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The map label for this gene is yngF [H]

Identifier: 23098272

GI number: 23098272

Start: 872257

End: 873297

Strand: Reverse

Name: yngF [H]

Synonym: OB0817

Alternate gene names: 23098272

Gene position: 873297-872257 (Counterclockwise)

Preceding gene: 23098274

Following gene: 23098266

Centisome position: 24.05

GC content: 33.24

Gene sequence:

>1041_bases
ATGGAACAAGATGTTGTATTGTTTAGTGAAAAAAATGGTATTGGAACCATAGAGTTAAATCGACCAAAAGCGATTAATTC
CTTATCTCAACGAATGATTGAATTAATTCATCAACAGTTAACCGCATGGAAAAATGACTCTAATATTAAATTTATCCTAT
TTTCAGGAAATGGACCAAAAGGATTTTGTGCTGGGGGAGACATCAAAACACTTTATCAAGCAAAAGAGAATGAATCTAAA
TACCAACAAGCAATTCAGTTTTTCCAACTAGAATACGAAACAGATGCACTTATTTATCATTATCCTAAACCTATATTAGC
CATTTTAGATGGTGTAACGATGGGAGGAGGAGTTGGTCTCACATATGGGGCTAGTCATCGTATTGTAACAGAAAGAACAA
AATGGGCGATGCCAGAGATGAATATTGGCTTTTTCCCAGACGTTGGAGCATCCTACTTTTTTAATCAAGCTCCTGGAAAA
ATTGGTTATTATCTTGCCTTATCAGCATCTGTTATATCTGGGTCTGACGCGATTTATGCAAATGCTGCAGATCACTATAT
CAAAACCGATACCTTAGATACATTCATCCATGAAATTACGGAAAAAGATTGGACAAGCGAGACAAATATCAACCAAACAA
TCGATAGTATTGTACAGAAATTTACTGCATCACCAGGCCAAAGTAGCTTAGAAAATCATCATTCTGAAATCGATGAATAT
TTTTCTCATTCTACTTTAGAAGAGATTATTACATCTTTAGAGAGTACGGATAGTGATTTTGCCAACAAAACTAAACAACT
ATTATTATCGAAATCACCTATCTCCTTGAAAGTTACCTTGGAGCAATTACGAAGAGGAAAAGATAAATCATTAGAAGCTT
GCTTTGATATGGATTTAATACTTGCGAAGAACTTCTTAAAATCAACTGATTTTTATGAAGGAGTTCGTTCTATTGTTATC
GATAAAGATAAAAAACCAAACTATCAATATAAGAAATTAGATGACGTTAAAGCTGATTTAGTAGAATCCTATTTTAATTA
A

Upstream 100 bases:

>100_bases
AATATAAATGATAGAATACTTAGAATAGATGATTAAATAAAGATAGATTTTTGATTATGTAAGCGTTATCTGAGAATCGA
AGAATGAAGGAGAGATTGAA

Downstream 100 bases:

>100_bases
ATAAACCGGCTACACGTACTATAATAGTGGGAGAGGTCATACAGAAATGACCTCTCCCATCAATTTTAGTTATTCTCTAG
ATTTAAAACCATCTTTCAGT

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: trans-2-enoyl-CoA; trans-3-enoyl-CoA; H2O

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MEQDVVLFSEKNGIGTIELNRPKAINSLSQRMIELIHQQLTAWKNDSNIKFILFSGNGPKGFCAGGDIKTLYQAKENESK
YQQAIQFFQLEYETDALIYHYPKPILAILDGVTMGGGVGLTYGASHRIVTERTKWAMPEMNIGFFPDVGASYFFNQAPGK
IGYYLALSASVISGSDAIYANAADHYIKTDTLDTFIHEITEKDWTSETNINQTIDSIVQKFTASPGQSSLENHHSEIDEY
FSHSTLEEIITSLESTDSDFANKTKQLLLSKSPISLKVTLEQLRRGKDKSLEACFDMDLILAKNFLKSTDFYEGVRSIVI
DKDKKPNYQYKKLDDVKADLVESYFN

Sequences:

>Translated_346_residues
MEQDVVLFSEKNGIGTIELNRPKAINSLSQRMIELIHQQLTAWKNDSNIKFILFSGNGPKGFCAGGDIKTLYQAKENESK
YQQAIQFFQLEYETDALIYHYPKPILAILDGVTMGGGVGLTYGASHRIVTERTKWAMPEMNIGFFPDVGASYFFNQAPGK
IGYYLALSASVISGSDAIYANAADHYIKTDTLDTFIHEITEKDWTSETNINQTIDSIVQKFTASPGQSSLENHHSEIDEY
FSHSTLEEIITSLESTDSDFANKTKQLLLSKSPISLKVTLEQLRRGKDKSLEACFDMDLILAKNFLKSTDFYEGVRSIVI
DKDKKPNYQYKKLDDVKADLVESYFN
>Mature_346_residues
MEQDVVLFSEKNGIGTIELNRPKAINSLSQRMIELIHQQLTAWKNDSNIKFILFSGNGPKGFCAGGDIKTLYQAKENESK
YQQAIQFFQLEYETDALIYHYPKPILAILDGVTMGGGVGLTYGASHRIVTERTKWAMPEMNIGFFPDVGASYFFNQAPGK
IGYYLALSASVISGSDAIYANAADHYIKTDTLDTFIHEITEKDWTSETNINQTIDSIVQKFTASPGQSSLENHHSEIDEY
FSHSTLEEIITSLESTDSDFANKTKQLLLSKSPISLKVTLEQLRRGKDKSLEACFDMDLILAKNFLKSTDFYEGVRSIVI
DKDKKPNYQYKKLDDVKADLVESYFN

Specific function: Unknown

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=341, Percent_Identity=36.6568914956012, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI37594469, Length=299, Percent_Identity=37.123745819398, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI194097323, Length=206, Percent_Identity=30.0970873786408, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87082183, Length=196, Percent_Identity=25, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144157, Length=334, Percent_Identity=36.8263473053892, Blast_Score=235, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI25144160, Length=334, Percent_Identity=36.8263473053892, Blast_Score=235, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17540714, Length=197, Percent_Identity=23.3502538071066, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=151, Percent_Identity=27.8145695364238, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=355, Percent_Identity=33.2394366197183, Blast_Score=182, Evalue=8e-47,
Organism=Drosophila melanogaster, GI28571730, Length=346, Percent_Identity=39.5953757225434, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI28571729, Length=346, Percent_Identity=39.5953757225434, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI20129971, Length=256, Percent_Identity=26.171875, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24653477, Length=256, Percent_Identity=26.171875, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24653139, Length=182, Percent_Identity=26.3736263736264, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922422, Length=200, Percent_Identity=26, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.17

Molecular weight: Translated: 38979; Mature: 38979

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQDVVLFSEKNGIGTIELNRPKAINSLSQRMIELIHQQLTAWKNDSNIKFILFSGNGPK
CCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
GFCAGGDIKTLYQAKENESKYQQAIQFFQLEYETDALIYHYPKPILAILDGVTMGGGVGL
CEECCCCHHHHHHHHCCHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHCCCCCCCCCEE
TYGASHRIVTERTKWAMPEMNIGFFPDVGASYFFNQAPGKIGYYLALSASVISGSDAIYA
EECCCCCEEECHHHHCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEEEEHEECCCCEEEE
NAADHYIKTDTLDTFIHEITEKDWTSETNINQTIDSIVQKFTASPGQSSLENHHSEIDEY
CCCCCCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
FSHSTLEEIITSLESTDSDFANKTKQLLLSKSPISLKVTLEQLRRGKDKSLEACFDMDLI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCHHHHHHHHHH
LAKNFLKSTDFYEGVRSIVIDKDKKPNYQYKKLDDVKADLVESYFN
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEQDVVLFSEKNGIGTIELNRPKAINSLSQRMIELIHQQLTAWKNDSNIKFILFSGNGPK
CCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
GFCAGGDIKTLYQAKENESKYQQAIQFFQLEYETDALIYHYPKPILAILDGVTMGGGVGL
CEECCCCHHHHHHHHCCHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHCCCCCCCCCEE
TYGASHRIVTERTKWAMPEMNIGFFPDVGASYFFNQAPGKIGYYLALSASVISGSDAIYA
EECCCCCEEECHHHHCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEEEEHEECCCCEEEE
NAADHYIKTDTLDTFIHEITEKDWTSETNINQTIDSIVQKFTASPGQSSLENHHSEIDEY
CCCCCCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
FSHSTLEEIITSLESTDSDFANKTKQLLLSKSPISLKVTLEQLRRGKDKSLEACFDMDLI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCHHHHHHHHHH
LAKNFLKSTDFYEGVRSIVIDKDKKPNYQYKKLDDVKADLVESYFN
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3S)-3-hydroxyacyl-CoA

Specific reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]