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The map label for this gene is sucC [H]

Identifier: 23098998

GI number: 23098998

Start: 1585509

End: 1586669

Strand: Direct

Name: sucC [H]

Synonym: OB1543

Alternate gene names: 23098998

Gene position: 1585509-1586669 (Clockwise)

Preceding gene: 23098997

Following gene: 23098999

Centisome position: 43.67

GC content: 36.43

Gene sequence:

>1161_bases
ATGAACATTCACGAGTATCAAGGTAAACAAGTTTTACGGGAATATGGGGTTAAGGTTCCTAACGGCTATGTTGCATATAC
AGTGGACGAAGCTGTACAAGCTGCGGAAAAGCTCGGAACATCTGTAAACGTTGTCAAAGCACAGATTCATGCTGGTGGCC
GCGGTAAAGCAGGTGGAGTTAAAGTTGCGAAAAGTCTTGATGAAGTTCGTACATATGCGGATGAAATATTAGGAAAGACA
TTAGTAACTCATCAAACTGGACCTGAAGGAAAAGAAGTAAAACGTTTACTAATTGAAGAAGGCTGTGACATTCAAAAGGA
ATATTATGTTGGGGTAGTATTAGATCGTGCAACTTCTAGAGTTGTTATGATGGCTTCTGAAGAAGGTGGAACTGAGATTG
AAGAAGTTGCTGAAGCAACTCCAGAAAAAATCTTTAAAGAAGTTATTGATCCAGTTGTTGGATTGACACCATTCCAAGCT
AGAAGACTAGCATTTAATATTAATATTCCTGAAGATTTACTAGGAAAAGCAGTTAAATTTATGTCTGGTCTTTATGATGC
TTTTGTTGCAAAAGATTGCTCTATTGCTGAAATTAATCCATTAGTAACAACTGGTGATGGTGAAGTATTAGCGCTCGATG
CAAAATTAAACTTTGATGATAATGCTCTTTATCGTCATAAAGATATTCAAGATTTAAGAGACTTTGAAGAAGAAGACGAA
AAAGAAATCCAAGCTTCTAAATATGACTTAAGCTATGTTTCTCTTGATGGAAATATTGGTTGTATGGTAAACGGAGCAGG
ACTAGCTATGTCTACTATGGATATTATTAAACATTATGGCGGCGATCCGGCTAACTTCCTTGATGTAGGGGGCGGTGCTA
CTGCAGAAAAAGTAACAGAAGCGTTTAAAATTATTCTTTCAGATAAAAACGTAAAAGGTATTTTTGTTAATATCTTTGGT
GGAATTATGAAGTGTGATGTAATTGCTGAAGGTGTTGTTGAAGCTACGAAACAAATTGGATTAGAGATTCCACTAGTTGT
ACGTCTTGAAGGTACAAATGTTGACGCAGGTAAGAAAATTTTAGATGAATCTGGCTTAAACATTACTACTGCAACATCTA
TGGCTGATGGAGCAGAGAAAATTGTTGCTGCAGTAAAATAA

Upstream 100 bases:

>100_bases
CAAGTTGCACAAAATTGTCAAACGTTGTTCGCTAATTCTTGTTAATTTCTCATTTTTTTAATACAATGGAAATGCATTGA
ATTTGATAGGAGGATGGAAG

Downstream 100 bases:

>100_bases
ACTTAGTAAACCGAGAACTTTACAAAGAGGAAAGGACGGACGAAAATGAGTGTTTATATTAATAAAGATACAAAAGTGAT
TGTCCAAGGAATTACTGGTG

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MNIHEYQGKQVLREYGVKVPNGYVAYTVDEAVQAAEKLGTSVNVVKAQIHAGGRGKAGGVKVAKSLDEVRTYADEILGKT
LVTHQTGPEGKEVKRLLIEEGCDIQKEYYVGVVLDRATSRVVMMASEEGGTEIEEVAEATPEKIFKEVIDPVVGLTPFQA
RRLAFNINIPEDLLGKAVKFMSGLYDAFVAKDCSIAEINPLVTTGDGEVLALDAKLNFDDNALYRHKDIQDLRDFEEEDE
KEIQASKYDLSYVSLDGNIGCMVNGAGLAMSTMDIIKHYGGDPANFLDVGGGATAEKVTEAFKIILSDKNVKGIFVNIFG
GIMKCDVIAEGVVEATKQIGLEIPLVVRLEGTNVDAGKKILDESGLNITTATSMADGAEKIVAAVK

Sequences:

>Translated_386_residues
MNIHEYQGKQVLREYGVKVPNGYVAYTVDEAVQAAEKLGTSVNVVKAQIHAGGRGKAGGVKVAKSLDEVRTYADEILGKT
LVTHQTGPEGKEVKRLLIEEGCDIQKEYYVGVVLDRATSRVVMMASEEGGTEIEEVAEATPEKIFKEVIDPVVGLTPFQA
RRLAFNINIPEDLLGKAVKFMSGLYDAFVAKDCSIAEINPLVTTGDGEVLALDAKLNFDDNALYRHKDIQDLRDFEEEDE
KEIQASKYDLSYVSLDGNIGCMVNGAGLAMSTMDIIKHYGGDPANFLDVGGGATAEKVTEAFKIILSDKNVKGIFVNIFG
GIMKCDVIAEGVVEATKQIGLEIPLVVRLEGTNVDAGKKILDESGLNITTATSMADGAEKIVAAVK
>Mature_386_residues
MNIHEYQGKQVLREYGVKVPNGYVAYTVDEAVQAAEKLGTSVNVVKAQIHAGGRGKAGGVKVAKSLDEVRTYADEILGKT
LVTHQTGPEGKEVKRLLIEEGCDIQKEYYVGVVLDRATSRVVMMASEEGGTEIEEVAEATPEKIFKEVIDPVVGLTPFQA
RRLAFNINIPEDLLGKAVKFMSGLYDAFVAKDCSIAEINPLVTTGDGEVLALDAKLNFDDNALYRHKDIQDLRDFEEEDE
KEIQASKYDLSYVSLDGNIGCMVNGAGLAMSTMDIIKHYGGDPANFLDVGGGATAEKVTEAFKIILSDKNVKGIFVNIFG
GIMKCDVIAEGVVEATKQIGLEIPLVVRLEGTNVDAGKKILDESGLNITTATSMADGAEKIVAAVK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=389, Percent_Identity=48.3290488431877, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI157779135, Length=383, Percent_Identity=45.6919060052219, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI294862256, Length=359, Percent_Identity=45.4038997214485, Blast_Score=316, Evalue=2e-86,
Organism=Escherichia coli, GI1786948, Length=386, Percent_Identity=54.1450777202073, Blast_Score=422, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539378, Length=394, Percent_Identity=48.2233502538071, Blast_Score=366, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17567829, Length=388, Percent_Identity=44.5876288659794, Blast_Score=330, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6321683, Length=392, Percent_Identity=45.1530612244898, Blast_Score=348, Evalue=9e-97,
Organism=Drosophila melanogaster, GI161078106, Length=375, Percent_Identity=47.7333333333333, Blast_Score=333, Evalue=9e-92,
Organism=Drosophila melanogaster, GI24645208, Length=375, Percent_Identity=47.7333333333333, Blast_Score=333, Evalue=9e-92,
Organism=Drosophila melanogaster, GI281361397, Length=376, Percent_Identity=47.8723404255319, Blast_Score=332, Evalue=2e-91,
Organism=Drosophila melanogaster, GI281361395, Length=376, Percent_Identity=47.8723404255319, Blast_Score=332, Evalue=2e-91,
Organism=Drosophila melanogaster, GI21356231, Length=397, Percent_Identity=45.3400503778337, Blast_Score=320, Evalue=1e-87,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 41583; Mature: 41583

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIHEYQGKQVLREYGVKVPNGYVAYTVDEAVQAAEKLGTSVNVVKAQIHAGGRGKAGGV
CCCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCH
KVAKSLDEVRTYADEILGKTLVTHQTGPEGKEVKRLLIEEGCDIQKEYYVGVVLDRATSR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCE
VVMMASEEGGTEIEEVAEATPEKIFKEVIDPVVGLTPFQARRLAFNINIPEDLLGKAVKF
EEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHH
MSGLYDAFVAKDCSIAEINPLVTTGDGEVLALDAKLNFDDNALYRHKDIQDLRDFEEEDE
HHHHHHHHHHCCCCCEECCCEEECCCCCEEEEEEEECCCCCCHHHCCCHHHHHHHHHHHH
KEIQASKYDLSYVSLDGNIGCMVNGAGLAMSTMDIIKHYGGDPANFLDVGGGATAEKVTE
HHHHHHHEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHH
AFKIILSDKNVKGIFVNIFGGIMKCDVIAEGVVEATKQIGLEIPLVVRLEGTNVDAGKKI
HHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHH
LDESGLNITTATSMADGAEKIVAAVK
HHCCCCEEEEECCHHCCHHHHHHHCC
>Mature Secondary Structure
MNIHEYQGKQVLREYGVKVPNGYVAYTVDEAVQAAEKLGTSVNVVKAQIHAGGRGKAGGV
CCCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCH
KVAKSLDEVRTYADEILGKTLVTHQTGPEGKEVKRLLIEEGCDIQKEYYVGVVLDRATSR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCE
VVMMASEEGGTEIEEVAEATPEKIFKEVIDPVVGLTPFQARRLAFNINIPEDLLGKAVKF
EEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHH
MSGLYDAFVAKDCSIAEINPLVTTGDGEVLALDAKLNFDDNALYRHKDIQDLRDFEEEDE
HHHHHHHHHHCCCCCEECCCEEECCCCCEEEEEEEECCCCCCHHHCCCHHHHHHHHHHHH
KEIQASKYDLSYVSLDGNIGCMVNGAGLAMSTMDIIKHYGGDPANFLDVGGGATAEKVTE
HHHHHHHEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHH
AFKIILSDKNVKGIFVNIFGGIMKCDVIAEGVVEATKQIGLEIPLVVRLEGTNVDAGKKI
HHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHH
LDESGLNITTATSMADGAEKIVAAVK
HHCCCCEEEEECCHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]