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The map label for this gene is rnr [H]

Identifier: 23099883

GI number: 23099883

Start: 2481156

End: 2483390

Strand: Reverse

Name: rnr [H]

Synonym: OB2428

Alternate gene names: 23099883

Gene position: 2483390-2481156 (Counterclockwise)

Preceding gene: 23099884

Following gene: 23099882

Centisome position: 68.4

GC content: 37.05

Gene sequence:

>2235_bases
ATGAAAGAAGGTGAAAGTATGAAAGAGAAAATAATAAATTATTTTAAAGAATCTGGAACAAAACCATTATCTGTACAGGA
ATTAGAAGAAGCATTCCAACTTGAAAATGCAGATGATTTTAAAGATCTTGTCAAGGCGTTAAATGAATTAGAACTTGAAG
GGGAATTGGTTCGAACAAGAAAAAATCGATTTGGACTACCGGATAAAATGAATTTGGTAAAAGGAAATATACAAATGCAT
GCAAAGGGATTTGCATTTTTAATTGCTGAGGATGAAAATTCAAAAGATGTATATATCCATGCAAATGATATGGGGTCAGC
AATGAATGGCGATAAAGTATTGGTTCGATTAGAAAAACCTTATTCTGATGGTGCGAGACCAGAAGGGAAAGTCATACGTA
TCTTAGAAAGAGCTGTTATTCAAGTAGTTGGTACGTATGAAGATAATCGTTCGTTTGGGTTCGTAATCGCTGATGATAAG
CGGATACCAAGTGATATCTTTATCCCTAAGGCAAATACGCACGGAGCTGTACAAGGGCATAAGGTAATAGCCCGCATCTC
CAAGTATCCTGAGGGCCGAAATAGTGCTGAAGGCGAAATTATCCATATTCTAGGCCATAAAAATGATCCGGGTATTGATA
TTTTATCCATTATTCATAAACATGGAATTCAAGTTGATTTCCCAGAGGATGTATTAGAACAGGCTCAACAGACCCCAGAA
GAGATTCATCCAGACGAGATAAATGGTAGAAGAGATCTTCGTAACGAAACTATTGTAACGATTGATGGTGCAGATGCAAA
GGACTTAGATGACGCAGTAACCGTTAAGAAATTATCTAACGGAAATTATAAATTAGGTGTATACATTGCCGATGTAAGTC
ATTATGTAAAAGAGGAATCTCCTATTGATCGCGAAGCTCTTGAAAGAGGAACAAGTGTCTACTTAGTTGACCGAGTTATC
CCGATGATACCTCATCGATTATCTAATGGAATTTGTTCATTAAATCCAAAAGTTGATCGATTAACACTTGGTTGTGAAAT
GGAAATTAATCATCAAGGTCAGGTAGTTGAACATGAAATCTTTCAAAGTGTTATTCATTCTACTGAACGTATGACATATA
GTGATGTGAATAAAATCTTGGTAGATCAAGATGAAGAACTGCGAGACAAGTATGAACCACTTGTTCCGATGTTTGAAGAA
ATGGAGAATTTAGCTTCCATCTTAAGAGAAAAACGATTTGGTCGCGGTGCGATTGATTTTGATTTCAAAGAAGCACAAGT
TCTAGTGGATGACATGGGAAGACCAACTGATGTCGCAATAAGAGAGCGTTCTGTTGCTGAACGACTTATTGAAGAATTTA
TGCTTGCTGCAAATGAAACGATTGCAGAGCATTTCCATTGGATGGATGTACCATTTATCCATCGTATTCACGAAGAACCT
GACGAAGGAAAATTAGAAAAATTCTTTGACTTTTTAGCAGGCCTAGGTATTTCTGTGAAAGGTACAGCAGGAGATATCCA
CCCTCAAGAGTTACAGAAAGTTATTGATTCCATTCGTGGGGAACCAGAAGAGATGATTGTATCGAAATTAATGCTACGCT
CTATGCAGCAAGCGAAATATGATCCTCAAAGTATTGGACACTTTGGTTTAGCGACCGATTTCTATACCCATTTCACTTCT
CCAATTAGACGTTATCCAGATTTAATTGTACATCGTTTAATCCGAACGTACTTGATTGAGAAGAAAATGGACAGTAAAAC
GTTGAAACATTGGAAATCCCGCATGCCTGAAATCGCTAGACATACTTCAGAGCGGGAGAGAAGAGCAGTTGATGCGGAAC
GTGATACAGATGAAATGAAAAAAGCAGAATATATGAAAGACAAAATTGGCGAAGAGTTTACAGGATTAATTAGTTCAGTT
ACCAATTTTGGTATGTTTGTTGAATTGGAGAACACGGTAGAAGGACTTATTCATGTCAGCTATCTAACAGATGATTATTA
TCACTTCGATGAACGTAGTCAAGCGCTGATTGGTGAGCGTACCGCAAACATTTATCGTGTCGGTGATGAAGTAGATGTTA
AAGTGGTCCATGTGAATACAGATGAGTATACCGTTGATTTTGAATTGGTTTCTTCTGGTAAAGCAACTCCAAAAAAGAAA
AAGAGACAGCGAGTACCGAAAAAGGTAGTGCAGTCTTCTAAAAAAACAAAGCCAAAGAATAAAAAGAAAAGATAA

