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The map label for this gene is desK [H]

Identifier: 23100306

GI number: 23100306

Start: 2934906

End: 2936048

Strand: Reverse

Name: desK [H]

Synonym: OB2851

Alternate gene names: 23100306

Gene position: 2936048-2934906 (Counterclockwise)

Preceding gene: 23100307

Following gene: 23100305

Centisome position: 80.87

GC content: 36.75

Gene sequence:

>1143_bases
ATGCAGCATTGGTATCATCTTTTTCCGAAAAATACAGGTCTAAGTCTGTTTGCATGGATTGCATTTTGTTTACTTCCATT
CTATTTTATCTTACGCTCCTCTTCGCTGATCGATATTGTGGTAGGGGTTATTATGATTGTCATATTCTTTGCAACTTACC
GATTGGCGTTTATTAAAAAAGGTTGGACAGTTTATGTATCTGTAGGCATTGAAATCTTCATCAGTGTGGGGGTAACTCTA
TATTTTGGCTATGTCTATTTTGCATTATTTTTAGCTTTCTTTATCGGGAACATCCAGAATAAGGCTGGTTTTATTTCACT
ATATATCATTCATCTTGTTACGACCTTAACAGCGGTAAGCTTTGGTTTTTTCATTCAAGAAGAGATGTTTTATAATCAAT
GGCCGTTTATTGTGATTTGTGTTATTGGTGTTATATTACTGCCATTTACTATGTATAATCGAAATAAGCGAGAGAAGTTA
GAAAATCAACTAGAGGATGCGAATCAAAAAATCGCTCAATTAATTGTACTTGAGGAACGCGAACGTATTGCTCGAGATTT
ACATGATACCTTGGGACAAAAGCTTTCACTAATGGGATTAAAAAGTGAACTTGCAGGGAAATTGGTAGATGCAAAACCGG
AGTCGGCGAAGAAAGAATTGGCAGATATTCATCAGACTGCAAGGACAGCATTGAAAGAGGTTCGTGAACTCGTTGCTGGG
ATGAAAGGCACCAAATTGAAAGATGAACTTATCCGTGTTCGCCAATTGCTAGAAGTAGCACAAATAACCTGTGAAATAGA
AGATAATATTAAGCATTCAGAAGTTCCGTTACTCATTGAAAATGTATTAAGTATGTGTCTAAAAGAAGCCGTAACCAATG
TAGTGAAGCATAGTGAGGCAACAGAGTGTAAAATAGTCGTCAAGCAAACACCGGATAAATGGATGATTCGCATTATTGAT
AATGGTATAGGTATTCAAGATAAAGTACATACATTTAAAGGAAATGGAATTCTTGGGATGAAGGAGCGATTGGGATTCGT
TAATGGAAACCTATCGTTTGATGAGACGAATAAGAGCAAAACCATACTTAGCATCCAAGTGCCACGAGTAATTCAACAAA
CGGAACAGGAGGGGTCGAATTGA

Upstream 100 bases:

>100_bases
CTAAAAATTTAATAGGTTAGAATCAAAACCCTTTATAAACACTTATGAAGGGTTTTTGTTATACTAAGCAAAACAAGCAA
TGAATGGAGGAGAGATTGGA

Downstream 100 bases:

>100_bases
TTCGAATTGTAATTGCTGAAGATCAACAATTGTTGCTTGGAGCTTTGGGCACGCTTCTTAGTATGGAAGAGGACATGGAA
GTGGTTGGGCAAGCGAAGAA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MQHWYHLFPKNTGLSLFAWIAFCLLPFYFILRSSSLIDIVVGVIMIVIFFATYRLAFIKKGWTVYVSVGIEIFISVGVTL
YFGYVYFALFLAFFIGNIQNKAGFISLYIIHLVTTLTAVSFGFFIQEEMFYNQWPFIVICVIGVILLPFTMYNRNKREKL
ENQLEDANQKIAQLIVLEERERIARDLHDTLGQKLSLMGLKSELAGKLVDAKPESAKKELADIHQTARTALKEVRELVAG
MKGTKLKDELIRVRQLLEVAQITCEIEDNIKHSEVPLLIENVLSMCLKEAVTNVVKHSEATECKIVVKQTPDKWMIRIID
NGIGIQDKVHTFKGNGILGMKERLGFVNGNLSFDETNKSKTILSIQVPRVIQQTEQEGSN

