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The map label for this gene is fabH

Identifier: 23098659

GI number: 23098659

Start: 1253168

End: 1254106

Strand: Direct

Name: fabH

Synonym: OB1204

Alternate gene names: 23098659

Gene position: 1253168-1254106 (Clockwise)

Preceding gene: 23098658

Following gene: 23098660

Centisome position: 34.52

GC content: 38.66

Gene sequence:

>939_bases
ATGAATATCGGTATATTAGGAACCGGACATTACTTGCCAACAAATGTTGTTACAAATAATGATTTAGAAAAAATCGTAGA
TACGAATGATGAATGGATTCGTACTCGAACTGGTATAAGGGAAAGAAGGTTAGCAACAGAAGAAGTTGACACTTCTGATA
TGGCTTTTCACGCAGCTCTTGGAGCATTAGAAGAAGCAAATTTGGCGGCAGAAGATATTGATTTAATATTAGTAGCAACG
GTTACACCAAACACATCATTTCCATCTGTAGCTTGTATTATTCAGGACCAACTAGGAGCGAAGAATGCAGCTGCTATGGA
TGTGAGTGCTGCATGTGCTGGTTTTATGTATGGTTTGATTACTGCTAAACAGTTTATTGATACAGGAGCTTACAAACATG
TACTGGTAGTAGGTGCAGAGAAACTTTCTAAAATTACTGATTGGTCTGATCGTACCACATGTGTATTATTTGGAGATGGC
GCAGGCGCAGCAGTAGTTGGTGAAGTAGGTGAGGGCAAAGGTATCCTTTCATTTGAGTTAGGTGCAAATGGTGCAGGTGC
AAAAGAATTATATCTGAATCATGATGATCACATTATCATGAATGGTAGGGAAGTATATAAATTTGCAGTGCGTCAAATGC
CAGATTCTACTGTAAACGTTATTGAACAGTTAGGTTTATCACGTGACGATGTAGACTATCTAGTCCCTCATCAGGCGAAT
ATTCGTATAATGGAAGCTGCCAGAGAAAGGTTAGGTATCTCTGAAGATAAAATGGCCAAATCAATAGAGAAATTTGGAAA
TAATTCCTCTGCATCTATACCTATGGCTTTATCTGAGGCAGTAAAAGAGGGTAAAATAAAAGATAATGATTTAATAGTAT
TAGTTGGTTTTGGTGGAGGCTTAACCTGGGGAGCTGTTGCGCTTCGTTGGGGCAAGTAA

Upstream 100 bases:

>100_bases
GATAAGTTATTCACTTGCTTTTTTGTTTTTTATACATTAAAATTAGTACCAAGTCATAATAATTGATAGTAATTATGAGT
ATAAAGGGGAGAGCTGTGAA

Downstream 100 bases:

>100_bases
CCGGTTATTTTGGAAGGAGGATATAAAACATTGAATAAGCGAGTTGTTATTACGGGACTAGGAGCATTAAGCCCAGTGGG
CAATAATGTAGATGAAATGT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNIGILGTGHYLPTNVVTNNDLEKIVDTNDEWIRTRTGIRERRLATEEVDTSDMAFHAALGALEEANLAAEDIDLILVAT
VTPNTSFPSVACIIQDQLGAKNAAAMDVSAACAGFMYGLITAKQFIDTGAYKHVLVVGAEKLSKITDWSDRTTCVLFGDG
AGAAVVGEVGEGKGILSFELGANGAGAKELYLNHDDHIIMNGREVYKFAVRQMPDSTVNVIEQLGLSRDDVDYLVPHQAN
IRIMEAARERLGISEDKMAKSIEKFGNNSSASIPMALSEAVKEGKIKDNDLIVLVGFGGGLTWGAVALRWGK

Sequences:

>Translated_312_residues
MNIGILGTGHYLPTNVVTNNDLEKIVDTNDEWIRTRTGIRERRLATEEVDTSDMAFHAALGALEEANLAAEDIDLILVAT
VTPNTSFPSVACIIQDQLGAKNAAAMDVSAACAGFMYGLITAKQFIDTGAYKHVLVVGAEKLSKITDWSDRTTCVLFGDG
AGAAVVGEVGEGKGILSFELGANGAGAKELYLNHDDHIIMNGREVYKFAVRQMPDSTVNVIEQLGLSRDDVDYLVPHQAN
IRIMEAARERLGISEDKMAKSIEKFGNNSSASIPMALSEAVKEGKIKDNDLIVLVGFGGGLTWGAVALRWGK
>Mature_312_residues
MNIGILGTGHYLPTNVVTNNDLEKIVDTNDEWIRTRTGIRERRLATEEVDTSDMAFHAALGALEEANLAAEDIDLILVAT
VTPNTSFPSVACIIQDQLGAKNAAAMDVSAACAGFMYGLITAKQFIDTGAYKHVLVVGAEKLSKITDWSDRTTCVLFGDG
AGAAVVGEVGEGKGILSFELGANGAGAKELYLNHDDHIIMNGREVYKFAVRQMPDSTVNVIEQLGLSRDDVDYLVPHQAN
IRIMEAARERLGISEDKMAKSIEKFGNNSSASIPMALSEAVKEGKIKDNDLIVLVGFGGGLTWGAVALRWGK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=318, Percent_Identity=46.5408805031447, Blast_Score=283, Evalue=9e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_OCEIH (Q8ERU6)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692125.1
- ProteinModelPortal:   Q8ERU6
- SMR:   Q8ERU6
- GeneID:   1017368
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1204
- NMPDR:   fig|221109.1.peg.1203
- HOGENOM:   HBG649927
- OMA:   YIVPHQA
- ProtClustDB:   PRK09352
- BioCyc:   OIHE221109:OB1204-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 33471; Mature: 33471

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 237-237 ACT_SITE 267-267

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGILGTGHYLPTNVVTNNDLEKIVDTNDEWIRTRTGIRERRLATEEVDTSDMAFHAAL
CCEEEEECCCCCCCCCEECCCHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
GALEEANLAAEDIDLILVATVTPNTSFPSVACIIQDQLGAKNAAAMDVSAACAGFMYGLI
HHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHH
TAKQFIDTGAYKHVLVVGAEKLSKITDWSDRTTCVLFGDGAGAAVVGEVGEGKGILSFEL
HHHHHHHCCCCEEEEEECHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCEEEEEEC
GANGAGAKELYLNHDDHIIMNGREVYKFAVRQMPDSTVNVIEQLGLSRDDVDYLVPHQAN
CCCCCCCEEEEECCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEECCCCCC
IRIMEAARERLGISEDKMAKSIEKFGNNSSASIPMALSEAVKEGKIKDNDLIVLVGFGGG
EEHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCC
LTWGAVALRWGK
CCCCCEEEECCC
>Mature Secondary Structure
MNIGILGTGHYLPTNVVTNNDLEKIVDTNDEWIRTRTGIRERRLATEEVDTSDMAFHAAL
CCEEEEECCCCCCCCCEECCCHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
GALEEANLAAEDIDLILVATVTPNTSFPSVACIIQDQLGAKNAAAMDVSAACAGFMYGLI
HHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHH
TAKQFIDTGAYKHVLVVGAEKLSKITDWSDRTTCVLFGDGAGAAVVGEVGEGKGILSFEL
HHHHHHHCCCCEEEEEECHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCEEEEEEC
GANGAGAKELYLNHDDHIIMNGREVYKFAVRQMPDSTVNVIEQLGLSRDDVDYLVPHQAN
CCCCCCCEEEEECCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEECCCCCC
IRIMEAARERLGISEDKMAKSIEKFGNNSSASIPMALSEAVKEGKIKDNDLIVLVGFGGG
EEHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCC
LTWGAVALRWGK
CCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376