Click here to switch to the map view.

The map label for this gene is fadE [H]

Identifier: 23099848

GI number: 23099848

Start: 2442792

End: 2444576

Strand: Reverse

Name: fadE [H]

Synonym: OB2393

Alternate gene names: 23099848

Gene position: 2444576-2442792 (Counterclockwise)

Preceding gene: 23099849

Following gene: 23099846

Centisome position: 67.33

GC content: 35.69

Gene sequence:

>1785_bases
ATGAGTGAAACAAAAGAAAAAATATTTAAAGGTGGAGCATTTTTAGTAGAGGATATAACAGGAGAAGACATTATTACTCC
AGAAGATTTTACAGATGAGCACAAGATGATAGCGAAAACTACAGAAGATTTTGTATTAGGAGAAGTTGTCCCGAAAATTG
ATAATCTGGAGAACCATGAGTTTGAGCATTCTGTTGATTTATTGAAAAAAGCAGGCGATCTAGGATTACTTGGAGCAGAT
GTACCTGAACAATATGGTGGTCTGGCTTTAGATAAAATCAGTTCTTCTTTAATTACAGAGAAGTTTTCTCGTGCAGGTGG
GTTCTCTGTAACACACGGGGCACATGTTGGAATAGGTTCTTTGCCTATTGTGTTTTTCGGTAATGATGAACAAAAAGAAA
ATTATTTACCGAAACTTGCAACAGGAGAGCTGTTGGCAGCATATGCATTAACGGAACCTAGCTCTGGTTCAGACGCATTA
GGAGCAAAAACAACTGCAAAATTAAATGACGCAGGTACACATTATATTCTTAATGGTGAAAAACAATGGATTACAAACTC
TGCATTTGCTGATGTATTCATAGTTTATGCAAAAATTGACGGAGAACATTTTACAGCATTTATTGTAGAAAGAGAATTTC
CAGGCGTATCTACTGGACCAGAAGAAAAGAAAATGGGAATTAAGAGTTCCTCTACTCGTACGCTAGTATTGGAAGACGCT
GAAGTTCCGATAGAAAACTTATTAGGAGAAAAAGGAAGAGGTCATGTTATCGCATTTAATATCTTAAATGTTGGTCGTTA
TAAACTTGCGGTAGGTGGCGTTGGCGGATCCAAGCGCGCCATTGAATTAGCTGCAAAGTATACAAATGAAAGAAAACAAT
TTAACACTCCTATTTCAAGCTTTAATCTAACAAAAGAGAAACTTGCTACAATGGCAGCAGGTATTTATGCAAACGAAAGT
TCAGTTTATCGTACAGTTGGATTATTTGAACAACGTATGGGAGCATTGACAGATGAACAATTAAAAGACGGGAGAGAAGT
TGCTCGTTCCATTGCTGAATATCAAATTGAATGCTCTATGACAAAATATATGGCTACTGAACTATTAGATTATGTGGTTG
ATGAAGCTGTACAAATGCATGGCGGTTATGGATTTATGCAAGAATATGAAGTAGAACGTGCGTATCGTGATTCTCGTATT
AACCGTATATTTGAAGGTACAAATGAAATTAACCGTCTGTTAGTCCCTGGCACACTAATAAAGAAAGCGATAAAAGGTGA
GTTGCCATTATTACAAAAAGCACAAGGCCTTCAAGAAGAATTAATGATGATGATGCCTGAAGAAGTAGGAACAGAAGCAC
TAGAACAAGAGAAATATTTACTAAAAAATGCGAAGAAAATGGTTTTACTTGGAGCTGGATTGGCAGCGCAAAAATACGGC
CAAAAATTAGAAAATGAACAAGAAATCCTTGTTAATCTTGCTAATATGGTTGCAGAAGTTTTTAATATGGAATCTGCCAT
TTTACGTACAGAAAAGGCAATATCTAAAGTTGGGGAAGAAAAATCGAAACAAAAGTTATTATATACAGAAGTTTATGCAC
AAGAAGCATTTAATCGTATTGAAGCAGAAGCGAAAGATATTCTTGTAACGGTAGAGGATGGCGATACACTACGAATGATG
CTTTCATCATTACGTAAATTAACGCGTCATACACCAGTTAATGTTGTAAAGAAAAAACGTGAAATAGCAGCTCTAATTAT
TGAAGAAGAGAAATATGTAATTTAA

Upstream 100 bases:

>100_bases
AGTTTGGTGTTGTTACGATGTGTATTGGCGGTGGTATGGGTGCTGCTGGGGTATTTGAATTACTTTAATTTAAAATCCAA
TTATGGAGAGGGAGAAAAAC

Downstream 100 bases:

>100_bases
TTCAAAGTTAAAGAGGTTGGGACGACAAAAGTATTCACGCAAAAGATAAAACTAAATGATTGTTCTATGAACACATGTTT
AGAAGATACTGCGCTTATCC

Product: acetyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MSETKEKIFKGGAFLVEDITGEDIITPEDFTDEHKMIAKTTEDFVLGEVVPKIDNLENHEFEHSVDLLKKAGDLGLLGAD
VPEQYGGLALDKISSSLITEKFSRAGGFSVTHGAHVGIGSLPIVFFGNDEQKENYLPKLATGELLAAYALTEPSSGSDAL
GAKTTAKLNDAGTHYILNGEKQWITNSAFADVFIVYAKIDGEHFTAFIVEREFPGVSTGPEEKKMGIKSSSTRTLVLEDA
EVPIENLLGEKGRGHVIAFNILNVGRYKLAVGGVGGSKRAIELAAKYTNERKQFNTPISSFNLTKEKLATMAAGIYANES
SVYRTVGLFEQRMGALTDEQLKDGREVARSIAEYQIECSMTKYMATELLDYVVDEAVQMHGGYGFMQEYEVERAYRDSRI
NRIFEGTNEINRLLVPGTLIKKAIKGELPLLQKAQGLQEELMMMMPEEVGTEALEQEKYLLKNAKKMVLLGAGLAAQKYG
QKLENEQEILVNLANMVAEVFNMESAILRTEKAISKVGEEKSKQKLLYTEVYAQEAFNRIEAEAKDILVTVEDGDTLRMM
LSSLRKLTRHTPVNVVKKKREIAALIIEEEKYVI

Sequences:

>Translated_594_residues
MSETKEKIFKGGAFLVEDITGEDIITPEDFTDEHKMIAKTTEDFVLGEVVPKIDNLENHEFEHSVDLLKKAGDLGLLGAD
VPEQYGGLALDKISSSLITEKFSRAGGFSVTHGAHVGIGSLPIVFFGNDEQKENYLPKLATGELLAAYALTEPSSGSDAL
GAKTTAKLNDAGTHYILNGEKQWITNSAFADVFIVYAKIDGEHFTAFIVEREFPGVSTGPEEKKMGIKSSSTRTLVLEDA
EVPIENLLGEKGRGHVIAFNILNVGRYKLAVGGVGGSKRAIELAAKYTNERKQFNTPISSFNLTKEKLATMAAGIYANES
SVYRTVGLFEQRMGALTDEQLKDGREVARSIAEYQIECSMTKYMATELLDYVVDEAVQMHGGYGFMQEYEVERAYRDSRI
NRIFEGTNEINRLLVPGTLIKKAIKGELPLLQKAQGLQEELMMMMPEEVGTEALEQEKYLLKNAKKMVLLGAGLAAQKYG
QKLENEQEILVNLANMVAEVFNMESAILRTEKAISKVGEEKSKQKLLYTEVYAQEAFNRIEAEAKDILVTVEDGDTLRMM
LSSLRKLTRHTPVNVVKKKREIAALIIEEEKYVI
>Mature_593_residues
SETKEKIFKGGAFLVEDITGEDIITPEDFTDEHKMIAKTTEDFVLGEVVPKIDNLENHEFEHSVDLLKKAGDLGLLGADV
PEQYGGLALDKISSSLITEKFSRAGGFSVTHGAHVGIGSLPIVFFGNDEQKENYLPKLATGELLAAYALTEPSSGSDALG
AKTTAKLNDAGTHYILNGEKQWITNSAFADVFIVYAKIDGEHFTAFIVEREFPGVSTGPEEKKMGIKSSSTRTLVLEDAE
VPIENLLGEKGRGHVIAFNILNVGRYKLAVGGVGGSKRAIELAAKYTNERKQFNTPISSFNLTKEKLATMAAGIYANESS
VYRTVGLFEQRMGALTDEQLKDGREVARSIAEYQIECSMTKYMATELLDYVVDEAVQMHGGYGFMQEYEVERAYRDSRIN
RIFEGTNEINRLLVPGTLIKKAIKGELPLLQKAQGLQEELMMMMPEEVGTEALEQEKYLLKNAKKMVLLGAGLAAQKYGQ
KLENEQEILVNLANMVAEVFNMESAILRTEKAISKVGEEKSKQKLLYTEVYAQEAFNRIEAEAKDILVTVEDGDTLRMML
SSLRKLTRHTPVNVVKKKREIAALIIEEEKYVI

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=564, Percent_Identity=33.3333333333333, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI4557235, Length=513, Percent_Identity=35.4775828460039, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI76496475, Length=513, Percent_Identity=35.4775828460039, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI4557233, Length=403, Percent_Identity=33.4987593052109, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI7656849, Length=400, Percent_Identity=34.5, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI226958412, Length=394, Percent_Identity=34.010152284264, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI187960098, Length=394, Percent_Identity=33.756345177665, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4557231, Length=396, Percent_Identity=34.3434343434343, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI226958414, Length=375, Percent_Identity=34.6666666666667, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI4501857, Length=404, Percent_Identity=32.1782178217822, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI4501859, Length=391, Percent_Identity=30.9462915601023, Blast_Score=181, Evalue=3e-45,
Organism=Homo sapiens, GI4503943, Length=396, Percent_Identity=29.7979797979798, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI7669494, Length=374, Percent_Identity=30.2139037433155, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI211971008, Length=425, Percent_Identity=24, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI48976061, Length=425, Percent_Identity=24, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI87081958, Length=353, Percent_Identity=30.8781869688385, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1786223, Length=365, Percent_Identity=26.027397260274, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI87081702, Length=359, Percent_Identity=26.4623955431755, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082384, Length=371, Percent_Identity=24.2587601078167, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985184, Length=421, Percent_Identity=38.9548693586698, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71985192, Length=379, Percent_Identity=36.9393139841689, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17569725, Length=405, Percent_Identity=34.0740740740741, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17534899, Length=406, Percent_Identity=33.2512315270936, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17570075, Length=386, Percent_Identity=33.160621761658, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17538396, Length=398, Percent_Identity=33.1658291457286, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17533517, Length=398, Percent_Identity=32.1608040201005, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17508101, Length=389, Percent_Identity=29.8200514138817, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17506239, Length=406, Percent_Identity=30.7881773399015, Blast_Score=172, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=394, Percent_Identity=28.9340101522843, Blast_Score=158, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71990804, Length=257, Percent_Identity=34.6303501945525, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=35.2941176470588, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982178, Length=286, Percent_Identity=32.1678321678322, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17505929, Length=389, Percent_Identity=25.1928020565553, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=27.2479564032698, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17531909, Length=252, Percent_Identity=26.984126984127, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540912, Length=389, Percent_Identity=23.1362467866324, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=285, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=285, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562446, Length=345, Percent_Identity=22.8985507246377, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281363737, Length=496, Percent_Identity=35.8870967741936, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI21356377, Length=413, Percent_Identity=32.6876513317191, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24660351, Length=393, Percent_Identity=33.8422391857506, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24646207, Length=419, Percent_Identity=31.980906921241, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24666513, Length=403, Percent_Identity=33.9950372208437, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI21355753, Length=386, Percent_Identity=35.2331606217617, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19920834, Length=395, Percent_Identity=29.3670886075949, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI221473076, Length=366, Percent_Identity=24.0437158469945, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24652780, Length=267, Percent_Identity=24.7191011235955, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45550141, Length=366, Percent_Identity=24.0437158469945, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 65816; Mature: 65685

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETKEKIFKGGAFLVEDITGEDIITPEDFTDEHKMIAKTTEDFVLGEVVPKIDNLENHE
CCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
FEHSVDLLKKAGDLGLLGADVPEQYGGLALDKISSSLITEKFSRAGGFSVTHGAHVGIGS
HHHHHHHHHHCCCCCEECCCCCHHHCCEEHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
LPIVFFGNDEQKENYLPKLATGELLAAYALTEPSSGSDALGAKTTAKLNDAGTHYILNGE
EEEEEECCCCHHHHCCCCCCCCHHHHHHEECCCCCCCCCCCCCCEEEECCCCCEEEECCC
KQWITNSAFADVFIVYAKIDGEHFTAFIVEREFPGVSTGPEEKKMGIKSSSTRTLVLEDA
HHHHCCCHHEEEEEEEEEECCCEEEEEEEEECCCCCCCCCHHHHCCCCCCCCEEEEEECC
EVPIENLLGEKGRGHVIAFNILNVGRYKLAVGGVGGSKRAIELAAKYTNERKQFNTPISS
CCCHHHHCCCCCCCCEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHH
FNLTKEKLATMAAGIYANESSVYRTVGLFEQRMGALTDEQLKDGREVARSIAEYQIECSM
CCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
TKYMATELLDYVVDEAVQMHGGYGFMQEYEVERAYRDSRINRIFEGTNEINRLLVPGTLI
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHEEECCHHHH
KKAIKGELPLLQKAQGLQEELMMMMPEEVGTEALEQEKYLLKNAKKMVLLGAGLAAQKYG
HHHHHCCCCHHHHHCCHHHHHHHHCCHHHCHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
QKLENEQEILVNLANMVAEVFNMESAILRTEKAISKVGEEKSKQKLLYTEVYAQEAFNRI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
EAEAKDILVTVEDGDTLRMMLSSLRKLTRHTPVNVVKKKREIAALIIEEEKYVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCC
>Mature Secondary Structure 
SETKEKIFKGGAFLVEDITGEDIITPEDFTDEHKMIAKTTEDFVLGEVVPKIDNLENHE
CCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
FEHSVDLLKKAGDLGLLGADVPEQYGGLALDKISSSLITEKFSRAGGFSVTHGAHVGIGS
HHHHHHHHHHCCCCCEECCCCCHHHCCEEHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
LPIVFFGNDEQKENYLPKLATGELLAAYALTEPSSGSDALGAKTTAKLNDAGTHYILNGE
EEEEEECCCCHHHHCCCCCCCCHHHHHHEECCCCCCCCCCCCCCEEEECCCCCEEEECCC
KQWITNSAFADVFIVYAKIDGEHFTAFIVEREFPGVSTGPEEKKMGIKSSSTRTLVLEDA
HHHHCCCHHEEEEEEEEEECCCEEEEEEEEECCCCCCCCCHHHHCCCCCCCCEEEEEECC
EVPIENLLGEKGRGHVIAFNILNVGRYKLAVGGVGGSKRAIELAAKYTNERKQFNTPISS
CCCHHHHCCCCCCCCEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHH
FNLTKEKLATMAAGIYANESSVYRTVGLFEQRMGALTDEQLKDGREVARSIAEYQIECSM
CCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
TKYMATELLDYVVDEAVQMHGGYGFMQEYEVERAYRDSRINRIFEGTNEINRLLVPGTLI
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHEEECCHHHH
KKAIKGELPLLQKAQGLQEELMMMMPEEVGTEALEQEKYLLKNAKKMVLLGAGLAAQKYG
HHHHHCCCCHHHHHCCHHHHHHHHCCHHHCHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
QKLENEQEILVNLANMVAEVFNMESAILRTEKAISKVGEEKSKQKLLYTEVYAQEAFNRI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
EAEAKDILVTVEDGDTLRMMLSSLRKLTRHTPVNVVKKKREIAALIIEEEKYVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]