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The map label for this gene is gcvPB

Identifier: 23099357

GI number: 23099357

Start: 1932135

End: 1933592

Strand: Reverse

Name: gcvPB

Synonym: OB1902

Alternate gene names: 23099357

Gene position: 1933592-1932135 (Counterclockwise)

Preceding gene: 23099358

Following gene: 23099355

Centisome position: 53.26

GC content: 38.34

Gene sequence:

>1458_bases
ATGTCTAATAAAAATTTTCCTTTAATATTTGAAAGAAGTAAAGAAGGTAGAACCAGTTATAGTTTACCAGAGTTAGATGT
GGAGTCATTTGATTTAGAAGCGGAATTAGGTTCGGAATATGTGAGACAGACTCCTCCAGAACTTCCAGAAGTAAGTGAAC
TTGATATAATACGTCATTACACAGGGCTATCAAATCGTAACTATGGCGTTGATTCCGGATTCTATCCACTAGGTTCATGT
ACGATGAAATATAATCCGAAGATAAATGAAGATATCGCTAGATTAGATGGATTTAGTCATATCCATCCGTATCAAGATGT
CAGCACTGTACAAGGTGCAATGGCAATGATGTTTGATCTTCAAGAATCTCTAAAAGAAATAACTGGCATGCACGAAGTCT
CCCTGCAGTCTGCTGCTGGAGCACAAGGGGAATGGACTGCACTAATGATGATTCGAGCATTTCATGAGTCTAGAGGAGAC
TATGGACGAACGAAGGTTATTGTTCCAGATTCTGCTCATGGAACAAATCCAGCTTCTGCAGCAGTTGCTGGATTTGAAGC
TGTTACGGTTAAATCTAATCAAGAAGGTTTAGTAGATTTAGATGATTTGAGACAGGTAGTAGGAGAAGATACAGCTGCCT
TAATGTTAACAAACCCTAATACATTAGGATTGTTTGAAAAAGATATCTTGACGATGGCTGAAATAGTCCATGAAGCAGGC
GGTAAGTTATATTATGATGGAGCTAATCTGAATGCAATCATGGGATATGTTCGTCCAGGAGACATGGGTTTTGATGCAGT
TCACTTAAACCTTCATAAGACATTTACCGGCCCGCATGGTGGTGGAGGGCCTGGATCAGGTCCAGTTGGTGTTAGCGAAG
AACTTGCTGCATTTTTACCGAAACCATTGATTGTGAAAAAGAATGATGGTTATGATTTTGATGAAAATAGACCTCAATCT
ATTGGAAGAGTTAAACCATTCTATGGGAATTTTGGCATAAACTTACGTGCGTATACGTATATTCGGACGATGGGAGCAGA
AGGTCTTAAAAAGGTCAGTGAATATGCTGTGTTAAATGCAAATTACATGATGCGACAGTTGGAAGATGTATTTGAACTTC
CTTACCCACAACATTGCAAACATGAATTTGTATTATCAGGTAGTAAGCAAAAGAAACTTGGAGTTAGAACATTAGATATG
GCAAAACGATTATTAGACTTTGGTTATCATCCACCTACAATCTACTTCCCGTTGAATGTAGAAGAAGGATTGATGGTAGA
ACCAACTGAAACAGAATCTAAAGAAACATTAGATGGATTTATTGATACGATGCGCACAATAGCAAAAGAAGTTGAAGAAA
ACCCTGAAATAGTTCAGGAAGCTCCTCATCAGACAATTGTAAAGCGTATGGATGAAACAAGGGCTGCTAGAAAACCCGTT
CTTAGATATCATCCATAA

Upstream 100 bases:

>100_bases
AAAGACGATAAGTCACTAGAGGGTTATATGTTAATTGCAGTAACAGAGGTACGAACAAAGCAAGAAATCGATCAATTTGT
GAAAGAATTGGGGGATATTC

Downstream 100 bases:

>100_bases
GCAATCTATACTATTAGTAAAATAAAATTTAGGTTCGAATAGAAAAGACAAAAACCGAACAACATCACATGATGGTTCGG
TTTTTATCTTTTTATGTTAT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSNKNFPLIFERSKEGRTSYSLPELDVESFDLEAELGSEYVRQTPPELPEVSELDIIRHYTGLSNRNYGVDSGFYPLGSC
TMKYNPKINEDIARLDGFSHIHPYQDVSTVQGAMAMMFDLQESLKEITGMHEVSLQSAAGAQGEWTALMMIRAFHESRGD
YGRTKVIVPDSAHGTNPASAAVAGFEAVTVKSNQEGLVDLDDLRQVVGEDTAALMLTNPNTLGLFEKDILTMAEIVHEAG
GKLYYDGANLNAIMGYVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVSEELAAFLPKPLIVKKNDGYDFDENRPQS
IGRVKPFYGNFGINLRAYTYIRTMGAEGLKKVSEYAVLNANYMMRQLEDVFELPYPQHCKHEFVLSGSKQKKLGVRTLDM
AKRLLDFGYHPPTIYFPLNVEEGLMVEPTETESKETLDGFIDTMRTIAKEVEENPEIVQEAPHQTIVKRMDETRAARKPV
LRYHP

Sequences:

>Translated_485_residues
MSNKNFPLIFERSKEGRTSYSLPELDVESFDLEAELGSEYVRQTPPELPEVSELDIIRHYTGLSNRNYGVDSGFYPLGSC
TMKYNPKINEDIARLDGFSHIHPYQDVSTVQGAMAMMFDLQESLKEITGMHEVSLQSAAGAQGEWTALMMIRAFHESRGD
YGRTKVIVPDSAHGTNPASAAVAGFEAVTVKSNQEGLVDLDDLRQVVGEDTAALMLTNPNTLGLFEKDILTMAEIVHEAG
GKLYYDGANLNAIMGYVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVSEELAAFLPKPLIVKKNDGYDFDENRPQS
IGRVKPFYGNFGINLRAYTYIRTMGAEGLKKVSEYAVLNANYMMRQLEDVFELPYPQHCKHEFVLSGSKQKKLGVRTLDM
AKRLLDFGYHPPTIYFPLNVEEGLMVEPTETESKETLDGFIDTMRTIAKEVEENPEIVQEAPHQTIVKRMDETRAARKPV
LRYHP
>Mature_484_residues
SNKNFPLIFERSKEGRTSYSLPELDVESFDLEAELGSEYVRQTPPELPEVSELDIIRHYTGLSNRNYGVDSGFYPLGSCT
MKYNPKINEDIARLDGFSHIHPYQDVSTVQGAMAMMFDLQESLKEITGMHEVSLQSAAGAQGEWTALMMIRAFHESRGDY
GRTKVIVPDSAHGTNPASAAVAGFEAVTVKSNQEGLVDLDDLRQVVGEDTAALMLTNPNTLGLFEKDILTMAEIVHEAGG
KLYYDGANLNAIMGYVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVSEELAAFLPKPLIVKKNDGYDFDENRPQSI
GRVKPFYGNFGINLRAYTYIRTMGAEGLKKVSEYAVLNANYMMRQLEDVFELPYPQHCKHEFVLSGSKQKKLGVRTLDMA
KRLLDFGYHPPTIYFPLNVEEGLMVEPTETESKETLDGFIDTMRTIAKEVEENPEIVQEAPHQTIVKRMDETRAARKPVL
RYHP

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=448, Percent_Identity=40.1785714285714, Blast_Score=276, Evalue=2e-74,
Organism=Escherichia coli, GI1789269, Length=429, Percent_Identity=41.4918414918415, Blast_Score=281, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17535605, Length=409, Percent_Identity=40.5867970660147, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI32564013, Length=363, Percent_Identity=41.8732782369146, Blast_Score=248, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6323843, Length=428, Percent_Identity=42.9906542056075, Blast_Score=308, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24645648, Length=459, Percent_Identity=38.7799564270153, Blast_Score=280, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_OCEIH (Q8CXE1)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692823.1
- ProteinModelPortal:   Q8CXE1
- SMR:   Q8CXE1
- GeneID:   1018394
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1902
- NMPDR:   fig|221109.1.peg.1902
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- BioCyc:   OIHE221109:OB1902-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 53971; Mature: 53840

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKNFPLIFERSKEGRTSYSLPELDVESFDLEAELGSEYVRQTPPELPEVSELDIIRHY
CCCCCCCEEEECCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
TGLSNRNYGVDSGFYPLGSCTMKYNPKINEDIARLDGFSHIHPYQDVSTVQGAMAMMFDL
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
QESLKEITGMHEVSLQSAAGAQGEWTALMMIRAFHESRGDYGRTKVIVPDSAHGTNPASA
HHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHH
AVAGFEAVTVKSNQEGLVDLDDLRQVVGEDTAALMLTNPNTLGLFEKDILTMAEIVHEAG
HHHCCEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GKLYYDGANLNAIMGYVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVSEELAAFLP
CEEEECCCCCEEEEEEECCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCC
KPLIVKKNDGYDFDENRPQSIGRVKPFYGNFGINLRAYTYIRTMGAEGLKKVSEYAVLNA
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHCHHHHHHHHHHHHHHH
NYMMRQLEDVFELPYPQHCKHEFVLSGSKQKKLGVRTLDMAKRLLDFGYHPPTIYFPLNV
HHHHHHHHHHHCCCCCHHCCCCEEECCCCCHHCCCHHHHHHHHHHHCCCCCCEEEEEECC
EEGLMVEPTETESKETLDGFIDTMRTIAKEVEENPEIVQEAPHQTIVKRMDETRAARKPV
CCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCC
LRYHP
CCCCC
>Mature Secondary Structure 
SNKNFPLIFERSKEGRTSYSLPELDVESFDLEAELGSEYVRQTPPELPEVSELDIIRHY
CCCCCCEEEECCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
TGLSNRNYGVDSGFYPLGSCTMKYNPKINEDIARLDGFSHIHPYQDVSTVQGAMAMMFDL
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
QESLKEITGMHEVSLQSAAGAQGEWTALMMIRAFHESRGDYGRTKVIVPDSAHGTNPASA
HHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHH
AVAGFEAVTVKSNQEGLVDLDDLRQVVGEDTAALMLTNPNTLGLFEKDILTMAEIVHEAG
HHHCCEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GKLYYDGANLNAIMGYVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVSEELAAFLP
CEEEECCCCCEEEEEEECCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCC
KPLIVKKNDGYDFDENRPQSIGRVKPFYGNFGINLRAYTYIRTMGAEGLKKVSEYAVLNA
CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHCHHHHHHHHHHHHHHH
NYMMRQLEDVFELPYPQHCKHEFVLSGSKQKKLGVRTLDMAKRLLDFGYHPPTIYFPLNV
HHHHHHHHHHHCCCCCHHCCCCEEECCCCCHHCCCHHHHHHHHHHHCCCCCCEEEEEECC
EEGLMVEPTETESKETLDGFIDTMRTIAKEVEENPEIVQEAPHQTIVKRMDETRAARKPV
CCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCC
LRYHP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376