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The map label for this gene is glcD [H]

Identifier: 23098714

GI number: 23098714

Start: 1304344

End: 1305702

Strand: Reverse

Name: glcD [H]

Synonym: OB1259

Alternate gene names: 23098714

Gene position: 1305702-1304344 (Counterclockwise)

Preceding gene: 23098715

Following gene: 23098711

Centisome position: 35.96

GC content: 39.15

Gene sequence:

>1359_bases
GTGTATGTAGAACAACTTATAGAAAAATTAGGAATGGATAATGTCTCACAAAAGGAAAGCATCCTAATTCGCCATGGATA
TGATGAATCCCCACATAAAGCGGTAGAACCAGATGTTGTTTGTTTTCCAACATCCAAAGAAGACGTACAAGCAATTCTTG
AAATCGCACGAAATAATCAAATTCCCGTGACACCATTTGGAACAGGATCGGGACTTGAAGGCTCATCCATTCCGGTTAAA
AAAGGGATCTCCATTAATTTTGAACAAATGGATACCGTTCTTGAATTCTCACCTGAGAATATGACAGTTACTGTCCAGCC
AGGTATTACACGTTTTCGACTGAATGATTATATAAACTCAGCTGGTCTTTATTTCCCGGTAGACCCAGGAGTAGATGCTA
CTATCGGTGGAATGGTCGCAACGAATGCAAGTGGAACAACAGCAGTTCGTTATGGAGCAATGAAAGATCAATTGATAGAT
TTAGAAGTAGTGATGGCTGATGGAACGATTATTCATACAGCTTCCAAAGCTAAGAAATCTTCTTCTGGATATTTAATTAC
CAACCTCTTTGCAGGATCAGAAGGTACTTTAGGGATAATTACAGAGGTAACATTGAAACTTCACCCTATTCCCGAATATA
CAATTATGGCTAGATGTACATTTGAAACCATTAATGAATGTGCTACAGCCAGTCAGCAATTATTATTAAGTGGTATCCCG
TTAAAGAGGATAGAATTAATGGATGCAGCTAGTGTTGCAGAGGTAAATCGCCAAAACGGATACAAATTCTCGGTGCGCCC
CTCTCTTTTCTTTGAATTTGCTGGCGCAAAACAAGCAGTGGAAGCTGAAGTAGAGCTTGCTCAAACTATTCTAGATAATT
TAAGTTGTGAACATTGGTCTGTAGCATTAGATCCTGATGAACAACAAGAACTTTGGAAAGCACGTTATGATCTGTCCTAT
TCTTTCCAATCTGTAAAGGGAATGGATGAAGTAGGAGCAGATGTATGTGTTCCTATTAAAGAATTACCTGAATTAATAAC
CTATGCGAGAGAGTTAATTGATGAAACTGGGTTAAAAGGTGGCGTATGGGGCCATGTCGGTGACGGAAACTTCCATACTC
TAATATTATTTGACCCTTTAGTTAATGGTGAGAGACAATTAGCTGAATCTGTCAACGAGGCACTAGCCATCCGGGCGATA
GAGGTTGGCGGAAGCTGTACAGGCGAACATGGTGTTGGAATTGGCAAGCAAAAGTATCAAGAACTAGAACATGGCAATTC
CCTACCTATTATGCAAAATATAAAACAATTATTCGACCCAACTGGTATTCTTAATCCAGGGAAGATTTTTATGAATTAA

Upstream 100 bases:

>100_bases
TCATTACCAATTATAGTGTTAATAGCTCATATGATTTACTAGCGCTTATTTTTGTTTCAACCAAAAATTTTGATATATCA
TTTTCACGAGGTGAACAGCA

Downstream 100 bases:

>100_bases
ATAATAGACAAATAAAATAAGTATAGTGATCTTCATTAAAGATGATCACTATACTTATTTTTTTACTTTCTCCAATGCCG
TTGGTCCTTACGGGCAGATT

Product: D-lactate dehydrogenase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MYVEQLIEKLGMDNVSQKESILIRHGYDESPHKAVEPDVVCFPTSKEDVQAILEIARNNQIPVTPFGTGSGLEGSSIPVK
KGISINFEQMDTVLEFSPENMTVTVQPGITRFRLNDYINSAGLYFPVDPGVDATIGGMVATNASGTTAVRYGAMKDQLID
LEVVMADGTIIHTASKAKKSSSGYLITNLFAGSEGTLGIITEVTLKLHPIPEYTIMARCTFETINECATASQQLLLSGIP
LKRIELMDAASVAEVNRQNGYKFSVRPSLFFEFAGAKQAVEAEVELAQTILDNLSCEHWSVALDPDEQQELWKARYDLSY
SFQSVKGMDEVGADVCVPIKELPELITYARELIDETGLKGGVWGHVGDGNFHTLILFDPLVNGERQLAESVNEALAIRAI
EVGGSCTGEHGVGIGKQKYQELEHGNSLPIMQNIKQLFDPTGILNPGKIFMN

Sequences:

>Translated_452_residues
MYVEQLIEKLGMDNVSQKESILIRHGYDESPHKAVEPDVVCFPTSKEDVQAILEIARNNQIPVTPFGTGSGLEGSSIPVK
KGISINFEQMDTVLEFSPENMTVTVQPGITRFRLNDYINSAGLYFPVDPGVDATIGGMVATNASGTTAVRYGAMKDQLID
LEVVMADGTIIHTASKAKKSSSGYLITNLFAGSEGTLGIITEVTLKLHPIPEYTIMARCTFETINECATASQQLLLSGIP
LKRIELMDAASVAEVNRQNGYKFSVRPSLFFEFAGAKQAVEAEVELAQTILDNLSCEHWSVALDPDEQQELWKARYDLSY
SFQSVKGMDEVGADVCVPIKELPELITYARELIDETGLKGGVWGHVGDGNFHTLILFDPLVNGERQLAESVNEALAIRAI
EVGGSCTGEHGVGIGKQKYQELEHGNSLPIMQNIKQLFDPTGILNPGKIFMN
>Mature_452_residues
MYVEQLIEKLGMDNVSQKESILIRHGYDESPHKAVEPDVVCFPTSKEDVQAILEIARNNQIPVTPFGTGSGLEGSSIPVK
KGISINFEQMDTVLEFSPENMTVTVQPGITRFRLNDYINSAGLYFPVDPGVDATIGGMVATNASGTTAVRYGAMKDQLID
LEVVMADGTIIHTASKAKKSSSGYLITNLFAGSEGTLGIITEVTLKLHPIPEYTIMARCTFETINECATASQQLLLSGIP
LKRIELMDAASVAEVNRQNGYKFSVRPSLFFEFAGAKQAVEAEVELAQTILDNLSCEHWSVALDPDEQQELWKARYDLSY
SFQSVKGMDEVGADVCVPIKELPELITYARELIDETGLKGGVWGHVGDGNFHTLILFDPLVNGERQLAESVNEALAIRAI
EVGGSCTGEHGVGIGKQKYQELEHGNSLPIMQNIKQLFDPTGILNPGKIFMN

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=454, Percent_Identity=40.3083700440529, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI37595754, Length=477, Percent_Identity=38.3647798742138, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI119964728, Length=426, Percent_Identity=30.2816901408451, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI4501993, Length=481, Percent_Identity=24.7401247401247, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789351, Length=422, Percent_Identity=31.5165876777251, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787977, Length=494, Percent_Identity=25.1012145748988, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI48994907, Length=259, Percent_Identity=26.6409266409266, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI48994914, Length=376, Percent_Identity=21.0106382978723, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71992373, Length=452, Percent_Identity=42.4778761061947, Blast_Score=354, Evalue=5e-98,
Organism=Caenorhabditis elegans, GI71992381, Length=452, Percent_Identity=40.929203539823, Blast_Score=333, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI71992392, Length=380, Percent_Identity=42.6315789473684, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17534361, Length=456, Percent_Identity=27.6315789473684, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17556096, Length=494, Percent_Identity=23.8866396761134, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320027, Length=467, Percent_Identity=36.4025695931477, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6320023, Length=440, Percent_Identity=30, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6320764, Length=440, Percent_Identity=26.5909090909091, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI18921117, Length=437, Percent_Identity=27.4599542334096, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24639277, Length=437, Percent_Identity=27.4599542334096, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24639275, Length=437, Percent_Identity=27.4599542334096, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24653753, Length=245, Percent_Identity=28.1632653061224, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 49307; Mature: 49307

