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The map label for this gene is fadE [H]

Identifier: 23098269

GI number: 23098269

Start: 868128

End: 869825

Strand: Direct

Name: fadE [H]

Synonym: OB0814

Alternate gene names: 23098269

Gene position: 868128-869825 (Clockwise)

Preceding gene: 23098268

Following gene: 23098270

Centisome position: 23.91

GC content: 34.81

Gene sequence:

>1698_bases
TTGGCATGCTTTTTGCATGTATATAATTGGAAGGAGGTTTTAAGAATGAAACTTACTGATAAGAGATCTTTGTTCCCTGA
TGAAAGGGGATTAGAAGTAGACAGCTATTCAATCAATTTAAATGAAGACGAACAACTAATTTCTAAAACGATACATCAAT
TAGTGGAAGAGAAAATTTTGCCTAATATGGACCAATTAGAAGATCATGACTATACGTTACAGAAAAAGAGAATGAAAGAA
GTTGGACAATTAGGGTTAATGGGTGCAGAAGTCCCGGAAGAATATGGTGGACTTGAAGCTGGAAAACGAATGTCTGGCAT
TATTGCAGAAAAAATGGGATATGCTGCTTCCTTCAGTGTAGCATTTAATATTCACTCTGGTGTTGGTACGTTACCGTATG
TTTATTTCGGCAATGAGGCTCAAAAAAATCAATATTTACCAAAACTTGCTTCAGGTGAATGGGTTGGAGCATATGCATTA
ACAGAACCAAATGCCGGATCAGATGCATTGGCTTCCAAAACGACAGCAAAATGGAATGACGAGAACCAGACATGGACTAT
CAATGGAGAGAAGCAATGGATTACAAATGCACATATTGCAAATGTATATGTGGTATTTGCGAATACAGAACAAGGTATTA
CGGCCTTTATTGTTGAAAGAACATTTAAAGGGGTATCTATAGGGCCTGAAGAGAAGAAATTAGGTATCAAAGGTTCATCC
ACAGCGACATTAATTTTAGAGGATGTAGAATTAGATTCTGCACAAGTTCTAGGTGAAGTTGGAAAAGGTCATCGTATCGC
ATTAAATATACTAAATCTAGCAAGATTGAAAATTGCTTTCTCCAACATAGGCATGTCGAAACAAGCACTAGAATTTGCTA
TTAAATATGGTAAAGACCGTCAACAGTTTGGCAAAAATATTGTTGAGTTTGGATTAATCCAAGAAAAAATAGCAAATATG
GCTACAGCTATCTATAAGTCAGAGTGTACGGCATACTACACTGCTAGTTTGCTTGATCGACAATTGATAGATAATGGTAA
AGAAAATTTTATTTCATCGCTTGCTCGTTTTTCTATGGATTGTTCCATCAACAAAGTGCTCGCATCTGAATCGCTTGATA
TGATAGTAGATGAGGCATTACAAATCCATGGTGGATATGGTTATATGCAAGAATATGAGGTAGAAAGATTATATCGCGAT
TCGAGGATCAATCGATTGTTTGAAGGAACATCTGAAATCAATCGTTTAACAATTGCGAAATCATTTTTAAAACAGTACGA
TGAAGAGAAACTAAATGAAGAGATAAGATTAGAGCAAAGTGTATACATTCGACAAGGGATAATATTATTAAACAAAATGT
TGAAAGCGGTTACTTCAAGTGATAGGGAAACAAAACAAATGTATCAAGGGGTAATTGCGGATACAGTGATGGATGTATAT
GCAATGAAAACAGCTGAGATGAATAGTGATCACTCCGAAGTAACGAAGCATATGACTCAAATTATATTAGAAGAGAATTT
ACAACGAATTCTTGAAAGAACCAAACGTATCATTGTAGCTCTAGAGGGTGATGATTTAGAAAAAAGCCGTTATTTAGATG
AAATTAAGGATTTATTAATTCCTGATTTTATTAATATCTACGAAGCAAAGGAGAATATTGCTAAATCACTAATAAGAAAA
GGGGGATATTATGTCTAA

Upstream 100 bases:

>100_bases
ACTTGAATAAACATGTCAAATTAGGCAGTTTTGACATTGAGTGTCTATACAATTTGACAATATAATACCTTGAATGTAGG
GGAAGTGACTTCAATTTGAG

Downstream 100 bases:

>100_bases
GATCGGATTTATTGGATTAGGAAACATGGGGTTACCGATGTCTATTGGTTTAATGAACAGTGGATATGAGGTCATAGGCT
TTGATGTTAACGAGGAAAGA

Product: butyryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MACFLHVYNWKEVLRMKLTDKRSLFPDERGLEVDSYSINLNEDEQLISKTIHQLVEEKILPNMDQLEDHDYTLQKKRMKE
VGQLGLMGAEVPEEYGGLEAGKRMSGIIAEKMGYAASFSVAFNIHSGVGTLPYVYFGNEAQKNQYLPKLASGEWVGAYAL
TEPNAGSDALASKTTAKWNDENQTWTINGEKQWITNAHIANVYVVFANTEQGITAFIVERTFKGVSIGPEEKKLGIKGSS
TATLILEDVELDSAQVLGEVGKGHRIALNILNLARLKIAFSNIGMSKQALEFAIKYGKDRQQFGKNIVEFGLIQEKIANM
ATAIYKSECTAYYTASLLDRQLIDNGKENFISSLARFSMDCSINKVLASESLDMIVDEALQIHGGYGYMQEYEVERLYRD
SRINRLFEGTSEINRLTIAKSFLKQYDEEKLNEEIRLEQSVYIRQGIILLNKMLKAVTSSDRETKQMYQGVIADTVMDVY
AMKTAEMNSDHSEVTKHMTQIILEENLQRILERTKRIIVALEGDDLEKSRYLDEIKDLLIPDFINIYEAKENIAKSLIRK
GGYYV

Sequences:

>Translated_565_residues
MACFLHVYNWKEVLRMKLTDKRSLFPDERGLEVDSYSINLNEDEQLISKTIHQLVEEKILPNMDQLEDHDYTLQKKRMKE
VGQLGLMGAEVPEEYGGLEAGKRMSGIIAEKMGYAASFSVAFNIHSGVGTLPYVYFGNEAQKNQYLPKLASGEWVGAYAL
TEPNAGSDALASKTTAKWNDENQTWTINGEKQWITNAHIANVYVVFANTEQGITAFIVERTFKGVSIGPEEKKLGIKGSS
TATLILEDVELDSAQVLGEVGKGHRIALNILNLARLKIAFSNIGMSKQALEFAIKYGKDRQQFGKNIVEFGLIQEKIANM
ATAIYKSECTAYYTASLLDRQLIDNGKENFISSLARFSMDCSINKVLASESLDMIVDEALQIHGGYGYMQEYEVERLYRD
SRINRLFEGTSEINRLTIAKSFLKQYDEEKLNEEIRLEQSVYIRQGIILLNKMLKAVTSSDRETKQMYQGVIADTVMDVY
AMKTAEMNSDHSEVTKHMTQIILEENLQRILERTKRIIVALEGDDLEKSRYLDEIKDLLIPDFINIYEAKENIAKSLIRK
GGYYV
>Mature_564_residues
ACFLHVYNWKEVLRMKLTDKRSLFPDERGLEVDSYSINLNEDEQLISKTIHQLVEEKILPNMDQLEDHDYTLQKKRMKEV
GQLGLMGAEVPEEYGGLEAGKRMSGIIAEKMGYAASFSVAFNIHSGVGTLPYVYFGNEAQKNQYLPKLASGEWVGAYALT
EPNAGSDALASKTTAKWNDENQTWTINGEKQWITNAHIANVYVVFANTEQGITAFIVERTFKGVSIGPEEKKLGIKGSST
ATLILEDVELDSAQVLGEVGKGHRIALNILNLARLKIAFSNIGMSKQALEFAIKYGKDRQQFGKNIVEFGLIQEKIANMA
TAIYKSECTAYYTASLLDRQLIDNGKENFISSLARFSMDCSINKVLASESLDMIVDEALQIHGGYGYMQEYEVERLYRDS
RINRLFEGTSEINRLTIAKSFLKQYDEEKLNEEIRLEQSVYIRQGIILLNKMLKAVTSSDRETKQMYQGVIADTVMDVYA
MKTAEMNSDHSEVTKHMTQIILEENLQRILERTKRIIVALEGDDLEKSRYLDEIKDLLIPDFINIYEAKENIAKSLIRKG
GYYV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=40.0544959128065, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI4557233, Length=413, Percent_Identity=36.5617433414044, Blast_Score=259, Evalue=6e-69,
Organism=Homo sapiens, GI4557235, Length=404, Percent_Identity=37.6237623762376, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI76496475, Length=404, Percent_Identity=37.6237623762376, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI226958412, Length=434, Percent_Identity=31.3364055299539, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI4501859, Length=394, Percent_Identity=33.248730964467, Blast_Score=212, Evalue=9e-55,
Organism=Homo sapiens, GI226958414, Length=385, Percent_Identity=32.987012987013, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI187960098, Length=404, Percent_Identity=31.1881188118812, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI4557231, Length=404, Percent_Identity=31.1881188118812, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI7656849, Length=394, Percent_Identity=29.9492385786802, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI4501857, Length=392, Percent_Identity=29.5918367346939, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI4503943, Length=386, Percent_Identity=31.0880829015544, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI7669494, Length=360, Percent_Identity=31.9444444444444, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI38505218, Length=332, Percent_Identity=24.3975903614458, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1786223, Length=395, Percent_Identity=28.1012658227848, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI87081958, Length=396, Percent_Identity=28.7878787878788, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87082384, Length=305, Percent_Identity=23.9344262295082, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081702, Length=352, Percent_Identity=25.8522727272727, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=401, Percent_Identity=35.1620947630923, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17538396, Length=402, Percent_Identity=32.5870646766169, Blast_Score=215, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17508101, Length=387, Percent_Identity=32.8165374677003, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17506239, Length=393, Percent_Identity=32.5699745547074, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71985192, Length=322, Percent_Identity=34.472049689441, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17569725, Length=400, Percent_Identity=29.25, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17534899, Length=399, Percent_Identity=30.0751879699248, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17533517, Length=395, Percent_Identity=29.1139240506329, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17570075, Length=424, Percent_Identity=28.0660377358491, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=37.4517374517375, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17534353, Length=413, Percent_Identity=30.5084745762712, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32563615, Length=258, Percent_Identity=37.2093023255814, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17505929, Length=389, Percent_Identity=28.0205655526992, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71982178, Length=285, Percent_Identity=29.8245614035088, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17551932, Length=389, Percent_Identity=27.7634961439589, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17531909, Length=253, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI86563381, Length=287, Percent_Identity=24.0418118466899, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86563383, Length=287, Percent_Identity=24.0418118466899, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540912, Length=271, Percent_Identity=23.9852398523985, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21356377, Length=414, Percent_Identity=36.7149758454106, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI281363737, Length=415, Percent_Identity=35.6626506024096, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24646207, Length=398, Percent_Identity=34.1708542713568, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24666513, Length=393, Percent_Identity=33.0788804071247, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24660351, Length=398, Percent_Identity=33.4170854271357, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI21355753, Length=404, Percent_Identity=31.1881188118812, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI19920834, Length=387, Percent_Identity=29.9741602067183, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24652780, Length=308, Percent_Identity=25.3246753246753, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45550141, Length=344, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221473076, Length=344, Percent_Identity=25, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281365206, Length=493, Percent_Identity=22.7180527383367, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585193, Length=493, Percent_Identity=22.7180527383367, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585195, Length=493, Percent_Identity=22.7180527383367, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585191, Length=493, Percent_Identity=22.7180527383367, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 64018; Mature: 63887

