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The map label for this gene is gmk

Identifier: 23098957

GI number: 23098957

Start: 1545155

End: 1545775

Strand: Direct

Name: gmk

Synonym: OB1502

Alternate gene names: 23098957

Gene position: 1545155-1545775 (Clockwise)

Preceding gene: 23098956

Following gene: 23098958

Centisome position: 42.56

GC content: 34.14

Gene sequence:

>621_bases
TTGATAAAAGAGAAAGGCATTTTATTTATTCTATCTGGCCCATCCGGAGTGGGAAAAGGGACGGTAAGAAAGAAACTATT
TGAAGAAGAAACAGATTTACAATACTCTATTTCTATGACAACAAGAGATAGACGACCTGGTGAAGTAGATGGTGTTGATT
ATTTTTATAAAACGAAAGAAGAATTTGAACAATTAATTAAAGACGGCCAGCTTTTAGAATATGCTCAATATGTCAATAAT
TATTATGGAACACCTCGTAACTATGTGGAAGAAACGTTAGAAAATGGTCAAGATGTTTTCTTAGAAATAGAAGTGCAAGG
TGCATTGCAAGTAAAAGAAAATTTCCCAGAAGGCGTATTTATATTCTTGTTCCCACCAAGTCTTGATGAGTTAAAAAACC
GCATTGTGAGTCGTGGAACAGAATCCCAAGAATTGGTTTTAAATCGATTAAAGGAAGCTCGCAATGAAATCGAGATGATG
GATGCTTATGATTATGTAGTGGTTAATGATAAAGTACAGCATGCGGTAGATAAAGTAAAAACAATAATCAAAAGTGAGCA
TTTGAAACGAGAGCGAATTGCAAAACAATATAAAAAGATACTGGAGGATGGGTTATCATGA

Upstream 100 bases:

>100_bases
TGTTGTTCTTTCTGCTGTACAGCCAGAAACTGTTGGTCAGCGAGTAATTAGTAACGATGAAATTTCAGATGAGTAGAATC
ACATAGTAGGAGGAAATAAG

Downstream 100 bases:

>100_bases
TGTTAGAACCTTCTATTGACTCTTTACAAAAACGAATTAAATCTAAATACAGTCTAGTAACATTATCTGCAAGAAGAGCA
AGACAACTGAGTGAGACAAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MIKEKGILFILSGPSGVGKGTVRKKLFEEETDLQYSISMTTRDRRPGEVDGVDYFYKTKEEFEQLIKDGQLLEYAQYVNN
YYGTPRNYVEETLENGQDVFLEIEVQGALQVKENFPEGVFIFLFPPSLDELKNRIVSRGTESQELVLNRLKEARNEIEMM
DAYDYVVVNDKVQHAVDKVKTIIKSEHLKRERIAKQYKKILEDGLS

Sequences:

>Translated_206_residues
MIKEKGILFILSGPSGVGKGTVRKKLFEEETDLQYSISMTTRDRRPGEVDGVDYFYKTKEEFEQLIKDGQLLEYAQYVNN
YYGTPRNYVEETLENGQDVFLEIEVQGALQVKENFPEGVFIFLFPPSLDELKNRIVSRGTESQELVLNRLKEARNEIEMM
DAYDYVVVNDKVQHAVDKVKTIIKSEHLKRERIAKQYKKILEDGLS
>Mature_206_residues
MIKEKGILFILSGPSGVGKGTVRKKLFEEETDLQYSISMTTRDRRPGEVDGVDYFYKTKEEFEQLIKDGQLLEYAQYVNN
YYGTPRNYVEETLENGQDVFLEIEVQGALQVKENFPEGVFIFLFPPSLDELKNRIVSRGTESQELVLNRLKEARNEIEMM
DAYDYVVVNDKVQHAVDKVKTIIKSEHLKRERIAKQYKKILEDGLS

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=187, Percent_Identity=33.6898395721925, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI226874833, Length=187, Percent_Identity=33.6898395721925, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI4504221, Length=187, Percent_Identity=33.6898395721925, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI14780902, Length=188, Percent_Identity=28.1914893617021, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=26.9662921348315, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI21361598, Length=200, Percent_Identity=26.5, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI111154074, Length=172, Percent_Identity=26.1627906976744, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1790080, Length=204, Percent_Identity=39.2156862745098, Blast_Score=163, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17508835, Length=171, Percent_Identity=34.5029239766082, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI193203132, Length=171, Percent_Identity=34.5029239766082, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17556244, Length=124, Percent_Identity=31.4516129032258, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=40.6593406593407, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356141, Length=151, Percent_Identity=38.4105960264901, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI161077626, Length=184, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45554489, Length=184, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45554481, Length=184, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24640542, Length=184, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI85724806, Length=184, Percent_Identity=26.0869565217391, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI116007136, Length=184, Percent_Identity=26.0869565217391, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI85816281, Length=127, Percent_Identity=29.1338582677165, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85816106, Length=127, Percent_Identity=29.1338582677165, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551002, Length=127, Percent_Identity=29.1338582677165, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161077752, Length=153, Percent_Identity=30.0653594771242, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_OCEIH (Q8ER28)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692423.1
- ProteinModelPortal:   Q8ER28
- SMR:   Q8ER28
- GeneID:   1017762
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1502
- NMPDR:   fig|221109.1.peg.1504
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- BioCyc:   OIHE221109:OB1502-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23915; Mature: 23915

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKEKGILFILSGPSGVGKGTVRKKLFEEETDLQYSISMTTRDRRPGEVDGVDYFYKTKE
CCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHCHH
EFEQLIKDGQLLEYAQYVNNYYGTPRNYVEETLENGQDVFLEIEVQGALQVKENFPEGVF
HHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCEEEHHCCCCCCEE
IFLFPPSLDELKNRIVSRGTESQELVLNRLKEARNEIEMMDAYDYVVVNDKVQHAVDKVK
EEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHH
TIIKSEHLKRERIAKQYKKILEDGLS
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKEKGILFILSGPSGVGKGTVRKKLFEEETDLQYSISMTTRDRRPGEVDGVDYFYKTKE
CCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHCHH
EFEQLIKDGQLLEYAQYVNNYYGTPRNYVEETLENGQDVFLEIEVQGALQVKENFPEGVF
HHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCEEEHHCCCCCCEE
IFLFPPSLDELKNRIVSRGTESQELVLNRLKEARNEIEMMDAYDYVVVNDKVQHAVDKVK
EEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHH
TIIKSEHLKRERIAKQYKKILEDGLS
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376