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The map label for this gene is coaW

Identifier: 23100137

GI number: 23100137

Start: 2753702

End: 2754490

Strand: Direct

Name: coaW

Synonym: OB2682

Alternate gene names: 23100137

Gene position: 2753702-2754490 (Clockwise)

Preceding gene: 23100118

Following gene: 23100138

Centisome position: 75.85

GC content: 35.99

Gene sequence:

>789_bases
ATGAAACGAATAGGTATCGATGCTGGAGGTTCTCTAGTTAAAGTTGCTTACGAAGAACATGGAAAAATGCATTTGAAAAC
ATACTCATCTCATAAAATGGAAGAAGTAATTCAGTGGTTAAAAACGCTTTCTCCATATGCTTCATTCCATATTACTGGGG
GAAGATCGAGAGAATTAAACTTAGAAGGATATCGTGTCTATACCATTCCAGAATTTAAAGCAATTATGGAAGGAACATCC
TATCTGCTGCATCAAGAACGTAAACTACCAAAAAGTGACTATTTACTGGTGAATATTGGAACAGGTACTTCAATTTTTTA
TAATGAAAATCGTATTGCTGGAACAGGAATTGGAGGTGGTTTATTAACCGGACTCGGGGAACTATTAACAAAAGAGTCTT
CTTATACTCAACTTATCCAAATGGCAAAACAAGGTGACCGTACTAAAAGCGACTTAATGGTCAGAGATATTTATAAAGAT
TCTACCTCACCGATTGATGAAACACTCACCGCTGCTAATTTTGGAAAAGTTGGATTAGATCCTTCAAATTCCAAAGAAGA
TCAAATGGCTGCTTTAATACAATTAATTGGAGAAACAATACTTTTGATATCACATGGAGCTGCACAATCAGTAAAGACAA
GCCAGATTGTTTTTATTGGCGGTACATTAACAAATAATCAACCTTTACAACGTGTATTCCTACATTTCCAAGAACAAATG
AACTATACCGCTACTTTCCTAAATAATGGTGGTCATGCTGGTGCAATTGGCGCTATGCTATCCTCCTGA

Upstream 100 bases:

>100_bases
AATTTATTAGGGAATTCCCCTAAACCGCAGTTTTACGGAAACTTCCACACCGTGGTAAACTATTAGCAATTACTTGAGTG
AGATAGTGAGGAGGATGTAA

Downstream 100 bases:

>100_bases
TGGTAATTTTCATACCTTTGGTGGATAGTTTCCTCTTCCATATTTTGGTAACCTAATAGTCTAATCAGACAAGATGGGAG
TTAACAAACATTGCTAAAAA

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-II; Pantothenic acid kinase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MKRIGIDAGGSLVKVAYEEHGKMHLKTYSSHKMEEVIQWLKTLSPYASFHITGGRSRELNLEGYRVYTIPEFKAIMEGTS
YLLHQERKLPKSDYLLVNIGTGTSIFYNENRIAGTGIGGGLLTGLGELLTKESSYTQLIQMAKQGDRTKSDLMVRDIYKD
STSPIDETLTAANFGKVGLDPSNSKEDQMAALIQLIGETILLISHGAAQSVKTSQIVFIGGTLTNNQPLQRVFLHFQEQM
NYTATFLNNGGHAGAIGAMLSS

Sequences:

>Translated_262_residues
MKRIGIDAGGSLVKVAYEEHGKMHLKTYSSHKMEEVIQWLKTLSPYASFHITGGRSRELNLEGYRVYTIPEFKAIMEGTS
YLLHQERKLPKSDYLLVNIGTGTSIFYNENRIAGTGIGGGLLTGLGELLTKESSYTQLIQMAKQGDRTKSDLMVRDIYKD
STSPIDETLTAANFGKVGLDPSNSKEDQMAALIQLIGETILLISHGAAQSVKTSQIVFIGGTLTNNQPLQRVFLHFQEQM
NYTATFLNNGGHAGAIGAMLSS
>Mature_262_residues
MKRIGIDAGGSLVKVAYEEHGKMHLKTYSSHKMEEVIQWLKTLSPYASFHITGGRSRELNLEGYRVYTIPEFKAIMEGTS
YLLHQERKLPKSDYLLVNIGTGTSIFYNENRIAGTGIGGGLLTGLGELLTKESSYTQLIQMAKQGDRTKSDLMVRDIYKD
STSPIDETLTAANFGKVGLDPSNSKEDQMAALIQLIGETILLISHGAAQSVKTSQIVFIGGTLTNNQPLQRVFLHFQEQM
NYTATFLNNGGHAGAIGAMLSS

