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The map label for this gene is pyrC [H]

Identifier: 23098944

GI number: 23098944

Start: 1528764

End: 1530056

Strand: Direct

Name: pyrC [H]

Synonym: OB1489

Alternate gene names: 23098944

Gene position: 1528764-1530056 (Clockwise)

Preceding gene: 23098943

Following gene: 23098945

Centisome position: 42.11

GC content: 38.36

Gene sequence:

>1293_bases
ATGAAAACAATCTTATTAAACGCAAATCGCTTACTGCCATCTAATGAATTAGAGAAAGTAGAAGTACTTATAGAAGATAA
TAAAATAATAAAAATTGCATCTCAGATTCCTGATAAGGTAGAAAACTATATTGATATAGAAGGAAAGTTACTGTTGCCTG
GACTAATTGATGTTCATATTCATTTACGCGAACCGGGTGGAGAACATAAGGAAACAATTAAAACAGGAACAATGGCAGCT
GCAAGGGGTGGATATACGACTGTATGCGCAATGCCAAATACAAATCCAGTTCCCGATCATCCAGAAGCTTTAACGAGTTT
ACTTTCTAAAATAGCGGATGATGCACATATACGTGTATTACCTTATGCATCAATTACTAAGAGCTTAAAGGGAGAAGAAA
GGACAGATATCCAATCACTAATCGATGCTGGTGCATTTGCCTTTACAGATGACGGGGTTGGTATACAAACAGCAGATCAA
ATGTATCAAGCAATGAAAGATGCAGCACGACATAACACTACCATCGTGGCACATTGTGAAGATAATAGTCTCGTATATGG
CGGTGTGTTGCATGAAGGAGAAGTAAGTGAACGTTTAAGCTTACCTGGAATTCCTTCCTTAAGTGAGTCAGTACAGATTG
CGAGAGATGTATTATTAGCAGAAGCGACAGGATGTCATTATCATGTCTGTCATGTTAGCACAAAAGAATCGGTACGTGTA
ATCCGCGATGCTAAGAAAGCAGGCATACATGTAACTGCAGAGGTTTCTCCACACCATCTATTACTTAATGAGACCGATAT
TCCTGACGACAATGCAGACTGGAAGATGAATCCTCCGTTGCGTTCAACGGAAGATCAACAAGCACTATTCGATGGTCTAA
TGGATGGAACCATTGACCTAATTGCAACCGATCATGCACCTCATGCTACGGAAGAGAAAGCAGTTGGATTCAAGGAAGCT
CCTTTTGGAATCGTAGGACTAGAAACAGCATTTCCGCTTTTATATACACATCTAGTTTTAAAAGGAAAAATGACGCTGTA
TCAATTAGTAGAAAGAATGACTGAAAAGCCAGCAGCGACATTTCAACTTCCATATGGAAAATTAGAAGAAGATTCAGTGG
CTGACATAACCGTTATTGACTTAGAAAAAGAAGAAACGATTCATCGTGAAACATTTTATTCAAAAGGTAAAAACACACCT
TTCGATAATTGGAAAGTAAAAGGAATTCCTGTACTTACAATGGTAAATGGAGTAGTTGTATACGAGGAGGCTAAACAACA
TGAAGAAGCGTAA

Upstream 100 bases:

>100_bases
GTAGAGAGTGAAAAATCAAGGATTTTTAAACAAATGTCCAATGGGGTTTACGTACGAATGGCAATTATCATGCACGTATT
ATCAGAATGGGGGATTATTC

Downstream 100 bases:

>100_bases
ATTAATACTAGAAGATGGAACTGTTTTTAATGGGACAGCGTTTGGAAGTGATGCCGAATCAAGTGGTGAGATTGTATTTA
ATACTGGAATGACAGGTTAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKTILLNANRLLPSNELEKVEVLIEDNKIIKIASQIPDKVENYIDIEGKLLLPGLIDVHIHLREPGGEHKETIKTGTMAA
ARGGYTTVCAMPNTNPVPDHPEALTSLLSKIADDAHIRVLPYASITKSLKGEERTDIQSLIDAGAFAFTDDGVGIQTADQ
MYQAMKDAARHNTTIVAHCEDNSLVYGGVLHEGEVSERLSLPGIPSLSESVQIARDVLLAEATGCHYHVCHVSTKESVRV
IRDAKKAGIHVTAEVSPHHLLLNETDIPDDNADWKMNPPLRSTEDQQALFDGLMDGTIDLIATDHAPHATEEKAVGFKEA
PFGIVGLETAFPLLYTHLVLKGKMTLYQLVERMTEKPAATFQLPYGKLEEDSVADITVIDLEKEETIHRETFYSKGKNTP
FDNWKVKGIPVLTMVNGVVVYEEAKQHEEA

Sequences:

