Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 23099151

GI number: 23099151

Start: 1737985

End: 1739325

Strand: Direct

Name: accC [H]

Synonym: OB1696

Alternate gene names: 23099151

Gene position: 1737985-1739325 (Clockwise)

Preceding gene: 23099150

Following gene: 23099152

Centisome position: 47.87

GC content: 35.94

Gene sequence:

>1341_bases
ATGATTAAGAGAATGTTGATTGCTAATCGAGGTGAAATTGCTCGGAGAATCATTCGTACATGTAGACAATTAAATATTGA
AACAATTGCCATATACTCAGATGCCGATAAAGATGCTTTATTTGTAAAAGAAGCAGACGAATCTTATTTAGTTGGTGGAA
ATCGAGTACAGGAAAGTTATTTGAATGTAGATAAAATCTTTGAAATAGCGAAACAGGCAAACATAGATGCTATTCACCCT
GGTTATGGATTCCTTAGCGAGAATGCTAGTTTTGCTAATCGTTGCTTGAAAGAAAAGATTACGTTTATAGGACCATCTCC
TGAAATAATTGAACTAATGGGGGACAAAATAGCAGCTAGAAGAACGATGAAACAGGCAGGTGTACCCATTGTTCCGGGTA
CAGAAGAAGCGATTTCTTCGGTTGAAGAAGCTGTGAAGTATGCATCTGAGATTGGTTATCCTATTATGCTTAAAGCAGCT
GCTGGAGGCGGCGGTATCGGAATGCAAATTGTTCATAACGATGATGAATTAGTGAAAGCATTTGATAGCAATTCAAAAAG
AGCAGCTAATTTTTTTGGTAACGGTTCCATGTTTTTAGAGAAAAAAATAGAAGAAACAAGACATATTGAATTTCAAGTTT
TGGCTGACCATCATGGGAATGTTGTTCATTTATTCGAAAGAGAGTGTTCCATTCAGAGAAGGAATCAAAAAGTAATAGAA
GAAGCTCCATCTCCATTCGTATCAGATAGATTGCGCAAAGATATGGGAGAAGCATCCATTCGAGCAACAAAACAAATAAA
CTATACGAATGCTGGAACGATTGAATTTCTTGTTGATAAGGAAGAAAACTACTACTTTTTAGAAATGAATACACGTATAC
AAGTGGAACACCCCATAACAGAGGAAACCACAGGTATCGATATTGTTGAACATCAAATTAAAATAGCACAAGGGGAATCA
CTGCAAATAACACAAAATGACATACGACAAACTGGTCATGCTATTGAAGCTAGAATCTATGCAGAAGACCCGATAACATT
TTTCCCTTCACCCGGTAAAATTACTCAATTCTCTTTACCAAAAGGAGAGTGTATTCGAAATGAATGTGCAGTTAAAGAAG
GAGATCAAGTCACACCATTTTACGATCCAATGATAGCAAAGCTCATTGTTACGGGCGATACAAGGTCTGAAGCGATTGCT
AATTTAAAAGTTGCGATGAATCAATTTATAGTAGAAGGAATTAAGACAAATATCACAATGATAAAAGAAATTATCGATTA
CCCCGCTTATGTGAATGGGGATACGACGACAACATTTATCCAAGATTATTATCAAAAATAA

Upstream 100 bases:

>100_bases
CTTACGTGATGCAAAATTGCTAGAGATTGGCGAAGGAACATCAGAGATTCAAAGGCTTGTAATTGCTAGACAGTTAGGAT
GTTAATGTGAGGAGGATTCT

Downstream 100 bases:

>100_bases
GGAGGAATTATCAATGGAAGTAAAAGCAAGTATGGCAGGAAATGTATGGAAGATTACGGTAGAACAAGGAAATAAAGTAG
AGTCTGGACAGGATATCGTT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MIKRMLIANRGEIARRIIRTCRQLNIETIAIYSDADKDALFVKEADESYLVGGNRVQESYLNVDKIFEIAKQANIDAIHP
GYGFLSENASFANRCLKEKITFIGPSPEIIELMGDKIAARRTMKQAGVPIVPGTEEAISSVEEAVKYASEIGYPIMLKAA
AGGGGIGMQIVHNDDELVKAFDSNSKRAANFFGNGSMFLEKKIEETRHIEFQVLADHHGNVVHLFERECSIQRRNQKVIE
EAPSPFVSDRLRKDMGEASIRATKQINYTNAGTIEFLVDKEENYYFLEMNTRIQVEHPITEETTGIDIVEHQIKIAQGES
LQITQNDIRQTGHAIEARIYAEDPITFFPSPGKITQFSLPKGECIRNECAVKEGDQVTPFYDPMIAKLIVTGDTRSEAIA
NLKVAMNQFIVEGIKTNITMIKEIIDYPAYVNGDTTTTFIQDYYQK

