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The map label for this gene is ffh [H]

Identifier: 23098986

GI number: 23098986

Start: 1576133

End: 1577479

Strand: Direct

Name: ffh [H]

Synonym: OB1531

Alternate gene names: 23098986

Gene position: 1576133-1577479 (Clockwise)

Preceding gene: 23098985

Following gene: 23098987

Centisome position: 43.41

GC content: 37.94

Gene sequence:

>1347_bases
ATGGCGTTTGAAGGATTGGCTGACCGCCTGCAGAGCACGATTAAGAAGATAACAGGTAAAGGCAAAGTATCTGAGCAAGA
TGTAAAAGAAATGACAAGAGAAGTACGTCTAGCTTTATTGGAAGCAGATGTTAACTTTAAGGTTGTAAAACAACTAATAA
CAAAAATCAAAGAGCGTGCTATTGGACAAGAGGTAATGGAAAGTTTAACTCCTGGCCAACAAGTTATAAAAGTAGTAAAA
GAAGAATTAACGCAATTAATGGGTGGAGAACAAAGTAAGATTGCTGTAGCTGATCGTTCTCCTACTGTAATTATGATGGT
CGGATTGCAAGGTGCAGGTAAAACAACCACAACTGGTAAGCTAGCCAATCACTTGCGTAAAAAACACAATCGAAATCCTC
TTTTAGTAGCCTGTGATGTTTATCGACCTGCTGCAATTAAGCAATTAGAAACACTAGGTACACAACTTGATATGCCAGTA
TTTTCAATGGGAACGGAAGCGAACCCTGTTGATATTGCACATCAAGCAATTGAACATGCAAAGGAAGAGCATCGCGACTA
TGTGATTATAGATACAGCCGGTCGATTGCATGTTGATGAGAATTTAATGGATGAGTTACAGTCCATTAAAAATGATGTGA
AGCCGGATGAAATATTTCTTGTTGTCGATTCGATGACTGGTCAAGATGCAGTAAATGTAGCTGAAAGTTTTAATGAGCAA
CTTGATATTACAGGAGTTGTGTTAACAAAACTTGATGGAGATACCCGTGGAGGGGCTGCGCTATCGATTAAGTCAGTTAC
AGATAAACCAATTAAATTTGCAGGTATGGGAGAGAAACTAGATCAATTAGAAGCTTTCCATCCTGAAAGAATGGCTTCCC
GTATCTTAGGAATGGGAGACGTACTATCATTAATTGAAAAAGCGCAAACGAATGTTGATGAGAAACAAGCAAAAGAACTT
GAAGAAAAAATGCGTACGATGTCCTTTACATTTGATGATTTCCTAGAACAGATGGGTCAAGTGAAGCAAATGGGGCCTCT
GGATGAATTGATGGACATGATTCCTGGAGCAGGAAAAATGAAAGGATTAAAAAATGCACAATTTGACGAAAAACAACTTG
GACAAGTAGAAGCAATTATTCAATCGATGACGAAGAAAGAACGTCAAGAACCAAGTATTATTAACGGAAGCCGTCGTAAG
CGTATTGCGAAAGGATCAGGTACCTCCGTTGCACAAGTGAATCGTTTATTAAAGCAATTCAATGAGATGAAAAAAATGAT
GAAACAAATGACCAATATGCAAAAAGGGAAAAAAGGAAAAGGTGGATTTAATTTACCTTTCATGTAA

Upstream 100 bases:

>100_bases
CGTGTTAAGCTGTTAGAGAAGTTGAAATTAATGACAACAGATAAGCATGTACATGAACATATTCAAAAACTAAAAGACTT
AGATTAGGGGGACACCTTCT

Downstream 100 bases:

>100_bases
CCCTTGATTTATAAGTATTTATGTACTAAAATAACCTTGTAATGGAAAAACACTTTACAGACTTTTGTATTTCTGATAGA
ATTTAAACTTGTCAGGATAA

Product: signal recognition particle

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAFEGLADRLQSTIKKITGKGKVSEQDVKEMTREVRLALLEADVNFKVVKQLITKIKERAIGQEVMESLTPGQQVIKVVK
EELTQLMGGEQSKIAVADRSPTVIMMVGLQGAGKTTTTGKLANHLRKKHNRNPLLVACDVYRPAAIKQLETLGTQLDMPV
FSMGTEANPVDIAHQAIEHAKEEHRDYVIIDTAGRLHVDENLMDELQSIKNDVKPDEIFLVVDSMTGQDAVNVAESFNEQ
LDITGVVLTKLDGDTRGGAALSIKSVTDKPIKFAGMGEKLDQLEAFHPERMASRILGMGDVLSLIEKAQTNVDEKQAKEL
EEKMRTMSFTFDDFLEQMGQVKQMGPLDELMDMIPGAGKMKGLKNAQFDEKQLGQVEAIIQSMTKKERQEPSIINGSRRK
RIAKGSGTSVAQVNRLLKQFNEMKKMMKQMTNMQKGKKGKGGFNLPFM

Sequences:

>Translated_448_residues
MAFEGLADRLQSTIKKITGKGKVSEQDVKEMTREVRLALLEADVNFKVVKQLITKIKERAIGQEVMESLTPGQQVIKVVK
EELTQLMGGEQSKIAVADRSPTVIMMVGLQGAGKTTTTGKLANHLRKKHNRNPLLVACDVYRPAAIKQLETLGTQLDMPV
FSMGTEANPVDIAHQAIEHAKEEHRDYVIIDTAGRLHVDENLMDELQSIKNDVKPDEIFLVVDSMTGQDAVNVAESFNEQ
LDITGVVLTKLDGDTRGGAALSIKSVTDKPIKFAGMGEKLDQLEAFHPERMASRILGMGDVLSLIEKAQTNVDEKQAKEL
EEKMRTMSFTFDDFLEQMGQVKQMGPLDELMDMIPGAGKMKGLKNAQFDEKQLGQVEAIIQSMTKKERQEPSIINGSRRK
RIAKGSGTSVAQVNRLLKQFNEMKKMMKQMTNMQKGKKGKGGFNLPFM
>Mature_447_residues
AFEGLADRLQSTIKKITGKGKVSEQDVKEMTREVRLALLEADVNFKVVKQLITKIKERAIGQEVMESLTPGQQVIKVVKE
ELTQLMGGEQSKIAVADRSPTVIMMVGLQGAGKTTTTGKLANHLRKKHNRNPLLVACDVYRPAAIKQLETLGTQLDMPVF
SMGTEANPVDIAHQAIEHAKEEHRDYVIIDTAGRLHVDENLMDELQSIKNDVKPDEIFLVVDSMTGQDAVNVAESFNEQL
DITGVVLTKLDGDTRGGAALSIKSVTDKPIKFAGMGEKLDQLEAFHPERMASRILGMGDVLSLIEKAQTNVDEKQAKELE
EKMRTMSFTFDDFLEQMGQVKQMGPLDELMDMIPGAGKMKGLKNAQFDEKQLGQVEAIIQSMTKKERQEPSIINGSRRKR
IAKGSGTSVAQVNRLLKQFNEMKKMMKQMTNMQKGKKGKGGFNLPFM

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=456, Percent_Identity=34.6491228070175, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI226371618, Length=404, Percent_Identity=34.9009900990099, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI89061728, Length=162, Percent_Identity=38.2716049382716, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI23308697, Length=314, Percent_Identity=25.796178343949, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI295424842, Length=314, Percent_Identity=25.796178343949, Blast_Score=106, Evalue=5e-23,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=53.3018867924528, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=35.8565737051793, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=450, Percent_Identity=31.3333333333333, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI193206261, Length=297, Percent_Identity=29.96632996633, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=464, Percent_Identity=33.8362068965517, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6320498, Length=313, Percent_Identity=27.1565495207668, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17647949, Length=439, Percent_Identity=32.1184510250569, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24641198, Length=309, Percent_Identity=26.8608414239482, Blast_Score=108, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49730; Mature: 49598

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEGLADRLQSTIKKITGKGKVSEQDVKEMTREVRLALLEADVNFKVVKQLITKIKERA
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IGQEVMESLTPGQQVIKVVKEELTQLMGGEQSKIAVADRSPTVIMMVGLQGAGKTTTTGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCCCCHHHH
LANHLRKKHNRNPLLVACDVYRPAAIKQLETLGTQLDMPVFSMGTEANPVDIAHQAIEHA
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHH
KEEHRDYVIIDTAGRLHVDENLMDELQSIKNDVKPDEIFLVVDSMTGQDAVNVAESFNEQ
HHHCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCC
LDITGVVLTKLDGDTRGGAALSIKSVTDKPIKFAGMGEKLDQLEAFHPERMASRILGMGD
CCEEEEEEEEECCCCCCCCEEEEECCCCCCEEECCCCHHHHHHHHCCHHHHHHHHHCHHH
VLSLIEKAQTNVDEKQAKELEEKMRTMSFTFDDFLEQMGQVKQMGPLDELMDMIPGAGKM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHH
KGLKNAQFDEKQLGQVEAIIQSMTKKERQEPSIINGSRRKRIAKGSGTSVAQVNRLLKQF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
NEMKKMMKQMTNMQKGKKGKGGFNLPFM
HHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AFEGLADRLQSTIKKITGKGKVSEQDVKEMTREVRLALLEADVNFKVVKQLITKIKERA
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IGQEVMESLTPGQQVIKVVKEELTQLMGGEQSKIAVADRSPTVIMMVGLQGAGKTTTTGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCCCCHHHH
LANHLRKKHNRNPLLVACDVYRPAAIKQLETLGTQLDMPVFSMGTEANPVDIAHQAIEHA
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHH
KEEHRDYVIIDTAGRLHVDENLMDELQSIKNDVKPDEIFLVVDSMTGQDAVNVAESFNEQ
HHHCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCC
LDITGVVLTKLDGDTRGGAALSIKSVTDKPIKFAGMGEKLDQLEAFHPERMASRILGMGD
CCEEEEEEEEECCCCCCCCEEEEECCCCCCEEECCCCHHHHHHHHCCHHHHHHHHHCHHH
VLSLIEKAQTNVDEKQAKELEEKMRTMSFTFDDFLEQMGQVKQMGPLDELMDMIPGAGKM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHH
KGLKNAQFDEKQLGQVEAIIQSMTKKERQEPSIINGSRRKRIAKGSGTSVAQVNRLLKQF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
NEMKKMMKQMTNMQKGKKGKGGFNLPFM
HHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]