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The map label for this gene is hemH

Identifier: 23098623

GI number: 23098623

Start: 1217831

End: 1218769

Strand: Direct

Name: hemH

Synonym: OB1168

Alternate gene names: 23098623

Gene position: 1217831-1218769 (Clockwise)

Preceding gene: 23098622

Following gene: 23098624

Centisome position: 33.54

GC content: 36.0

Gene sequence:

>939_bases
ATGGAAAAGAAAAAAATCGGATTATTAGTAATGGCATATGGAACTCCATATAAAGAGGAGGATATTGAACCGTATTATAC
ACATATTCGTCATGGCCGAAAACCTGATCCAGAAGCATTACAGGATTTAAAAGAACGCTATGAAGCTATTGGAGGAATTT
CTCCATTAGCAAAGATTACAGAAGAACAGACGAAGGCATTAGAGAAGAAACTGAATGCGAATCAGGACCAATATGAGTTT
AAAGCATATATTGGTTTAAAACATATTCATCCGTTTATCGAGGATACTGTAGAAGAGATGGCAAAGGATGGTATTAAAGA
AGCTATTTCTCTTGTTCTAGCACCTCATTATTCTACTTTCAGTGTTAAATCTTATAATAAGCGTGCAAATGAAACAGCTG
AAAAGTATGGCATTCAATTAGATTCCGTAGAAGATTGGTATACTGAGCCTGGTTTTATTAAGTTCTGGGCAGATGGAATA
AAAGCAACTTATGCAGAAATGACGGAGGAAGAGCGAAATAATTCTGTGTTAATTGTATCTGCACATAGTCTTCCTGAAAA
AATTCTTAAAGATGGTGACCCATACAAGCATCAACTAGAAGAAACTGCAAAACTAATTGTGGAAGAAGCGGATGTAAAAA
ATTATGCAGTAGGATGGCAAAGTGAAGGCAATACACCAGATCCTTGGCTTGGTCCAGATGTGCAGGACTTAACGAGAGAG
TTATATGAAAGTGAAGGATATAAAGCATTTATTTATACTCCAGTAGGTTTCGTAGCGGATCATTTGGAAGTTCTCTATGA
TAATGATTATGAGTGTAAAGTTGTATGTGATGAGATTGGTGCAAGCTATTATCGCCCAGATATGCCAAATGTTCATCCTG
AGTTCATTGAGACATTAGCAAATGTTGTAATGAAAAAAGCAAAGAGTGAAGTTAGATGA

Upstream 100 bases:

>100_bases
GGGGTAACACCAGATATTGAACCAGCTACATTAAAGAAATTAACAGAGTTGGTTCATAATTATAGCAAACAGAAGTAAAT
TTTAAAGAGGTGTATGTAAC

Downstream 100 bases:

>100_bases
CCACTAACAAGAAGGTTGTTGTTGTTGGCGGCGGAATTACAGGTCTATCCGCCGCCTACTATCTTCAAAAAGAAAAAGAA
GCGCAAGAATTGCCAATTGA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MEKKKIGLLVMAYGTPYKEEDIEPYYTHIRHGRKPDPEALQDLKERYEAIGGISPLAKITEEQTKALEKKLNANQDQYEF
KAYIGLKHIHPFIEDTVEEMAKDGIKEAISLVLAPHYSTFSVKSYNKRANETAEKYGIQLDSVEDWYTEPGFIKFWADGI
KATYAEMTEEERNNSVLIVSAHSLPEKILKDGDPYKHQLEETAKLIVEEADVKNYAVGWQSEGNTPDPWLGPDVQDLTRE
LYESEGYKAFIYTPVGFVADHLEVLYDNDYECKVVCDEIGASYYRPDMPNVHPEFIETLANVVMKKAKSEVR

Sequences:

>Translated_312_residues
MEKKKIGLLVMAYGTPYKEEDIEPYYTHIRHGRKPDPEALQDLKERYEAIGGISPLAKITEEQTKALEKKLNANQDQYEF
KAYIGLKHIHPFIEDTVEEMAKDGIKEAISLVLAPHYSTFSVKSYNKRANETAEKYGIQLDSVEDWYTEPGFIKFWADGI
KATYAEMTEEERNNSVLIVSAHSLPEKILKDGDPYKHQLEETAKLIVEEADVKNYAVGWQSEGNTPDPWLGPDVQDLTRE
LYESEGYKAFIYTPVGFVADHLEVLYDNDYECKVVCDEIGASYYRPDMPNVHPEFIETLANVVMKKAKSEVR
>Mature_312_residues
MEKKKIGLLVMAYGTPYKEEDIEPYYTHIRHGRKPDPEALQDLKERYEAIGGISPLAKITEEQTKALEKKLNANQDQYEF
KAYIGLKHIHPFIEDTVEEMAKDGIKEAISLVLAPHYSTFSVKSYNKRANETAEKYGIQLDSVEDWYTEPGFIKFWADGI
KATYAEMTEEERNNSVLIVSAHSLPEKILKDGDPYKHQLEETAKLIVEEADVKNYAVGWQSEGNTPDPWLGPDVQDLTRE
LYESEGYKAFIYTPVGFVADHLEVLYDNDYECKVVCDEIGASYYRPDMPNVHPEFIETLANVVMKKAKSEVR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=275, Percent_Identity=31.6363636363636, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI60499025, Length=275, Percent_Identity=31.6363636363636, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1786681, Length=231, Percent_Identity=24.6753246753247, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324750, Length=280, Percent_Identity=29.2857142857143, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17864156, Length=332, Percent_Identity=30.421686746988, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI45552018, Length=176, Percent_Identity=35.7954545454545, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=28.125, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_OCEIH (Q8ERX9)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692089.1
- ProteinModelPortal:   Q8ERX9
- SMR:   Q8ERX9
- GeneID:   1017309
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1168
- NMPDR:   fig|221109.1.peg.1168
- HOGENOM:   HBG697135
- OMA:   LAPHFST
- ProtClustDB:   PRK12435
- BioCyc:   OIHE221109:OB1168-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 35761; Mature: 35761

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKKIGLLVMAYGTPYKEEDIEPYYTHIRHGRKPDPEALQDLKERYEAIGGISPLAKIT
CCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
EEQTKALEKKLNANQDQYEFKAYIGLKHIHPFIEDTVEEMAKDGIKEAISLVLAPHYSTF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
SVKSYNKRANETAEKYGIQLDSVEDWYTEPGFIKFWADGIKATYAEMTEEERNNSVLIVS
EEHHHHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEE
AHSLPEKILKDGDPYKHQLEETAKLIVEEADVKNYAVGWQSEGNTPDPWLGPDVQDLTRE
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCHHHHHHH
LYESEGYKAFIYTPVGFVADHLEVLYDNDYECKVVCDEIGASYYRPDMPNVHPEFIETLA
HHHCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEHHHHCCHHCCCCCCCCCHHHHHHHH
NVVMKKAKSEVR
HHHHHHHHHHCC
>Mature Secondary Structure
MEKKKIGLLVMAYGTPYKEEDIEPYYTHIRHGRKPDPEALQDLKERYEAIGGISPLAKIT
CCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
EEQTKALEKKLNANQDQYEFKAYIGLKHIHPFIEDTVEEMAKDGIKEAISLVLAPHYSTF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
SVKSYNKRANETAEKYGIQLDSVEDWYTEPGFIKFWADGIKATYAEMTEEERNNSVLIVS
EEHHHHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEE
AHSLPEKILKDGDPYKHQLEETAKLIVEEADVKNYAVGWQSEGNTPDPWLGPDVQDLTRE
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCHHHHHHH
LYESEGYKAFIYTPVGFVADHLEVLYDNDYECKVVCDEIGASYYRPDMPNVHPEFIETLA
HHHCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEHHHHCCHHCCCCCCCCCHHHHHHHH
NVVMKKAKSEVR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376