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The map label for this gene is hisG

Identifier: 23098007

GI number: 23098007

Start: 583972

End: 584598

Strand: Reverse

Name: hisG

Synonym: OB0552

Alternate gene names: 23098007

Gene position: 584598-583972 (Counterclockwise)

Preceding gene: 23098008

Following gene: 23098006

Centisome position: 16.1

GC content: 37.16

Gene sequence:

>627_bases
ATGCAACCTGTTACCATTGCTCTAGCGAAAGGAAGACCAGCGAAACAAACCATTAAGTTACTCCAAGCTGCAGGGTTAAC
ATTTGAAGAACTAGATGCAACGTCAAGAAAACTTGTATTTTACAATGAAGATCGTACTGCACGGGTCATATTTCTAAAAG
GAATGGATGTACCTATTTACGTTGAAAAAGGTGCGGCTGATATCGGAATTGTCGGTAAAGACAATATCATCGAATCCCAA
GCAGAAGTTTACGAGTTACTTGACCTTGGCATTGGTAAATGTAAGTTCTCTATTGCAGCTAAGCAAGGAGTAACACTTTC
TTCCGATAATGAAATCACTATTGCAACAAAATATCCAATTGTAGCTAAGCGATATTTTAGTAAAAGAAACCAATCGATAG
ATGTCGTAAAACTAAATGGATCTGTTGAACTAGCTCCCCTAATCGGACTGGCAGATTATATTGTAGACATTGTCGAAACA
GGAAATACATTAAGAGAAAATGGGTTAGAAATTCTTGAAGATATTGAGACAATTAGTACAAAAGCAATCGTGAATAAAGC
TAGCTTCGCAACACGTTCTGCTGAAATACAAAGCATCATTAATCGATTAAGTACAGTAGTGGGGTGA

Upstream 100 bases:

>100_bases
TAGATTCAAATAGTTACCAACTAAAGAGTTCAGATATACAAACAACATTTTCATCCATTGATCAAACATTACAACATGTA
TTAAAAAAGAGGTGAACATA

Downstream 100 bases:

>100_bases
AAAACATGGAAATACTTTCTTTACATCAATGGAAGCAACAACAGGATACAAAGTCTTCTACTATTCGGAACAAACAAGTC
GATCAAGATGTACTTCGCAT

Product: ATP-phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MQPVTIALAKGRPAKQTIKLLQAAGLTFEELDATSRKLVFYNEDRTARVIFLKGMDVPIYVEKGAADIGIVGKDNIIESQ
AEVYELLDLGIGKCKFSIAAKQGVTLSSDNEITIATKYPIVAKRYFSKRNQSIDVVKLNGSVELAPLIGLADYIVDIVET
GNTLRENGLEILEDIETISTKAIVNKASFATRSAEIQSIINRLSTVVG

Sequences:

>Translated_208_residues
MQPVTIALAKGRPAKQTIKLLQAAGLTFEELDATSRKLVFYNEDRTARVIFLKGMDVPIYVEKGAADIGIVGKDNIIESQ
AEVYELLDLGIGKCKFSIAAKQGVTLSSDNEITIATKYPIVAKRYFSKRNQSIDVVKLNGSVELAPLIGLADYIVDIVET
GNTLRENGLEILEDIETISTKAIVNKASFATRSAEIQSIINRLSTVVG
>Mature_208_residues
MQPVTIALAKGRPAKQTIKLLQAAGLTFEELDATSRKLVFYNEDRTARVIFLKGMDVPIYVEKGAADIGIVGKDNIIESQ
AEVYELLDLGIGKCKFSIAAKQGVTLSSDNEITIATKYPIVAKRYFSKRNQSIDVVKLNGSVELAPLIGLADYIVDIVET
GNTLRENGLEILEDIETISTKAIVNKASFATRSAEIQSIINRLSTVVG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=224, Percent_Identity=31.6964285714286, Blast_Score=87, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=169, Percent_Identity=28.9940828402367, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_OCEIH (Q8ESR7)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691473.1
- ProteinModelPortal:   Q8ESR7
- SMR:   Q8ESR7
- GeneID:   1015850
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0552
- NMPDR:   fig|221109.1.peg.555
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- BioCyc:   OIHE221109:OB0552-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 22633; Mature: 22633

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPVTIALAKGRPAKQTIKLLQAAGLTFEELDATSRKLVFYNEDRTARVIFLKGMDVPIY
CCCEEEEEECCCCHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCCEEEEEEEECCCCEEE
VEKGAADIGIVGKDNIIESQAEVYELLDLGIGKCKFSIAAKQGVTLSSDNEITIATKYPI
EECCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCEEEEECCCH
VAKRYFSKRNQSIDVVKLNGSVELAPLIGLADYIVDIVETGNTLRENGLEILEDIETIST
HHHHHHHHCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KAIVNKASFATRSAEIQSIINRLSTVVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQPVTIALAKGRPAKQTIKLLQAAGLTFEELDATSRKLVFYNEDRTARVIFLKGMDVPIY
CCCEEEEEECCCCHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCCEEEEEEEECCCCEEE
VEKGAADIGIVGKDNIIESQAEVYELLDLGIGKCKFSIAAKQGVTLSSDNEITIATKYPI
EECCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCEEEEECCCH
VAKRYFSKRNQSIDVVKLNGSVELAPLIGLADYIVDIVETGNTLRENGLEILEDIETIST
HHHHHHHHCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KAIVNKASFATRSAEIQSIINRLSTVVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376