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The map label for this gene is capL [H]

Identifier: 23100350

GI number: 23100350

Start: 2982561

End: 2983907

Strand: Reverse

Name: capL [H]

Synonym: OB2895

Alternate gene names: 23100350

Gene position: 2983907-2982561 (Counterclockwise)

Preceding gene: 23100351

Following gene: 23100349

Centisome position: 82.19

GC content: 32.67

Gene sequence:

>1347_bases
ATGACTATAAACACAGTAGAATTTAAAAATTCATTAGCTGACAGATTAACTGAGAAAATTAATAATAAATCAGCAACGCT
TGGTGTTGTTGGTTTAGGATACGTAGGGCTCCCTTTAGCCGTAGAAAAAGCGAAAGCTGGCTATAAAGTTATTGGATTTG
ATGTACAACTGGAAAAGATTGAAAAACTGGCACAGGGTATAAATTATATAGGTGATGTTAATGACGAAGAGTTAATTCAA
GTAATTAATAAAGATAAATTTTATGCAACTAATGATTATTCTTTAATAAATAATGTTGATGTCGTAGTTATATGTGTTCC
AACTCCTTTAGATATACACAAACAAGCTGATATTTCCTATGTTGAAAGTGCAACTGCTAAGATTTCACAATACCTACATA
AAGGAATGTTGGTGGTGCTTGAGAGTACAACATATCCAGGTACTACGGAGGAAGTACTTAAACCTTTACTGGAAGAGTCA
GGTTTGAAATGTGGAGAAGATTTTTTCTTAGCATATTCTCCAGAACGCGTTGATCCTGGCAATAAACAATTTAACACTGC
TAATACTCCGAAAGTAGTTGGAGGTATAACGAAGAGTTGTACGAAGGTAGCTGCAACTATGTATCGAAATGTTTTACAAG
CAGATATACACGAAGTATCAACTCCTGCAGTAGCTGAAATGGAAAAAATATTAGAGAATACGTTTAGAAATATAAATATA
GGTTTAGCAAATGAAATGGCGATATTATGTAATAAAATGGGGATTGATGTATGGGAAGTTATAGATGCAGCTGCGACTAA
GCCATATGGGTTCATGCCATTTTATCCAGGCCCAGGTTTGGGTGGTCATTGTATACCTATTGATCCATGGTATTTAACCT
GGAAAGCCAGAGAGTTTAATTACCATACTAAATTAATTGAAACTGCTGGTGAAATAAATAATTTAATGCCTGATTATGTC
ATTAATAGGTGTATGGATTTATTAAATAAAGAAGGTAAAGCGTTAAATGGATCTAATATCTTAGTATTAGGTGTAGCATA
CAAAAAAGATATTGATGACTTTCGTGAATCTCCTGTTATTTCAATTCTGGAACAATTAGAGCGTGCAAAAGCAAATTGGA
ATGTCATAGATCCAAATGTTCAAAAGTTTACTTTACTAGAAAAAGAATATTCAACTAATGCTAACATTACGAATGAGATA
TTAAGTGAAGCAGATTTAGTTTTAATTACAACAGATCATAACAGTTTTGATTATAAGACAATCGCCGAAAATACTAATTT
AATTTTTGATACCCGCAATGCTATTCCGTCGGAATTCGTGGAAAAGAGTAACTATTATAAGTTATAA

Upstream 100 bases:

>100_bases
ATGAATATTGTCTTTGCAGAGCGTCGAATTTTGGAGACGATGAAGGCTTAAATTTTAAACAGTTCATATAAATTATGATT
CATATGATGAGGGGTAAGAA

Downstream 100 bases:

>100_bases
GAATATATTTTTGGAGGCAATAAAAATGAGAACTATAAAAAAAGCAATTATTCCCGCTGCGGGGCTAGGGACGCGTTTCT
TACCTGCAACAAAAGCAATG

Product: UDP-glucose:GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTINTVEFKNSLADRLTEKINNKSATLGVVGLGYVGLPLAVEKAKAGYKVIGFDVQLEKIEKLAQGINYIGDVNDEELIQ
VINKDKFYATNDYSLINNVDVVVICVPTPLDIHKQADISYVESATAKISQYLHKGMLVVLESTTYPGTTEEVLKPLLEES
GLKCGEDFFLAYSPERVDPGNKQFNTANTPKVVGGITKSCTKVAATMYRNVLQADIHEVSTPAVAEMEKILENTFRNINI
GLANEMAILCNKMGIDVWEVIDAAATKPYGFMPFYPGPGLGGHCIPIDPWYLTWKAREFNYHTKLIETAGEINNLMPDYV
INRCMDLLNKEGKALNGSNILVLGVAYKKDIDDFRESPVISILEQLERAKANWNVIDPNVQKFTLLEKEYSTNANITNEI
LSEADLVLITTDHNSFDYKTIAENTNLIFDTRNAIPSEFVEKSNYYKL

Sequences:

>Translated_448_residues
MTINTVEFKNSLADRLTEKINNKSATLGVVGLGYVGLPLAVEKAKAGYKVIGFDVQLEKIEKLAQGINYIGDVNDEELIQ
VINKDKFYATNDYSLINNVDVVVICVPTPLDIHKQADISYVESATAKISQYLHKGMLVVLESTTYPGTTEEVLKPLLEES
GLKCGEDFFLAYSPERVDPGNKQFNTANTPKVVGGITKSCTKVAATMYRNVLQADIHEVSTPAVAEMEKILENTFRNINI
GLANEMAILCNKMGIDVWEVIDAAATKPYGFMPFYPGPGLGGHCIPIDPWYLTWKAREFNYHTKLIETAGEINNLMPDYV
INRCMDLLNKEGKALNGSNILVLGVAYKKDIDDFRESPVISILEQLERAKANWNVIDPNVQKFTLLEKEYSTNANITNEI
LSEADLVLITTDHNSFDYKTIAENTNLIFDTRNAIPSEFVEKSNYYKL
>Mature_447_residues
TINTVEFKNSLADRLTEKINNKSATLGVVGLGYVGLPLAVEKAKAGYKVIGFDVQLEKIEKLAQGINYIGDVNDEELIQV
INKDKFYATNDYSLINNVDVVVICVPTPLDIHKQADISYVESATAKISQYLHKGMLVVLESTTYPGTTEEVLKPLLEESG
LKCGEDFFLAYSPERVDPGNKQFNTANTPKVVGGITKSCTKVAATMYRNVLQADIHEVSTPAVAEMEKILENTFRNINIG
LANEMAILCNKMGIDVWEVIDAAATKPYGFMPFYPGPGLGGHCIPIDPWYLTWKAREFNYHTKLIETAGEINNLMPDYVI
NRCMDLLNKEGKALNGSNILVLGVAYKKDIDDFRESPVISILEQLERAKANWNVIDPNVQKFTLLEKEYSTNANITNEIL
SEADLVLITTDHNSFDYKTIAENTNLIFDTRNAIPSEFVEKSNYYKL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=444, Percent_Identity=23.1981981981982, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI48994968, Length=408, Percent_Identity=34.0686274509804, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788340, Length=390, Percent_Identity=21.7948717948718, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560350, Length=388, Percent_Identity=25.2577319587629, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17136908, Length=455, Percent_Identity=23.5164835164835, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 49979; Mature: 49847

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTINTVEFKNSLADRLTEKINNKSATLGVVGLGYVGLPLAVEKAKAGYKVIGFDVQLEKI
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHCCCCEEHHHCCCCEEEEEEEEHHHH
EKLAQGINYIGDVNDEELIQVINKDKFYATNDYSLINNVDVVVICVPTPLDIHKQADISY
HHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCEECCCCEEEEEECCCCCCCCCCCHHH
VESATAKISQYLHKGMLVVLESTTYPGTTEEVLKPLLEESGLKCGEDFFLAYSPERVDPG
HHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
NKQFNTANTPKVVGGITKSCTKVAATMYRNVLQADIHEVSTPAVAEMEKILENTFRNINI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEC
GLANEMAILCNKMGIDVWEVIDAAATKPYGFMPFYPGPGLGGHCIPIDPWYLTWKAREFN
CCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCC
YHTKLIETAGEINNLMPDYVINRCMDLLNKEGKALNGSNILVLGVAYKKDIDDFRESPVI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECCCCEEEEEEHHHHHHHHHHCCHHH
SILEQLERAKANWNVIDPNVQKFTLLEKEYSTNANITNEILSEADLVLITTDHNSFDYKT
HHHHHHHHHCCCCCEECCCCCEEEEEHHHHCCCCCHHHHHHCCCCEEEEEECCCCCCCEE
IAENTNLIFDTRNAIPSEFVEKSNYYKL
ECCCCCEEEECCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
TINTVEFKNSLADRLTEKINNKSATLGVVGLGYVGLPLAVEKAKAGYKVIGFDVQLEKI
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHCCCCEEHHHCCCCEEEEEEEEHHHH
EKLAQGINYIGDVNDEELIQVINKDKFYATNDYSLINNVDVVVICVPTPLDIHKQADISY
HHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCEECCCCEEEEEECCCCCCCCCCCHHH
VESATAKISQYLHKGMLVVLESTTYPGTTEEVLKPLLEESGLKCGEDFFLAYSPERVDPG
HHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
NKQFNTANTPKVVGGITKSCTKVAATMYRNVLQADIHEVSTPAVAEMEKILENTFRNINI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEC
GLANEMAILCNKMGIDVWEVIDAAATKPYGFMPFYPGPGLGGHCIPIDPWYLTWKAREFN
CCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCC
YHTKLIETAGEINNLMPDYVINRCMDLLNKEGKALNGSNILVLGVAYKKDIDDFRESPVI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECCCCEEEEEEHHHHHHHHHHCCHHH
SILEQLERAKANWNVIDPNVQKFTLLEKEYSTNANITNEILSEADLVLITTDHNSFDYKT
HHHHHHHHHCCCCCEECCCCCEEEEEHHHHCCCCCHHHHHHCCCCEEEEEECCCCCCCEE
IAENTNLIFDTRNAIPSEFVEKSNYYKL
ECCCCCEEEECCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]