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The map label for this gene is comEC [H]

Identifier: 23100138

GI number: 23100138

Start: 2754581

End: 2755660

Strand: Direct

Name: comEC [H]

Synonym: OB2683

Alternate gene names: 23100138

Gene position: 2754581-2755660 (Clockwise)

Preceding gene: 23100137

Following gene: 23100139

Centisome position: 75.87

GC content: 37.59

Gene sequence:

>1080_bases
TTGCTAAAAAAATTTATCTTCGTCCTATCTTTCATATTATTGCTGATCGGCTGTGGAGATACTCAGACATCTGAAGCTAA
TAATCTTTCAAATTCATCTACAGATGGCAACTTAAAAGTACACTTTATCGACGTTGGACAAGCAGATGCAACTTTATTTT
CCTATAAAAATGGAGATGAAGCTTATTCTGTCCTGTTTGATACTGGGGATTGGCAAGGTGACGAAGTAGTTCCTTATCTA
CAAGAACAAAATATTGATCATCTTGATCTTGCCATCATTAGTCATCCTGATGCTGATCATATCGGACAATTATCAGATGT
ACTAGAAAATATTCAAGTTGATGAAGTATGGATGTCTGGAAATGAAAGTACTTCCCAAACTTATTTAGATGCAATGGAAG
CTATTTTCGACCAAGATAGTACGTATCAAGAACCTCGTACTGGGGATGAGTACACAATAGGACCACTTGATATAGAGGTG
CTATATCCAGAAACAATCTCAGGCAAATCAAATGAGGAATCCATATCTATACGATTGGGTTACAATGAAGTTTCCTTTGT
ACTTACGGGAGATGCCGGTAAACAAGAGGAGCTTGAAATGATAGAATCTACCGAGTCACTTGATAGTACAGTCTTACATC
TTGGGCACCATGGATCTGATACTTCCTCTGACGCTGATTTTGTAAAGGAAGTCGATCCAGAGCTAGCAATTTATAGTGCT
GGAGAGGATAATTCATATGAACATCCGAGTGAAGAAGTAATTCGACTATTAAATAATGAGGAAATTGATTGGTATGGCAC
CGATGTCAATGGTACGATTATTGTTGAGACAGACGGACAAGAATACGCTGTACACACGGAACATCCTCATGATGATTCTG
AACAAACTGCGTGTGTAAATATTAATGAAAGTACAGAAGAACAACTTCAAGAGATAGTTCATATTGGTGCCTCTCGAGCA
GAGCAAATAGTAGAAGAACGTCCCTTTGAATCACTTCAAGATCTTGATAGCATACAAGGCATAGGGATGAGTCGAATTAC
AGATATTGAAGAACAAGGAATTGTTTGTCGTTTAGATTAA

Upstream 100 bases:

>100_bases
ATCCTCCTGATGGTAATTTTCATACCTTTGGTGGATAGTTTCCTCTTCCATATTTTGGTAACCTAATAGTCTAATCAGAC
AAGATGGGAGTTAACAAACA

Downstream 100 bases:

>100_bases
GGAGGATATCATTTGAAAGGAATCATTGATCGTTTCGAAAAAGACTTTGCTGTTATTCTCGTTGAAGAACAGCAAAAAGA
ATATGTACTCCAAAAATCTA

Product: late competence protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MLKKFIFVLSFILLLIGCGDTQTSEANNLSNSSTDGNLKVHFIDVGQADATLFSYKNGDEAYSVLFDTGDWQGDEVVPYL
QEQNIDHLDLAIISHPDADHIGQLSDVLENIQVDEVWMSGNESTSQTYLDAMEAIFDQDSTYQEPRTGDEYTIGPLDIEV
LYPETISGKSNEESISIRLGYNEVSFVLTGDAGKQEELEMIESTESLDSTVLHLGHHGSDTSSDADFVKEVDPELAIYSA
GEDNSYEHPSEEVIRLLNNEEIDWYGTDVNGTIIVETDGQEYAVHTEHPHDDSEQTACVNINESTEEQLQEIVHIGASRA
EQIVEERPFESLQDLDSIQGIGMSRITDIEEQGIVCRLD

Sequences:

>Translated_359_residues
MLKKFIFVLSFILLLIGCGDTQTSEANNLSNSSTDGNLKVHFIDVGQADATLFSYKNGDEAYSVLFDTGDWQGDEVVPYL
QEQNIDHLDLAIISHPDADHIGQLSDVLENIQVDEVWMSGNESTSQTYLDAMEAIFDQDSTYQEPRTGDEYTIGPLDIEV
LYPETISGKSNEESISIRLGYNEVSFVLTGDAGKQEELEMIESTESLDSTVLHLGHHGSDTSSDADFVKEVDPELAIYSA
GEDNSYEHPSEEVIRLLNNEEIDWYGTDVNGTIIVETDGQEYAVHTEHPHDDSEQTACVNINESTEEQLQEIVHIGASRA
EQIVEERPFESLQDLDSIQGIGMSRITDIEEQGIVCRLD
>Mature_359_residues
MLKKFIFVLSFILLLIGCGDTQTSEANNLSNSSTDGNLKVHFIDVGQADATLFSYKNGDEAYSVLFDTGDWQGDEVVPYL
QEQNIDHLDLAIISHPDADHIGQLSDVLENIQVDEVWMSGNESTSQTYLDAMEAIFDQDSTYQEPRTGDEYTIGPLDIEV
LYPETISGKSNEESISIRLGYNEVSFVLTGDAGKQEELEMIESTESLDSTVLHLGHHGSDTSSDADFVKEVDPELAIYSA
GEDNSYEHPSEEVIRLLNNEEIDWYGTDVNGTIIVETDGQEYAVHTEHPHDDSEQTACVNINESTEEQLQEIVHIGASRA
EQIVEERPFESLQDLDSIQGIGMSRITDIEEQGIVCRLD

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 39925; Mature: 39925

Theoretical pI: Translated: 3.72; Mature: 3.72

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKFIFVLSFILLLIGCGDTQTSEANNLSNSSTDGNLKVHFIDVGQADATLFSYKNGDE
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCC
AYSVLFDTGDWQGDEVVPYLQEQNIDHLDLAIISHPDADHIGQLSDVLENIQVDEVWMSG
EEEEEEECCCCCCCCCCCHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCEEEEEEECC
NESTSQTYLDAMEAIFDQDSTYQEPRTGDEYTIGPLDIEVLYPETISGKSNEESISIRLG
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCCEEEEEEC
YNEVSFVLTGDAGKQEELEMIESTESLDSTVLHLGHHGSDTSSDADFVKEVDPELAIYSA
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHCCCCEEEEEC
GEDNSYEHPSEEVIRLLNNEEIDWYGTDVNGTIIVETDGQEYAVHTEHPHDDSEQTACVN
CCCCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEEEECCCEEEEECCCCCCCCCCEEEEE
INESTEEQLQEIVHIGASRAEQIVEERPFESLQDLDSIQGIGMSRITDIEEQGIVCRLD
CCCHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHCCHHHCCEEEEEC
>Mature Secondary Structure
MLKKFIFVLSFILLLIGCGDTQTSEANNLSNSSTDGNLKVHFIDVGQADATLFSYKNGDE
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCC
AYSVLFDTGDWQGDEVVPYLQEQNIDHLDLAIISHPDADHIGQLSDVLENIQVDEVWMSG
EEEEEEECCCCCCCCCCCHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCEEEEEEECC
NESTSQTYLDAMEAIFDQDSTYQEPRTGDEYTIGPLDIEVLYPETISGKSNEESISIRLG
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEEEECCCCCCCCCCCCEEEEEEC
YNEVSFVLTGDAGKQEELEMIESTESLDSTVLHLGHHGSDTSSDADFVKEVDPELAIYSA
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHCCCCEEEEEC
GEDNSYEHPSEEVIRLLNNEEIDWYGTDVNGTIIVETDGQEYAVHTEHPHDDSEQTACVN
CCCCCCCCCHHHHHHHHCCCCCEEEECCCCCEEEEEECCCEEEEECCCCCCCCCCEEEEE
INESTEEQLQEIVHIGASRAEQIVEERPFESLQDLDSIQGIGMSRITDIEEQGIVCRLD
CCCHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHCCHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]