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The map label for this gene is pdhA [H]

Identifier: 23100332

GI number: 23100332

Start: 2963263

End: 2964339

Strand: Reverse

Name: pdhA [H]

Synonym: OB2877

Alternate gene names: 23100332

Gene position: 2964339-2963263 (Counterclockwise)

Preceding gene: 23100333

Following gene: 23100331

Centisome position: 81.65

GC content: 39.37

Gene sequence:

>1077_bases
ATGAAACGAAATATGCAGGAAGAATTTCCAATGATACGAATCATGGATCAAAATGGAAAAATTACTGATACGTCATATTT
AGAACAAATTGATAAAGCATTAGTGCAGCAATTTTATCGGCAACTGATTTGTATGCGGGCATTTGATCAAAAGGCAATCA
ACTTGCAGCGCCAAGGAAGAATTGGTACGTATCCAGGATTTGAAGGACAGGAAGGAGCACAGGTAGGAAGTGCTCTAGCA
CTTGATGAAGATGATTGGATGTTGCCAACGTATCGGGATCATGCTGCTAGTATTACATTTGGAAAGTCTTATACTATTCT
ATCCTCATGGAATGGGCGAGTGGAAGGGAATCTCCCGCCTGAAGGAAAGAATATTTTGCCTCCTTCCGTACCAATTGCAA
CACAGCTTCCGCTTGCAGCTGGTATAGCAATGGCCAATAAATATAAAAATTCTTCACAAGCTGTAATTGCTTATTTTGGA
GACGGGGCGACCTCTGAAGGGGATTTTCATGAAGGGTTAAACTTTGCAAGTGTATTTCAAGCACCGGTTGTCTTCTTCAA
TCAGAATAATCAATATGCGATTTCAACCCCAATATCGAGACAAATGAATTCGGAGACAATTGTACAAAAGTCAGTTGCAT
ATGAAATCCCCGGTATTCGAATTGACGGAAATGATATTTTTGCAGCATATTTTGAAACAAAAAAGGCATTAGAACGAGCG
AGAAATGGCGAGGGACCAAGCTTAATTGAAGCCGTAACATGGCGATATGGTGCCCATACAACTGCAGACGATCCTACCAA
GTATCGTAATCAAAAAGAAGAAAATGAAAAACATCGTCAGAATGATCCGATTACCAGATTGGAACTATTTATGAAAGCCT
ATGGTTTCTGGGATGAAGCAGTCGTAGAACAACTAAAAGAGGAAGTAAAAGAAGAAATCGATGGGGCGGTAAAAGATTTA
GAGACTATGCCACCTGCCGATGTAAATGATATTTATGATTATATGTTCGAAAAACCGACATGGACGATTGAACAGCAAAA
AGAAGAATATATAAAACATTTGCGAGGGGTGAAATAG

Upstream 100 bases:

>100_bases
TTCTCGCAAGCGAAGACCGAAATGGAATATCAGAGAGTAATTCCTTTAAGAAAGATTTTACTTATGGGAACAAAAATTTG
GAGCTAAAGAGGTGCTGACC

Downstream 100 bases:

>100_bases
ATGATAACCATAACGAAAACGAAACAATTGACCCTTATTCAGGCAATCACGGACGGAATGCGTACAATGCTTCACGAAAG
AGAAGAAGTCGTTGTATTAG

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKRNMQEEFPMIRIMDQNGKITDTSYLEQIDKALVQQFYRQLICMRAFDQKAINLQRQGRIGTYPGFEGQEGAQVGSALA
LDEDDWMLPTYRDHAASITFGKSYTILSSWNGRVEGNLPPEGKNILPPSVPIATQLPLAAGIAMANKYKNSSQAVIAYFG
DGATSEGDFHEGLNFASVFQAPVVFFNQNNQYAISTPISRQMNSETIVQKSVAYEIPGIRIDGNDIFAAYFETKKALERA
RNGEGPSLIEAVTWRYGAHTTADDPTKYRNQKEENEKHRQNDPITRLELFMKAYGFWDEAVVEQLKEEVKEEIDGAVKDL
ETMPPADVNDIYDYMFEKPTWTIEQQKEEYIKHLRGVK

Sequences:

>Translated_358_residues
MKRNMQEEFPMIRIMDQNGKITDTSYLEQIDKALVQQFYRQLICMRAFDQKAINLQRQGRIGTYPGFEGQEGAQVGSALA
LDEDDWMLPTYRDHAASITFGKSYTILSSWNGRVEGNLPPEGKNILPPSVPIATQLPLAAGIAMANKYKNSSQAVIAYFG
DGATSEGDFHEGLNFASVFQAPVVFFNQNNQYAISTPISRQMNSETIVQKSVAYEIPGIRIDGNDIFAAYFETKKALERA
RNGEGPSLIEAVTWRYGAHTTADDPTKYRNQKEENEKHRQNDPITRLELFMKAYGFWDEAVVEQLKEEVKEEIDGAVKDL
ETMPPADVNDIYDYMFEKPTWTIEQQKEEYIKHLRGVK
>Mature_358_residues
MKRNMQEEFPMIRIMDQNGKITDTSYLEQIDKALVQQFYRQLICMRAFDQKAINLQRQGRIGTYPGFEGQEGAQVGSALA
LDEDDWMLPTYRDHAASITFGKSYTILSSWNGRVEGNLPPEGKNILPPSVPIATQLPLAAGIAMANKYKNSSQAVIAYFG
DGATSEGDFHEGLNFASVFQAPVVFFNQNNQYAISTPISRQMNSETIVQKSVAYEIPGIRIDGNDIFAAYFETKKALERA
RNGEGPSLIEAVTWRYGAHTTADDPTKYRNQKEENEKHRQNDPITRLELFMKAYGFWDEAVVEQLKEEVKEEIDGAVKDL
ETMPPADVNDIYDYMFEKPTWTIEQQKEEYIKHLRGVK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=365, Percent_Identity=35.8904109589041, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI258645172, Length=365, Percent_Identity=35.8904109589041, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4885543, Length=312, Percent_Identity=31.7307692307692, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4505685, Length=294, Percent_Identity=31.9727891156463, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI291084742, Length=294, Percent_Identity=31.9727891156463, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI291084744, Length=301, Percent_Identity=31.2292358803987, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI291084757, Length=287, Percent_Identity=28.5714285714286, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI86563357, Length=360, Percent_Identity=34.1666666666667, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI86563355, Length=360, Percent_Identity=34.1666666666667, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI32564172, Length=309, Percent_Identity=31.7152103559871, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17536047, Length=309, Percent_Identity=31.7152103559871, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6321026, Length=333, Percent_Identity=30.3303303303303, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21355903, Length=365, Percent_Identity=31.5068493150685, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24639748, Length=310, Percent_Identity=27.0967741935484, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24639744, Length=295, Percent_Identity=29.8305084745763, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI28571106, Length=295, Percent_Identity=29.8305084745763, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24639740, Length=295, Percent_Identity=29.8305084745763, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24639746, Length=279, Percent_Identity=29.3906810035842, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40682; Mature: 40682

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNMQEEFPMIRIMDQNGKITDTSYLEQIDKALVQQFYRQLICMRAFDQKAINLQRQGR
CCCCCHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IGTYPGFEGQEGAQVGSALALDEDDWMLPTYRDHAASITFGKSYTILSSWNGRVEGNLPP
CCCCCCCCCCCCHHHCCEEEECCCCCCCCCCCCCCCEEEECCCEEEEECCCCEECCCCCC
EGKNILPPSVPIATQLPLAAGIAMANKYKNSSQAVIAYFGDGATSEGDFHEGLNFASVFQ
CCCCCCCCCCCCHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHH
APVVFFNQNNQYAISTPISRQMNSETIVQKSVAYEIPGIRIDGNDIFAAYFETKKALERA
CCEEEEECCCCEEEECCHHHHCCHHHHHHHHHHEECCCEEECCCCEEEHHHHHHHHHHHH
RNGEGPSLIEAVTWRYGAHTTADDPTKYRNQKEENEKHRQNDPITRLELFMKAYGFWDEA
HCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHH
VVEQLKEEVKEEIDGAVKDLETMPPADVNDIYDYMFEKPTWTIEQQKEEYIKHLRGVK
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRNMQEEFPMIRIMDQNGKITDTSYLEQIDKALVQQFYRQLICMRAFDQKAINLQRQGR
CCCCCHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IGTYPGFEGQEGAQVGSALALDEDDWMLPTYRDHAASITFGKSYTILSSWNGRVEGNLPP
CCCCCCCCCCCCHHHCCEEEECCCCCCCCCCCCCCCEEEECCCEEEEECCCCEECCCCCC
EGKNILPPSVPIATQLPLAAGIAMANKYKNSSQAVIAYFGDGATSEGDFHEGLNFASVFQ
CCCCCCCCCCCCHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHH
APVVFFNQNNQYAISTPISRQMNSETIVQKSVAYEIPGIRIDGNDIFAAYFETKKALERA
CCEEEEECCCCEEEECCHHHHCCHHHHHHHHHHEECCCEEECCCCEEEHHHHHHHHHHHH
RNGEGPSLIEAVTWRYGAHTTADDPTKYRNQKEENEKHRQNDPITRLELFMKAYGFWDEA
HCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHH
VVEQLKEEVKEEIDGAVKDLETMPPADVNDIYDYMFEKPTWTIEQQKEEYIKHLRGVK
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2200674 [H]