Upstream 100 bases:

>100_bases
GGTCATGTTATTACGATGGACAAAGAAAAAGATCAGCTTCATGAGGATATTTATCAATTTCTAGAAAGTTTAGATTGGTA
ACAAACAGGAAAAGAATATT

Downstream 100 bases:

>100_bases
ACTAAAAACTACATGAATGATCAAAATCATTCATGTAGTTTTTTGGATAAGCTTATCTGAGTAACATAAAATAGGCATAT
GACATATAAGTGAAGAAGAC

Product: ribonulease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 744; Mature: 744

Protein sequence:

>744_residues
MKEGESMKEKIINYFKESGTKPLSVQELEEAFQLENADDFKDLVKALNELELEGELVRTRKNRFGLPDKMNLVKGNIQMH
AKGFAFLIAEDENSKDVYIHANDMGSAMNGDKVLVRLEKPYSDGARPEGKVIRILERAVIQVVGTYEDNRSFGFVIADDK
RIPSDIFIPKANTHGAVQGHKVIARISKYPEGRNSAEGEIIHILGHKNDPGIDILSIIHKHGIQVDFPEDVLEQAQQTPE
EIHPDEINGRRDLRNETIVTIDGADAKDLDDAVTVKKLSNGNYKLGVYIADVSHYVKEESPIDREALERGTSVYLVDRVI
PMIPHRLSNGICSLNPKVDRLTLGCEMEINHQGQVVEHEIFQSVIHSTERMTYSDVNKILVDQDEELRDKYEPLVPMFEE
MENLASILREKRFGRGAIDFDFKEAQVLVDDMGRPTDVAIRERSVAERLIEEFMLAANETIAEHFHWMDVPFIHRIHEEP
DEGKLEKFFDFLAGLGISVKGTAGDIHPQELQKVIDSIRGEPEEMIVSKLMLRSMQQAKYDPQSIGHFGLATDFYTHFTS
PIRRYPDLIVHRLIRTYLIEKKMDSKTLKHWKSRMPEIARHTSERERRAVDAERDTDEMKKAEYMKDKIGEEFTGLISSV
TNFGMFVELENTVEGLIHVSYLTDDYYHFDERSQALIGERTANIYRVGDEVDVKVVHVNTDEYTVDFELVSSGKATPKKK
KRQRVPKKVVQSSKKTKPKNKKKR

Sequences:

>Translated_744_residues
MKEGESMKEKIINYFKESGTKPLSVQELEEAFQLENADDFKDLVKALNELELEGELVRTRKNRFGLPDKMNLVKGNIQMH
AKGFAFLIAEDENSKDVYIHANDMGSAMNGDKVLVRLEKPYSDGARPEGKVIRILERAVIQVVGTYEDNRSFGFVIADDK
RIPSDIFIPKANTHGAVQGHKVIARISKYPEGRNSAEGEIIHILGHKNDPGIDILSIIHKHGIQVDFPEDVLEQAQQTPE
EIHPDEINGRRDLRNETIVTIDGADAKDLDDAVTVKKLSNGNYKLGVYIADVSHYVKEESPIDREALERGTSVYLVDRVI
PMIPHRLSNGICSLNPKVDRLTLGCEMEINHQGQVVEHEIFQSVIHSTERMTYSDVNKILVDQDEELRDKYEPLVPMFEE
MENLASILREKRFGRGAIDFDFKEAQVLVDDMGRPTDVAIRERSVAERLIEEFMLAANETIAEHFHWMDVPFIHRIHEEP
DEGKLEKFFDFLAGLGISVKGTAGDIHPQELQKVIDSIRGEPEEMIVSKLMLRSMQQAKYDPQSIGHFGLATDFYTHFTS
PIRRYPDLIVHRLIRTYLIEKKMDSKTLKHWKSRMPEIARHTSERERRAVDAERDTDEMKKAEYMKDKIGEEFTGLISSV
TNFGMFVELENTVEGLIHVSYLTDDYYHFDERSQALIGERTANIYRVGDEVDVKVVHVNTDEYTVDFELVSSGKATPKKK
KRQRVPKKVVQSSKKTKPKNKKKR
>Mature_744_residues
MKEGESMKEKIINYFKESGTKPLSVQELEEAFQLENADDFKDLVKALNELELEGELVRTRKNRFGLPDKMNLVKGNIQMH
AKGFAFLIAEDENSKDVYIHANDMGSAMNGDKVLVRLEKPYSDGARPEGKVIRILERAVIQVVGTYEDNRSFGFVIADDK
RIPSDIFIPKANTHGAVQGHKVIARISKYPEGRNSAEGEIIHILGHKNDPGIDILSIIHKHGIQVDFPEDVLEQAQQTPE
EIHPDEINGRRDLRNETIVTIDGADAKDLDDAVTVKKLSNGNYKLGVYIADVSHYVKEESPIDREALERGTSVYLVDRVI
PMIPHRLSNGICSLNPKVDRLTLGCEMEINHQGQVVEHEIFQSVIHSTERMTYSDVNKILVDQDEELRDKYEPLVPMFEE
MENLASILREKRFGRGAIDFDFKEAQVLVDDMGRPTDVAIRERSVAERLIEEFMLAANETIAEHFHWMDVPFIHRIHEEP
DEGKLEKFFDFLAGLGISVKGTAGDIHPQELQKVIDSIRGEPEEMIVSKLMLRSMQQAKYDPQSIGHFGLATDFYTHFTS
PIRRYPDLIVHRLIRTYLIEKKMDSKTLKHWKSRMPEIARHTSERERRAVDAERDTDEMKKAEYMKDKIGEEFTGLISSV
TNFGMFVELENTVEGLIHVSYLTDDYYHFDERSQALIGERTANIYRVGDEVDVKVVHVNTDEYTVDFELVSSGKATPKKK
KRQRVPKKVVQSSKKTKPKNKKKR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=489, Percent_Identity=33.1288343558282, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI190014625, Length=517, Percent_Identity=28.8201160541586, Blast_Score=207, Evalue=4e-53,
Organism=Homo sapiens, GI190014623, Length=517, Percent_Identity=28.8201160541586, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI19115966, Length=569, Percent_Identity=30.0527240773286, Blast_Score=197, Evalue=4e-50,
Organism=Homo sapiens, GI219521928, Length=567, Percent_Identity=29.8059964726631, Blast_Score=196, Evalue=5e-50,
Organism=Escherichia coli, GI87082383, Length=703, Percent_Identity=39.1180654338549, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1787542, Length=651, Percent_Identity=26.1136712749616, Blast_Score=159, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17553506, Length=497, Percent_Identity=31.58953722334, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI212645896, Length=638, Percent_Identity=26.8025078369906, Blast_Score=182, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6324552, Length=628, Percent_Identity=29.7770700636943, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320499, Length=428, Percent_Identity=23.1308411214953, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323943, Length=365, Percent_Identity=24.9315068493151, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24649634, Length=465, Percent_Identity=30.5376344086021, Blast_Score=214, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24654592, Length=588, Percent_Identity=27.3809523809524, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19922976, Length=588, Percent_Identity=27.3809523809524, Blast_Score=193, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24654597, Length=588, Percent_Identity=27.3809523809524, Blast_Score=193, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 85154; Mature: 85154

