTPSTVPVLNDSFEGKSIPLLEMLGSP
EWDLEKDYNITSIDEEAIGSLSGKIALVQRGKIPFYQLAKKAEELGAEAVLIYNNEAGPFQGSVEFRDDPVQIPVAAISK
EDGEWLKQQVEENNHYFIDATRVDQPIQVAPFSSRGPVTINWQIKPDIIAPGTDIWSTVPGGYQAMNGTSMATPHVAGAA
AVIKEAKPNWTNDQIIGAIQTSADQLMNDEELVTSTEQGMGVIDVNKAIDTSTIIHNGQLQFGKVDNYRDEFQHQLIIEN
MTDETQSYRFDIPYKDKGISWKLPKAFQLEPFEKKEIPIEASVTGLQLEKGVHQGWIALEEGDAAYQLPYIIVNKEADQP
KTAGFEFSLKALSDDLYQYQLYMTESARKLEVDLYDPDTLVYKRRLLEEKDIDQGLHNGELTAKEAGKEGLYLAIVTVYL
DDGTYESSEAMVYIK

Sequences:

>Translated_735_residues
MHIGKLIPIFLYIILLLIFSYPQLTTFAEYNQKESIIIEVEGDPHEQVEYIKDYHPFIEVISVYDTIFNGIALRGSPEQL
QKMESLEFIKGIHSVQQYQAIPTTKTSVLSELQPSITELEPYSWNHTSYTGKGVKVGVIDTGIDYDHPDLQANYMNGYDL
VDLDEDPMETQPEQGVPTSHGTHVAGIIAANGDLKGMAPDAEIYAYRALGPGGAGTSVQVLAAMEKAIEDEVDIINLSLG
NNVNVPDYPTSQAVNRAAELGIFVVIANGNSGPDAWTVGSPATANKAFSVGASTTPSTVPVLNDSFEGKSIPLLEMLGSP
EWDLEKDYNITSIDEEAIGSLSGKIALVQRGKIPFYQLAKKAEELGAEAVLIYNNEAGPFQGSVEFRDDPVQIPVAAISK
EDGEWLKQQVEENNHYFIDATRVDQPIQVAPFSSRGPVTINWQIKPDIIAPGTDIWSTVPGGYQAMNGTSMATPHVAGAA
AVIKEAKPNWTNDQIIGAIQTSADQLMNDEELVTSTEQGMGVIDVNKAIDTSTIIHNGQLQFGKVDNYRDEFQHQLIIEN
MTDETQSYRFDIPYKDKGISWKLPKAFQLEPFEKKEIPIEASVTGLQLEKGVHQGWIALEEGDAAYQLPYIIVNKEADQP
KTAGFEFSLKALSDDLYQYQLYMTESARKLEVDLYDPDTLVYKRRLLEEKDIDQGLHNGELTAKEAGKEGLYLAIVTVYL
DDGTYESSEAMVYIK
>Mature_735_residues
MHIGKLIPIFLYIILLLIFSYPQLTTFAEYNQKESIIIEVEGDPHEQVEYIKDYHPFIEVISVYDTIFNGIALRGSPEQL
QKMESLEFIKGIHSVQQYQAIPTTKTSVLSELQPSITELEPYSWNHTSYTGKGVKVGVIDTGIDYDHPDLQANYMNGYDL
VDLDEDPMETQPEQGVPTSHGTHVAGIIAANGDLKGMAPDAEIYAYRALGPGGAGTSVQVLAAMEKAIEDEVDIINLSLG
NNVNVPDYPTSQAVNRAAELGIFVVIANGNSGPDAWTVGSPATANKAFSVGASTTPSTVPVLNDSFEGKSIPLLEMLGSP
EWDLEKDYNITSIDEEAIGSLSGKIALVQRGKIPFYQLAKKAEELGAEAVLIYNNEAGPFQGSVEFRDDPVQIPVAAISK
EDGEWLKQQVEENNHYFIDATRVDQPIQVAPFSSRGPVTINWQIKPDIIAPGTDIWSTVPGGYQAMNGTSMATPHVAGAA
AVIKEAKPNWTNDQIIGAIQTSADQLMNDEELVTSTEQGMGVIDVNKAIDTSTIIHNGQLQFGKVDNYRDEFQHQLIIEN
MTDETQSYRFDIPYKDKGISWKLPKAFQLEPFEKKEIPIEASVTGLQLEKGVHQGWIALEEGDAAYQLPYIIVNKEADQP
KTAGFEFSLKALSDDLYQYQLYMTESARKLEVDLYDPDTLVYKRRLLEEKDIDQGLHNGELTAKEAGKEGLYLAIVTVYL
DDGTYESSEAMVYIK

Specific function: Not required for growth or sporulation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=172, Percent_Identity=32.5581395348837, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI76443679, Length=213, Percent_Identity=32.8638497652582, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983555, Length=191, Percent_Identity=32.9842931937173, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=176, Percent_Identity=34.6590909090909, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324576, Length=176, Percent_Identity=32.9545454545455, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319893, Length=180, Percent_Identity=32.7777777777778, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550681, Length=171, Percent_Identity=32.1637426900585, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR010259
- InterPro:   IPR003137 [H]

Pfam domain/function: PF05922 Inhibitor_I9; PF02225 PA; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 81096; Mature: 81096

