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The map label for this gene is rspB [H]

Identifier: 23100270

GI number: 23100270

Start: 2894468

End: 2895484

Strand: Reverse

Name: rspB [H]

Synonym: OB2815

Alternate gene names: 23100270

Gene position: 2895484-2894468 (Counterclockwise)

Preceding gene: 23100271

Following gene: 23100269

Centisome position: 79.75

GC content: 38.25

Gene sequence:

>1017_bases
ATGGAGACAGTAACTTATGCTGGACCAAAGAACATTTTATTTCAGAATAATCGAAAACCAACGATAACCAAAGGTTGGGC
AATTATAAAAACGTCATATGCTGGGATTTGTGGGAGTGATTTAAGTATATTTGCTGGTGTGCATCCACGTGCAGAGGCCC
CTTTAGTCATGGGGCATGAGTTCTCAGGAACGATTGAAGAAGGTCACCCAACTTTAAAGAAAGGAACAAGGGTAACGGTC
AATCCTTTATTACGTTGTGGTGAATGCTATCCTTGTCAAAATGGGTATAGCCATGTATGTGAGAACTTGAAATTAGTGGG
TATAGATTGTGATGGTGGGATGGGAGAGTATGTGAAAGTTCCCATACATAGCATCGTACCTTTGAAAGATAATATTTCAA
TGAAATTAGGTGCGCTAATTGAGCCAGTTGCAGTTGCTGTACACGCGATAAGGCAAGGTAACTACATGCCTGGAGATAGC
GTCGTAATTTTCGGTGCAGGAACGATTGGTCTTTGTGTAGCTTTAACTTTAAGGTCTTATGGAGCAAAGAATTTGATAAT
CGTGGAACCAAATAAATTACGATTAGAGAAGGCGAAACAACTCGGTTTTCAAACGTTGGATCCATTATCTGAGAATGTAA
CAGAGAAAATAGTAGAAGGAACCGATAATATTGGTGCAGATTACGTCTTTGATTGTGCGGGACATCCTTCTGTAGTGGAA
GCCATTACCGAAGTTGTAAGAGTAAGAGGAAATATAGTTATTGTAGCTATGTATAAGCAGCCCCCAACCCTTGATATGAG
ACAAGGAATGTTTAAAGAATTAAATATACAATTTGTACGTGTTTATACAGATAAAGATTTTCAAATAGCCATTGACTTAG
TAGACAATCACAAGGAGTATGAAGATATAATAACGCATGTCTTACAACCTGAAGAAGCACAAAAAGGCTTCGATTTATTA
ACTACTCATACAGATGCAGTCAAAGTAATGTATGAATTCAATAGGGGGGAGTTGTAA

Upstream 100 bases:

>100_bases
TTGTTCCAGCTATATCTCTGTTCATTCCTAAATTATTTGGAGTAATGGAATAGAATCTAAATCATAGAGAATGTAATACT
AAGATGGAAGGAAAGGTGTT

Downstream 100 bases:

>100_bases
TGAATGAATTGTTCAATTTGACTGGAAAAGTAGCTGTCATAACAGGTGGAAATCGAGGCATTGGAAAAAGTATTGCAACT
GGATTGGCTAGTGCTGGGGC

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
METVTYAGPKNILFQNNRKPTITKGWAIIKTSYAGICGSDLSIFAGVHPRAEAPLVMGHEFSGTIEEGHPTLKKGTRVTV
NPLLRCGECYPCQNGYSHVCENLKLVGIDCDGGMGEYVKVPIHSIVPLKDNISMKLGALIEPVAVAVHAIRQGNYMPGDS
VVIFGAGTIGLCVALTLRSYGAKNLIIVEPNKLRLEKAKQLGFQTLDPLSENVTEKIVEGTDNIGADYVFDCAGHPSVVE
AITEVVRVRGNIVIVAMYKQPPTLDMRQGMFKELNIQFVRVYTDKDFQIAIDLVDNHKEYEDIITHVLQPEEAQKGFDLL
TTHTDAVKVMYEFNRGEL

Sequences:

>Translated_338_residues
METVTYAGPKNILFQNNRKPTITKGWAIIKTSYAGICGSDLSIFAGVHPRAEAPLVMGHEFSGTIEEGHPTLKKGTRVTV
NPLLRCGECYPCQNGYSHVCENLKLVGIDCDGGMGEYVKVPIHSIVPLKDNISMKLGALIEPVAVAVHAIRQGNYMPGDS
VVIFGAGTIGLCVALTLRSYGAKNLIIVEPNKLRLEKAKQLGFQTLDPLSENVTEKIVEGTDNIGADYVFDCAGHPSVVE
AITEVVRVRGNIVIVAMYKQPPTLDMRQGMFKELNIQFVRVYTDKDFQIAIDLVDNHKEYEDIITHVLQPEEAQKGFDLL
TTHTDAVKVMYEFNRGEL
>Mature_338_residues
METVTYAGPKNILFQNNRKPTITKGWAIIKTSYAGICGSDLSIFAGVHPRAEAPLVMGHEFSGTIEEGHPTLKKGTRVTV
NPLLRCGECYPCQNGYSHVCENLKLVGIDCDGGMGEYVKVPIHSIVPLKDNISMKLGALIEPVAVAVHAIRQGNYMPGDS
VVIFGAGTIGLCVALTLRSYGAKNLIIVEPNKLRLEKAKQLGFQTLDPLSENVTEKIVEGTDNIGADYVFDCAGHPSVVE
AITEVVRVRGNIVIVAMYKQPPTLDMRQGMFKELNIQFVRVYTDKDFQIAIDLVDNHKEYEDIITHVLQPEEAQKGFDLL
TTHTDAVKVMYEFNRGEL

