Click here to switch to the map view.

The map label for this gene is comC [H]

Identifier: 23100301

GI number: 23100301

Start: 2929805

End: 2930875

Strand: Reverse

Name: comC [H]

Synonym: OB2846

Alternate gene names: 23100301

Gene position: 2930875-2929805 (Counterclockwise)

Preceding gene: 23100302

Following gene: 23100300

Centisome position: 80.73

GC content: 40.71

Gene sequence:

>1071_bases
ATGAGTAATATAGCCGTATCGGAAAAGGACTTACAACGGTTTTGTCGAGATCTTTTAAAACAAAGTTTGCCTGATGAGGA
AGCGGAAGTAATTGCAGAAACATTGGTCGATGCAGATTTGCGTGGGGTTACTTCACATGGTGTACAGCGTGTAGCGGGAT
ATTTAAAAAGAATGGAAGATGGAATTATCGAGAGGAAGACTGATATTAGTGTAGTTCAGGATTCTTTTGCAACCGCTTTA
CTTGATGCGAATAACGGTTGGGGTCAGGTTGCTGGGGTGAAAGCCATGGAGATGGCGATTCAGAAGGCAGGACAATATGG
CACTTCGTTCGTAGGTGTGTCGAATTCGAATCATTTTGGAACCGCTTCCTTTTATACGAGGATGGCTGCAGAAAAAGGAT
TTATAGGAATTTCAATGACAAATGCATCTCCGATTATGGTGCCCTTTGGAGCTAAAGAACCTTCATTAGGTCCAAATCCT
ATTTCCATTTCGATTCCAGCTGGTGAAGGGAAGAAACCAATTATCTTGGATATGTCAACAAGTAATGTTGCCAGAGGGAA
GATTATGGTTGCCAAGAAGAATAAGGAATCCATCCCAGAAGGTTGGGCGATCACGAAGGATGGAAAACAAACAACGGATG
CGGATGAAGCATGGGAAGGATTTGTACTTCCAATGGGGCCTAAGGGATCTGGCTTAGCAATTATCATCGACATTCTAAGT
GGTGTTCTAACTGGTTCACTATTTGGGAAGCGAATCCCGAGACAATATGATGATCCATACCCGCAACAATTAGGACATTT
ATTCGGTGCGATTAACATTGAAAACTTCGGTGAGCCGGAGCTTTTTTATCAAAATGTTCTAGAGAAAATTGAAGAGACTA
TCTCAAGTGAACCAAGTGAAGGTTTTGATCAAGTGTATATGCCGGGGGATATGGAATCACAGCGTAAGAAAGAATATAAA
GAAAATGGTATTCCATTAAGTCAAGAAATTATTAATGAACTAAGAAAAACGGGAGAAAAATATGGGGTAGATCTAGAACA
CTATTTATCTCAAAACAAGCAGCGTAATTAG

Upstream 100 bases:

>100_bases
GAATACGTTTTATTAAAAATTCAGAATAAACTTGACAATGATCCTCTTACTAAATTATAGTTGATATATCAGATATCAAC
TCAATGCTAGGAGGGAATAA

Downstream 100 bases:

>100_bases
ATAAAGCGTTTATTAGATAGTTTCCTGGCAAAATAATTTAAAAGATAAAGGAGAGAAGCGAACATGGATTACGGGGAATT
TAGTAAACGATTTTCAACGA

Product: malate dehydrogenase

Products: NA

Alternate protein names: (R)-2-hydroxyacid dehydrogenase; (R)-sulfolactate dehydrogenase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSNIAVSEKDLQRFCRDLLKQSLPDEEAEVIAETLVDADLRGVTSHGVQRVAGYLKRMEDGIIERKTDISVVQDSFATAL
LDANNGWGQVAGVKAMEMAIQKAGQYGTSFVGVSNSNHFGTASFYTRMAAEKGFIGISMTNASPIMVPFGAKEPSLGPNP
ISISIPAGEGKKPIILDMSTSNVARGKIMVAKKNKESIPEGWAITKDGKQTTDADEAWEGFVLPMGPKGSGLAIIIDILS
GVLTGSLFGKRIPRQYDDPYPQQLGHLFGAINIENFGEPELFYQNVLEKIEETISSEPSEGFDQVYMPGDMESQRKKEYK
ENGIPLSQEIINELRKTGEKYGVDLEHYLSQNKQRN

Sequences:

>Translated_356_residues
MSNIAVSEKDLQRFCRDLLKQSLPDEEAEVIAETLVDADLRGVTSHGVQRVAGYLKRMEDGIIERKTDISVVQDSFATAL
LDANNGWGQVAGVKAMEMAIQKAGQYGTSFVGVSNSNHFGTASFYTRMAAEKGFIGISMTNASPIMVPFGAKEPSLGPNP
ISISIPAGEGKKPIILDMSTSNVARGKIMVAKKNKESIPEGWAITKDGKQTTDADEAWEGFVLPMGPKGSGLAIIIDILS
GVLTGSLFGKRIPRQYDDPYPQQLGHLFGAINIENFGEPELFYQNVLEKIEETISSEPSEGFDQVYMPGDMESQRKKEYK
ENGIPLSQEIINELRKTGEKYGVDLEHYLSQNKQRN
>Mature_355_residues
SNIAVSEKDLQRFCRDLLKQSLPDEEAEVIAETLVDADLRGVTSHGVQRVAGYLKRMEDGIIERKTDISVVQDSFATALL
DANNGWGQVAGVKAMEMAIQKAGQYGTSFVGVSNSNHFGTASFYTRMAAEKGFIGISMTNASPIMVPFGAKEPSLGPNPI
SISIPAGEGKKPIILDMSTSNVARGKIMVAKKNKESIPEGWAITKDGKQTTDADEAWEGFVLPMGPKGSGLAIIIDILSG
VLTGSLFGKRIPRQYDDPYPQQLGHLFGAINIENFGEPELFYQNVLEKIEETISSEPSEGFDQVYMPGDMESQRKKEYKE
NGIPLSQEIINELRKTGEKYGVDLEHYLSQNKQRN

Specific function: Catalyzes the reduction of sulfopyruvate to (R)- sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynth

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=331, Percent_Identity=38.368580060423, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1787020, Length=346, Percent_Identity=28.9017341040462, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1790000, Length=320, Percent_Identity=27.5, Blast_Score=121, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17507179, Length=351, Percent_Identity=32.7635327635328, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17536633, Length=349, Percent_Identity=30.945558739255, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45553211, Length=327, Percent_Identity=34.2507645259939, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24667912, Length=327, Percent_Identity=34.2507645259939, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24667904, Length=327, Percent_Identity=34.2507645259939, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24667908, Length=327, Percent_Identity=34.2507645259939, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24658010, Length=341, Percent_Identity=29.9120234604106, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24648360, Length=346, Percent_Identity=28.0346820809249, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.272 [H]

Molecular weight: Translated: 39017; Mature: 38885

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIAVSEKDLQRFCRDLLKQSLPDEEAEVIAETLVDADLRGVTSHGVQRVAGYLKRMED
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIIERKTDISVVQDSFATALLDANNGWGQVAGVKAMEMAIQKAGQYGTSFVGVSNSNHFG
HHHHCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
TASFYTRMAAEKGFIGISMTNASPIMVPFGAKEPSLGPNPISISIPAGEGKKPIILDMST
HHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEEECC
SNVARGKIMVAKKNKESIPEGWAITKDGKQTTDADEAWEGFVLPMGPKGSGLAIIIDILS
CCCCCCEEEEEECCCCCCCCCCEECCCCCCCCCHHHHHCCCEEECCCCCCCHHHHHHHHH
GVLTGSLFGKRIPRQYDDPYPQQLGHLFGAINIENFGEPELFYQNVLEKIEETISSEPSE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
GFDQVYMPGDMESQRKKEYKENGIPLSQEIINELRKTGEKYGVDLEHYLSQNKQRN
CCCCEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
>Mature Secondary Structure 
SNIAVSEKDLQRFCRDLLKQSLPDEEAEVIAETLVDADLRGVTSHGVQRVAGYLKRMED
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIIERKTDISVVQDSFATALLDANNGWGQVAGVKAMEMAIQKAGQYGTSFVGVSNSNHFG
HHHHCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
TASFYTRMAAEKGFIGISMTNASPIMVPFGAKEPSLGPNPISISIPAGEGKKPIILDMST
HHHHHHHHHHHCCCEEEEECCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEEECC
SNVARGKIMVAKKNKESIPEGWAITKDGKQTTDADEAWEGFVLPMGPKGSGLAIIIDILS
CCCCCCEEEEEECCCCCCCCCCEECCCCCCCCCHHHHHCCCEEECCCCCCCHHHHHHHHH
GVLTGSLFGKRIPRQYDDPYPQQLGHLFGAINIENFGEPELFYQNVLEKIEETISSEPSE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
GFDQVYMPGDMESQRKKEYKENGIPLSQEIINELRKTGEKYGVDLEHYLSQNKQRN
CCCCEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10850983 [H]