Sequences:

>Translated_446_residues
MIKRMLIANRGEIARRIIRTCRQLNIETIAIYSDADKDALFVKEADESYLVGGNRVQESYLNVDKIFEIAKQANIDAIHP
GYGFLSENASFANRCLKEKITFIGPSPEIIELMGDKIAARRTMKQAGVPIVPGTEEAISSVEEAVKYASEIGYPIMLKAA
AGGGGIGMQIVHNDDELVKAFDSNSKRAANFFGNGSMFLEKKIEETRHIEFQVLADHHGNVVHLFERECSIQRRNQKVIE
EAPSPFVSDRLRKDMGEASIRATKQINYTNAGTIEFLVDKEENYYFLEMNTRIQVEHPITEETTGIDIVEHQIKIAQGES
LQITQNDIRQTGHAIEARIYAEDPITFFPSPGKITQFSLPKGECIRNECAVKEGDQVTPFYDPMIAKLIVTGDTRSEAIA
NLKVAMNQFIVEGIKTNITMIKEIIDYPAYVNGDTTTTFIQDYYQK
>Mature_446_residues
MIKRMLIANRGEIARRIIRTCRQLNIETIAIYSDADKDALFVKEADESYLVGGNRVQESYLNVDKIFEIAKQANIDAIHP
GYGFLSENASFANRCLKEKITFIGPSPEIIELMGDKIAARRTMKQAGVPIVPGTEEAISSVEEAVKYASEIGYPIMLKAA
AGGGGIGMQIVHNDDELVKAFDSNSKRAANFFGNGSMFLEKKIEETRHIEFQVLADHHGNVVHLFERECSIQRRNQKVIE
EAPSPFVSDRLRKDMGEASIRATKQINYTNAGTIEFLVDKEENYYFLEMNTRIQVEHPITEETTGIDIVEHQIKIAQGES
LQITQNDIRQTGHAIEARIYAEDPITFFPSPGKITQFSLPKGECIRNECAVKEGDQVTPFYDPMIAKLIVTGDTRSEAIA
NLKVAMNQFIVEGIKTNITMIKEIIDYPAYVNGDTTTTFIQDYYQK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=45.8612975391499, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=47.8651685393258, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=47.8651685393258, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=47.8651685393258, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=44.2953020134228, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=44.2953020134228, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=44.2953020134228, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI38679960, Length=492, Percent_Identity=28.8617886178862, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI38679977, Length=492, Percent_Identity=28.8617886178862, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI38679967, Length=492, Percent_Identity=28.8617886178862, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI38679974, Length=492, Percent_Identity=28.8617886178862, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI38679971, Length=492, Percent_Identity=28.8617886178862, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=28.5148514851485, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI18105007, Length=243, Percent_Identity=25.5144032921811, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1789654, Length=442, Percent_Identity=46.606334841629, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1786216, Length=263, Percent_Identity=25.4752851711027, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=46.3963963963964, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567343, Length=444, Percent_Identity=45.045045045045, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=446, Percent_Identity=45.067264573991, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI133931226, Length=458, Percent_Identity=32.3144104803493, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=30.7086614173228, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=30.7086614173228, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193204318, Length=204, Percent_Identity=24.0196078431373, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=44.2696629213483, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=43.7777777777778, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321376, Length=450, Percent_Identity=44.2222222222222, Blast_Score=352, Evalue=7e-98,
Organism=Saccharomyces cerevisiae, GI6323863, Length=470, Percent_Identity=31.063829787234, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6324343, Length=512, Percent_Identity=28.3203125, Blast_Score=226, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6322331, Length=309, Percent_Identity=22.0064724919094, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=45.5156950672646, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI281363050, Length=450, Percent_Identity=43.3333333333333, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=450, Percent_Identity=43.3333333333333, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=450, Percent_Identity=43.3333333333333, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=450, Percent_Identity=43.3333333333333, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=450, Percent_Identity=43.3333333333333, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652212, Length=450, Percent_Identity=43.3333333333333, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=450, Percent_Identity=43.3333333333333, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=450, Percent_Identity=43.3333333333333, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=450, Percent_Identity=43.3333333333333, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=450, Percent_Identity=43.3333333333333, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=403, Percent_Identity=45.409429280397, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI161076409, Length=496, Percent_Identity=28.2258064516129, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161076407, Length=496, Percent_Identity=28.2258064516129, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24586460, Length=496, Percent_Identity=28.2258064516129, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24586458, Length=496, Percent_Identity=28.2258064516129, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI45555749, Length=227, Percent_Identity=25.5506607929515, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642586, Length=236, Percent_Identity=25.4237288135593, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50092; Mature: 50092