Specific function: Not known; probable catabolic enzyme [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=324, Percent_Identity=26.5432098765432, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI71743840, Length=337, Percent_Identity=25.2225519287834, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI262073058, Length=337, Percent_Identity=25.2225519287834, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787863, Length=347, Percent_Identity=31.700288184438, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI226510992, Length=310, Percent_Identity=30, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790045, Length=304, Percent_Identity=28.2894736842105, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788073, Length=310, Percent_Identity=27.741935483871, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790718, Length=279, Percent_Identity=28.673835125448, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788407, Length=298, Percent_Identity=28.5234899328859, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788075, Length=331, Percent_Identity=27.4924471299094, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786825, Length=269, Percent_Identity=27.8810408921933, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082125, Length=322, Percent_Identity=27.639751552795, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786552, Length=340, Percent_Identity=24.7058823529412, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI87081918, Length=282, Percent_Identity=24.113475177305, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=318, Percent_Identity=28.9308176100629, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562878, Length=315, Percent_Identity=26.3492063492064, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=350, Percent_Identity=29.7142857142857, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6319258, Length=297, Percent_Identity=30.976430976431, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6323099, Length=338, Percent_Identity=31.3609467455621, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6322619, Length=304, Percent_Identity=28.9473684210526, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319955, Length=304, Percent_Identity=28.9473684210526, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320033, Length=273, Percent_Identity=25.6410256410256, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=294, Percent_Identity=27.891156462585, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737897, Length=343, Percent_Identity=29.7376093294461, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17137530, Length=330, Percent_Identity=28.1818181818182, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI17737895, Length=346, Percent_Identity=23.6994219653179, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550770, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45551930, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221457811, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 37204; Mature: 37204

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVTYAGPKNILFQNNRKPTITKGWAIIKTSYAGICGSDLSIFAGVHPRAEAPLVMGHE
CCCEECCCCCCEEEECCCCCCEECCEEEEEECCCCCCCCCCEEEECCCCCCCCCEEECCC
FSGTIEEGHPTLKKGTRVTVNPLLRCGECYPCQNGYSHVCENLKLVGIDCDGGMGEYVKV
CCCCCCCCCCCHHCCCEEEECHHHHCCCCCCCCCCHHHHHCCCEEEEEECCCCCCCEEEE
PIHSIVPLKDNISMKLGALIEPVAVAVHAIRQGNYMPGDSVVIFGAGTIGLCVALTLRSY
CHHHEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHC
GAKNLIIVEPNKLRLEKAKQLGFQTLDPLSENVTEKIVEGTDNIGADYVFDCAGHPSVVE
CCCEEEEECCCHHHHHHHHHCCCHHCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHH
AITEVVRVRGNIVIVAMYKQPPTLDMRQGMFKELNIQFVRVYTDKDFQIAIDLVDNHKEY
HHHHHHHHCCCEEEEEEECCCCCCHHHHCHHHHCCEEEEEEEECCCEEEEEEEECCCHHH
EDIITHVLQPEEAQKGFDLLTTHTDAVKVMYEFNRGEL
HHHHHHHCCCHHHHCCCEEEEECCCCEEEEEECCCCCC
>Mature Secondary Structure
METVTYAGPKNILFQNNRKPTITKGWAIIKTSYAGICGSDLSIFAGVHPRAEAPLVMGHE
CCCEECCCCCCEEEECCCCCCEECCEEEEEECCCCCCCCCCEEEECCCCCCCCCEEECCC
FSGTIEEGHPTLKKGTRVTVNPLLRCGECYPCQNGYSHVCENLKLVGIDCDGGMGEYVKV
CCCCCCCCCCCHHCCCEEEECHHHHCCCCCCCCCCHHHHHCCCEEEEEECCCCCCCEEEE
PIHSIVPLKDNISMKLGALIEPVAVAVHAIRQGNYMPGDSVVIFGAGTIGLCVALTLRSY
CHHHEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHC
GAKNLIIVEPNKLRLEKAKQLGFQTLDPLSENVTEKIVEGTDNIGADYVFDCAGHPSVVE
CCCEEEEECCCHHHHHHHHHCCCHHCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHH
AITEVVRVRGNIVIVAMYKQPPTLDMRQGMFKELNIQFVRVYTDKDFQIAIDLVDNHKEY
HHHHHHHHCCCEEEEEEECCCCCCHHHHCHHHHCCEEEEEEEECCCEEEEEEEECCCHHH
EDIITHVLQPEEAQKGFDLLTTHTDAVKVMYEFNRGEL
HHHHHHHCCCHHHHCCCEEEEECCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7545940; 9097039; 9278503 [H]