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The map label for this gene is (rmlA1 [H]

Identifier: 23099876

GI number: 23099876

Start: 2475384

End: 2476316

Strand: Reverse

Name: (rmlA1 [H]

Synonym: OB2421

Alternate gene names: 23099876

Gene position: 2476316-2475384 (Counterclockwise)

Preceding gene: 23099877

Following gene: 23099875

Centisome position: 68.21

GC content: 36.98

Gene sequence:

>933_bases
ATGAAGGGGATTTTACTCGCAGGTGGAAGCGGAACACGACTGTCTCCAAGTACGGATAGCTTAAATAAGCACTTACTTCC
GGTTTATGACAAGCCGATGATTTATTATCCACTATCAGTATTAATGCTAGGTGGTTTAAAAGAAATTATGATTATCAGTA
CGCCAGAGGATATTTCTCGATTTGAAAGGCTACTTGGTGATGGATCGCAATTAGGAATTAGTATTACTTATCGAGTGCAG
GAAGAACCAAAAGGAATTCCAGAAGCACTTATTATTGCTGAAGATTTTATTGGCACAGAGGATGTCACTTTGATGCTTGC
CGATAATATATTTTATGGTCAAGGGTTTACTACGTTATTAAGAAAAGCAATTAAAGATCATCAGCATGCAACGGTGTTTG
GTTACCGTGTCAAAGATCCGGAGCGATTTGGCGTTGTTGAATTTGACCATAATCAAAAAGCAATTTCTATTGAAGAAAAG
CCTGAAGATCCCAAATCTGATTTTGCTGTAACAGGTTTATATATGTATGATTATCGAGCAGTTAATATTGCGAAGAATTT
AGAGCCCTCTGACAGAGGAGAATTAGAAATTACGGATATTAACAAAGAGTACCTAAAGTGCAATCAATTAGATGTCGAGT
TGTTAGGTAGAGGGTTTGCATGGATGGATGCCGGCACACAAGAAGCACTATTCGATGCAGCGGAATTCATAAAAACAACT
CAACAACGACAGGGATTTAAAATCGCATGTTTAGAAGAAATTGCGTTTTATATGGGTTATATTTCCAAAGAAGCATTATA
TGAAAGAGGAAAAACGATGGAAAAAAATGATTACGGTCAATATCTTATGGAAATTGCCGATAGAAAGCATCATCAGCAAT
ACTGGGATTCGATCGATCATCATCCAATGTTAGGACTGGTTGAAAATGAATAA

Upstream 100 bases:

>100_bases
CTATATTTAAAGGGAATGAACAAATGAACAGGAAATTTTATTTCAAGATAGCAATAAAACAGGCTTTAAACGCTAATAAG
ATTAGGAAGGTGTGTTACTA

Downstream 100 bases:

>100_bases
GTCAGCAATTTTAATAACAGGTGGAGCTGGATTTATTGGATCAAATTTTATCCATTACTTTATGGATGTATATCCGGAAG
TTCCGATTGTTAATATAGAT

Product: glucose 1-phosphate thymidyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKGILLAGGSGTRLSPSTDSLNKHLLPVYDKPMIYYPLSVLMLGGLKEIMIISTPEDISRFERLLGDGSQLGISITYRVQ
EEPKGIPEALIIAEDFIGTEDVTLMLADNIFYGQGFTTLLRKAIKDHQHATVFGYRVKDPERFGVVEFDHNQKAISIEEK
PEDPKSDFAVTGLYMYDYRAVNIAKNLEPSDRGELEITDINKEYLKCNQLDVELLGRGFAWMDAGTQEALFDAAEFIKTT
QQRQGFKIACLEEIAFYMGYISKEALYERGKTMEKNDYGQYLMEIADRKHHQQYWDSIDHHPMLGLVENE

Sequences:

>Translated_310_residues
MKGILLAGGSGTRLSPSTDSLNKHLLPVYDKPMIYYPLSVLMLGGLKEIMIISTPEDISRFERLLGDGSQLGISITYRVQ
EEPKGIPEALIIAEDFIGTEDVTLMLADNIFYGQGFTTLLRKAIKDHQHATVFGYRVKDPERFGVVEFDHNQKAISIEEK
PEDPKSDFAVTGLYMYDYRAVNIAKNLEPSDRGELEITDINKEYLKCNQLDVELLGRGFAWMDAGTQEALFDAAEFIKTT
QQRQGFKIACLEEIAFYMGYISKEALYERGKTMEKNDYGQYLMEIADRKHHQQYWDSIDHHPMLGLVENE
>Mature_310_residues
MKGILLAGGSGTRLSPSTDSLNKHLLPVYDKPMIYYPLSVLMLGGLKEIMIISTPEDISRFERLLGDGSQLGISITYRVQ
EEPKGIPEALIIAEDFIGTEDVTLMLADNIFYGQGFTTLLRKAIKDHQHATVFGYRVKDPERFGVVEFDHNQKAISIEEK
PEDPKSDFAVTGLYMYDYRAVNIAKNLEPSDRGELEITDINKEYLKCNQLDVELLGRGFAWMDAGTQEALFDAAEFIKTT
QQRQGFKIACLEEIAFYMGYISKEALYERGKTMEKNDYGQYLMEIADRKHHQQYWDSIDHHPMLGLVENE

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=250, Percent_Identity=25.2, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI11761619, Length=250, Percent_Identity=25.2, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1790224, Length=294, Percent_Identity=58.1632653061224, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1788351, Length=285, Percent_Identity=56.8421052631579, Blast_Score=348, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI133931050, Length=229, Percent_Identity=24.8908296943231, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355443, Length=252, Percent_Identity=24.2063492063492, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644084, Length=252, Percent_Identity=24.2063492063492, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 35300; Mature: 35300

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGILLAGGSGTRLSPSTDSLNKHLLPVYDKPMIYYPLSVLMLGGLKEIMIISTPEDISR
CCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCHHHHH
FERLLGDGSQLGISITYRVQEEPKGIPEALIIAEDFIGTEDVTLMLADNIFYGQGFTTLL
HHHHHCCCCEEEEEEEEEECCCCCCCCCEEEEEHHHCCCCCEEEEEECCEEECCCHHHHH
RKAIKDHQHATVFGYRVKDPERFGVVEFDHNQKAISIEEKPEDPKSDFAVTGLYMYDYRA
HHHHHCCCCEEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEEEEEE
VNIAKNLEPSDRGELEITDINKEYLKCNQLDVELLGRGFAWMDAGTQEALFDAAEFIKTT
EEHHHCCCCCCCCCEEEEECCHHHHHHCCCCHHHHCCCEEEECCCCHHHHHHHHHHHHHH
QQRQGFKIACLEEIAFYMGYISKEALYERGKTMEKNDYGQYLMEIADRKHHQQYWDSIDH
HHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
HPMLGLVENE
CCEEEEEECC
>Mature Secondary Structure
MKGILLAGGSGTRLSPSTDSLNKHLLPVYDKPMIYYPLSVLMLGGLKEIMIISTPEDISR
CCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCHHHHH
FERLLGDGSQLGISITYRVQEEPKGIPEALIIAEDFIGTEDVTLMLADNIFYGQGFTTLL
HHHHHCCCCEEEEEEEEEECCCCCCCCCEEEEEHHHCCCCCEEEEEECCEEECCCHHHHH
RKAIKDHQHATVFGYRVKDPERFGVVEFDHNQKAISIEEKPEDPKSDFAVTGLYMYDYRA
HHHHHCCCCEEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEEEEEE
VNIAKNLEPSDRGELEITDINKEYLKCNQLDVELLGRGFAWMDAGTQEALFDAAEFIKTT
EEHHHCCCCCCCCCEEEEECCHHHHHHCCCCHHHHCCCEEEECCCCHHHHHHHHHHHHHH
QQRQGFKIACLEEIAFYMGYISKEALYERGKTMEKNDYGQYLMEIADRKHHQQYWDSIDH
HHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
HPMLGLVENE
CCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]