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGKLIPIFLYIILLLIFSYPQLTTFAEYNQKESIIIEVEGDPHEQVEYIKDYHPFIEV
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
ISVYDTIFNGIALRGSPEQLQKMESLEFIKGIHSVQQYQAIPTTKTSVLSELQPSITELE
HHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHCC
PYSWNHTSYTGKGVKVGVIDTGIDYDHPDLQANYMNGYDLVDLDEDPMETQPEQGVPTSH
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCC
GTHVAGIIAANGDLKGMAPDAEIYAYRALGPGGAGTSVQVLAAMEKAIEDEVDIINLSLG
CCEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECC
NNVNVPDYPTSQAVNRAAELGIFVVIANGNSGPDAWTVGSPATANKAFSVGASTTPSTVP
CCCCCCCCCCHHHHHHHHHCEEEEEEECCCCCCCCEECCCCCCCCCEEECCCCCCCCCCC
VLNDSFEGKSIPLLEMLGSPEWDLEKDYNITSIDEEAIGSLSGKIALVQRGKIPFYQLAK
EECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHH
KAEELGAEAVLIYNNEAGPFQGSVEFRDDPVQIPVAAISKEDGEWLKQQVEENNHYFIDA
HHHHCCCCEEEEECCCCCCCCCCEEECCCCEEEEEEEECCCCHHHHHHHHHCCCCEEEEE
TRVDQPIQVAPFSSRGPVTINWQIKPDIIAPGTDIWSTVPGGYQAMNGTSMATPHVAGAA
CCCCCCEEECCCCCCCCEEEEEEECCCEECCCCHHHHCCCCCCEECCCCCCCCCCHHHHH
AVIKEAKPNWTNDQIIGAIQTSADQLMNDEELVTSTEQGMGVIDVNKAIDTSTIIHNGQL
HHHHHCCCCCCCCCEEEEEHHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCEEEEECCEE
QFGKVDNYRDEFQHQLIIENMTDETQSYRFDIPYKDKGISWKLPKAFQLEPFEKKEIPIE
EECCCCCHHHHHHHHEEECCCCCCCCCEEEECCCCCCCCEEECCCCCCCCCCCCCCCCEE
ASVTGLQLEKGVHQGWIALEEGDAAYQLPYIIVNKEADQPKTAGFEFSLKALSDDLYQYQ
ECCCCEEHHCCCCCCEEEEECCCCEEECCEEEEECCCCCCCCCCCEEEHHHHHCCCEEEE
LYMTESARKLEVDLYDPDTLVYKRRLLEEKDIDQGLHNGELTAKEAGKEGLYLAIVTVYL
EEEECCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEHHHCCCCCEEEEEEEEEE
DDGTYESSEAMVYIK
ECCCCCCCCCEEEEC
>Mature Secondary Structure
MHIGKLIPIFLYIILLLIFSYPQLTTFAEYNQKESIIIEVEGDPHEQVEYIKDYHPFIEV
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
ISVYDTIFNGIALRGSPEQLQKMESLEFIKGIHSVQQYQAIPTTKTSVLSELQPSITELE
HHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHCC
PYSWNHTSYTGKGVKVGVIDTGIDYDHPDLQANYMNGYDLVDLDEDPMETQPEQGVPTSH
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCCCC
GTHVAGIIAANGDLKGMAPDAEIYAYRALGPGGAGTSVQVLAAMEKAIEDEVDIINLSLG
CCEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECC
NNVNVPDYPTSQAVNRAAELGIFVVIANGNSGPDAWTVGSPATANKAFSVGASTTPSTVP
CCCCCCCCCCHHHHHHHHHCEEEEEEECCCCCCCCEECCCCCCCCCEEECCCCCCCCCCC
VLNDSFEGKSIPLLEMLGSPEWDLEKDYNITSIDEEAIGSLSGKIALVQRGKIPFYQLAK
EECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHH
KAEELGAEAVLIYNNEAGPFQGSVEFRDDPVQIPVAAISKEDGEWLKQQVEENNHYFIDA
HHHHCCCCEEEEECCCCCCCCCCEEECCCCEEEEEEEECCCCHHHHHHHHHCCCCEEEEE
TRVDQPIQVAPFSSRGPVTINWQIKPDIIAPGTDIWSTVPGGYQAMNGTSMATPHVAGAA
CCCCCCEEECCCCCCCCEEEEEEECCCEECCCCHHHHCCCCCCEECCCCCCCCCCHHHHH
AVIKEAKPNWTNDQIIGAIQTSADQLMNDEELVTSTEQGMGVIDVNKAIDTSTIIHNGQL
HHHHHCCCCCCCCCEEEEEHHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCEEEEECCEE
QFGKVDNYRDEFQHQLIIENMTDETQSYRFDIPYKDKGISWKLPKAFQLEPFEKKEIPIE
EECCCCCHHHHHHHHEEECCCCCCCCCEEEECCCCCCCCEEECCCCCCCCCCCCCCCCEE
ASVTGLQLEKGVHQGWIALEEGDAAYQLPYIIVNKEADQPKTAGFEFSLKALSDDLYQYQ
ECCCCEEHHCCCCCCEEEEECCCCEEECCEEEEECCCCCCCCCCCEEEHHHHHCCCEEEE
LYMTESARKLEVDLYDPDTLVYKRRLLEEKDIDQGLHNGELTAKEAGKEGLYLAIVTVYL
EEEECCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEHHHCCCCCEEEEEEEEEE
DDGTYESSEAMVYIK
ECCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1938892; 7934828; 9384377; 10658653 [H]