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG5146

COG function: function code H; Pantothenate kinase, acetyl-CoA regulated

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II pantothenate kinase family

Homologues:

Organism=Homo sapiens, GI8922665, Length=181, Percent_Identity=35.9116022099448, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI13375789, Length=179, Percent_Identity=33.5195530726257, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI85838513, Length=286, Percent_Identity=28.3216783216783, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI24430175, Length=195, Percent_Identity=33.8461538461538, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI24430167, Length=195, Percent_Identity=33.8461538461538, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI23510402, Length=179, Percent_Identity=32.4022346368715, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI23510400, Length=180, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI32565377, Length=334, Percent_Identity=25.4491017964072, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI25144310, Length=333, Percent_Identity=25.5255255255255, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25144312, Length=217, Percent_Identity=28.110599078341, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17864532, Length=183, Percent_Identity=34.9726775956284, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI20544160, Length=183, Percent_Identity=34.9726775956284, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24667450, Length=183, Percent_Identity=34.9726775956284, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24667454, Length=183, Percent_Identity=34.9726775956284, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI20544156, Length=183, Percent_Identity=34.9726775956284, Blast_Score=84, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAW_OCEIH (Q8EN08)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693603.1
- ProteinModelPortal:   Q8EN08
- SMR:   Q8EN08
- GeneID:   1015837
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2682
- NMPDR:   fig|221109.1.peg.2682
- HOGENOM:   HBG339744
- OMA:   LTASNFG
- ProtClustDB:   PRK13317
- BioCyc:   OIHE221109:OB2682-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_01273
- InterPro:   IPR011602
- InterPro:   IPR014642
- InterPro:   IPR004567
- PANTHER:   PTHR12280:SF4
- TIGRFAMs:   TIGR00555

Pfam domain/function: PF03630 Fumble

EC number: =2.7.1.33

Molecular weight: Translated: 28739; Mature: 28739

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: ACT_SITE 71-71 BINDING 101-101 BINDING 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIGIDAGGSLVKVAYEEHGKMHLKTYSSHKMEEVIQWLKTLSPYASFHITGGRSRELN
CCEECCCCCCCEEEEEEHHCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEC
LEGYRVYTIPEFKAIMEGTSYLLHQERKLPKSDYLLVNIGTGTSIFYNENRIAGTGIGGG
CCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCEEEECCCCHH
LLTGLGELLTKESSYTQLIQMAKQGDRTKSDLMVRDIYKDSTSPIDETLTAANFGKVGLD
HHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCC
PSNSKEDQMAALIQLIGETILLISHGAAQSVKTSQIVFIGGTLTNNQPLQRVFLHFQEQM
CCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECEECCCCHHHHHHHHHHHHC
NYTATFLNNGGHAGAIGAMLSS
CEEEEEECCCCCCHHHHHHHCC
>Mature Secondary Structure
MKRIGIDAGGSLVKVAYEEHGKMHLKTYSSHKMEEVIQWLKTLSPYASFHITGGRSRELN
CCEECCCCCCCEEEEEEHHCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEC
LEGYRVYTIPEFKAIMEGTSYLLHQERKLPKSDYLLVNIGTGTSIFYNENRIAGTGIGGG
CCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCEEEECCCCHH
LLTGLGELLTKESSYTQLIQMAKQGDRTKSDLMVRDIYKDSTSPIDETLTAANFGKVGLD
HHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCC
PSNSKEDQMAALIQLIGETILLISHGAAQSVKTSQIVFIGGTLTNNQPLQRVFLHFQEQM
CCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECEECCCCHHHHHHHHHHHHC
NYTATFLNNGGHAGAIGAMLSS
CEEEEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376