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The map label for this gene is fabF [H]

Identifier: 23098660

GI number: 23098660

Start: 1254137

End: 1255375

Strand: Direct

Name: fabF [H]

Synonym: OB1205

Alternate gene names: 23098660

Gene position: 1254137-1255375 (Clockwise)

Preceding gene: 23098659

Following gene: 23098661

Centisome position: 34.54

GC content: 40.6

Gene sequence:

>1239_bases
TTGAATAAGCGAGTTGTTATTACGGGACTAGGAGCATTAAGCCCAGTGGGCAATAATGTAGATGAAATGTGGGAAAGTGT
TACGACAGGAAAATCAGGAATAGATTTTGTTACAAAGGTGGATAAAGATTTATTTCCAGCAAAGGTAGCGGCAGAAGTGA
AAAACTTTGATCCTACACTGTATATGGATAAAAAAGACGCACGTAAAATGGATCCATTTACACAATATGCAGTTGCTGCT
GCTAAAATGGCTGTAGAAGATGCTAATTTAACCATTAATGAAGCGAACGCTGAACGAGTAGGTGTATGGATTGGATCTGG
TATTGGTGGTATGAAGACTTGGGAAGACCAACATACCAAGTTCATGGAGAAAGGCGCAAAACGCGTAAGTCCTTTCTTTG
TACCGATGATGATTCCAGATATGGCTGCTGGTCAGGTTTCGATTCAATTAGGAGCGAAGGGAATTAATTCTTGTTCGGTT
ACAGCATGTGCATCTGGTGCCAATTCTATCGGTGATGCTTTCAAGGCTATTCAGCGTGGAGATGCAGATATTATGATTTC
GGGCGGTACAGAGGCTCCGATATCAGATATGGCATTCGCTGGATTCTCTTCTTCAAAAGCGTTATCTACAAATGAGGATC
CACAAAAAGCAAGTAGACCTTTTGATAAAAATCGTAACGGATTTGTTATGGGAGAAGGAGCAGGGATCTTGATATTAGAG
TCTTTAGAATCTGCCCTGCAAAGAGATGCGACGATTTATGGAGAGATAGTAGGATATGGTGCCACTGGAGACGCTTATCA
TATCACTGCGCCTGCAGAGAATGGCGAGGGTGCAACCCGAGCAATGCAAATAGCGTTAAAAGATGCTAATCTAGAACCTT
CGGATGTACAGTATGTGAATGCTCATGGAACAAGCACAGATTTAAATGATAAATATGAGACGCAAGCAATCAAAGCTGTA
TTTGGTGACCATGCAAGTGATTTAGCAATTTCGTCTACGAAGTCGATGACTGGCCACTTATTAGGAGCTGCTGGTGGAAT
TGAAGCGGTAATATCTATTAAAGCAATTCAAGATAGTATAATTCCGCCGACGATTAATTATGAAACGCCTGATCCAGATT
GTGATTTGGATTATGTACCAAATGAAGCAAGAAAACAAACAGTAGATGCGGTGGTAAGTAATTCATTAGGTTTTGGCGGA
CATAACGTTGCCTTGGTATTTAAAAAATTTGTGAAATAA

Upstream 100 bases:

>100_bases
TTTAATAGTATTAGTTGGTTTTGGTGGAGGCTTAACCTGGGGAGCTGTTGCGCTTCGTTGGGGCAAGTAACCGGTTATTT
TGGAAGGAGGATATAAAACA

Downstream 100 bases:

>100_bases
TCGTATGCTATATGTTTTTAAAAGGAGATTGGGGTATAAATTACCTTGATCTCTTTTTAATTTTGGGGAAATCTAGCATT
CTTTTCTGTTTTTAAACATA

Product: 3-oxoacyl-(acyl-carrier protein) synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MNKRVVITGLGALSPVGNNVDEMWESVTTGKSGIDFVTKVDKDLFPAKVAAEVKNFDPTLYMDKKDARKMDPFTQYAVAA
AKMAVEDANLTINEANAERVGVWIGSGIGGMKTWEDQHTKFMEKGAKRVSPFFVPMMIPDMAAGQVSIQLGAKGINSCSV
TACASGANSIGDAFKAIQRGDADIMISGGTEAPISDMAFAGFSSSKALSTNEDPQKASRPFDKNRNGFVMGEGAGILILE
SLESALQRDATIYGEIVGYGATGDAYHITAPAENGEGATRAMQIALKDANLEPSDVQYVNAHGTSTDLNDKYETQAIKAV
FGDHASDLAISSTKSMTGHLLGAAGGIEAVISIKAIQDSIIPPTINYETPDPDCDLDYVPNEARKQTVDAVVSNSLGFGG
HNVALVFKKFVK

Sequences:

>Translated_412_residues
MNKRVVITGLGALSPVGNNVDEMWESVTTGKSGIDFVTKVDKDLFPAKVAAEVKNFDPTLYMDKKDARKMDPFTQYAVAA
AKMAVEDANLTINEANAERVGVWIGSGIGGMKTWEDQHTKFMEKGAKRVSPFFVPMMIPDMAAGQVSIQLGAKGINSCSV
TACASGANSIGDAFKAIQRGDADIMISGGTEAPISDMAFAGFSSSKALSTNEDPQKASRPFDKNRNGFVMGEGAGILILE
SLESALQRDATIYGEIVGYGATGDAYHITAPAENGEGATRAMQIALKDANLEPSDVQYVNAHGTSTDLNDKYETQAIKAV
FGDHASDLAISSTKSMTGHLLGAAGGIEAVISIKAIQDSIIPPTINYETPDPDCDLDYVPNEARKQTVDAVVSNSLGFGG
HNVALVFKKFVK
>Mature_412_residues
MNKRVVITGLGALSPVGNNVDEMWESVTTGKSGIDFVTKVDKDLFPAKVAAEVKNFDPTLYMDKKDARKMDPFTQYAVAA
AKMAVEDANLTINEANAERVGVWIGSGIGGMKTWEDQHTKFMEKGAKRVSPFFVPMMIPDMAAGQVSIQLGAKGINSCSV
TACASGANSIGDAFKAIQRGDADIMISGGTEAPISDMAFAGFSSSKALSTNEDPQKASRPFDKNRNGFVMGEGAGILILE
SLESALQRDATIYGEIVGYGATGDAYHITAPAENGEGATRAMQIALKDANLEPSDVQYVNAHGTSTDLNDKYETQAIKAV
FGDHASDLAISSTKSMTGHLLGAAGGIEAVISIKAIQDSIIPPTINYETPDPDCDLDYVPNEARKQTVDAVVSNSLGFGG
HNVALVFKKFVK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=45.1923076923077, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI223972627, Length=416, Percent_Identity=33.1730769230769, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI41872631, Length=429, Percent_Identity=24.2424242424242, Blast_Score=112, Evalue=9e-25,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=50.2439024390244, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=39.7094430992736, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=35.6796116504854, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=41.2213740458015, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17550940, Length=410, Percent_Identity=26.8292682926829, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI212642053, Length=431, Percent_Identity=26.4501160092807, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=38.3073496659243, Blast_Score=291, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=42.9577464788732, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI19920632, Length=431, Percent_Identity=26.2180974477958, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI221330659, Length=431, Percent_Identity=26.2180974477958, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24581345, Length=435, Percent_Identity=24.5977011494253, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43609; Mature: 43609

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRVVITGLGALSPVGNNVDEMWESVTTGKSGIDFVTKVDKDLFPAKVAAEVKNFDPTL
CCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCHHCHHHHHHHHHCCCCEE
YMDKKDARKMDPFTQYAVAAAKMAVEDANLTINEANAERVGVWIGSGIGGMKTWEDQHTK
EECCHHHHCCCHHHHHHHHHHHHHEECCCEEEECCCCCEEEEEEECCCCCCCCCHHHHHH
FMEKGAKRVSPFFVPMMIPDMAAGQVSIQLGAKGINSCSVTACASGANSIGDAFKAIQRG
HHHHHHHHCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCC
DADIMISGGTEAPISDMAFAGFSSSKALSTNEDPQKASRPFDKNRNGFVMGEGAGILILE
CCEEEEECCCCCCHHHHEECCCCCCCCCCCCCCHHHHCCCCCCCCCEEEEECCCCEEEEH
SLESALQRDATIYGEIVGYGATGDAYHITAPAENGEGATRAMQIALKDANLEPSDVQYVN
HHHHHHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCHHEEEEEEEECCCCCCCCEEEEE
AHGTSTDLNDKYETQAIKAVFGDHASDLAISSTKSMTGHLLGAAGGIEAVISIKAIQDSI
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHHHHEECCCCCEEEEEEEHHHHCC
IPPTINYETPDPDCDLDYVPNEARKQTVDAVVSNSLGFGGHNVALVFKKFVK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNKRVVITGLGALSPVGNNVDEMWESVTTGKSGIDFVTKVDKDLFPAKVAAEVKNFDPTL
CCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCHHCHHHHHHHHHCCCCEE
YMDKKDARKMDPFTQYAVAAAKMAVEDANLTINEANAERVGVWIGSGIGGMKTWEDQHTK
EECCHHHHCCCHHHHHHHHHHHHHEECCCEEEECCCCCEEEEEEECCCCCCCCCHHHHHH
FMEKGAKRVSPFFVPMMIPDMAAGQVSIQLGAKGINSCSVTACASGANSIGDAFKAIQRG
HHHHHHHHCCCEEEEECCCCCCCCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCC
DADIMISGGTEAPISDMAFAGFSSSKALSTNEDPQKASRPFDKNRNGFVMGEGAGILILE
CCEEEEECCCCCCHHHHEECCCCCCCCCCCCCCHHHHCCCCCCCCCEEEEECCCCEEEEH
SLESALQRDATIYGEIVGYGATGDAYHITAPAENGEGATRAMQIALKDANLEPSDVQYVN
HHHHHHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCHHEEEEEEEECCCCCCCCEEEEE
AHGTSTDLNDKYETQAIKAVFGDHASDLAISSTKSMTGHLLGAAGGIEAVISIKAIQDSI
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHHHHEECCCCCEEEEEEEHHHHCC
IPPTINYETPDPDCDLDYVPNEARKQTVDAVVSNSLGFGGHNVALVFKKFVK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]