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The map label for this gene is serA [H]

Identifier: 23100299

GI number: 23100299

Start: 2927861

End: 2928820

Strand: Reverse

Name: serA [H]

Synonym: OB2844

Alternate gene names: 23100299

Gene position: 2928820-2927861 (Counterclockwise)

Preceding gene: 23100300

Following gene: 23100298

Centisome position: 80.67

GC content: 38.54

Gene sequence:

>960_bases
ATGGTATTTCGAGTATTAGTCCCGCAAAAGATTGCACAAGAAGGAATTAGATTACTAGAGGAAAACGGTGCTAGTATTGT
TGTTCCACCTAGCCATGATGAAGCTACACTTGTTGAGTATGTAAGCGATGTTGATGCTATTATTGCTAGAACGGAAATAT
ATTCCGAAAAGGTATTAGAAAATGCCAATCGTTTAAAAATTATTGCAAGGCATGGGATTGGTGTGGATAATATTGATGTA
AAGGCTGCTACAAAATACGGTATCAAAGTTACGAATACACCGTCAGCAAATATAAATGCAGTGGCAGAACTTGTGTTAAC
ATTCATGCTAGCTAGTACGCGACATTTATTGCCAATTGATGAGGCAGTACGTGCTGGGAATTTTGATATCCGCAATCAGC
TATTTGGATATGAGTTAAATGGAAAAACGGTTGGGATTATTGGCTTCGGAAATATCGGCCGGTTAATTGCGGAAAAATGT
AGGTTAGGATTAGGAATGAATATCGTAGTCTTCGATCCTTATGTGACTGCGGAAAGTGTAGAGCCATACGTAGAATTAAC
AGAATCATTGGAAGATTTATTGCGAATATCCGATGTAGTTACTTTACATGTACCATATGTTCGCGCTACGCATCACCTTA
TCCATAAAGATTCATTCCAGATTATGAAAAAAGATGCGATATTAATTAATGCAGCTCGTGGTGGTGTCGTAGATGAAAAA
GCGCTGGTGGAGGCACTAATGAACGGAGAAATCAGAGGAGCATGCGTGGATGTTTTTGAAGAGGAGCCGCCAAAGCAAGA
GAATCCTTTATTTAAATTAGAGAATGTGATTGTTACTCCGCACTTAGGAGCGCAGACGTATGAAGCATTTAAAAAAATGG
CAATAGATGCTGCAAATGAAATCATATCAGTAAAAAATGGCAATGCTCCAGAACACTTAATTCATCCGGTGACAACATAA

Upstream 100 bases:

>100_bases
AGTTACTAGGGAACCGGTAAATCCTTTATCACCAAATGATAGACTAGAGTTAGAGGAGCTATTAAAAAGCTGGAATACGC
AAGAGGTGAGGTGACAGCGA

Downstream 100 bases:

>100_bases
TTTTAATAGGAGAGGTGACAAATGATGAAAATTACGGATTTGGAATTACATGCAGTCGGTATTCCTCGTCATACAGGATT
TGTGAATAAACATGTTATTG

Product: hypothetical protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MVFRVLVPQKIAQEGIRLLEENGASIVVPPSHDEATLVEYVSDVDAIIARTEIYSEKVLENANRLKIIARHGIGVDNIDV
KAATKYGIKVTNTPSANINAVAELVLTFMLASTRHLLPIDEAVRAGNFDIRNQLFGYELNGKTVGIIGFGNIGRLIAEKC
RLGLGMNIVVFDPYVTAESVEPYVELTESLEDLLRISDVVTLHVPYVRATHHLIHKDSFQIMKKDAILINAARGGVVDEK
ALVEALMNGEIRGACVDVFEEEPPKQENPLFKLENVIVTPHLGAQTYEAFKKMAIDAANEIISVKNGNAPEHLIHPVTT

Sequences:

>Translated_319_residues
MVFRVLVPQKIAQEGIRLLEENGASIVVPPSHDEATLVEYVSDVDAIIARTEIYSEKVLENANRLKIIARHGIGVDNIDV
KAATKYGIKVTNTPSANINAVAELVLTFMLASTRHLLPIDEAVRAGNFDIRNQLFGYELNGKTVGIIGFGNIGRLIAEKC
RLGLGMNIVVFDPYVTAESVEPYVELTESLEDLLRISDVVTLHVPYVRATHHLIHKDSFQIMKKDAILINAARGGVVDEK
ALVEALMNGEIRGACVDVFEEEPPKQENPLFKLENVIVTPHLGAQTYEAFKKMAIDAANEIISVKNGNAPEHLIHPVTT
>Mature_319_residues
MVFRVLVPQKIAQEGIRLLEENGASIVVPPSHDEATLVEYVSDVDAIIARTEIYSEKVLENANRLKIIARHGIGVDNIDV
KAATKYGIKVTNTPSANINAVAELVLTFMLASTRHLLPIDEAVRAGNFDIRNQLFGYELNGKTVGIIGFGNIGRLIAEKC
RLGLGMNIVVFDPYVTAESVEPYVELTESLEDLLRISDVVTLHVPYVRATHHLIHKDSFQIMKKDAILINAARGGVVDEK
ALVEALMNGEIRGACVDVFEEEPPKQENPLFKLENVIVTPHLGAQTYEAFKKMAIDAANEIISVKNGNAPEHLIHPVTT

