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The map label for this gene is hisD

Identifier: 23098006

GI number: 23098006

Start: 582683

End: 583966

Strand: Reverse

Name: hisD

Synonym: OB0551

Alternate gene names: 23098006

Gene position: 583966-582683 (Counterclockwise)

Preceding gene: 23098007

Following gene: 23098005

Centisome position: 16.08

GC content: 38.47

Gene sequence:

>1284_bases
ATGGAAATACTTTCTTTACATCAATGGAAGCAACAACAGGATACAAAGTCTTCTACTATTCGGAACAAACAAGTCGATCA
AGATGTACTTCGCATTATTGAACAAGTCCAAATACAAGGGGATGAAGCATTAAAACACTATACGCTTCAATTTGACCAAG
TTAATCTAAATTCATTTGAGGTTACGAGTAACGAATGGGAACAAGCGATCAAAAAAGTAGATTCTACATTATTAGATGCT
TTAGAGACCGCAGCTGGAAATATCCAACGCTATCAATCTGAAATGCTAGAATCCAACTGGTCAATTACTCCAGAAACAGG
AGTGAAACTAGGTCAACAAGTAAACCCGCTTGATCGTGTAGGGATTTATATTCCTGGTGGAAAAGCAAGCTACCCTTCTA
CGGTATTAATGGATGCAATTCCAGCAAAGGTCGCCGGAGTGAAGGAGATTATCATTACCTCTCCACCTAATAAAAATGGA
GAAATAGATCCAGTAGTTTTAGCTGCAGCAAAAATTGCGGGAGTTACTAAGGTGTATAAAGTTGGTGGAGCTCAAGCAAT
TGCAGCACTTACCTACGGAACTGAAACGATTCCTAGTGTCGATAAAATTGTCGGCCCAGGTAATATATATGTTACCAGAG
CAAAGAAATGGGTATTTGGAGATATAGCGATTGACATGATAGCCGGACCTAGCGAGATTTGTATTTTTGCAGATTCCAGT
GCTCCTGTTCCCTATGTTGCAGCAGATCTACTTTCACAAGCCGAACACGATGAAGAAGCATCTTCTCTTTGTATTACTAC
TGACCGTTCCTTTGCGAAATTATTGCAGGAGGAAGTAAATCGTCAAATTCCTTTATTAGAACGAAAAGAAATCATTGAAG
CTTCTATTTCTCAAAATGGAAAGATCATCATTTGCGATAACAATGAAGAAGCGATTAACACTATCAATCAACTAGCACCA
GAACATTTACAATTAATGACGATTGATTCAGAACAACTCTGCCCAAAAATTAAGCATGCCGGTGCAATATTTATCGGCAA
TTATTCTAGCGAACCATTAGGTGATTATTTTGCCGGGCCAAGTCATACATTACCCACTAATGGCACAGCTAAATTTTCTT
CTCCACTTGGAGTCTATGATTTTGTTAAAAAAACGAGTCTAATCCAATACTCTAAAAACAAATTAGCAGAAGCTGCAGAT
ACAATAATTACACTTGCAGAAGCGGAAGGCCTAACAGCACATGCAAATGCAATCCGTATTCGAAAGGAGAATGACAATGC
GTAA

Upstream 100 bases:

>100_bases
TTAGTACAAAAGCAATCGTGAATAAAGCTAGCTTCGCAACACGTTCTGCTGAAATACAAAGCATCATTAATCGATTAAGT
ACAGTAGTGGGGTGAAAAAC

Downstream 100 bases:

>100_bases
AGCATCTTTAAGCAGAAAAACCAATGAGACATCTGTTCATTTAACTCTAGAATTAGATGGAGAAGGAACATCTACTATCG
AAACAGGAATAGGTTTCTTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MEILSLHQWKQQQDTKSSTIRNKQVDQDVLRIIEQVQIQGDEALKHYTLQFDQVNLNSFEVTSNEWEQAIKKVDSTLLDA
LETAAGNIQRYQSEMLESNWSITPETGVKLGQQVNPLDRVGIYIPGGKASYPSTVLMDAIPAKVAGVKEIIITSPPNKNG
EIDPVVLAAAKIAGVTKVYKVGGAQAIAALTYGTETIPSVDKIVGPGNIYVTRAKKWVFGDIAIDMIAGPSEICIFADSS
APVPYVAADLLSQAEHDEEASSLCITTDRSFAKLLQEEVNRQIPLLERKEIIEASISQNGKIIICDNNEEAINTINQLAP
EHLQLMTIDSEQLCPKIKHAGAIFIGNYSSEPLGDYFAGPSHTLPTNGTAKFSSPLGVYDFVKKTSLIQYSKNKLAEAAD
TIITLAEAEGLTAHANAIRIRKENDNA

Sequences:

>Translated_427_residues
MEILSLHQWKQQQDTKSSTIRNKQVDQDVLRIIEQVQIQGDEALKHYTLQFDQVNLNSFEVTSNEWEQAIKKVDSTLLDA
LETAAGNIQRYQSEMLESNWSITPETGVKLGQQVNPLDRVGIYIPGGKASYPSTVLMDAIPAKVAGVKEIIITSPPNKNG
EIDPVVLAAAKIAGVTKVYKVGGAQAIAALTYGTETIPSVDKIVGPGNIYVTRAKKWVFGDIAIDMIAGPSEICIFADSS
APVPYVAADLLSQAEHDEEASSLCITTDRSFAKLLQEEVNRQIPLLERKEIIEASISQNGKIIICDNNEEAINTINQLAP
EHLQLMTIDSEQLCPKIKHAGAIFIGNYSSEPLGDYFAGPSHTLPTNGTAKFSSPLGVYDFVKKTSLIQYSKNKLAEAAD
TIITLAEAEGLTAHANAIRIRKENDNA
>Mature_427_residues
MEILSLHQWKQQQDTKSSTIRNKQVDQDVLRIIEQVQIQGDEALKHYTLQFDQVNLNSFEVTSNEWEQAIKKVDSTLLDA
LETAAGNIQRYQSEMLESNWSITPETGVKLGQQVNPLDRVGIYIPGGKASYPSTVLMDAIPAKVAGVKEIIITSPPNKNG
EIDPVVLAAAKIAGVTKVYKVGGAQAIAALTYGTETIPSVDKIVGPGNIYVTRAKKWVFGDIAIDMIAGPSEICIFADSS
APVPYVAADLLSQAEHDEEASSLCITTDRSFAKLLQEEVNRQIPLLERKEIIEASISQNGKIIICDNNEEAINTINQLAP
EHLQLMTIDSEQLCPKIKHAGAIFIGNYSSEPLGDYFAGPSHTLPTNGTAKFSSPLGVYDFVKKTSLIQYSKNKLAEAAD
TIITLAEAEGLTAHANAIRIRKENDNA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=403, Percent_Identity=39.7022332506204, Blast_Score=293, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=398, Percent_Identity=38.6934673366834, Blast_Score=271, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_OCEIH (Q8ESR8)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691472.1
- ProteinModelPortal:   Q8ESR8
- SMR:   Q8ESR8
- GeneID:   1015849
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0551
- NMPDR:   fig|221109.1.peg.554
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- BioCyc:   OIHE221109:OB0551-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46545; Mature: 46545

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 321-321 ACT_SITE 322-322 BINDING 123-123 BINDING 185-185 BINDING 208-208 BINDING 231-231 BINDING 253-253 BINDING 256-256 BINDING 322-322 BINDING 355-355 BINDING 409-409 BINDING 414-414

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILSLHQWKQQQDTKSSTIRNKQVDQDVLRIIEQVQIQGDEALKHYTLQFDQVNLNSFE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEEECCCEEE
VTSNEWEQAIKKVDSTLLDALETAAGNIQRYQSEMLESNWSITPETGVKLGQQVNPLDRV
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHC
GIYIPGGKASYPSTVLMDAIPAKVAGVKEIIITSPPNKNGEIDPVVLAAAKIAGVTKVYK
EEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
VGGAQAIAALTYGTETIPSVDKIVGPGNIYVTRAKKWVFGDIAIDMIAGPSEICIFADSS
CCCCCEEEEEECCCCCCCCHHHHCCCCCEEEEECCEEEEEEEEEEEECCCCEEEEEECCC
APVPYVAADLLSQAEHDEEASSLCITTDRSFAKLLQEEVNRQIPLLERKEIIEASISQNG
CCCHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
KIIICDNNEEAINTINQLAPEHLQLMTIDSEQLCPKIKHAGAIFIGNYSSEPLGDYFAGP
EEEEECCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCEEEEECCCCCCCCHHCCCC
SHTLPTNGTAKFSSPLGVYDFVKKTSLIQYSKNKLAEAADTIITLAEAEGLTAHANAIRI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEECCEEEE
RKENDNA
EECCCCC
>Mature Secondary Structure
MEILSLHQWKQQQDTKSSTIRNKQVDQDVLRIIEQVQIQGDEALKHYTLQFDQVNLNSFE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEEECCCEEE
VTSNEWEQAIKKVDSTLLDALETAAGNIQRYQSEMLESNWSITPETGVKLGQQVNPLDRV
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHC
GIYIPGGKASYPSTVLMDAIPAKVAGVKEIIITSPPNKNGEIDPVVLAAAKIAGVTKVYK
EEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
VGGAQAIAALTYGTETIPSVDKIVGPGNIYVTRAKKWVFGDIAIDMIAGPSEICIFADSS
CCCCCEEEEEECCCCCCCCHHHHCCCCCEEEEECCEEEEEEEEEEEECCCCEEEEEECCC
APVPYVAADLLSQAEHDEEASSLCITTDRSFAKLLQEEVNRQIPLLERKEIIEASISQNG
CCCHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
KIIICDNNEEAINTINQLAPEHLQLMTIDSEQLCPKIKHAGAIFIGNYSSEPLGDYFAGP
EEEEECCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCEEEEECCCCCCCCHHCCCC
SHTLPTNGTAKFSSPLGVYDFVKKTSLIQYSKNKLAEAADTIITLAEAEGLTAHANAIRI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEECCEEEE
RKENDNA
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376