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The map label for this gene is Hgd [H]

Identifier: 23098270

GI number: 23098270

Start: 869818

End: 870717

Strand: Direct

Name: Hgd [H]

Synonym: OB0815

Alternate gene names: 23098270

Gene position: 869818-870717 (Clockwise)

Preceding gene: 23098269

Following gene: 23098271

Centisome position: 23.96

GC content: 35.0

Gene sequence:

>900_bases
ATGTCTAAGATCGGATTTATTGGATTAGGAAACATGGGGTTACCGATGTCTATTGGTTTAATGAACAGTGGATATGAGGT
CATAGGCTTTGATGTTAACGAGGAAAGATCGCTGCTTTTTAAAAAGTCTGGAGGAAATATTGCTCTTTCGAGTGCTGACT
TAGTTGCAGAAAGTGATGTAATTCTTACTAGTTTGCCATCGAATAAAGCAGTGGAAGCTGTATATCTGAATAAAGGTGGA
TTGCTTGATCATTGTAATTCTTCACAAGTAGTGATTGATACAAGCACGGTCGCTCCTGAGTTAAATCAGCAATTGGAGGC
TTCCTTGTCAGAAAGATCAATCCCATTTTTAGCAGCTCCGGTTAGTGGTGGAGTGGTTGGTGCAGAAAACCAAACTTTAA
CGGTGATGGTTGGAGGAAAAGAAGAAACTTTTCAAAAAGTGAAAGATATTCTGAACGTTATTGGAGGAAATGTCTTTCAT
GTTGGAGAACAAATAGATAAAGGAACTACAGTAAAGCTTATCAATAATCTATTGATTGGGTTTTATACTGCAGGAGTAAG
TGAAGCACTTCAAATTGCTAATCAAAAAGATATCGATTTAAACGATTTATTTTCGATGATGAATGTTAGCTATGGACAAA
GTCGAATATATGAAAGAAACTATAAAACGTTTATAGAACCAAATGATTTTAATCCAGGGTTTGCATTAAAGTTATTAAGA
AAAGATTTAGAGTTTGCTATGGAAGTAGCGGACAATAATCAATTAGACTTGCCAATTAGTAAATCGTTACTAGATTTGTA
TAGGAATTTAGAACATCAAGGATATGGGGATCAAGATATGGCAGTACTTTATAAATATCTGAAAGATACTATTGATCAAA
ATAAGGAGGCGACGACATGA

Upstream 100 bases:

>100_bases
TATTTAGATGAAATTAAGGATTTATTAATTCCTGATTTTATTAATATCTACGAAGCAAAGGAGAATATTGCTAAATCACT
AATAAGAAAAGGGGGATATT

Downstream 100 bases:

>100_bases
TTAGTTCTGAAACAAAACACATGCAAAATTATATTAATGGGAAATGGGTAGATGCCAAAAGCGGGAAGCAAGAAGTGATT
CCTAATCCCGCAACAGGAGA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSKIGFIGLGNMGLPMSIGLMNSGYEVIGFDVNEERSLLFKKSGGNIALSSADLVAESDVILTSLPSNKAVEAVYLNKGG
LLDHCNSSQVVIDTSTVAPELNQQLEASLSERSIPFLAAPVSGGVVGAENQTLTVMVGGKEETFQKVKDILNVIGGNVFH
VGEQIDKGTTVKLINNLLIGFYTAGVSEALQIANQKDIDLNDLFSMMNVSYGQSRIYERNYKTFIEPNDFNPGFALKLLR
KDLEFAMEVADNNQLDLPISKSLLDLYRNLEHQGYGDQDMAVLYKYLKDTIDQNKEATT

Sequences:

>Translated_299_residues
MSKIGFIGLGNMGLPMSIGLMNSGYEVIGFDVNEERSLLFKKSGGNIALSSADLVAESDVILTSLPSNKAVEAVYLNKGG
LLDHCNSSQVVIDTSTVAPELNQQLEASLSERSIPFLAAPVSGGVVGAENQTLTVMVGGKEETFQKVKDILNVIGGNVFH
VGEQIDKGTTVKLINNLLIGFYTAGVSEALQIANQKDIDLNDLFSMMNVSYGQSRIYERNYKTFIEPNDFNPGFALKLLR
KDLEFAMEVADNNQLDLPISKSLLDLYRNLEHQGYGDQDMAVLYKYLKDTIDQNKEATT
>Mature_298_residues
SKIGFIGLGNMGLPMSIGLMNSGYEVIGFDVNEERSLLFKKSGGNIALSSADLVAESDVILTSLPSNKAVEAVYLNKGGL
LDHCNSSQVVIDTSTVAPELNQQLEASLSERSIPFLAAPVSGGVVGAENQTLTVMVGGKEETFQKVKDILNVIGGNVFHV
GEQIDKGTTVKLINNLLIGFYTAGVSEALQIANQKDIDLNDLFSMMNVSYGQSRIYERNYKTFIEPNDFNPGFALKLLRK
DLEFAMEVADNNQLDLPISKSLLDLYRNLEHQGYGDQDMAVLYKYLKDTIDQNKEATT

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=297, Percent_Identity=30.6397306397306, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=25.0883392226148, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI145693186, Length=284, Percent_Identity=32.0422535211268, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=32.3024054982818, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789092, Length=283, Percent_Identity=26.8551236749117, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=26.0416666666667, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17557316, Length=298, Percent_Identity=31.5436241610738, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=33.6769759450172, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=33.6769759450172, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=22.7758007117438, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 32647; Mature: 32515

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIGFIGLGNMGLPMSIGLMNSGYEVIGFDVNEERSLLFKKSGGNIALSSADLVAESDV
CCCCEEEEECCCCCCEEEEEECCCCEEEEECCCCCCEEEEEECCCCEEEECCCCEECCCE
ILTSLPSNKAVEAVYLNKGGLLDHCNSSQVVIDTSTVAPELNQQLEASLSERSIPFLAAP
EEEECCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEC
VSGGVVGAENQTLTVMVGGKEETFQKVKDILNVIGGNVFHVGEQIDKGTTVKLINNLLIG
CCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECHHCCCCCHHHHHHHHHHH
FYTAGVSEALQIANQKDIDLNDLFSMMNVSYGQSRIYERNYKTFIEPNDFNPGFALKLLR
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCEEECCCCCCCHHHHHHHH
KDLEFAMEVADNNQLDLPISKSLLDLYRNLEHQGYGDQDMAVLYKYLKDTIDQNKEATT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SKIGFIGLGNMGLPMSIGLMNSGYEVIGFDVNEERSLLFKKSGGNIALSSADLVAESDV
CCCEEEEECCCCCCEEEEEECCCCEEEEECCCCCCEEEEEECCCCEEEECCCCEECCCE
ILTSLPSNKAVEAVYLNKGGLLDHCNSSQVVIDTSTVAPELNQQLEASLSERSIPFLAAP
EEEECCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEC
VSGGVVGAENQTLTVMVGGKEETFQKVKDILNVIGGNVFHVGEQIDKGTTVKLINNLLIG
CCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECHHCCCCCHHHHHHHHHHH
FYTAGVSEALQIANQKDIDLNDLFSMMNVSYGQSRIYERNYKTFIEPNDFNPGFALKLLR
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCEEECCCCCCCHHHHHHHH
KDLEFAMEVADNNQLDLPISKSLLDLYRNLEHQGYGDQDMAVLYKYLKDTIDQNKEATT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA