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The map label for this gene is argD

Identifier: 23098533

GI number: 23098533

Start: 1121249

End: 1122448

Strand: Direct

Name: argD

Synonym: OB1078

Alternate gene names: 23098533

Gene position: 1121249-1122448 (Clockwise)

Preceding gene: 23098532

Following gene: 23098534

Centisome position: 30.88

GC content: 36.92

Gene sequence:

>1200_bases
ATGTCTAGTACAACAAAAGTTTCATCAGCAGTAATGCAAACATATAATCGTTTTCCAATAACAGCAACGAAAGGAAAAGG
CAGCTTCCTATGGGATGATAATGGGGAGAAATACTTAGATTATACATCGGGGATTGCAACTTGTAATTTAGGGCATGTAC
CAGATAATGTACAACATGCTATATCAAACCAATTAAAAGATTTATGGCATTGCTCCAATTTATATCATATTCCTAGTCAA
GAAAAATTAGCCGCGTTACTTACTGAATATAGTTGCTTAGATCAAGTATTTTTTTGCAACAGTGGAGCAGAGGCAAATGA
AGCTGCAATTAAAATAGCAAAAAAGTATGCGAAAGATAAAGGGTATGATGACCGCACTGAAATCATTACTTTCGAACAGT
CTTTTCATGGGCGTACTGGATCTACTATGGCTGCTACTGCACAAGAAAAAATACATCAAGGATTTACTCCATTAACAGAA
GGGTTTCGATATCTTCCATTTAATAACAAAGAATCATTGTCTGAAATCGATAATGGGAAAACTTCTGCTGTATTATTAGA
AGTTATTCAAGGTGAAGGGGGCATACATACTGCAGAAAAAGATTGGTTAAAACAATTAGCTGCTATCTGTAAGCAAGCGG
ACATATTGCTAATGATTGATGAAATCCAGACGGGGATAGGACGCACGGGAAGTTTATTTGCCTATCAACCATATGGAATA
GAGCCAGATGTTATTACGGTAGCGAAAGGTTTGGGATCTGGATTTCCAATTGGTGCCATGCTAGCGAAACAACACATCGC
GGCATCATTTTCGCCTGGTACACATGGAAGTACTTTTGGAGGAAATCCAGTAGCTGCAGCAGCTGGTATCGCGACTTTAA
AAGAAATATTAAGTGATGGTTTTCTAGAAAATTGTAAGGAAGGTCAAGAGGAATTGTTTAATCAATTAAAAAGTATAAAA
GAAATCTCTCCTTTGATTAAAGACATTCGTGGTAAAGGTTATTTAATGGGTATAGAAGTTATGAATCAGGCTAGTGCGTG
GATTGAAAAACTTCGCGAAAAACAAATCCTTGTGCTACCAGCTGGTGAGAAAGTAGTACGTATATTACCTCCATTAACGA
CAACAAAAGAGGAACTACAAATATGTATACAAGCGTTGAAAGAAGTGGCATTAGAACTGGGGGGAAATACAAATGGATAA

Upstream 100 bases:

>100_bases
GCAGAGTCCGTTATTTTAAATGGTTTGAATCCAATTGAAATAAAGAATTATTTAGAAGGAAAAACAGTTGGAACAGTTTT
AACAGAAAGAGAGGTAGAGC

Downstream 100 bases:

>100_bases
AGGTTTTTTAGTATTAGAAACCGGAGAAGTATTTGAAGGAATTCTAATTGGAGATAAACAGGCAATCGAAGGTGAACTTG
TTTTTAATACCGGTATGACA

Product: N-acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSSTTKVSSAVMQTYNRFPITATKGKGSFLWDDNGEKYLDYTSGIATCNLGHVPDNVQHAISNQLKDLWHCSNLYHIPSQ
EKLAALLTEYSCLDQVFFCNSGAEANEAAIKIAKKYAKDKGYDDRTEIITFEQSFHGRTGSTMAATAQEKIHQGFTPLTE
GFRYLPFNNKESLSEIDNGKTSAVLLEVIQGEGGIHTAEKDWLKQLAAICKQADILLMIDEIQTGIGRTGSLFAYQPYGI
EPDVITVAKGLGSGFPIGAMLAKQHIAASFSPGTHGSTFGGNPVAAAAGIATLKEILSDGFLENCKEGQEELFNQLKSIK
EISPLIKDIRGKGYLMGIEVMNQASAWIEKLREKQILVLPAGEKVVRILPPLTTTKEELQICIQALKEVALELGGNTNG

Sequences:

>Translated_399_residues
MSSTTKVSSAVMQTYNRFPITATKGKGSFLWDDNGEKYLDYTSGIATCNLGHVPDNVQHAISNQLKDLWHCSNLYHIPSQ
EKLAALLTEYSCLDQVFFCNSGAEANEAAIKIAKKYAKDKGYDDRTEIITFEQSFHGRTGSTMAATAQEKIHQGFTPLTE
GFRYLPFNNKESLSEIDNGKTSAVLLEVIQGEGGIHTAEKDWLKQLAAICKQADILLMIDEIQTGIGRTGSLFAYQPYGI
EPDVITVAKGLGSGFPIGAMLAKQHIAASFSPGTHGSTFGGNPVAAAAGIATLKEILSDGFLENCKEGQEELFNQLKSIK
EISPLIKDIRGKGYLMGIEVMNQASAWIEKLREKQILVLPAGEKVVRILPPLTTTKEELQICIQALKEVALELGGNTNG
>Mature_398_residues
SSTTKVSSAVMQTYNRFPITATKGKGSFLWDDNGEKYLDYTSGIATCNLGHVPDNVQHAISNQLKDLWHCSNLYHIPSQE
KLAALLTEYSCLDQVFFCNSGAEANEAAIKIAKKYAKDKGYDDRTEIITFEQSFHGRTGSTMAATAQEKIHQGFTPLTEG
FRYLPFNNKESLSEIDNGKTSAVLLEVIQGEGGIHTAEKDWLKQLAAICKQADILLMIDEIQTGIGRTGSLFAYQPYGIE
PDVITVAKGLGSGFPIGAMLAKQHIAASFSPGTHGSTFGGNPVAAAAGIATLKEILSDGFLENCKEGQEELFNQLKSIKE
ISPLIKDIRGKGYLMGIEVMNQASAWIEKLREKQILVLPAGEKVVRILPPLTTTKEELQICIQALKEVALELGGNTNG

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=390, Percent_Identity=30, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=29.5194508009153, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI284507298, Length=303, Percent_Identity=31.3531353135314, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI37574042, Length=413, Percent_Identity=28.0871670702179, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI226442705, Length=413, Percent_Identity=27.6029055690073, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI226442709, Length=382, Percent_Identity=27.7486910994764, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI24119277, Length=430, Percent_Identity=23.7209302325581, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI188536080, Length=428, Percent_Identity=21.7289719626168, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI38679950, Length=428, Percent_Identity=21.7289719626168, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI38679946, Length=428, Percent_Identity=21.7289719626168, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1788044, Length=374, Percent_Identity=39.3048128342246, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1789759, Length=389, Percent_Identity=37.0179948586118, Blast_Score=271, Evalue=4e-74,
Organism=Escherichia coli, GI145693181, Length=379, Percent_Identity=34.8284960422164, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1789016, Length=406, Percent_Identity=30.5418719211823, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=30, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1786991, Length=393, Percent_Identity=27.9898218829517, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786349, Length=336, Percent_Identity=27.3809523809524, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=374, Percent_Identity=30.4812834224599, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI32564660, Length=428, Percent_Identity=30.3738317757009, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI25144274, Length=262, Percent_Identity=30.5343511450382, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=426, Percent_Identity=28.8732394366197, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71981843, Length=159, Percent_Identity=29.559748427673, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17541228, Length=439, Percent_Identity=22.7790432801822, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=36.4321608040201, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6323470, Length=397, Percent_Identity=33.2493702770781, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6324386, Length=378, Percent_Identity=26.1904761904762, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=443, Percent_Identity=26.410835214447, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357415, Length=387, Percent_Identity=29.4573643410853, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI161085790, Length=426, Percent_Identity=29.81220657277, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI28574759, Length=424, Percent_Identity=29.9528301886792, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356575, Length=417, Percent_Identity=24.9400479616307, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI281366494, Length=427, Percent_Identity=25.9953161592506, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24667139, Length=427, Percent_Identity=25.9953161592506, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24667143, Length=427, Percent_Identity=25.9953161592506, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_OCEIH (Q8CUM9)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691999.1
- ProteinModelPortal:   Q8CUM9
- SMR:   Q8CUM9
- GeneID:   1016977
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1078
- NMPDR:   fig|221109.1.peg.1079
- HOGENOM:   HBG725944
- OMA:   TYNRFPI
- ProtClustDB:   CLSK2755894
- BioCyc:   OIHE221109:OB1078-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 43410; Mature: 43279

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 135-135 BINDING 138-138 BINDING 277-277 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTTKVSSAVMQTYNRFPITATKGKGSFLWDDNGEKYLDYTSGIATCNLGHVPDNVQHA
CCCHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCEEEECCCCCCEEECCCCCHHHHHH
ISNQLKDLWHCSNLYHIPSQEKLAALLTEYSCLDQVFFCNSGAEANEAAIKIAKKYAKDK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCC
GYDDRTEIITFEQSFHGRTGSTMAATAQEKIHQGFTPLTEGFRYLPFNNKESLSEIDNGK
CCCCCHHEEEEEHHHCCCCCCHHHHHHHHHHHCCCCCHHCCCEECCCCCHHHHHHHCCCC
TSAVLLEVIQGEGGIHTAEKDWLKQLAAICKQADILLMIDEIQTGIGRTGSLFAYQPYGI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCEEEECCCCC
EPDVITVAKGLGSGFPIGAMLAKQHIAASFSPGTHGSTFGGNPVAAAAGIATLKEILSDG
CCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FLENCKEGQEELFNQLKSIKEISPLIKDIRGKGYLMGIEVMNQASAWIEKLREKQILVLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEE
AGEKVVRILPPLTTTKEELQICIQALKEVALELGGNTNG
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSTTKVSSAVMQTYNRFPITATKGKGSFLWDDNGEKYLDYTSGIATCNLGHVPDNVQHA
CCHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCEEEECCCCCCEEECCCCCHHHHHH
ISNQLKDLWHCSNLYHIPSQEKLAALLTEYSCLDQVFFCNSGAEANEAAIKIAKKYAKDK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCC
GYDDRTEIITFEQSFHGRTGSTMAATAQEKIHQGFTPLTEGFRYLPFNNKESLSEIDNGK
CCCCCHHEEEEEHHHCCCCCCHHHHHHHHHHHCCCCCHHCCCEECCCCCHHHHHHHCCCC
TSAVLLEVIQGEGGIHTAEKDWLKQLAAICKQADILLMIDEIQTGIGRTGSLFAYQPYGI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCEEEECCCCC
EPDVITVAKGLGSGFPIGAMLAKQHIAASFSPGTHGSTFGGNPVAAAAGIATLKEILSDG
CCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FLENCKEGQEELFNQLKSIKEISPLIKDIRGKGYLMGIEVMNQASAWIEKLREKQILVLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCEEEEEE
AGEKVVRILPPLTTTKEELQICIQALKEVALELGGNTNG
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376