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=307, Percent_Identity=33.5504885993485, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI4557497, Length=279, Percent_Identity=37.9928315412186, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI61743967, Length=279, Percent_Identity=37.9928315412186, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI145580578, Length=279, Percent_Identity=37.2759856630824, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI4557499, Length=279, Percent_Identity=37.2759856630824, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI145580575, Length=279, Percent_Identity=37.2759856630824, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI6912396, Length=256, Percent_Identity=32.8125, Blast_Score=131, Evalue=7e-31,
Organism=Escherichia coli, GI87082289, Length=277, Percent_Identity=33.5740072202166, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1789279, Length=286, Percent_Identity=35.3146853146853, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1787645, Length=276, Percent_Identity=31.1594202898551, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788660, Length=256, Percent_Identity=28.515625, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=311, Percent_Identity=38.5852090032154, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25147481, Length=266, Percent_Identity=31.9548872180451, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=330, Percent_Identity=32.7272727272727, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6322116, Length=328, Percent_Identity=32.3170731707317, Blast_Score=145, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6324055, Length=293, Percent_Identity=30.7167235494881, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=324, Percent_Identity=26.2345679012346, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=187, Percent_Identity=29.9465240641711, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=190, Percent_Identity=25.7894736842105, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6325144, Length=147, Percent_Identity=26.530612244898, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=316, Percent_Identity=34.8101265822785, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24646446, Length=279, Percent_Identity=35.1254480286738, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646448, Length=279, Percent_Identity=35.1254480286738, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646452, Length=279, Percent_Identity=35.1254480286738, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646450, Length=279, Percent_Identity=35.1254480286738, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI62472511, Length=277, Percent_Identity=35.0180505415162, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24585516, Length=314, Percent_Identity=29.6178343949045, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28571528, Length=287, Percent_Identity=34.8432055749129, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI45552429, Length=323, Percent_Identity=30.030959752322, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24585514, Length=323, Percent_Identity=30.030959752322, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28574282, Length=323, Percent_Identity=30.030959752322, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28574284, Length=323, Percent_Identity=30.030959752322, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45551003, Length=323, Percent_Identity=30.030959752322, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28574286, Length=324, Percent_Identity=28.7037037037037, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35060; Mature: 35060

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFRVLVPQKIAQEGIRLLEENGASIVVPPSHDEATLVEYVSDVDAIIARTEIYSEKVLE
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
NANRLKIIARHGIGVDNIDVKAATKYGIKVTNTPSANINAVAELVLTFMLASTRHLLPID
CCCCEEEEEECCCCCCCCEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHH
EAVRAGNFDIRNQLFGYELNGKTVGIIGFGNIGRLIAEKCRLGLGMNIVVFDPYVTAESV
HHHHCCCCCHHHCEEEEEECCCEEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
EPYVELTESLEDLLRISDVVTLHVPYVRATHHLIHKDSFQIMKKDAILINAARGGVVDEK
CHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHCCHHHHHCCCEEEEECCCCCCCCHH
ALVEALMNGEIRGACVDVFEEEPPKQENPLFKLENVIVTPHLGAQTYEAFKKMAIDAANE
HHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEECCEEECCCCCHHHHHHHHHHHHHHHHH
IISVKNGNAPEHLIHPVTT
EEEECCCCCHHHCCCCCCC
>Mature Secondary Structure
MVFRVLVPQKIAQEGIRLLEENGASIVVPPSHDEATLVEYVSDVDAIIARTEIYSEKVLE
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
NANRLKIIARHGIGVDNIDVKAATKYGIKVTNTPSANINAVAELVLTFMLASTRHLLPID
CCCCEEEEEECCCCCCCCEEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHH
EAVRAGNFDIRNQLFGYELNGKTVGIIGFGNIGRLIAEKCRLGLGMNIVVFDPYVTAESV
HHHHCCCCCHHHCEEEEEECCCEEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
EPYVELTESLEDLLRISDVVTLHVPYVRATHHLIHKDSFQIMKKDAILINAARGGVVDEK
CHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHCCHHHHHCCCEEEEECCCCCCCCHH
ALVEALMNGEIRGACVDVFEEEPPKQENPLFKLENVIVTPHLGAQTYEAFKKMAIDAANE
HHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEECCEEECCCCCHHHHHHHHHHHHHHHHH
IISVKNGNAPEHLIHPVTT
EEEECCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]