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The map label for this gene is pabA [H]

Identifier: 23097981

GI number: 23097981

Start: 558093

End: 558704

Strand: Reverse

Name: pabA [H]

Synonym: OB0526

Alternate gene names: 23097981

Gene position: 558704-558093 (Counterclockwise)

Preceding gene: 23097982

Following gene: 23097980

Centisome position: 15.39

GC content: 36.6

Gene sequence:

>612_bases
ATGATTTTATTAATCGATAACTACGACTCATTTACGTATAACCTCTATCAATATATTTCTGAATTTAATAAGGAAGTCCG
TGTTATTCGAAATGACGCAATAACACCTAATGAAATACGAGCCATGCATCCTGAAGCAATTATTATATCTCCTGGACCAG
GTTCTCCGACAAAAGCAGGAAATTGCTTGAAGATTGTACGGGAAGTATATCGAGAATTCCCAATACTCGGTATTTGTCTA
GGACATCAGGTACTTGCAGAAGCTTTAGGGGGAGAAATAAAACAAGCCAAAGTGATAAAACACGGAAAAACGTCACCTAT
CTCAATAAAAGATTCACAGTTATTACATTCACTTCAACATCCAATACAGGTCATGCGTTACCATTCACTTATTGTTGATC
GAAAAAGTCTATCTGCCGATTACCAAGTGACAGCACGATCTCTGGATGATAATGAGATTATGGCAATCGAACATAAACAA
CTACCACTCTTTGGAATGCAGTTTCACCCAGAATCAATCGGTACAAAGGATGGAAAGCAAATCATTAAGAATTTCTTAAT
CCAAATCAAAGCCTTACAGGAGGATGAAAATAATGAAGCACTCACTTCATAA

Upstream 100 bases:

>100_bases
TACTTACAAGCAGGAGCAGGAATCGTTTATGATTCCATACCTACAAGTGAGTATATTGAAACGCTAAATAAAGCCAAATC
ATTTATGGAGGTGGACGATC

Downstream 100 bases:

>100_bases
AATTATTGAACGACAAGATTTATCCACAGAAGAAATAAAAGAAGTATTTAAACATTGTTTCTCACAAGAAGTATCTGATT
CGGAACTAGCAGCCATTCTT

Product: anthranilate synthase component II

Products: NA

Alternate protein names: ADC synthase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MILLIDNYDSFTYNLYQYISEFNKEVRVIRNDAITPNEIRAMHPEAIIISPGPGSPTKAGNCLKIVREVYREFPILGICL
GHQVLAEALGGEIKQAKVIKHGKTSPISIKDSQLLHSLQHPIQVMRYHSLIVDRKSLSADYQVTARSLDDNEIMAIEHKQ
LPLFGMQFHPESIGTKDGKQIIKNFLIQIKALQEDENNEALTS

Sequences:

>Translated_203_residues
MILLIDNYDSFTYNLYQYISEFNKEVRVIRNDAITPNEIRAMHPEAIIISPGPGSPTKAGNCLKIVREVYREFPILGICL
GHQVLAEALGGEIKQAKVIKHGKTSPISIKDSQLLHSLQHPIQVMRYHSLIVDRKSLSADYQVTARSLDDNEIMAIEHKQ
LPLFGMQFHPESIGTKDGKQIIKNFLIQIKALQEDENNEALTS
>Mature_203_residues
MILLIDNYDSFTYNLYQYISEFNKEVRVIRNDAITPNEIRAMHPEAIIISPGPGSPTKAGNCLKIVREVYREFPILGICL
GHQVLAEALGGEIKQAKVIKHGKTSPISIKDSQLLHSLQHPIQVMRYHSLIVDRKSLSADYQVTARSLDDNEIMAIEHKQ
LPLFGMQFHPESIGTKDGKQIIKNFLIQIKALQEDENNEALTS

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=182, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1789760, Length=186, Percent_Identity=51.6129032258064, Blast_Score=200, Evalue=6e-53,
Organism=Escherichia coli, GI1787517, Length=200, Percent_Identity=36, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786215, Length=151, Percent_Identity=29.8013245033113, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788854, Length=197, Percent_Identity=24.3654822335025, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322638, Length=186, Percent_Identity=44.6236559139785, Blast_Score=164, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6324361, Length=209, Percent_Identity=30.1435406698565, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322331, Length=152, Percent_Identity=27.6315789473684, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24642586, Length=149, Percent_Identity=29.5302013422819, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45555749, Length=149, Percent_Identity=29.5302013422819, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 22934; Mature: 22934

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLIDNYDSFTYNLYQYISEFNKEVRVIRNDAITPNEIRAMHPEAIIISPGPGSPTKAG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCEEEEECCCCCCCCCC
NCLKIVREVYREFPILGICLGHQVLAEALGGEIKQAKVIKHGKTSPISIKDSQLLHSLQH
HHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
PIQVMRYHSLIVDRKSLSADYQVTARSLDDNEIMAIEHKQLPLFGMQFHPESIGTKDGKQ
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCEECEEECCHHCCCCHHHH
IIKNFLIQIKALQEDENNEALTS
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MILLIDNYDSFTYNLYQYISEFNKEVRVIRNDAITPNEIRAMHPEAIIISPGPGSPTKAG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCEEEEECCCCCCCCCC
NCLKIVREVYREFPILGICLGHQVLAEALGGEIKQAKVIKHGKTSPISIKDSQLLHSLQH
HHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
PIQVMRYHSLIVDRKSLSADYQVTARSLDDNEIMAIEHKQLPLFGMQFHPESIGTKDGKQ
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCEECEEECCHHCCCCHHHH
IIKNFLIQIKALQEDENNEALTS
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350604; 2403545; 9278503; 2546924; 8096767 [H]