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The map label for this gene is gcvPA

Identifier: 23099358

GI number: 23099358

Start: 1933585

End: 1934934

Strand: Reverse

Name: gcvPA

Synonym: OB1903

Alternate gene names: 23099358

Gene position: 1934934-1933585 (Counterclockwise)

Preceding gene: 23099359

Following gene: 23099357

Centisome position: 53.3

GC content: 36.3

Gene sequence:

>1350_bases
ATGGAATTTCGTTACCTACCAATGACTAATCAAGATAAGCAGGAAATGCTTGATGCAATTGGAATTAAATCCACAGAAGA
ACTTTTTTCTGACATTCCAGAGCATGTACGATTTAAGGGTGAGATGAATCTAAAAGCACCGATAAGTGAGTATGAACTAA
CAAAAGAGTTAACAGAGCTTGCTAGTCGCAATATTCATACAAAAGAATATACATCTTTTTTAGGAGCAGGTGTTTACGAT
CATTACATACCTTCTGTAGTTGATCATGTAATTTCTCGCTCAGAATTTTATACGGCTTATACCCCATATCAACCAGAAAT
ATCACAAGGGGAATTACAGGCAATCTTTGAATTCCAAACAATGATATCCGAATTAACAGGATTACCGGTTGCAAACTCTT
CTATGTACGATGGAGGAACAGCTTTAGCAGAAGCAGTCAATCTTAGTGCTGCTCATACAAAAAGAAAAAAAGTACTCGTA
TCAAAAGCGGTTCATCCAGAATATCGTGCTGTAATTGATTCTTACACAAGAGGCCAATCCATTGATATAGTGGAAATCGA
TACTGTAAATGGAGTCACTGATTTAGCTCAATTAGATCAAGCAATCGATGAGACGATTGCTGGTGTAGTTGTTCAATATC
CTAACTTTTTTGGACAATTAGAGCCAATGAAAAAAATCGAACAATTACTTGAAAATCACCAGAAAACCATGTTAATTGTC
TCTAGTAATCCCTTAGCTCTTGGATATTTAACCCCTCCTGGAGAATTTGGGGCAGATATTGTGACAGGTGATACACAAGT
ATTCGGTATCCCGGCACAATTTGGTGGTCCTCACTGTGGATATTTTGCAACTTCAAAAAAACTAATGCGTAAAGTTCCAG
GGAGACTTGTAGGAGAGACAGTTGATGAAGAGGGAACAAGAGGTTATGTATTAACTTTACAAGCTCGAGAACAACATATA
CGAAGAGATAAAGCAACATCTAATATTTGTTCAAATCAAGCTCTGAATGCATTAGCTAGTTCGGTTGCAATGAGTTCGAT
TGGTAAGCATGGATTACGTAAATTAGCCAGTGTAAATATGCAAAAAGCAAGATATGCTAGAAAAAAACTGCTTGAAGCTG
GCGTTGAGCTTGCATTTGACGGATCATTCTTTAATGAGTTTGTAATAAAAGTTCCAGGTTCTGTCTCAAAAATAAATAAG
CAATTATTAGATAAAGGTATTATTGCTGGTTATGATCTAGCAAAAGACGATAAGTCACTAGAGGGTTATATGTTAATTGC
AGTAACAGAGGTACGAACAAAGCAAGAAATCGATCAATTTGTGAAAGAATTGGGGGATATTCATGTCTAA

Upstream 100 bases:

>100_bases
AATAGGCACTGAAGTTGATGTGAAAGTTCGAAAACGTATATTGAAGGCTAAAATAGTTCCGACACCGTTTTATAAACGGG
GAAGATAAGGGGGAGAACCA

Downstream 100 bases:

>100_bases
TAAAAATTTTCCTTTAATATTTGAAAGAAGTAAAGAAGGTAGAACCAGTTATAGTTTACCAGAGTTAGATGTGGAGTCAT
TTGATTTAGAAGCGGAATTA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MEFRYLPMTNQDKQEMLDAIGIKSTEELFSDIPEHVRFKGEMNLKAPISEYELTKELTELASRNIHTKEYTSFLGAGVYD
HYIPSVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMISELTGLPVANSSMYDGGTALAEAVNLSAAHTKRKKVLV
SKAVHPEYRAVIDSYTRGQSIDIVEIDTVNGVTDLAQLDQAIDETIAGVVVQYPNFFGQLEPMKKIEQLLENHQKTMLIV
SSNPLALGYLTPPGEFGADIVTGDTQVFGIPAQFGGPHCGYFATSKKLMRKVPGRLVGETVDEEGTRGYVLTLQAREQHI
RRDKATSNICSNQALNALASSVAMSSIGKHGLRKLASVNMQKARYARKKLLEAGVELAFDGSFFNEFVIKVPGSVSKINK
QLLDKGIIAGYDLAKDDKSLEGYMLIAVTEVRTKQEIDQFVKELGDIHV

Sequences:

>Translated_449_residues
MEFRYLPMTNQDKQEMLDAIGIKSTEELFSDIPEHVRFKGEMNLKAPISEYELTKELTELASRNIHTKEYTSFLGAGVYD
HYIPSVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMISELTGLPVANSSMYDGGTALAEAVNLSAAHTKRKKVLV
SKAVHPEYRAVIDSYTRGQSIDIVEIDTVNGVTDLAQLDQAIDETIAGVVVQYPNFFGQLEPMKKIEQLLENHQKTMLIV
SSNPLALGYLTPPGEFGADIVTGDTQVFGIPAQFGGPHCGYFATSKKLMRKVPGRLVGETVDEEGTRGYVLTLQAREQHI
RRDKATSNICSNQALNALASSVAMSSIGKHGLRKLASVNMQKARYARKKLLEAGVELAFDGSFFNEFVIKVPGSVSKINK
QLLDKGIIAGYDLAKDDKSLEGYMLIAVTEVRTKQEIDQFVKELGDIHV
>Mature_449_residues
MEFRYLPMTNQDKQEMLDAIGIKSTEELFSDIPEHVRFKGEMNLKAPISEYELTKELTELASRNIHTKEYTSFLGAGVYD
HYIPSVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMISELTGLPVANSSMYDGGTALAEAVNLSAAHTKRKKVLV
SKAVHPEYRAVIDSYTRGQSIDIVEIDTVNGVTDLAQLDQAIDETIAGVVVQYPNFFGQLEPMKKIEQLLENHQKTMLIV
SSNPLALGYLTPPGEFGADIVTGDTQVFGIPAQFGGPHCGYFATSKKLMRKVPGRLVGETVDEEGTRGYVLTLQAREQHI
RRDKATSNICSNQALNALASSVAMSSIGKHGLRKLASVNMQKARYARKKLLEAGVELAFDGSFFNEFVIKVPGSVSKINK
QLLDKGIIAGYDLAKDDKSLEGYMLIAVTEVRTKQEIDQFVKELGDIHV

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=439, Percent_Identity=36.6742596810934, Blast_Score=267, Evalue=2e-71,
Organism=Escherichia coli, GI1789269, Length=442, Percent_Identity=32.3529411764706, Blast_Score=198, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17535605, Length=399, Percent_Identity=39.0977443609023, Blast_Score=254, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6323843, Length=457, Percent_Identity=35.8862144420131, Blast_Score=261, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24645648, Length=397, Percent_Identity=38.0352644836272, Blast_Score=274, Evalue=7e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_OCEIH (Q8CXE0)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692824.1
- ProteinModelPortal:   Q8CXE0
- SMR:   Q8CXE0
- GeneID:   1018395
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1903
- NMPDR:   fig|221109.1.peg.1903
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   OIHE221109:OB1903-MONOMER
- BRENDA:   1.4.4.2
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 49746; Mature: 49746

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFRYLPMTNQDKQEMLDAIGIKSTEELFSDIPEHVRFKGEMNLKAPISEYELTKELTEL
CCEEECCCCCCCHHHHHHHHCCCCHHHHHHHCHHHHEECCCCCCCCCCHHHHHHHHHHHH
ASRNIHTKEYTSFLGAGVYDHYIPSVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHCEEEECCCCCCCCCCHHHHHHHHHH
MISELTGLPVANSSMYDGGTALAEAVNLSAAHTKRKKVLVSKAVHPEYRAVIDSYTRGQS
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
IDIVEIDTVNGVTDLAQLDQAIDETIAGVVVQYPNFFGQLEPMKKIEQLLENHQKTMLIV
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCCEEEEE
SSNPLALGYLTPPGEFGADIVTGDTQVFGIPAQFGGPHCGYFATSKKLMRKVPGRLVGET
ECCCEEEEEECCCCCCCCCEEECCCEEEEECHHCCCCCCCHHHHHHHHHHHCCHHHHCCC
VDEEGTRGYVLTLQAREQHIRRDKATSNICSNQALNALASSVAMSSIGKHGLRKLASVNM
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
QKARYARKKLLEAGVELAFDGSFFNEFVIKVPGSVSKINKQLLDKGIIAGYDLAKDDKSL
HHHHHHHHHHHHHCCCEEECCHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
EGYMLIAVTEVRTKQEIDQFVKELGDIHV
CCEEEEEEEHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEFRYLPMTNQDKQEMLDAIGIKSTEELFSDIPEHVRFKGEMNLKAPISEYELTKELTEL
CCEEECCCCCCCHHHHHHHHCCCCHHHHHHHCHHHHEECCCCCCCCCCHHHHHHHHHHHH
ASRNIHTKEYTSFLGAGVYDHYIPSVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHCEEEECCCCCCCCCCHHHHHHHHHH
MISELTGLPVANSSMYDGGTALAEAVNLSAAHTKRKKVLVSKAVHPEYRAVIDSYTRGQS
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
IDIVEIDTVNGVTDLAQLDQAIDETIAGVVVQYPNFFGQLEPMKKIEQLLENHQKTMLIV
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCCEEEEE
SSNPLALGYLTPPGEFGADIVTGDTQVFGIPAQFGGPHCGYFATSKKLMRKVPGRLVGET
ECCCEEEEEECCCCCCCCCEEECCCEEEEECHHCCCCCCCHHHHHHHHHHHCCHHHHCCC
VDEEGTRGYVLTLQAREQHIRRDKATSNICSNQALNALASSVAMSSIGKHGLRKLASVNM
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
QKARYARKKLLEAGVELAFDGSFFNEFVIKVPGSVSKINKQLLDKGIIAGYDLAKDDKSL
HHHHHHHHHHHHHCCCEEECCHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
EGYMLIAVTEVRTKQEIDQFVKELGDIHV
CCEEEEEEEHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376