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The map label for this gene is ndk

Identifier: 23099242

GI number: 23099242

Start: 1824488

End: 1824934

Strand: Reverse

Name: ndk

Synonym: OB1787

Alternate gene names: 23099242

Gene position: 1824934-1824488 (Counterclockwise)

Preceding gene: 23099243

Following gene: 23099241

Centisome position: 50.27

GC content: 38.48

Gene sequence:

>447_bases
ATGGAGAAAACATTTTTAATGGTAAAACCTGATGGGGTTCAACGAGAATTAATTGGTGAAATCGTAAAAAGGTTTGAAAC
AAAGGGGTACAAGCTTGCTGGGGCGAAATTAATGCAAGTGTCAAATCAATTAGCTGAAACACATTACAGTGAACACAAAG
AACGTCCTTTCTTCGGTGAACTGGTTGATTTTATTACTTCTGGACCTGTATTTGCTATGGTTTGGGAAGGCGAGAATGTA
ATCGCAACAGCTCGAAAGATGATGGGGAAAACTAACCCGTTAGAGGCAGACCCGAGTACAATTCGCGGTGATTTTGGGAT
TAGTGTTGGAAAGAATATTATTCATGGCTCTGATTCAGCAGAAAGTGCTGAGAGAGAAATAACTCTATTCTTTACAGAAA
ATGAGATCGTGTCCTATGAGAAACAAGCAAACAATTGGATTTATTAA

Upstream 100 bases:

>100_bases
ATATATCGGAAAAAGAAGATCCTAAGTAATTGTTATTTTTAAGAAAATTTGATATTATTTTATAGGTTACTTATTTAAAT
ACATAAGTTGGGGTGATTTT

Downstream 100 bases:

>100_bases
TAAGTGAAAGCGGAAACATATATTGTTTTCACTTAACTCATGACCTCCGTTAAAATAAACGGAGGTTTTTATATATTTTT
GTTGATTCGGAGTGATATGA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MEKTFLMVKPDGVQRELIGEIVKRFETKGYKLAGAKLMQVSNQLAETHYSEHKERPFFGELVDFITSGPVFAMVWEGENV
IATARKMMGKTNPLEADPSTIRGDFGISVGKNIIHGSDSAESAEREITLFFTENEIVSYEKQANNWIY

Sequences:

>Translated_148_residues
MEKTFLMVKPDGVQRELIGEIVKRFETKGYKLAGAKLMQVSNQLAETHYSEHKERPFFGELVDFITSGPVFAMVWEGENV
IATARKMMGKTNPLEADPSTIRGDFGISVGKNIIHGSDSAESAEREITLFFTENEIVSYEKQANNWIY
>Mature_148_residues
MEKTFLMVKPDGVQRELIGEIVKRFETKGYKLAGAKLMQVSNQLAETHYSEHKERPFFGELVDFITSGPVFAMVWEGENV
IATARKMMGKTNPLEADPSTIRGDFGISVGKNIIHGSDSAESAEREITLFFTENEIVSYEKQANNWIY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=147, Percent_Identity=59.1836734693878, Blast_Score=199, Evalue=9e-52,
Organism=Homo sapiens, GI38045913, Length=148, Percent_Identity=60.1351351351351, Blast_Score=196, Evalue=7e-51,
Organism=Homo sapiens, GI4557797, Length=148, Percent_Identity=60.1351351351351, Blast_Score=195, Evalue=9e-51,
Organism=Homo sapiens, GI66392203, Length=148, Percent_Identity=55.4054054054054, Blast_Score=187, Evalue=2e-48,
Organism=Homo sapiens, GI66392227, Length=148, Percent_Identity=55.4054054054054, Blast_Score=187, Evalue=3e-48,
Organism=Homo sapiens, GI66392205, Length=148, Percent_Identity=55.4054054054054, Blast_Score=187, Evalue=3e-48,
Organism=Homo sapiens, GI4505409, Length=148, Percent_Identity=55.4054054054054, Blast_Score=187, Evalue=3e-48,
Organism=Homo sapiens, GI66392192, Length=148, Percent_Identity=55.4054054054054, Blast_Score=187, Evalue=3e-48,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=47.8260869565217, Blast_Score=160, Evalue=3e-40,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=36.8421052631579, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=36.8421052631579, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=33.5766423357664, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=32.8571428571429, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=30.6569343065693, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=44.5255474452555, Blast_Score=134, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17506807, Length=148, Percent_Identity=50, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71995094, Length=132, Percent_Identity=31.0606060606061, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322783, Length=147, Percent_Identity=53.7414965986395, Blast_Score=183, Evalue=1e-47,
Organism=Drosophila melanogaster, GI45549037, Length=147, Percent_Identity=57.1428571428571, Blast_Score=189, Evalue=6e-49,
Organism=Drosophila melanogaster, GI18860097, Length=146, Percent_Identity=32.1917808219178, Blast_Score=93, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_OCEIH (Q8EQB4)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692708.1
- ProteinModelPortal:   Q8EQB4
- SMR:   Q8EQB4
- GeneID:   1018281
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1787
- NMPDR:   fig|221109.1.peg.1788
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   OIHE221109:OB1787-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16711; Mature: 16711

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTFLMVKPDGVQRELIGEIVKRFETKGYKLAGAKLMQVSNQLAETHYSEHKERPFFGE
CCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LVDFITSGPVFAMVWEGENVIATARKMMGKTNPLEADPSTIRGDFGISVGKNIIHGSDSA
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCC
ESAEREITLFFTENEIVSYEKQANNWIY
CCCCCEEEEEEECCCHHHHHHHCCCCCC
>Mature Secondary Structure
MEKTFLMVKPDGVQRELIGEIVKRFETKGYKLAGAKLMQVSNQLAETHYSEHKERPFFGE
CCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LVDFITSGPVFAMVWEGENVIATARKMMGKTNPLEADPSTIRGDFGISVGKNIIHGSDSA
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCC
ESAEREITLFFTENEIVSYEKQANNWIY
CCCCCEEEEEEECCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376