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The map label for this gene is yrkA [H]

Identifier: 23099856

GI number: 23099856

Start: 2452363

End: 2453661

Strand: Reverse

Name: yrkA [H]

Synonym: OB2401

Alternate gene names: 23099856

Gene position: 2453661-2452363 (Counterclockwise)

Preceding gene: 23099857

Following gene: 23099855

Centisome position: 67.58

GC content: 34.8

Gene sequence:

>1299_bases
TTGGACATATCGACGATTATTAATTTAACTGCGGTGGCAATATTAATCGCATTAACCGCTTTTTTTGTAATGTCAGAATT
TGCTATTGTAAAAATTCGAAGTACACAACTAGAACCACATATAGAACAAGGAAAGAAAAGTGCTATTTATGCAAAAAGGG
TTGTAACACATTTAGATGAGTACTTATCTGCTTGTCAGTTGGGTATTACGATTACTGCCCTTGGTATTGGGCGTTTAGCA
GAACCGACTTTTGAACGGATGCTACACCCAGTATTAGAAGATTTCAATTTAAGTAGTGCTGTTGTTACAACAGCTTCCAT
AGCAATTTCATTCGCTGTTGCAACGTTTCTACATGTGGTCGTTGGGGAACTCGCTCCGAAGACTTTAGCTATTCAAAAAG
CAGAAAGAGTTACATTATTCGTTGCCAGACCATTAACTTGGTTTTATCGATTACTATTCCCTTTTATTTGGTTCTTAAAT
GGTTCAGCAAGATTGCTTACCAAAGCAGTAGGGCTTAAACCTATGAGTGGACATGAAGAAACCCATACGGAAGAGGAATT
AAGACTTATTCTAGCAGACAGTTACAAAAGTGGTGAAATTAATCAATCAGAAATGATGTACGTGAATAACATTTTTGATT
TTGATGAAAGAGTTGCAAGAGAAATAATGGTACCACGTACGGAAATGGTATATTTCTCAAAAGAAGACAGTTTCGAAGCA
AATTTGGAAATTATTCGTGAAGGTCAATTTACGAGGTATCCTGTTGCTGATGAAGACAAGGATAATATTATTGGTTTGGT
GAATCTAAAAGAAGTCTTTACTGGACAACTAGATAATGACAGACCAAATTCAATTGAAAAGTTTATTCGACCCATTATTC
ATGTTTCCGAAGCTACACCAATAAAACAACTGTTACTAAAAATGCAGAAAGAAAGAATTCATATGGCAATCGTTAACGAT
GAATATGGCGGTACTGCAGGGTTAGTAACAGTAGAAGATATCTTAGAGGAAATTGTTGGAGATATTCGTGATGAGTTTGA
TGAAGATGAAACACCGGATTTTGAAACGGTAGACGAAAATACATTTCTTGTTTCAGGTAGACTAAGTTTAGATGAAGTAA
ATCAAAGGTTAAGTATCTATTTAGAAGACGATGAAGTAGATACAATTGGTGGATGGTTCTTTACTCATAATTTAGAAGCA
GATGTTGGAACTGTTATGGAATATGAAGGACATGAATTTGCACTTATTGAAAAAGATGGCTTCCAAATTAAACGAGTTAA
AATAACTAAAATAGCTTAA

Upstream 100 bases:

>100_bases
CTGTTTGGTTGAATCACCAACGTGCGTATTATTACAGAATTATTTTAAAGTAAATCAGGAGGTGAAATCCTTGTGCCATT
CATTGGTACAGGGATCTTAA

Downstream 100 bases:

>100_bases
AGATTGTTCGAAAAGTAGGGTAAAAAATGAGCTTCCACAGGATGTGGTGATTTTTGCTTTAGCCACAGGACATGGGCGAT
TTTAGCAGAAAGTCTCCTTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MDISTIINLTAVAILIALTAFFVMSEFAIVKIRSTQLEPHIEQGKKSAIYAKRVVTHLDEYLSACQLGITITALGIGRLA
EPTFERMLHPVLEDFNLSSAVVTTASIAISFAVATFLHVVVGELAPKTLAIQKAERVTLFVARPLTWFYRLLFPFIWFLN
GSARLLTKAVGLKPMSGHEETHTEEELRLILADSYKSGEINQSEMMYVNNIFDFDERVAREIMVPRTEMVYFSKEDSFEA
NLEIIREGQFTRYPVADEDKDNIIGLVNLKEVFTGQLDNDRPNSIEKFIRPIIHVSEATPIKQLLLKMQKERIHMAIVND
EYGGTAGLVTVEDILEEIVGDIRDEFDEDETPDFETVDENTFLVSGRLSLDEVNQRLSIYLEDDEVDTIGGWFFTHNLEA
DVGTVMEYEGHEFALIEKDGFQIKRVKITKIA

Sequences:

>Translated_432_residues
MDISTIINLTAVAILIALTAFFVMSEFAIVKIRSTQLEPHIEQGKKSAIYAKRVVTHLDEYLSACQLGITITALGIGRLA
EPTFERMLHPVLEDFNLSSAVVTTASIAISFAVATFLHVVVGELAPKTLAIQKAERVTLFVARPLTWFYRLLFPFIWFLN
GSARLLTKAVGLKPMSGHEETHTEEELRLILADSYKSGEINQSEMMYVNNIFDFDERVAREIMVPRTEMVYFSKEDSFEA
NLEIIREGQFTRYPVADEDKDNIIGLVNLKEVFTGQLDNDRPNSIEKFIRPIIHVSEATPIKQLLLKMQKERIHMAIVND
EYGGTAGLVTVEDILEEIVGDIRDEFDEDETPDFETVDENTFLVSGRLSLDEVNQRLSIYLEDDEVDTIGGWFFTHNLEA
DVGTVMEYEGHEFALIEKDGFQIKRVKITKIA
>Mature_432_residues
MDISTIINLTAVAILIALTAFFVMSEFAIVKIRSTQLEPHIEQGKKSAIYAKRVVTHLDEYLSACQLGITITALGIGRLA
EPTFERMLHPVLEDFNLSSAVVTTASIAISFAVATFLHVVVGELAPKTLAIQKAERVTLFVARPLTWFYRLLFPFIWFLN
GSARLLTKAVGLKPMSGHEETHTEEELRLILADSYKSGEINQSEMMYVNNIFDFDERVAREIMVPRTEMVYFSKEDSFEA
NLEIIREGQFTRYPVADEDKDNIIGLVNLKEVFTGQLDNDRPNSIEKFIRPIIHVSEATPIKQLLLKMQKERIHMAIVND
EYGGTAGLVTVEDILEEIVGDIRDEFDEDETPDFETVDENTFLVSGRLSLDEVNQRLSIYLEDDEVDTIGGWFFTHNLEA
DVGTVMEYEGHEFALIEKDGFQIKRVKITKIA

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=392, Percent_Identity=49.4897959183673, Blast_Score=399, Evalue=1e-111,
Organism=Escherichia coli, GI1790664, Length=433, Percent_Identity=23.3256351039261, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI145693175, Length=416, Percent_Identity=24.7596153846154, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1786879, Length=254, Percent_Identity=33.0708661417323, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1788119, Length=262, Percent_Identity=26.7175572519084, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082033, Length=236, Percent_Identity=24.5762711864407, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 48953; Mature: 48953

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISTIINLTAVAILIALTAFFVMSEFAIVKIRSTQLEPHIEQGKKSAIYAKRVVTHLDE
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHCCCHHHHHHHHHHHHHHH
YLSACQLGITITALGIGRLAEPTFERMLHPVLEDFNLSSAVVTTASIAISFAVATFLHVV
HHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
VGELAPKTLAIQKAERVTLFVARPLTWFYRLLFPFIWFLNGSARLLTKAVGLKPMSGHEE
HHHHCCHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
THTEEELRLILADSYKSGEINQSEMMYVNNIFDFDERVAREIMVPRTEMVYFSKEDSFEA
CCCHHHHEEEEECCCCCCCCCHHHEEEEHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCC
NLEIIREGQFTRYPVADEDKDNIIGLVNLKEVFTGQLDNDRPNSIEKFIRPIIHVSEATP
CCCEEECCCCEECCCCCCCCCCEEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCC
IKQLLLKMQKERIHMAIVNDEYGGTAGLVTVEDILEEIVGDIRDEFDEDETPDFETVDEN
HHHHHHHHHHCCEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
TFLVSGRLSLDEVNQRLSIYLEDDEVDTIGGWFFTHNLEADVGTVMEYEGHEFALIEKDG
EEEEECCCCHHHHCCEEEEEECCCCCCEECCEEEEECCCCCCCHHEEECCCEEEEEECCC
FQIKRVKITKIA
CEEEEEEEEECC
>Mature Secondary Structure
MDISTIINLTAVAILIALTAFFVMSEFAIVKIRSTQLEPHIEQGKKSAIYAKRVVTHLDE
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHCCCHHHHHHHHHHHHHHH
YLSACQLGITITALGIGRLAEPTFERMLHPVLEDFNLSSAVVTTASIAISFAVATFLHVV
HHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
VGELAPKTLAIQKAERVTLFVARPLTWFYRLLFPFIWFLNGSARLLTKAVGLKPMSGHEE
HHHHCCHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
THTEEELRLILADSYKSGEINQSEMMYVNNIFDFDERVAREIMVPRTEMVYFSKEDSFEA
CCCHHHHEEEEECCCCCCCCCHHHEEEEHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCC
NLEIIREGQFTRYPVADEDKDNIIGLVNLKEVFTGQLDNDRPNSIEKFIRPIIHVSEATP
CCCEEECCCCEECCCCCCCCCCEEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCC
IKQLLLKMQKERIHMAIVNDEYGGTAGLVTVEDILEEIVGDIRDEFDEDETPDFETVDEN
HHHHHHHHHHCCEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
TFLVSGRLSLDEVNQRLSIYLEDDEVDTIGGWFFTHNLEADVGTVMEYEGHEFALIEKDG
EEEEECCCCHHHHCCEEEEEECCCCCCEECCEEEEECCCCCCCHHEEECCCEEEEEECCC
FQIKRVKITKIA
CEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]