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEGESMKEKIINYFKESGTKPLSVQELEEAFQLENADDFKDLVKALNELELEGELVRTR
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHH
KNRFGLPDKMNLVKGNIQMHAKGFAFLIAEDENSKDVYIHANDMGSAMNGDKVLVRLEKP
HHHCCCCCCCCEEECCEEEEECCEEEEEEECCCCCEEEEEECCCCCCCCCCEEEEEEECC
YSDGARPEGKVIRILERAVIQVVGTYEDNRSFGFVIADDKRIPSDIFIPKANTHGAVQGH
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCCHHH
KVIARISKYPEGRNSAEGEIIHILGHKNDPGIDILSIIHKHGIQVDFPEDVLEQAQQTPE
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCHH
EIHPDEINGRRDLRNETIVTIDGADAKDLDDAVTVKKLSNGNYKLGVYIADVSHYVKEES
HCCCCCCCCCHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEEECHHHHHHCCC
PIDREALERGTSVYLVDRVIPMIPHRLSNGICSLNPKVDRLTLGCEMEINHQGQVVEHEI
CCCHHHHHCCCEEEEHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEECCCCCHHHHHH
FQSVIHSTERMTYSDVNKILVDQDEELRDKYEPLVPMFEEMENLASILREKRFGRGAIDF
HHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DFKEAQVLVDDMGRPTDVAIRERSVAERLIEEFMLAANETIAEHFHWMDVPFIHRIHEEP
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
DEGKLEKFFDFLAGLGISVKGTAGDIHPQELQKVIDSIRGEPEEMIVSKLMLRSMQQAKY
CCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
DPQSIGHFGLATDFYTHFTSPIRRYPDLIVHRLIRTYLIEKKMDSKTLKHWKSRMPEIAR
CHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHH
HTSERERRAVDAERDTDEMKKAEYMKDKIGEEFTGLISSVTNFGMFVELENTVEGLIHVS
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHEEEE
YLTDDYYHFDERSQALIGERTANIYRVGDEVDVKVVHVNTDEYTVDFELVSSGKATPKKK
EEECCHHHHCCHHHHHHHHHCCCEEECCCCCEEEEEEECCCCEEEEEEEECCCCCCCHHH
KRQRVPKKVVQSSKKTKPKNKKKR
HHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKEGESMKEKIINYFKESGTKPLSVQELEEAFQLENADDFKDLVKALNELELEGELVRTR
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHH
KNRFGLPDKMNLVKGNIQMHAKGFAFLIAEDENSKDVYIHANDMGSAMNGDKVLVRLEKP
HHHCCCCCCCCEEECCEEEEECCEEEEEEECCCCCEEEEEECCCCCCCCCCEEEEEEECC
YSDGARPEGKVIRILERAVIQVVGTYEDNRSFGFVIADDKRIPSDIFIPKANTHGAVQGH
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCCHHH
KVIARISKYPEGRNSAEGEIIHILGHKNDPGIDILSIIHKHGIQVDFPEDVLEQAQQTPE
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCHH
EIHPDEINGRRDLRNETIVTIDGADAKDLDDAVTVKKLSNGNYKLGVYIADVSHYVKEES
HCCCCCCCCCHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEEECHHHHHHCCC
PIDREALERGTSVYLVDRVIPMIPHRLSNGICSLNPKVDRLTLGCEMEINHQGQVVEHEI
CCCHHHHHCCCEEEEHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEEEECCCCCHHHHHH
FQSVIHSTERMTYSDVNKILVDQDEELRDKYEPLVPMFEEMENLASILREKRFGRGAIDF
HHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DFKEAQVLVDDMGRPTDVAIRERSVAERLIEEFMLAANETIAEHFHWMDVPFIHRIHEEP
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
DEGKLEKFFDFLAGLGISVKGTAGDIHPQELQKVIDSIRGEPEEMIVSKLMLRSMQQAKY
CCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
DPQSIGHFGLATDFYTHFTSPIRRYPDLIVHRLIRTYLIEKKMDSKTLKHWKSRMPEIAR
CHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHH
HTSERERRAVDAERDTDEMKKAEYMKDKIGEEFTGLISSVTNFGMFVELENTVEGLIHVS
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHEEEE
YLTDDYYHFDERSQALIGERTANIYRVGDEVDVKVVHVNTDEYTVDFELVSSGKATPKKK
EEECCHHHHCCHHHHHHHHHCCCEEECCCCCEEEEEEECCCCEEEEEEEECCCCCCCHHH
KRQRVPKKVVQSSKKTKPKNKKKR
HHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]