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The map label for this gene is ytkD [H]

Identifier: 23099774

GI number: 23099774

Start: 2370427

End: 2370915

Strand: Reverse

Name: ytkD [H]

Synonym: OB2319

Alternate gene names: 23099774

Gene position: 2370915-2370427 (Counterclockwise)

Preceding gene: 23099775

Following gene: 23099769

Centisome position: 65.3

GC content: 34.97

Gene sequence:

>489_bases
TTGAATAGATTTAAGGATTTCTATAATAATACTGTACAATTATCATTTTTGGATCATCCATTTTCTAAAGAGCCTAAGCA
CGTATGGGTTATCTGTCGTTATAAAGATAAATGGTTATTAACTGCTCATAAGGAACGAGGCATAGAATTCCCTGGTGGGA
AGGTTGAACCTGGAGAAACAGCTGAACAAGCGGCAGTTCGAGAAGTTATGGAGGAAACTGGTGGATCTGTAGAATCACTA
CATTATATTGGCCAGTATAAAGTGGATGGAAGAAATGACACAGTGATAAAAAATGTATATTTTGCTATGATTCATAAGTT
AGTTGAACAAGAAACGTATTATGAAACGAAAGGTCCGGTGTTACTATCCGTAATACCGAAAAATGTACGTAAGCGAAAAG
GGTATAGTTTTATTATGAAGGATGATGTGCTCCATACTTGTATGAAGCGGATCAAAACAATTTTTTACAATAATGATAGA
AGCGTGTAA

Upstream 100 bases:

>100_bases
GGAGAATATACATTGGTAGTGGATTTCACGTTTCAACATGATTGGAAAATTTCAAAGATAACATATCAGTAATTTTCAAT
CGAAGAAAGTAGTGGAAGAT

Downstream 100 bases:

>100_bases
GCCTTGGACTTACACGCTTCTATTTCGTATGAGTACCTGTTCAATTTTTTCTACGACTTTATACATTATCGTTGCAAGTA
CAGCAATAATTACTAAGCTC

Product: hypothetical protein

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MNRFKDFYNNTVQLSFLDHPFSKEPKHVWVICRYKDKWLLTAHKERGIEFPGGKVEPGETAEQAAVREVMEETGGSVESL
HYIGQYKVDGRNDTVIKNVYFAMIHKLVEQETYYETKGPVLLSVIPKNVRKRKGYSFIMKDDVLHTCMKRIKTIFYNNDR
SV

Sequences:

>Translated_162_residues
MNRFKDFYNNTVQLSFLDHPFSKEPKHVWVICRYKDKWLLTAHKERGIEFPGGKVEPGETAEQAAVREVMEETGGSVESL
HYIGQYKVDGRNDTVIKNVYFAMIHKLVEQETYYETKGPVLLSVIPKNVRKRKGYSFIMKDDVLHTCMKRIKTIFYNNDR
SV
>Mature_162_residues
MNRFKDFYNNTVQLSFLDHPFSKEPKHVWVICRYKDKWLLTAHKERGIEFPGGKVEPGETAEQAAVREVMEETGGSVESL
HYIGQYKVDGRNDTVIKNVYFAMIHKLVEQETYYETKGPVLLSVIPKNVRKRKGYSFIMKDDVLHTCMKRIKTIFYNNDR
SV

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR014078 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18982; Mature: 18982

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFKDFYNNTVQLSFLDHPFSKEPKHVWVICRYKDKWLLTAHKERGIEFPGGKVEPGET
CCCCHHHHCCEEEEEEECCCCCCCCCEEEEEEEECCCEEEEEHHHCCCCCCCCCCCCCCH
AEQAAVREVMEETGGSVESLHYIGQYKVDGRNDTVIKNVYFAMIHKLVEQETYYETKGPV
HHHHHHHHHHHHHCCCHHEEHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE
LLSVIPKNVRKRKGYSFIMKDDVLHTCMKRIKTIFYNNDRSV
EEEECCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNRFKDFYNNTVQLSFLDHPFSKEPKHVWVICRYKDKWLLTAHKERGIEFPGGKVEPGET
CCCCHHHHCCEEEEEEECCCCCCCCCEEEEEEEECCCEEEEEHHHCCCCCCCCCCCCCCH
AEQAAVREVMEETGGSVESLHYIGQYKVDGRNDTVIKNVYFAMIHKLVEQETYYETKGPV
HHHHHHHHHHHHHCCCHHEEHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCE
LLSVIPKNVRKRKGYSFIMKDDVLHTCMKRIKTIFYNNDRSV
EEEECCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]