>Translated_430_residues
MKTILLNANRLLPSNELEKVEVLIEDNKIIKIASQIPDKVENYIDIEGKLLLPGLIDVHIHLREPGGEHKETIKTGTMAA
ARGGYTTVCAMPNTNPVPDHPEALTSLLSKIADDAHIRVLPYASITKSLKGEERTDIQSLIDAGAFAFTDDGVGIQTADQ
MYQAMKDAARHNTTIVAHCEDNSLVYGGVLHEGEVSERLSLPGIPSLSESVQIARDVLLAEATGCHYHVCHVSTKESVRV
IRDAKKAGIHVTAEVSPHHLLLNETDIPDDNADWKMNPPLRSTEDQQALFDGLMDGTIDLIATDHAPHATEEKAVGFKEA
PFGIVGLETAFPLLYTHLVLKGKMTLYQLVERMTEKPAATFQLPYGKLEEDSVADITVIDLEKEETIHRETFYSKGKNTP
FDNWKVKGIPVLTMVNGVVVYEEAKQHEEA
>Mature_430_residues
MKTILLNANRLLPSNELEKVEVLIEDNKIIKIASQIPDKVENYIDIEGKLLLPGLIDVHIHLREPGGEHKETIKTGTMAA
ARGGYTTVCAMPNTNPVPDHPEALTSLLSKIADDAHIRVLPYASITKSLKGEERTDIQSLIDAGAFAFTDDGVGIQTADQ
MYQAMKDAARHNTTIVAHCEDNSLVYGGVLHEGEVSERLSLPGIPSLSESVQIARDVLLAEATGCHYHVCHVSTKESVRV
IRDAKKAGIHVTAEVSPHHLLLNETDIPDDNADWKMNPPLRSTEDQQALFDGLMDGTIDLIATDHAPHATEEKAVGFKEA
PFGIVGLETAFPLLYTHLVLKGKMTLYQLVERMTEKPAATFQLPYGKLEEDSVADITVIDLEKEETIHRETFYSKGKNTP
FDNWKVKGIPVLTMVNGVVVYEEAKQHEEA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=375, Percent_Identity=35.2, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=25.4385964912281, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4503375, Length=458, Percent_Identity=25.3275109170306, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4503051, Length=453, Percent_Identity=24.0618101545254, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI62422571, Length=453, Percent_Identity=24.0618101545254, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI4503379, Length=460, Percent_Identity=24.3478260869565, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4503377, Length=468, Percent_Identity=25.2136752136752, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786722, Length=435, Percent_Identity=26.8965517241379, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87082175, Length=443, Percent_Identity=24.1534988713318, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790784, Length=208, Percent_Identity=27.8846153846154, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193204318, Length=375, Percent_Identity=32.5333333333333, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17539558, Length=454, Percent_Identity=23.3480176211454, Blast_Score=95, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6322218, Length=397, Percent_Identity=27.9596977329975, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24642586, Length=381, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI18859883, Length=449, Percent_Identity=25.1670378619154, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47341; Mature: 47341

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTILLNANRLLPSNELEKVEVLIEDNKIIKIASQIPDKVENYIDIEGKLLLPGLIDVHI
CCEEEEECCCCCCCCCCCEEEEEEECCCEEEEHHHCCHHHHHEECCCCCEECCCEEEEEE
HLREPGGEHKETIKTGTMAAARGGYTTVCAMPNTNPVPDHPEALTSLLSKIADDAHIRVL
EEECCCCCHHHHHHHCCHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
PYASITKSLKGEERTDIQSLIDAGAFAFTDDGVGIQTADQMYQAMKDAARHNTTIVAHCE
EHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEC
DNSLVYGGVLHEGEVSERLSLPGIPSLSESVQIARDVLLAEATGCHYHVCHVSTKESVRV
CCCEEEECEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
IRDAKKAGIHVTAEVSPHHLLLNETDIPDDNADWKMNPPLRSTEDQQALFDGLMDGTIDL
HHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHATEEKAVGFKEAPFGIVGLETAFPLLYTHLVLKGKMTLYQLVERMTEKPAAT
EEECCCCCCCHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEE
FQLPYGKLEEDSVADITVIDLEKEETIHRETFYSKGKNTPFDNWKVKGIPVLTMVNGVVV
EECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCEEECCEEEEEECCCEEE
YEEAKQHEEA
EECHHHCCCC
>Mature Secondary Structure
MKTILLNANRLLPSNELEKVEVLIEDNKIIKIASQIPDKVENYIDIEGKLLLPGLIDVHI
CCEEEEECCCCCCCCCCCEEEEEEECCCEEEEHHHCCHHHHHEECCCCCEECCCEEEEEE
HLREPGGEHKETIKTGTMAAARGGYTTVCAMPNTNPVPDHPEALTSLLSKIADDAHIRVL
EEECCCCCHHHHHHHCCHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
PYASITKSLKGEERTDIQSLIDAGAFAFTDDGVGIQTADQMYQAMKDAARHNTTIVAHCE
EHHHHHHHHCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEC
DNSLVYGGVLHEGEVSERLSLPGIPSLSESVQIARDVLLAEATGCHYHVCHVSTKESVRV
CCCEEEECEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
IRDAKKAGIHVTAEVSPHHLLLNETDIPDDNADWKMNPPLRSTEDQQALFDGLMDGTIDL
HHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHATEEKAVGFKEAPFGIVGLETAFPLLYTHLVLKGKMTLYQLVERMTEKPAAT
EEECCCCCCCHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEE
FQLPYGKLEEDSVADITVIDLEKEETIHRETFYSKGKNTPFDNWKVKGIPVLTMVNGVVV
EECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCEEECCEEEEEECCCEEE
YEEAKQHEEA
EECHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]