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The map label for this gene is yiaE [C]

Identifier: 23098172

GI number: 23098172

Start: 762858

End: 763316

Strand: Direct

Name: yiaE [C]

Synonym: OB0717

Alternate gene names: 23098172

Gene position: 762858-763316 (Clockwise)

Preceding gene: 23098171

Following gene: 23098175

Centisome position: 21.01

GC content: 35.95

Gene sequence:

>459_bases
GTGGAGAAAGAAATTGGAATTAATTATGTAGATTTCGATACATTAATTCAAACTTCCGATGTCATAATTGTTCAAACTCC
ACTAACGAAAGATACGAAGAATAAGTTTGATAAAAATGTAATCAGCCAAATGAAAGATGATGCAGTTCTAGTTAATTGTG
CCAGAGGTGGCATCGTTGAAAAAGAAGCACTAGCGGAAGCTGTGAAAGACGGTAAAATTCGTTATGGTGGGGATGTATGG
TATCCACAGCCTGCGCCAAAAGATCATCCATGGCGTGCAATAGAACAAACTGGACTTACGGTTCACTATTCTGGTATGAC
TGTAGAAGCGCAAGAAAGAATTCAAACAGGAGTACAGGAAATTCTCACTAGTTATATGAATAATAACCCAATTAACGATT
CGTATTTAATCGTAGATAATCATAAAATTGCAAACCAAAGTTATCAAACACAAAGCTAA

Upstream 100 bases:

>100_bases
AAGGAGAATGGGACTTACCTAAAGTTGGTGCAAGAGCACATGATATGATAGGTAAAAAAATCGGCATCTTTAATATCATG
ACCCATATCGAAAAGAAGAT

Downstream 100 bases:

>100_bases
TTGTTGTACTCACATTATGAACCAAAAAAAGCCTTTGCTTCAGTTTCTAGAAGCAAAGGCTTTAAAGTTATCTATTTTTA
AAAAGACTCTCTTTAGCTAG

Product: hypothetical protein

Products: NA

Alternate protein names: NAD-dependent formate dehydrogenase; FDH [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MEKEIGINYVDFDTLIQTSDVIIVQTPLTKDTKNKFDKNVISQMKDDAVLVNCARGGIVEKEALAEAVKDGKIRYGGDVW
YPQPAPKDHPWRAIEQTGLTVHYSGMTVEAQERIQTGVQEILTSYMNNNPINDSYLIVDNHKIANQSYQTQS

Sequences:

>Translated_152_residues
MEKEIGINYVDFDTLIQTSDVIIVQTPLTKDTKNKFDKNVISQMKDDAVLVNCARGGIVEKEALAEAVKDGKIRYGGDVW
YPQPAPKDHPWRAIEQTGLTVHYSGMTVEAQERIQTGVQEILTSYMNNNPINDSYLIVDNHKIANQSYQTQS
>Mature_152_residues
MEKEIGINYVDFDTLIQTSDVIIVQTPLTKDTKNKFDKNVISQMKDDAVLVNCARGGIVEKEALAEAVKDGKIRYGGDVW
YPQPAPKDHPWRAIEQTGLTVHYSGMTVEAQERIQTGVQEILTSYMNNNPINDSYLIVDNHKIANQSYQTQS

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082289, Length=111, Percent_Identity=31.5315315315315, Blast_Score=68, Evalue=3e-13,
Organism=Escherichia coli, GI1787645, Length=78, Percent_Identity=38.4615384615385, Blast_Score=61, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324964, Length=144, Percent_Identity=45.1388888888889, Blast_Score=124, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6324980, Length=144, Percent_Identity=45.1388888888889, Blast_Score=123, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=120, Percent_Identity=32.5, Blast_Score=71, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45551003, Length=90, Percent_Identity=46.6666666666667, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574284, Length=90, Percent_Identity=46.6666666666667, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571528, Length=111, Percent_Identity=34.2342342342342, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45552429, Length=90, Percent_Identity=46.6666666666667, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585514, Length=90, Percent_Identity=46.6666666666667, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574282, Length=90, Percent_Identity=46.6666666666667, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574286, Length=103, Percent_Identity=38.8349514563107, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585516, Length=102, Percent_Identity=35.2941176470588, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=150, Percent_Identity=30, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 17117; Mature: 17117

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEIGINYVDFDTLIQTSDVIIVQTPLTKDTKNKFDKNVISQMKDDAVLVNCARGGIVE
CCCCCCCEEECHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCC
KEALAEAVKDGKIRYGGDVWYPQPAPKDHPWRAIEQTGLTVHYSGMTVEAQERIQTGVQE
HHHHHHHHHCCCEEECCCEECCCCCCCCCCCHHHHHCCCEEEECCEEEHHHHHHHHHHHH
ILTSYMNNNPINDSYLIVDNHKIANQSYQTQS
HHHHHHCCCCCCCCEEEEECCEECCCCCCCCC
>Mature Secondary Structure
MEKEIGINYVDFDTLIQTSDVIIVQTPLTKDTKNKFDKNVISQMKDDAVLVNCARGGIVE
CCCCCCCEEECHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCC
KEALAEAVKDGKIRYGGDVWYPQPAPKDHPWRAIEQTGLTVHYSGMTVEAQERIQTGVQE
HHHHHHHHHCCCEEECCCEECCCCCCCCCCCHHHHHCCCEEEECCEEEHHHHHHHHHHHH
ILTSYMNNNPINDSYLIVDNHKIANQSYQTQS
HHHHHHCCCCCCCCEEEEECCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1954846; 2357236; 1597184; 8484798 [H]