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The map label for this gene is fadA [H]

Identifier: 23099849

GI number: 23099849

Start: 2444609

End: 2445784

Strand: Reverse

Name: fadA [H]

Synonym: OB2394

Alternate gene names: 23099849

Gene position: 2445784-2444609 (Counterclockwise)

Preceding gene: 23099850

Following gene: 23099848

Centisome position: 67.37

GC content: 40.48

Gene sequence:

>1176_bases
GTGAAGGAAGCAGTTATTGTTGCTGGTGCGAGAACACCAGTAGGAAAAGCAAATAAAGGTTCACTAGCAAATGTTCGTCC
AGATGATTTAGCTGCATTAACAATAAAAGAAACATTAAAGCGCGCTGGAAATTACGATGGGAATATAGATGATGTCATTA
TCGGATGTGCAACTCCGGAAGCAGAACAAGGAATGAACATGGCAAGAAATGTGGCGGGACTTGCAGGACTGAAAAATGAT
GTTCCCGGAATTACAATAAATCGCTATTGCTCTTCAGGGTTACAAAGTATTGCTTACGGTGCTGAAAGAATTATGGTTGG
TGCAAGTGATGCGATTATTGCTGGTGGAGCAGAGTCAATGAGTATGTTGCCTATGGGAGGGCATGTACTTAAGCCGAATC
CTAAACTTGTAGAAAGTGCTCCAGGTTATTACATGGGTATGGGGCACACAGCAGAAGAAGTAGCAAATCGATTTAACATT
TCGAGAGAGGATCAAGATGCTTTTGCAGTACAAAGTCATCAACGAGCAGCCAAAGCACTGGAAGAAGGCAAGTTTGACGA
TGAAATTGTTCCTGTTGAAGTAAGTCAACGACTTGTTGGTCAGAATAATAAAGTAGAAGAGAAAAGTTTCATTTTTGATC
AGGATGAAGGGGTACGTGCAGGAACAACTTCTGAAATTTTAAGTAAATTACGACCTGCTTTTCATGTGAAGGGATCTGTA
ACTGCAGGGAATGCTTCACAAATGAGTGATGGAGCTGCTTCAGTACTATTAATGGAAAGAGGAAAAGCAGAAGCGGAGGG
TCTAACTCCACTATTGAAGTTTCGATCTTTTGCAGTTGCTGGTGTAGAACCTGAAATTATGGGAGTAGGACCAGTGGAAG
CCATTCCAAAAGCCTTGAAAATAGCTGGACTAGAATTATCTGATATTGGGTTGTTTGAATTAAACGAAGCTTTTGCTTCC
CAATCTTTACGTGTAATTCAAGCTTTAGATTTAAATATGGATAAAGTGAATGTAAATGGTGGAGCAATTGCCTTGGGTCA
TCCTTTGGGCTGTACAGGAACGAAGCTTACATTATCATTAATGCATGAAATGAAACGAAGAAATGAACAGTTTGGTGTTG
TTACGATGTGTATTGGCGGTGGTATGGGTGCTGCTGGGGTATTTGAATTACTTTAA

Upstream 100 bases:

>100_bases
TTTAAGTTTAATAGCTGAACCATTGACACAACAGCGTATGCAACACATGTTGGTCAAAGGGAAACCATTGCGTAACTAAG
CGATAAAGGGGGATAAAAAC

Downstream 100 bases:

>100_bases
TTTAAAATCCAATTATGGAGAGGGAGAAAAACATGAGTGAAACAAAAGAAAAAATATTTAAAGGTGGAGCATTTTTAGTA
GAGGATATAACAGGAGAAGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKEAVIVAGARTPVGKANKGSLANVRPDDLAALTIKETLKRAGNYDGNIDDVIIGCATPEAEQGMNMARNVAGLAGLKND
VPGITINRYCSSGLQSIAYGAERIMVGASDAIIAGGAESMSMLPMGGHVLKPNPKLVESAPGYYMGMGHTAEEVANRFNI
SREDQDAFAVQSHQRAAKALEEGKFDDEIVPVEVSQRLVGQNNKVEEKSFIFDQDEGVRAGTTSEILSKLRPAFHVKGSV
TAGNASQMSDGAASVLLMERGKAEAEGLTPLLKFRSFAVAGVEPEIMGVGPVEAIPKALKIAGLELSDIGLFELNEAFAS
QSLRVIQALDLNMDKVNVNGGAIALGHPLGCTGTKLTLSLMHEMKRRNEQFGVVTMCIGGGMGAAGVFELL

Sequences:

>Translated_391_residues
MKEAVIVAGARTPVGKANKGSLANVRPDDLAALTIKETLKRAGNYDGNIDDVIIGCATPEAEQGMNMARNVAGLAGLKND
VPGITINRYCSSGLQSIAYGAERIMVGASDAIIAGGAESMSMLPMGGHVLKPNPKLVESAPGYYMGMGHTAEEVANRFNI
SREDQDAFAVQSHQRAAKALEEGKFDDEIVPVEVSQRLVGQNNKVEEKSFIFDQDEGVRAGTTSEILSKLRPAFHVKGSV
TAGNASQMSDGAASVLLMERGKAEAEGLTPLLKFRSFAVAGVEPEIMGVGPVEAIPKALKIAGLELSDIGLFELNEAFAS
QSLRVIQALDLNMDKVNVNGGAIALGHPLGCTGTKLTLSLMHEMKRRNEQFGVVTMCIGGGMGAAGVFELL
>Mature_391_residues
MKEAVIVAGARTPVGKANKGSLANVRPDDLAALTIKETLKRAGNYDGNIDDVIIGCATPEAEQGMNMARNVAGLAGLKND
VPGITINRYCSSGLQSIAYGAERIMVGASDAIIAGGAESMSMLPMGGHVLKPNPKLVESAPGYYMGMGHTAEEVANRFNI
SREDQDAFAVQSHQRAAKALEEGKFDDEIVPVEVSQRLVGQNNKVEEKSFIFDQDEGVRAGTTSEILSKLRPAFHVKGSV
TAGNASQMSDGAASVLLMERGKAEAEGLTPLLKFRSFAVAGVEPEIMGVGPVEAIPKALKIAGLELSDIGLFELNEAFAS
QSLRVIQALDLNMDKVNVNGGAIALGHPLGCTGTKLTLSLMHEMKRRNEQFGVVTMCIGGGMGAAGVFELL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=45.8227848101266, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=41.7721518987342, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI167614485, Length=401, Percent_Identity=39.9002493765586, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=34.4913151364764, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI4504327, Length=437, Percent_Identity=31.1212814645309, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI194353979, Length=243, Percent_Identity=35.8024691358025, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI48994986, Length=394, Percent_Identity=45.4314720812183, Blast_Score=307, Evalue=6e-85,
Organism=Escherichia coli, GI1788554, Length=409, Percent_Identity=44.4987775061125, Blast_Score=304, Evalue=7e-84,
Organism=Escherichia coli, GI1787663, Length=410, Percent_Identity=44.1463414634146, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=41.871921182266, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=32.7830188679245, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=400, Percent_Identity=37.25, Blast_Score=257, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=34.9127182044888, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=34.25, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17551802, Length=441, Percent_Identity=31.9727891156463, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=28.8607594936709, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=41.3533834586466, Blast_Score=263, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=35.5, Blast_Score=213, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=42.0792079207921, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI17648125, Length=397, Percent_Identity=38.7909319899244, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24640423, Length=402, Percent_Identity=34.3283582089552, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17137578, Length=435, Percent_Identity=33.7931034482759, Blast_Score=194, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41142; Mature: 41142

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEAVIVAGARTPVGKANKGSLANVRPDDLAALTIKETLKRAGNYDGNIDDVIIGCATPE
CCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
AEQGMNMARNVAGLAGLKNDVPGITINRYCSSGLQSIAYGAERIMVGASDAIIAGGAESM
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCC
SMLPMGGHVLKPNPKLVESAPGYYMGMGHTAEEVANRFNISREDQDAFAVQSHQRAAKAL
EECCCCCEEECCCCHHHHCCCCEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
EEGKFDDEIVPVEVSQRLVGQNNKVEEKSFIFDQDEGVRAGTTSEILSKLRPAFHVKGSV
HHCCCCCCEECHHHHHHHHCCCCCCCHHHEEECCCCCCCCCCHHHHHHHCCCCEEECCCE
TAGNASQMSDGAASVLLMERGKAEAEGLTPLLKFRSFAVAGVEPEIMGVGPVEAIPKALK
ECCCHHHCCCCHHEEEEEECCCCCHHCCHHHHHHHHHHEECCCCCEEECCCHHHHHHHHH
IAGLELSDIGLFELNEAFASQSLRVIQALDLNMDKVNVNGGAIALGHPLGCTGTKLTLSL
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCHHHHHHH
MHEMKRRNEQFGVVTMCIGGGMGAAGVFELL
HHHHHHCCCCCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure
MKEAVIVAGARTPVGKANKGSLANVRPDDLAALTIKETLKRAGNYDGNIDDVIIGCATPE
CCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
AEQGMNMARNVAGLAGLKNDVPGITINRYCSSGLQSIAYGAERIMVGASDAIIAGGAESM
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCC
SMLPMGGHVLKPNPKLVESAPGYYMGMGHTAEEVANRFNISREDQDAFAVQSHQRAAKAL
EECCCCCEEECCCCHHHHCCCCEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
EEGKFDDEIVPVEVSQRLVGQNNKVEEKSFIFDQDEGVRAGTTSEILSKLRPAFHVKGSV
HHCCCCCCEECHHHHHHHHCCCCCCCHHHEEECCCCCCCCCCHHHHHHHCCCCEEECCCE
TAGNASQMSDGAASVLLMERGKAEAEGLTPLLKFRSFAVAGVEPEIMGVGPVEAIPKALK
ECCCHHHCCCCHHEEEEEECCCCCHHCCHHHHHHHHHHEECCCCCEEECCCHHHHHHHHH
IAGLELSDIGLFELNEAFASQSLRVIQALDLNMDKVNVNGGAIALGHPLGCTGTKLTLSL
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCHHHHHHH
MHEMKRRNEQFGVVTMCIGGGMGAAGVFELL
HHHHHHCCCCCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]