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The map label for this gene is rpiA2

Identifier: 23100154

GI number: 23100154

Start: 2769786

End: 2770460

Strand: Reverse

Name: rpiA2

Synonym: OB2699

Alternate gene names: 23100154

Gene position: 2770460-2769786 (Counterclockwise)

Preceding gene: 23100155

Following gene: 23100153

Centisome position: 76.31

GC content: 37.19

Gene sequence:

>675_bases
GTGGAATACAGTGATAAACAAATTGCAGCACAAGAAGCGGTAAGGTATATCAAAGATGGTATGGTTATTGGAATTGGTTC
TGGATCAACCGTAAATGAATTTCTCTATTGTTTAGCAGCTAGAATGAGAAAAGAGAGATTACAAGTAGTAGGGATACCTG
CGTCGAAAAAATCAGAGCGATTAGCAACGGAGCTTGGAATCCCTTTAACTACTTTTGCTACTTATCAAAACGTTGATATT
GCAATTGACGGAACAGATGAGATCGATGACCAGCTGTATTTAGTTAAAGGTGGGGGCGGCTCACTAGTAAGAGAAAAAAT
GATCGATTTGGTTGCTGAAACCTTTATCGTAATTGCTAGTGGTAAAAAGAAAATAAAGAAGCTAGGATCGTTCCCAGTAC
CAGTTGAAGTAGTACCATTTGGATGGCAGGCTACCGAACAAAGGCTGCAACAATTTGGATGTCAGACCAATTTGCGGATG
GTGGAAGAAGACATTTTTGTCTCGGACAATCAGAACTATATTATTGATTGTGATTTTAAAGAAATCGATGATGCAGAAGC
ATTACATCGATCATTAAAACAAATTGTAGGTGTAATCGAAACTGGGATTTTTATAAATATGGTAGATAAAGCAATTGTTG
CAGATAACGGTGAGTTATCCATATTGGAAAAATAA

Upstream 100 bases:

>100_bases
GTAGTCCTGTTATTTATTGCGTTTTTCCCGAATATCGCATTCTATATTCCGAAACTTATTAATCCTAGCTTATTCTAATT
AGTAGAAAGGAACGATTATA

Downstream 100 bases:

>100_bases
AAGTTAATTGGGAGGGGTCTATATGAAAGATATTATAACGTTAGGAGAGGCAATGGTAGTATTTAACCCAGCATCTACTG
GACCGATGAAATTTGTAAAT

Product: ribose 5-phosphate isomerase

Products: NA

Alternate protein names: Phosphoriboisomerase A 2; PRI 2

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MEYSDKQIAAQEAVRYIKDGMVIGIGSGSTVNEFLYCLAARMRKERLQVVGIPASKKSERLATELGIPLTTFATYQNVDI
AIDGTDEIDDQLYLVKGGGGSLVREKMIDLVAETFIVIASGKKKIKKLGSFPVPVEVVPFGWQATEQRLQQFGCQTNLRM
VEEDIFVSDNQNYIIDCDFKEIDDAEALHRSLKQIVGVIETGIFINMVDKAIVADNGELSILEK

Sequences:

>Translated_224_residues
MEYSDKQIAAQEAVRYIKDGMVIGIGSGSTVNEFLYCLAARMRKERLQVVGIPASKKSERLATELGIPLTTFATYQNVDI
AIDGTDEIDDQLYLVKGGGGSLVREKMIDLVAETFIVIASGKKKIKKLGSFPVPVEVVPFGWQATEQRLQQFGCQTNLRM
VEEDIFVSDNQNYIIDCDFKEIDDAEALHRSLKQIVGVIETGIFINMVDKAIVADNGELSILEK
>Mature_224_residues
MEYSDKQIAAQEAVRYIKDGMVIGIGSGSTVNEFLYCLAARMRKERLQVVGIPASKKSERLATELGIPLTTFATYQNVDI
AIDGTDEIDDQLYLVKGGGGSLVREKMIDLVAETFIVIASGKKKIKKLGSFPVPVEVVPFGWQATEQRLQQFGCQTNLRM
VEEDIFVSDNQNYIIDCDFKEIDDAEALHRSLKQIVGVIETGIFINMVDKAIVADNGELSILEK

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=227, Percent_Identity=35.6828193832599, Blast_Score=141, Evalue=5e-34,
Organism=Escherichia coli, GI1789280, Length=202, Percent_Identity=34.6534653465347, Blast_Score=121, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17551758, Length=223, Percent_Identity=33.1838565022422, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324669, Length=237, Percent_Identity=36.7088607594937, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281364072, Length=219, Percent_Identity=35.1598173515982, Blast_Score=118, Evalue=3e-27,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA2_OCEIH (Q8EMZ1)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693620.1
- ProteinModelPortal:   Q8EMZ1
- SMR:   Q8EMZ1
- GeneID:   1017038
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2699
- NMPDR:   fig|221109.1.peg.2699
- HOGENOM:   HBG515603
- OMA:   TANYFIE
- BioCyc:   OIHE221109:OB2699-MONOMER
- BRENDA:   5.3.1.6
- HAMAP:   MF_00170
- InterPro:   IPR014036
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF00455 DeoR; PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 24828; Mature: 24828

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYSDKQIAAQEAVRYIKDGMVIGIGSGSTVNEFLYCLAARMRKERLQVVGIPASKKSER
CCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCHHH
LATELGIPLTTFATYQNVDIAIDGTDEIDDQLYLVKGGGGSLVREKMIDLVAETFIVIAS
HHHHHCCCCEEEEEECCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEC
GKKKIKKLGSFPVPVEVVPFGWQATEQRLQQFGCQTNLRMVEEDIFVSDNQNYIIDCDFK
CHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEHHHEEEEECCCCEEEECCCH
EIDDAEALHRSLKQIVGVIETGIFINMVDKAIVADNGELSILEK
HCCCHHHHHHHHHHHHHHHHCCHHEEHHHHHHEECCCCEEEECC
>Mature Secondary Structure
MEYSDKQIAAQEAVRYIKDGMVIGIGSGSTVNEFLYCLAARMRKERLQVVGIPASKKSER
CCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCHHH
LATELGIPLTTFATYQNVDIAIDGTDEIDDQLYLVKGGGGSLVREKMIDLVAETFIVIAS
HHHHHCCCCEEEEEECCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEC
GKKKIKKLGSFPVPVEVVPFGWQATEQRLQQFGCQTNLRMVEEDIFVSDNQNYIIDCDFK
CHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEHHHEEEEECCCCEEEECCCH
EIDDAEALHRSLKQIVGVIETGIFINMVDKAIVADNGELSILEK
HCCCHHHHHHHHHHHHHHHHCCHHEEHHHHHHEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376