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The map label for this gene is zupT

Identifier: 23099882

GI number: 23099882

Start: 2480161

End: 2480967

Strand: Reverse

Name: zupT

Synonym: OB2427

Alternate gene names: 23099882

Gene position: 2480967-2480161 (Counterclockwise)

Preceding gene: 23099883

Following gene: 23099881

Centisome position: 68.34

GC content: 35.94

Gene sequence:

>807_bases
ATGGATAACATGTTATTGGCATTCCTGCTTACCTTATTTGCAGGATTAGCAACAGGTGTTGGGAGTTTGATTGCTTTCAT
GGCAAAGACCACCAACACGAAATTTTTATCTTTTGCTTTAGGGCTTTCTGCGGGAGTAATGATTTATGTATCGATGGTTG
ATATCTTTTTTAAAGCAAAAGATGCGCTAACTGCATATCTAGGCGATACACAAGGATATTGGCTTACAGTTATAGCCTTT
TTCGGTGGAATGTTATTAATTGGATTTATTGATCGATTTATTCCTAAATATACAAATCCTCATGAAGTGAAAAAAGTAGA
AGATATGAAGAAGCCACATCAACCTTTACGAGATCCGGATTTAATGAAAATGGGCCTTTTTACAGCTCTCGCGCTTGCCA
TTCATAATTTTCCAGAGGGGATTGCAACTTTTGTATCGACATTACATGATCCTTCTATTGGTTTAGCGATTGCGATTGCA
GTAGCGATTCATAATATCCCTGAAGGAATTGCCGTTTCTGTTCCAATTTATTATGCAACTGGTGATCGAAAAAAAGCTTT
TAAATATTCATTCTTATCTGGTTTAGCCGAACCTTTAGGTGCGATAGTTGCAATACTTATCTTAATGCCTTTCTTAAATG
ATTTGATGTTTGGAATTATATTTGCAATGGTTGCTGGTATAATGGTATTTATATCGTTGGATGAATTATTACCTGCAGCT
CGAAAGTATGATGAAGCACATATGTCAATGTATGGTGTGATTTCAGGTATGGCACTTATGGCAGTCAGTCTATTATTATT
AGCATGA

Upstream 100 bases:

>100_bases
AGTGAAGAAGACTATATAATGACTAATTAATTTTTTCAATATATAATGAATGAAAAAATTATATTCAAAACAGTTGGAAC
AACTATGTGGGGGAGTATAG

Downstream 100 bases:

>100_bases
TGGGTGTGTTCCAGTTGGAATACACTTATTTTTTTGATAAAATAAAGGTCTATCGTTGTTCAAATGACTAATAAAATGAT
TGGTGCTTCGATATAGAGAG

Product: zinc transporter ZupT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MDNMLLAFLLTLFAGLATGVGSLIAFMAKTTNTKFLSFALGLSAGVMIYVSMVDIFFKAKDALTAYLGDTQGYWLTVIAF
FGGMLLIGFIDRFIPKYTNPHEVKKVEDMKKPHQPLRDPDLMKMGLFTALALAIHNFPEGIATFVSTLHDPSIGLAIAIA
VAIHNIPEGIAVSVPIYYATGDRKKAFKYSFLSGLAEPLGAIVAILILMPFLNDLMFGIIFAMVAGIMVFISLDELLPAA
RKYDEAHMSMYGVISGMALMAVSLLLLA

Sequences:

>Translated_268_residues
MDNMLLAFLLTLFAGLATGVGSLIAFMAKTTNTKFLSFALGLSAGVMIYVSMVDIFFKAKDALTAYLGDTQGYWLTVIAF
FGGMLLIGFIDRFIPKYTNPHEVKKVEDMKKPHQPLRDPDLMKMGLFTALALAIHNFPEGIATFVSTLHDPSIGLAIAIA
VAIHNIPEGIAVSVPIYYATGDRKKAFKYSFLSGLAEPLGAIVAILILMPFLNDLMFGIIFAMVAGIMVFISLDELLPAA
RKYDEAHMSMYGVISGMALMAVSLLLLA
>Mature_268_residues
MDNMLLAFLLTLFAGLATGVGSLIAFMAKTTNTKFLSFALGLSAGVMIYVSMVDIFFKAKDALTAYLGDTQGYWLTVIAF
FGGMLLIGFIDRFIPKYTNPHEVKKVEDMKKPHQPLRDPDLMKMGLFTALALAIHNFPEGIATFVSTLHDPSIGLAIAIA
VAIHNIPEGIAVSVPIYYATGDRKKAFKYSFLSGLAEPLGAIVAILILMPFLNDLMFGIIFAMVAGIMVFISLDELLPAA
RKYDEAHMSMYGVISGMALMAVSLLLLA

Specific function: Mediates zinc uptake. May also transport other divalent cations

COG id: COG0428

COG function: function code P; Predicted divalent heavy-metal cations transporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily

Homologues:

Organism=Homo sapiens, GI229577422, Length=140, Percent_Identity=32.8571428571429, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI229577418, Length=140, Percent_Identity=32.8571428571429, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789419, Length=266, Percent_Identity=36.8421052631579, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17507805, Length=317, Percent_Identity=23.9747634069401, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24652846, Length=171, Percent_Identity=29.8245614035088, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ZUPT_OCEIH (Q8ENQ1)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693348.1
- GeneID:   1017226
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2427
- NMPDR:   fig|221109.1.peg.2424
- HOGENOM:   HBG620552
- OMA:   VSVPIYY
- ProtClustDB:   PRK04201
- BioCyc:   OIHE221109:OB2427-MONOMER
- HAMAP:   MF_00548
- InterPro:   IPR003689

Pfam domain/function: PF02535 Zip

EC number: NA

Molecular weight: Translated: 29074; Mature: 29074

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10372764)-; HASH(0x10377064)-; HASH(0x10606fe8)-; HASH(0xe201b78)-; HASH(0x101d3794)-; HASH(0x10203af0)-; HASH(0x107e1a98)-; HASH(0x108364d0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNMLLAFLLTLFAGLATGVGSLIAFMAKTTNTKFLSFALGLSAGVMIYVSMVDIFFKAK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DALTAYLGDTQGYWLTVIAFFGGMLLIGFIDRFIPKYTNPHEVKKVEDMKKPHQPLRDPD
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHH
LMKMGLFTALALAIHNFPEGIATFVSTLHDPSIGLAIAIAVAIHNIPEGIAVSVPIYYAT
HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEC
GDRKKAFKYSFLSGLAEPLGAIVAILILMPFLNDLMFGIIFAMVAGIMVFISLDELLPAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKYDEAHMSMYGVISGMALMAVSLLLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12235376