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00046 HISTONE_H2A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVEQLIEKLGMDNVSQKESILIRHGYDESPHKAVEPDVVCFPTSKEDVQAILEIARNNQ
CCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCC
IPVTPFGTGSGLEGSSIPVKKGISINFEQMDTVLEFSPENMTVTVQPGITRFRLNDYINS
CCEEECCCCCCCCCCCCCCCCCCEECHHHHHHHHEECCCCEEEEECCCCEEEEEHHHHCC
AGLYFPVDPGVDATIGGMVATNASGTTAVRYGAMKDQLIDLEVVMADGTIIHTASKAKKS
CCEEEECCCCCCCEECCEEEECCCCCEEEEECCCCCCEEEEEEEEECCEEEEECHHCCCC
SSGYLITNLFAGSEGTLGIITEVTLKLHPIPEYTIMARCTFETINECATASQQLLLSGIP
CCCEEEEEEECCCCCCEEEEEEEEEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCC
LKRIELMDAASVAEVNRQNGYKFSVRPSLFFEFAGAKQAVEAEVELAQTILDNLSCEHWS
HHHHHHHHHHHHHHHHHCCCEEEEECHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEE
VALDPDEQQELWKARYDLSYSFQSVKGMDEVGADVCVPIKELPELITYARELIDETGLKG
EEECCCHHHHHHHHHHCCCCCHHHHCCHHHCCCCEEECHHHHHHHHHHHHHHHHHCCCCC
GVWGHVGDGNFHTLILFDPLVNGERQLAESVNEALAIRAIEVGGSCTGEHGVGIGKQKYQ
CCEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHH
ELEHGNSLPIMQNIKQLFDPTGILNPGKIFMN
HHHCCCCCCHHHHHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure
MYVEQLIEKLGMDNVSQKESILIRHGYDESPHKAVEPDVVCFPTSKEDVQAILEIARNNQ
CCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCC
IPVTPFGTGSGLEGSSIPVKKGISINFEQMDTVLEFSPENMTVTVQPGITRFRLNDYINS
CCEEECCCCCCCCCCCCCCCCCCEECHHHHHHHHEECCCCEEEEECCCCEEEEEHHHHCC
AGLYFPVDPGVDATIGGMVATNASGTTAVRYGAMKDQLIDLEVVMADGTIIHTASKAKKS
CCEEEECCCCCCCEECCEEEECCCCCEEEEECCCCCCEEEEEEEEECCEEEEECHHCCCC
SSGYLITNLFAGSEGTLGIITEVTLKLHPIPEYTIMARCTFETINECATASQQLLLSGIP
CCCEEEEEEECCCCCCEEEEEEEEEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHCCCC
LKRIELMDAASVAEVNRQNGYKFSVRPSLFFEFAGAKQAVEAEVELAQTILDNLSCEHWS
HHHHHHHHHHHHHHHHHCCCEEEEECHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEE
VALDPDEQQELWKARYDLSYSFQSVKGMDEVGADVCVPIKELPELITYARELIDETGLKG
EEECCCHHHHHHHHHHCCCCCHHHHCCHHHCCCCEEECHHHHHHHHHHHHHHHHHCCCCC
GVWGHVGDGNFHTLILFDPLVNGERQLAESVNEALAIRAIEVGGSCTGEHGVGIGKQKYQ
CCEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHH
ELEHGNSLPIMQNIKQLFDPTGILNPGKIFMN
HHHCCCCCCHHHHHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]