Sequences:

>Translated_380_residues
MQHWYHLFPKNTGLSLFAWIAFCLLPFYFILRSSSLIDIVVGVIMIVIFFATYRLAFIKKGWTVYVSVGIEIFISVGVTL
YFGYVYFALFLAFFIGNIQNKAGFISLYIIHLVTTLTAVSFGFFIQEEMFYNQWPFIVICVIGVILLPFTMYNRNKREKL
ENQLEDANQKIAQLIVLEERERIARDLHDTLGQKLSLMGLKSELAGKLVDAKPESAKKELADIHQTARTALKEVRELVAG
MKGTKLKDELIRVRQLLEVAQITCEIEDNIKHSEVPLLIENVLSMCLKEAVTNVVKHSEATECKIVVKQTPDKWMIRIID
NGIGIQDKVHTFKGNGILGMKERLGFVNGNLSFDETNKSKTILSIQVPRVIQQTEQEGSN
>Mature_380_residues
MQHWYHLFPKNTGLSLFAWIAFCLLPFYFILRSSSLIDIVVGVIMIVIFFATYRLAFIKKGWTVYVSVGIEIFISVGVTL
YFGYVYFALFLAFFIGNIQNKAGFISLYIIHLVTTLTAVSFGFFIQEEMFYNQWPFIVICVIGVILLPFTMYNRNKREKL
ENQLEDANQKIAQLIVLEERERIARDLHDTLGQKLSLMGLKSELAGKLVDAKPESAKKELADIHQTARTALKEVRELVAG
MKGTKLKDELIRVRQLLEVAQITCEIEDNIKHSEVPLLIENVLSMCLKEAVTNVVKHSEATECKIVVKQTPDKWMIRIID
NGIGIQDKVHTFKGNGILGMKERLGFVNGNLSFDETNKSKTILSIQVPRVIQQTEQEGSN

Specific function: Member of the two-component regulatory system desR/desK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates desR by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=206, Percent_Identity=29.126213592233, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787474, Length=198, Percent_Identity=26.7676767676768, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43291; Mature: 43291

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHWYHLFPKNTGLSLFAWIAFCLLPFYFILRSSSLIDIVVGVIMIVIFFATYRLAFIKK
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GWTVYVSVGIEIFISVGVTLYFGYVYFALFLAFFIGNIQNKAGFISLYIIHLVTTLTAVS
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
FGFFIQEEMFYNQWPFIVICVIGVILLPFTMYNRNKREKLENQLEDANQKIAQLIVLEER
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ERIARDLHDTLGQKLSLMGLKSELAGKLVDAKPESAKKELADIHQTARTALKEVRELVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
MKGTKLKDELIRVRQLLEVAQITCEIEDNIKHSEVPLLIENVLSMCLKEAVTNVVKHSEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TECKIVVKQTPDKWMIRIIDNGIGIQDKVHTFKGNGILGMKERLGFVNGNLSFDETNKSK
CCEEEEEEECCCHHHHHHHCCCCCCCHHHHEECCCCCEEHHHHCCCCCCCCCCCCCCCCC
TILSIQVPRVIQQTEQEGSN
EEEEEECHHHHHHHHHCCCC
>Mature Secondary Structure
MQHWYHLFPKNTGLSLFAWIAFCLLPFYFILRSSSLIDIVVGVIMIVIFFATYRLAFIKK
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GWTVYVSVGIEIFISVGVTLYFGYVYFALFLAFFIGNIQNKAGFISLYIIHLVTTLTAVS
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
FGFFIQEEMFYNQWPFIVICVIGVILLPFTMYNRNKREKLENQLEDANQKIAQLIVLEER
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ERIARDLHDTLGQKLSLMGLKSELAGKLVDAKPESAKKELADIHQTARTALKEVRELVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
MKGTKLKDELIRVRQLLEVAQITCEIEDNIKHSEVPLLIENVLSMCLKEAVTNVVKHSEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TECKIVVKQTPDKWMIRIIDNGIGIQDKVHTFKGNGILGMKERLGFVNGNLSFDETNKSK
CCEEEEEEECCCHHHHHHHCCCCCCCHHHHEECCCCCEEHHHHCCCCCCCCCCCCCCCCC
TILSIQVPRVIQQTEQEGSN
EEEEEECHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]