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACFLHVYNWKEVLRMKLTDKRSLFPDERGLEVDSYSINLNEDEQLISKTIHQLVEEKIL
CEEEEEECCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHC
PNMDQLEDHDYTLQKKRMKEVGQLGLMGAEVPEEYGGLEAGKRMSGIIAEKMGYAASFSV
CCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCEEEEE
AFNIHSGVGTLPYVYFGNEAQKNQYLPKLASGEWVGAYALTEPNAGSDALASKTTAKWND
EEEECCCCCCCCEEEECCCHHCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCCCCC
ENQTWTINGEKQWITNAHIANVYVVFANTEQGITAFIVERTFKGVSIGPEEKKLGIKGSS
CCCEEEECCCCEEECCCEEEEEEEEEECCCCCCEEHEEHHHCCCCCCCCCCCCCCCCCCC
TATLILEDVELDSAQVLGEVGKGHRIALNILNLARLKIAFSNIGMSKQALEFAIKYGKDR
CEEEEEEECCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
QQFGKNIVEFGLIQEKIANMATAIYKSECTAYYTASLLDRQLIDNGKENFISSLARFSMD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
CSINKVLASESLDMIVDEALQIHGGYGYMQEYEVERLYRDSRINRLFEGTSEINRLTIAK
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
SFLKQYDEEKLNEEIRLEQSVYIRQGIILLNKMLKAVTSSDRETKQMYQGVIADTVMDVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AMKTAEMNSDHSEVTKHMTQIILEENLQRILERTKRIIVALEGDDLEKSRYLDEIKDLLI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHH
PDFINIYEAKENIAKSLIRKGGYYV
HHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ACFLHVYNWKEVLRMKLTDKRSLFPDERGLEVDSYSINLNEDEQLISKTIHQLVEEKIL
EEEEEECCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHC
PNMDQLEDHDYTLQKKRMKEVGQLGLMGAEVPEEYGGLEAGKRMSGIIAEKMGYAASFSV
CCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCEEEEE
AFNIHSGVGTLPYVYFGNEAQKNQYLPKLASGEWVGAYALTEPNAGSDALASKTTAKWND
EEEECCCCCCCCEEEECCCHHCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCCCCC
ENQTWTINGEKQWITNAHIANVYVVFANTEQGITAFIVERTFKGVSIGPEEKKLGIKGSS
CCCEEEECCCCEEECCCEEEEEEEEEECCCCCCEEHEEHHHCCCCCCCCCCCCCCCCCCC
TATLILEDVELDSAQVLGEVGKGHRIALNILNLARLKIAFSNIGMSKQALEFAIKYGKDR
CEEEEEEECCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
QQFGKNIVEFGLIQEKIANMATAIYKSECTAYYTASLLDRQLIDNGKENFISSLARFSMD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
CSINKVLASESLDMIVDEALQIHGGYGYMQEYEVERLYRDSRINRLFEGTSEINRLTIAK
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
SFLKQYDEEKLNEEIRLEQSVYIRQGIILLNKMLKAVTSSDRETKQMYQGVIADTVMDVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AMKTAEMNSDHSEVTKHMTQIILEENLQRILERTKRIIVALEGDDLEKSRYLDEIKDLLI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHH
PDFINIYEAKENIAKSLIRKGGYYV
HHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]