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The map label for this gene is fumC

Identifier: 23098587

GI number: 23098587

Start: 1183893

End: 1185278

Strand: Direct

Name: fumC

Synonym: OB1132

Alternate gene names: 23098587

Gene position: 1183893-1185278 (Clockwise)

Preceding gene: 23098585

Following gene: 28563919

Centisome position: 32.61

GC content: 36.44

Gene sequence:

>1386_bases
ATGGATTATCGTGTTGAAAAAGATACAATTGGGGAAATTCAAGTTCCTGCTGATAAATACTGGGGGGCGCAAACACAGCG
TAGTAAGCAAAATTTTCCAATTGGAAATGAAAAAATGCCAGTCGAAATTATTAAAGCGTTTGCAATTCTAAAACGAAGTA
CTGCTGAAGCTAATTTTGAATTAGGCTTAATGGAACGAGATAAAATGGAAGCAATTCAATATGCTGCTGATCAGGTATTA
AACGATTCTCTAACAGATCATTTCCCACTAGTCGTTTGGCAAACTGGTAGTGGTACGCAAAGTAATATGAATGTAAACGA
AGTATTAGCTTTTGTAGGTAATAAATGGTTACAAGAACAGGGAAGCGATTTAAAATTACATCCCAATGATGATGTAAATA
AATCTCAAAGTTCGAACGATACATATCCAACGGCAATGCATATTGCAGCCGTATTGAAATTAGAAGATACGGTATTACCA
GCTTTGAGTCAGTTGAAAAATACTTTTGCAGAAAAGCAAAGTGCTTTTGAAAATATCGTGAAAATTGGTCGTACACATTT
ACAGGATGCGACTCCTCTAACACTAGGCCAGGAAATCAGTGGGTGGCATCGTATGTTAGAGAAATCTGAAACGATGATTT
CAGAGAGTTTAGAGCATCTTCGTGAATTAGCAATAGGTGGAACAGCTGTAGGCACAGGCTTAAATGCACATCCAGATTTT
TCAGAGAAAGTTTGTAAGGCAATTAGTACATTCACAAACAAAAAATTCATATCTGCAAAAAATAAATTTCATTCATTAAC
AAGTCATGACGAAACTGTATATGCACATGGTGCACTAAAGGGACTAGCAGCAGATTTAATGAAAATTGCAAATGATGTTC
GTTGGTTAGCAAGCGGTCCACGCTGTGGCATTGGAGAAATTACGATTCCGGCGAATGAACCAGGAAGTTCAATTATGCCA
GGGAAGGTAAATCCGACTCAAAGTGAAGCTGTAACAATGGTAGTAACTCAAGTAATGGGGAATGATGCTGCTATTGGTTT
TGCCGCTAGTCAGGGGAATTTCGAATTGAATGTATTTAAGCCAGTAATTGCATATAATTTCTTACAATCAAGTCAATTAT
TAGCAGATAGTATAATTTCCTTCGATGAGCGCTGTGCGGTTGGAATCGAACCAAACCACGAGCAAATCGAAAAGAATCTT
AATGATTCTTTAATGTTGGTTACCGCATTAAATCCGCATATAGGATACGAAAATGCAGCAAAAATTGCTAAAAAAGCATT
TGCAGATAATTCAACTTTAAAAGAAACAGCTGTAGAATTAGGACTATTAACAGAAGAACAGTTTGATGAGTATGTTAATC
CAGAGGAAATGACATATCCTAAATAA

Upstream 100 bases:

>100_bases
CTCACTTTATGTTATATTTTATCATGAATGGATAGAAATCGAAAAAAATTGCAAAATTTGATACACTATCATTGAGGATC
TTACAAAGGGAGGAAATAAA

Downstream 100 bases:

>100_bases
AAGTAATGATTAAAAAGTATCCATTTTTTATGGATACTTTTTTATTATATTACATATTTAACAGGTTGGTATCGCCATGA
TTACATTTCTCCTACAAATT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MDYRVEKDTIGEIQVPADKYWGAQTQRSKQNFPIGNEKMPVEIIKAFAILKRSTAEANFELGLMERDKMEAIQYAADQVL
NDSLTDHFPLVVWQTGSGTQSNMNVNEVLAFVGNKWLQEQGSDLKLHPNDDVNKSQSSNDTYPTAMHIAAVLKLEDTVLP
ALSQLKNTFAEKQSAFENIVKIGRTHLQDATPLTLGQEISGWHRMLEKSETMISESLEHLRELAIGGTAVGTGLNAHPDF
SEKVCKAISTFTNKKFISAKNKFHSLTSHDETVYAHGALKGLAADLMKIANDVRWLASGPRCGIGEITIPANEPGSSIMP
GKVNPTQSEAVTMVVTQVMGNDAAIGFAASQGNFELNVFKPVIAYNFLQSSQLLADSIISFDERCAVGIEPNHEQIEKNL
NDSLMLVTALNPHIGYENAAKIAKKAFADNSTLKETAVELGLLTEEQFDEYVNPEEMTYPK

Sequences:

>Translated_461_residues
MDYRVEKDTIGEIQVPADKYWGAQTQRSKQNFPIGNEKMPVEIIKAFAILKRSTAEANFELGLMERDKMEAIQYAADQVL
NDSLTDHFPLVVWQTGSGTQSNMNVNEVLAFVGNKWLQEQGSDLKLHPNDDVNKSQSSNDTYPTAMHIAAVLKLEDTVLP
ALSQLKNTFAEKQSAFENIVKIGRTHLQDATPLTLGQEISGWHRMLEKSETMISESLEHLRELAIGGTAVGTGLNAHPDF
SEKVCKAISTFTNKKFISAKNKFHSLTSHDETVYAHGALKGLAADLMKIANDVRWLASGPRCGIGEITIPANEPGSSIMP
GKVNPTQSEAVTMVVTQVMGNDAAIGFAASQGNFELNVFKPVIAYNFLQSSQLLADSIISFDERCAVGIEPNHEQIEKNL
NDSLMLVTALNPHIGYENAAKIAKKAFADNSTLKETAVELGLLTEEQFDEYVNPEEMTYPK
>Mature_461_residues
MDYRVEKDTIGEIQVPADKYWGAQTQRSKQNFPIGNEKMPVEIIKAFAILKRSTAEANFELGLMERDKMEAIQYAADQVL
NDSLTDHFPLVVWQTGSGTQSNMNVNEVLAFVGNKWLQEQGSDLKLHPNDDVNKSQSSNDTYPTAMHIAAVLKLEDTVLP
ALSQLKNTFAEKQSAFENIVKIGRTHLQDATPLTLGQEISGWHRMLEKSETMISESLEHLRELAIGGTAVGTGLNAHPDF
SEKVCKAISTFTNKKFISAKNKFHSLTSHDETVYAHGALKGLAADLMKIANDVRWLASGPRCGIGEITIPANEPGSSIMP
GKVNPTQSEAVTMVVTQVMGNDAAIGFAASQGNFELNVFKPVIAYNFLQSSQLLADSIISFDERCAVGIEPNHEQIEKNL
NDSLMLVTALNPHIGYENAAKIAKKAFADNSTLKETAVELGLLTEEQFDEYVNPEEMTYPK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=57.1428571428571, Blast_Score=522, Evalue=1e-148,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=61.8421052631579, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI87082375, Length=466, Percent_Identity=39.0557939914163, Blast_Score=322, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=56.0344827586207, Blast_Score=528, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=56.8807339449541, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=56.3991323210412, Blast_Score=514, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24640179, Length=468, Percent_Identity=54.7008547008547, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24640177, Length=468, Percent_Identity=54.7008547008547, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=54.5258620689655, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24662684, Length=468, Percent_Identity=51.7094017094017, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=46.0215053763441, Blast_Score=420, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_OCEIH (Q8CUH5)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692053.1
- ProteinModelPortal:   Q8CUH5
- SMR:   Q8CUH5
- GeneID:   1017212
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1132
- NMPDR:   fig|221109.1.peg.1133
- HOGENOM:   HBG284369
- OMA:   RIEKDTM
- ProtClustDB:   PRK00485
- BioCyc:   OIHE221109:OB1132-MONOMER
- BRENDA:   4.2.1.2
- HAMAP:   MF_00743
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00979

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 50733; Mature: 50733

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 99-99

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYRVEKDTIGEIQVPADKYWGAQTQRSKQNFPIGNEKMPVEIIKAFAILKRSTAEANFE
CCCCCCCCCCCCEECCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCE
LGLMERDKMEAIQYAADQVLNDSLTDHFPLVVWQTGSGTQSNMNVNEVLAFVGNKWLQEQ
EECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHC
GSDLKLHPNDDVNKSQSSNDTYPTAMHIAAVLKLEDTVLPALSQLKNTFAEKQSAFENIV
CCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKSETMISESLEHLRELAIGGTAVGTGLNAHPDF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCH
SEKVCKAISTFTNKKFISAKNKFHSLTSHDETVYAHGALKGLAADLMKIANDVRWLASGP
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RCGIGEITIPANEPGSSIMPGKVNPTQSEAVTMVVTQVMGNDAAIGFAASQGNFELNVFK
CCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSSQLLADSIISFDERCAVGIEPNHEQIEKNLNDSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHH
KIAKKAFADNSTLKETAVELGLLTEEQFDEYVNPEEMTYPK
HHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDYRVEKDTIGEIQVPADKYWGAQTQRSKQNFPIGNEKMPVEIIKAFAILKRSTAEANFE
CCCCCCCCCCCCEECCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCE
LGLMERDKMEAIQYAADQVLNDSLTDHFPLVVWQTGSGTQSNMNVNEVLAFVGNKWLQEQ
EECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHC
GSDLKLHPNDDVNKSQSSNDTYPTAMHIAAVLKLEDTVLPALSQLKNTFAEKQSAFENIV
CCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKSETMISESLEHLRELAIGGTAVGTGLNAHPDF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCH
SEKVCKAISTFTNKKFISAKNKFHSLTSHDETVYAHGALKGLAADLMKIANDVRWLASGP
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RCGIGEITIPANEPGSSIMPGKVNPTQSEAVTMVVTQVMGNDAAIGFAASQGNFELNVFK
CCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSSQLLADSIISFDERCAVGIEPNHEQIEKNLNDSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHH
KIAKKAFADNSTLKETAVELGLLTEEQFDEYVNPEEMTYPK
HHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376