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The map label for this gene is hemE

Identifier: 23098622

GI number: 23098622

Start: 1216771

End: 1217808

Strand: Direct

Name: hemE

Synonym: OB1167

Alternate gene names: 23098622

Gene position: 1216771-1217808 (Clockwise)

Preceding gene: 23098621

Following gene: 23098623

Centisome position: 33.51

GC content: 36.22

Gene sequence:

>1038_bases
ATGTCTATAATTAAAAATGATACAATTATTAAAGCTTATCAAGGTGAAGAAACGGATTATACGCCAGCTTGGTTTATGCG
CCAGGCTGGAAGATCTCAGCCAGAATATCGTGCGTTGAAAGAAAAATATTCACTATTTGAAATTACACACCAACCAGAAT
TATGTGCGTATGTCACTCGTTTACCGGTAGAAAATTACGGGACAGATGCTGCTATCCTCTATAAAGATATTATGTCCCCA
TTACCTTATATAGGTGTGGATGTAGAAATTAAAAGTGGTATTGGCCCCGTAATTCATAATCCAATACGTAATTTACAAGA
CGTAGAAAAGCTTGGAGTAATTAATCCAGTCTCAGACGTACCTTACGTATTAGATACGATTCGATTATTGACAGAAGAGC
AACTAGAAGTTCCTCTAATAGGTTTCAGTGGTGCACCATTTACATTAGCAAGCTATATGATAGAAGGTGGGCCTTCCAAA
AATTATTCTAAGACAAAAGCATTAATGTATCGGGAGCCTGAAACTTGGTTTGCATTAATGGATAAATTAAGTGACATGAT
TATTAGTTATGTAGACGCTCAAGTAGAAGCAGGTGCTAAAGCGATACAAATATTTGATTCTTGGGTAGGATCATTAAATG
CAGAAGATTATCGTGTATTTATTAAACCAGTAATGACGAGGATTTTTTCTGAATTAAGACGACATGAAGTGCCTCTCATT
ACATTTGGAGTAGGAGCAAGACATTTGCTTATGGAATGGAATGATTTGCCCGTGGATGTAATTGGCTTAGATTGGAGAAC
CTCTATTAATGAAGCACGAGAAATGGGAGTAACGAAAGTTGTTCAAGGAAATCTAGATCCAGCTATTTTATTGTCAGATT
GGCAAACAATTGAACAGCGTACGAAGCAGATTTTAGATCAAGGTATGCAATCAGGCAAACATGTATTCAATCTTGGTCAT
GGGGTAACACCAGATATTGAACCAGCTACATTAAAGAAATTAACAGAGTTGGTTCATAATTATAGCAAACAGAAGTAA

Upstream 100 bases:

>100_bases
ATGAGGCAAATTGATGACAAACACCTGCCTTCCCTATACACTCAAGTATTTAATAGCTATAGTAGACTATGAAGATAAGA
GAATATAAAGGATGAATGAA

Downstream 100 bases:

>100_bases
ATTTTAAAGAGGTGTATGTAACATGGAAAAGAAAAAAATCGGATTATTAGTAATGGCATATGGAACTCCATATAAAGAGG
AGGATATTGAACCGTATTAT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSIIKNDTIIKAYQGEETDYTPAWFMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTRLPVENYGTDAAILYKDIMSP
LPYIGVDVEIKSGIGPVIHNPIRNLQDVEKLGVINPVSDVPYVLDTIRLLTEEQLEVPLIGFSGAPFTLASYMIEGGPSK
NYSKTKALMYREPETWFALMDKLSDMIISYVDAQVEAGAKAIQIFDSWVGSLNAEDYRVFIKPVMTRIFSELRRHEVPLI
TFGVGARHLLMEWNDLPVDVIGLDWRTSINEAREMGVTKVVQGNLDPAILLSDWQTIEQRTKQILDQGMQSGKHVFNLGH
GVTPDIEPATLKKLTELVHNYSKQK

Sequences:

>Translated_345_residues
MSIIKNDTIIKAYQGEETDYTPAWFMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTRLPVENYGTDAAILYKDIMSP
LPYIGVDVEIKSGIGPVIHNPIRNLQDVEKLGVINPVSDVPYVLDTIRLLTEEQLEVPLIGFSGAPFTLASYMIEGGPSK
NYSKTKALMYREPETWFALMDKLSDMIISYVDAQVEAGAKAIQIFDSWVGSLNAEDYRVFIKPVMTRIFSELRRHEVPLI
TFGVGARHLLMEWNDLPVDVIGLDWRTSINEAREMGVTKVVQGNLDPAILLSDWQTIEQRTKQILDQGMQSGKHVFNLGH
GVTPDIEPATLKKLTELVHNYSKQK
>Mature_344_residues
SIIKNDTIIKAYQGEETDYTPAWFMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTRLPVENYGTDAAILYKDIMSPL
PYIGVDVEIKSGIGPVIHNPIRNLQDVEKLGVINPVSDVPYVLDTIRLLTEEQLEVPLIGFSGAPFTLASYMIEGGPSKN
YSKTKALMYREPETWFALMDKLSDMIISYVDAQVEAGAKAIQIFDSWVGSLNAEDYRVFIKPVMTRIFSELRRHEVPLIT
FGVGARHLLMEWNDLPVDVIGLDWRTSINEAREMGVTKVVQGNLDPAILLSDWQTIEQRTKQILDQGMQSGKHVFNLGHG
VTPDIEPATLKKLTELVHNYSKQK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=38.1766381766382, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI2367337, Length=351, Percent_Identity=39.031339031339, Blast_Score=248, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=32.8611898016997, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=37.463976945245, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=37.463976945245, Blast_Score=234, Evalue=9e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_OCEIH (Q8ERY0)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692088.1
- ProteinModelPortal:   Q8ERY0
- SMR:   Q8ERY0
- GeneID:   1017308
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1167
- NMPDR:   fig|221109.1.peg.1167
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   OIHE221109:OB1167-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39064; Mature: 38933

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 46-46 BINDING 76-76 BINDING 152-152 BINDING 207-207 BINDING 320-320

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIKNDTIIKAYQGEETDYTPAWFMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTR
CCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCHHHHHHHH
LPVENYGTDAAILYKDIMSPLPYIGVDVEIKSGIGPVIHNPIRNLQDVEKLGVINPVSDV
CCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PYVLDTIRLLTEEQLEVPLIGFSGAPFTLASYMIEGGPSKNYSKTKALMYREPETWFALM
HHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHEEECCHHHHHHH
DKLSDMIISYVDAQVEAGAKAIQIFDSWVGSLNAEDYRVFIKPVMTRIFSELRRHEVPLI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
TFGVGARHLLMEWNDLPVDVIGLDWRTSINEAREMGVTKVVQGNLDPAILLSDWQTIEQR
EECCCCHHHHEECCCCCEEEEECCCHHHHHHHHHCCHHHHHCCCCCCEEEEHHHHHHHHH
TKQILDQGMQSGKHVFNLGHGVTPDIEPATLKKLTELVHNYSKQK
HHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SIIKNDTIIKAYQGEETDYTPAWFMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTR
CCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCHHHHHHHH
LPVENYGTDAAILYKDIMSPLPYIGVDVEIKSGIGPVIHNPIRNLQDVEKLGVINPVSDV
CCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PYVLDTIRLLTEEQLEVPLIGFSGAPFTLASYMIEGGPSKNYSKTKALMYREPETWFALM
HHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHEEECCHHHHHHH
DKLSDMIISYVDAQVEAGAKAIQIFDSWVGSLNAEDYRVFIKPVMTRIFSELRRHEVPLI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
TFGVGARHLLMEWNDLPVDVIGLDWRTSINEAREMGVTKVVQGNLDPAILLSDWQTIEQR
EECCCCHHHHEECCCCCEEEEECCCHHHHHHHHHCCHHHHHCCCCCCEEEEHHHHHHHHH
TKQILDQGMQSGKHVFNLGHGVTPDIEPATLKKLTELVHNYSKQK
HHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376