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRMLIANRGEIARRIIRTCRQLNIETIAIYSDADKDALFVKEADESYLVGGNRVQESY
CCCCCEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEEECCCHHHHHH
LNVDKIFEIAKQANIDAIHPGYGFLSENASFANRCLKEKITFIGPSPEIIELMGDKIAAR
CCHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHH
RTMKQAGVPIVPGTEEAISSVEEAVKYASEIGYPIMLKAAAGGGGIGMQIVHNDDELVKA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCHHHHHH
FDSNSKRAANFFGNGSMFLEKKIEETRHIEFQVLADHHGNVVHLFERECSIQRRNQKVIE
HCCCCCEEHHCCCCCCCHHHHHHHHHHCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHH
EAPSPFVSDRLRKDMGEASIRATKQINYTNAGTIEFLVDKEENYYFLEMNTRIQVEHPIT
HCCCCHHHHHHHHHCCHHHEEEEEEECCCCCCEEEEEEECCCCEEEEEECCEEEEECCCC
EETTGIDIVEHQIKIAQGESLQITQNDIRQTGHAIEARIYAEDPITFFPSPGKITQFSLP
CCCCCCEEEEHEEEEECCCEEEEEHHHHHHCCCEEEEEEEECCCEEECCCCCCEEEECCC
KGECIRNECAVKEGDQVTPFYDPMIAKLIVTGDTRSEAIANLKVAMNQFIVEGIKTNITM
CCHHHHHHHCCCCCCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IKEIIDYPAYVNGDTTTTFIQDYYQK
HHHHHCCCCEECCCCHHHHHHHHHCC
>Mature Secondary Structure
MIKRMLIANRGEIARRIIRTCRQLNIETIAIYSDADKDALFVKEADESYLVGGNRVQESY
CCCCCEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEEECCCHHHHHH
LNVDKIFEIAKQANIDAIHPGYGFLSENASFANRCLKEKITFIGPSPEIIELMGDKIAAR
CCHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHH
RTMKQAGVPIVPGTEEAISSVEEAVKYASEIGYPIMLKAAAGGGGIGMQIVHNDDELVKA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCHHHHHH
FDSNSKRAANFFGNGSMFLEKKIEETRHIEFQVLADHHGNVVHLFERECSIQRRNQKVIE
HCCCCCEEHHCCCCCCCHHHHHHHHHHCEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHH
EAPSPFVSDRLRKDMGEASIRATKQINYTNAGTIEFLVDKEENYYFLEMNTRIQVEHPIT
HCCCCHHHHHHHHHCCHHHEEEEEEECCCCCCEEEEEEECCCCEEEEEECCEEEEECCCC
EETTGIDIVEHQIKIAQGESLQITQNDIRQTGHAIEARIYAEDPITFFPSPGKITQFSLP
CCCCCCEEEEHEEEEECCCEEEEEHHHHHHCCCEEEEEEEECCCEEECCCCCCEEEECCC
KGECIRNECAVKEGDQVTPFYDPMIAKLIVTGDTRSEAIANLKVAMNQFIVEGIKTNITM
CCHHHHHHHCCCCCCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IKEIIDYPAYVNGDTTTTFIQDYYQK
HHHHHCCCCEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]